5KC2,2CHX,4A55,6BQ1


Conserved Protein Domain Family
PI3Ka

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pfam00613: PI3Ka 
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Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation.
Statistics
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PSSM-Id: 395488
Aligned: 12 rows
Threshold Bit Score: 189.463
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5KC2_C  295 KQVKP-DIKKRDYLNKIINYPPGTKLTAHEKGSIWKYR-Y-YLmNNKKALT------KLLQ-STNLREESERVEVLELMD 364  baker's yeast
P54673 1041 PPTNInSNEMREFFEQITALDPLSDLKQEKYNQLWTLRhY-SI-LFPQVLP------RLML-SVPWTQATAVDEAISLLD 1111 Dictyostelium disco...
2CHX_A  401 VRAEM-PNQLRKQLEAIIATDPLNPLTAEDKELLWHFR-YeSL-KHPKAYP------KLFS-SVKWGQQEIVAKTYQLLA 470  human
4A55_A  547 RDNEL-RENDKEQLRALCTRDPLSEITEQEKDFLWSHR-H-YCvTIPEILP------KLLL-SVKWNSRDEVAQMYCLVK 616  house mouse
P42338  526 VSSRG-GKKFLPVLKEILDRDPLSQLCENEMDLIWTLRqD-CReIFPQSLP------KLLL-SIKWNKLEDVAQLQALLQ 596  human
P54674 1327 VGLKKlDLDEARRLKALMDSDPLVQLSAEDKKLVYGYR-H-IYkSKPKALA------KFLL-SVNWIDPDQVTDAYRQMN 1397 Dictyostelium disco...
P54675 1061 NELPVvTMEEMDRVEQIILQDPLYSLNKEERLLIWKSR-Y-FChTKPQALS------KLLQ-SVEWTNYKQVGEAFQLLK 1131 Dictyostelium disco...
6BQ1_E 1106 ARFKN-TEAIGNEVTRLVRLDPGA------------------VsDVPEAI-------KFLV---TWHTIDADAPELSHVL 1156 human
P37297 1347 EGADS-NELTSDIVEATFAKDPTLAINLLQRCYSKKAEdV-LVgLVAKHAlmcvgspSALDlFIKGSHLS-SKKDLHATL 1423 Saccharomyces cerev...
P50520  258 KDLKP-NSKIRKELESILSYPPSEELSLEEKDLIWKFR-F-YLtRNKKAMT------KFLK-SVVWTDSSEVNQALSLLD 327  Schizosaccharomyces...
P54676  277 KDLKP-NSTELKGLTDILKQPPNTKVTSKEALLIWRFR-Y-YLtNNKKALT------KFLR-CVEWSESHQKNEALSIMP 346  Dictyostelium disco...
P42339  275 RDLKP-SNIERKSIQRVLKYPPTRTLSGDERQLLWKFR-F-SLmSEKRALT------KFLR-CVEWSDVQEAKQAIQLMY 344  thale cress
5KC2_C  365 S---WAE--IDIDDALELLGSTFKN---LSVRSYAVNRLKK-ASDKELELYLLQLVEAVCFEnlstfsdksnseftivda 435  baker's yeast
P54673 1112 R---WPK--LKPYESLELLDAKHAN---RKVREFAVTCLED-LSEDELLDILLQLVQVLKYE------------------ 1164 Dictyostelium disco...
2CHX_A  471 RrevWDQsaLDVGLTMQLLDCNFSD---ENVRAIAVQKLES-LEDDDVLHYLLQLVQAVKFE------------------ 528  human
4A55_A  617 D---WPP--IKPEQAMELLDCNYPD---PMVRSFAVRCLEKyLTDDKLSQYLIQLVQVLKYE------------------ 670  house mouse
P42338  597 I---WPK--LPPREALELLDFNYPD---QYVREYAVGCLRQ-MSDEELSQYLLQLVQVLKYE------------------ 649  human
P54674 1398 D---WAL--LKPVQALEILDAKFAD---EHVRNFAIKIINS-FSDAEFSDFLLQLTQVLKYE------------------ 1450 Dictyostelium disco...
P54675 1132 I---WPT--LSAVDALELLDPKFADc--VEIREYAVKCLDQ-MSDYELEIYMLQLVQAIKHD------------------ 1185 Dictyostelium disco...
