Conserved Protein Domain Family
BRCT

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pfam00533: BRCT 
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BRCA1 C Terminus (BRCT) domain
The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.
Statistics
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PSSM-Id: 278934
View PSSM: pfam00533
Aligned: 87 rows
Threshold Bit Score: 31.8962
Threshold Setting Gi: 1723501
Created: 15-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam00533 is a member of the superfamily cl00038.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z56_C          1 PISNIFAGLLFYVlsdyvtedTGIRITRAEL---EKTIVEHGGKLiynviLKRHSIGDVRLIs--------CKTTTECKA 69
gi 380865396  384 NKHTNLVTSSFNL--------------TKPM---KSFIRRNGLRV-----QESVTDETDFVIlgs----ppLRRTHKFLL 437
1L0B_A          1 -KERAERDISMVV----------SGLTPKEVmivQKFAEKYRLAL-----TDVITEETTHVIiktd-aefvCERTLKYFL 63
3COJ_B         18 gshmVNKRMSMVV----------SGLTPEEFmlvYKFARKHHITL-----TNLITEETTHVVmktd-aefvCERTLKYFL 81
gi 3024713     27 IYEIKFHEFVLFIle-----kKMGATRRTFL---TDLARKKGFRV-----ENELSNSVTHIVaennsgsdvLAWLKTHKM 93
2COE_A         16 PQDIKFQDLVVFIle-----kKMGTTRRALL---MELARRKGFRV-----ENELSDSVTHIVaennsgsdvLEWLQAQKV 82
gi 549065      27 GYEIKFNKLVIFImq-----rKMGMTRRTFL---MELARSKGFRV-----ESELSDSVTHIVaennsypevLDWLKGQAV 93
gi 74964344   173 VYSSVFQDVKISFt-------GLNLTKKQEL---YEKIGWMCGVV-----GDALYHETTHLVte------kaEQTEKYKA 231
gi 363548502 1089 VFQDQEHEPKFFIv-------SGPRSQRNEY---QQIIRRLKGKCcr--dSHQWSYQATHFIap------eiRRTEKFFA 1150
gi 296453012 1260 THEELKKQYIFQLs-------SLNPQERIDY---CHLIEKLGGLVi---eKQCFDPTCTHIVvg------hpLRNEKYLA 1320
                          90
                  ....*....|....*...
1Z56_C         70 LIDRGYDILHPNWVLDCI 87
gi 380865396  438 ATSLGIPLVSSQYLTDCI 455
1L0B_A         64 GIAGGKWIVSYSWVIKSI 81
3COJ_B         82 GIAGGKWVVSYFWVTQSI 99
gi 3024713     94 EKTTQFELLDISWLIECM 111
2COE_A         83 QVSSQPELLDVSWLIECI 100
gi 549065      94 GDSSRFEILDISWLTACM 111
gi 74964344   232 AVNNSIKLMRIGWIDDLW 249
gi 363548502 1151 AAASGSWILKTDYVADSK 1168
gi 296453012 1321 SVAAGKWVLHRSYLEACR 1338
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