6BQ1_E 1157 C---WAP--TDPPTGLSYFSSMYPPh--PLTAQYGVKVLRS-FPPDAILFYIPQIVQALRYD------------------ 1210 human
P37297 1424 Y---WAP--VSPLKSINLFLPEWQGn--SFILQFSIYSLES-QDVNLAFFYVPQIVQCLRYD------------------ 1477 Saccharomyces cerev...
P50520  328 S---WTE--IDIDDALELLSPSFVH---PKVRAYAVSRLET-ASNEELLLYLLQLVQALRYDnpis-------------- 384  Schizosaccharomyces...
P54676  347 K---WDP--IDIADSLELLSSAFTHkntIMVRRYAVEILKK-ADDEELLYYLLQLVQATKYEqf---------------- 404  Dictyostelium disco...
P42339  345 K---WEM--IDVCDALELLSPLFES---EEVRAYAVSVLER-ADDEELQCYLLQLVQALRFE------------------ 397  thale cress
5KC2_C  436 vssqklsgdsmllstshanqkllksissesetsgteslPIVISPLAEFLIRRALVNP-RLGSFFYWYLKSES------ED 508  baker's yeast
P54673 1165 --------------------------------------PFHDSKLSRFLLRKAILNR-NIGHSFFWYLKSDL------HD 1199 Dictyostelium disco...
2CHX_A  529 --------------------------------------PYHDSALARFLLKRGLRNK-RIGHFLFWFLRSEIa-----QS 564  human
4A55_A  671 --------------------------------------QYLDNLLVRFLLKKALTNQ-RIGHFFFWHLKSEM------HN 705  house mouse
P42338  650 --------------------------------------PFLDCALSRFLLERALGNR-RIGQFLFWHLRSEV------HI 684  human
P54674 1451 --------------------------------------PYHNSDLTHILIQRALSNRsRIGHFFFWFLKSEM------HT 1486 Dictyostelium disco...
P54675 1186 --------------------------------------VFHNSVLSLFLIGRVWQNMqVLGHPFFWHLRADI------DN 1221 Dictyostelium disco...
6BQ1_E 1211 ----------------------------------------KMGYVREYILWAASKSQ-LLAHQFIWNMKTNIyl--deEG 1247 human
P37297 1478 ----------------------------------------KTGYVERLILDTAKISV-LFSHQIIWNMLANCykddegIQ 1516 Saccharomyces cerev...
P50520  385 -----------------------------------sdeRFQPSPLALFLVNRAISSP-SIGNDLYWYLVVEI------ED 422  Schizosaccharomyces...
P54676  405 ------------------------------------dgNPSDSPLISFLFERSNKNF-ILGSHFYWYLTVDSv----lKS 443  Dictyostelium disco...
P42339  398 --------------------------------------RSDRSCLSQFLVQRALQNI-ELASFLRWYVAVEL------HD 432  thale cress
5KC2_C  509 KPY-LDQILSSFWSRLDKK-SRNILNDQV 535  baker's yeast
P54673 1200 SNL-SERFGILLESYLYAC-GAHRIELLK 1226 Dictyostelium discoideum
2CHX_A  565 RHY-QQRFAVILEAYLRGC-GTAMLHDFT 591  human
4A55_A  706 KTV-SQRFGLLLESYCRAC-GMYLKHLNR 732  house mouse
P42338  685 PAV-SVQFGVILEAYCRGS-VGHMKVLSK 711  human
P54674 1487 PEI-EERYGLLLEGYLRSC-GTHRQDLIK 1513 Dictyostelium discoideum
P54675 1222 QEV-CERFRVLSSGFLRYA-PTQLMESFK 1248 Dictyostelium discoideum
6BQ1_E 1248 HQK-DPDIGDLLDQLVEEI-TGSLSGPAK 1274 human
P37297 1517 EDEiKPTLDRIRERMVSSF-SQSHRDFYE 1544 Saccharomyces cerevisiae S288C
P50520  423 EPV-SKLFSSVMFLFQKEL-SKSVEGRLI 449  Schizosaccharomyces pombe 972h-
P54676  444 SIF-CSHYKTLQELYFRQLdHTDAQRVNA 471  Dictyostelium discoideum
P42339  433 HVY-AKRFYSTYELLEENI-IKLPPGVNG 459  thale cress
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