Conserved Protein Domain Family
Ion_trans

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pfam00520: Ion_trans 
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Ion transport protein
This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices
Statistics
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PSSM-Id: 249927
View PSSM: pfam00520
Aligned: 286 rows
Threshold Bit Score: 45.3563
Threshold Setting Gi: 38503242
Created: 28-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:
pfam00520 is classified as a model that may span more than one domain.
pfam00520 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LUT_B        224 IVETLCIIWFSFEFLVRFFACPSk----------------AGFFTNIMNIIDIVAIIPYFITLGTELAEKPedaqqgqQa 287
gi 75075040   139 IVETLCIIWFSFELVVRFFACPSk----------------TDFFKNIMNIIDIISIIPY--------------------- 181
gi 38503240   130 FIDAFYVVHMLFQFHTGFI-TPsssgfgrgelnekhkdiaLRYLGSYFL-IDLLSILPIPQVVVLAIVPRM-------Rr 200
gi 81886460   376 SIDVKYQMWKLGVVFTDNS-----------------------FLYLAWY--MTMSVLGHYNNFFFAA------------- 417
gi 74893161  1241 SVDWRYQVWKAGVTVTDNQ-----------------------FLYNLWY--LTFSVLGN-INYFFFAAH----------- 1283
gi 82227439  4820 QIWKFGVVFTDGTFLYLCWYLI------------------MSLLGHYNN--FFFACHLLDIAMGV--------------- 4864
gi 74893945   265 QVWKAGVTITDNSFLYSLWYFS------------------FSVMGNFNN--FFFAAHLLDVAVGF--------------- 309
gi 74764518  2376 VSLMGNKGTFAKRLEQQVTDGELl----------------YHVIYLVFC-VLGLSVHPF---CYSVL------------- 2422
gi 44888998  2410 IFSLVIVLALPRESGIRTFIGSVil--------------rFIFLLGPES----TLCLLGVVTVTLKSVHIV-------Si 2464
gi 313104120 2362 CNKIIFLMSFVGNCGTFTRGYR-------------------AMVLDVEFLYHLLYLLICAMGLFVHE------------- 2409
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LUT_B        288 --------------------------------MSlAILRVIRLV-RVFRIFKLSR-HSKGLQILG-QTLKaSMRELGLLI 332
gi 75075040   182 --------------------------------------------------------LATLITELVqEDGA-QRQQNMSLA 204
gi 38503240   201 pasl------------------------vakeLL-KWVIFCQYVpRIARIYPLFKeVTRTSGLVTeTAWA-GAALNLFLY 254
gi 81886460   418 ---------------------------------------------HLLDIAMGFKtLRTILSSVT-HNGK-QLVLTVGLL 450
gi 74893161  1284 ----------------------------------------------LLDVAVSIPsLKTILQSVT-HNGK-QLILTCMLL 1315
gi 82227439  4865 ------------------------------------------------------KtLRTILSSVT-HNGK-QLMMTVGLL 4888
gi 74893945   310 ------------------------------------------------------KtLRTILQSVT-HNGK-QLVLTVMLL 333
gi 74764518  2423 ----------------------------------------------LFDVVYREEtLLNVIRSVT-RNGW-SIILTAALA 2454
gi 44888998  2465 mgnkgtlekqlikiitdfqllyhciyiafcfcGLiFHPFFYSLL--LFDVVYREEtLVNVIRSVT-RNGR-SIVLTAVLA 2540
gi 313104120 2410 ---------------------------------------FFYSL-LLFDLVYREEtLLNVIKSVT-RNGR-SIILTAVLA 2447
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LUT_B        333 FFLFIGVILFSSAVYFAEADE----------------------------------------------------------- 353
gi 75075040   205 ILRII-RLVRVFRIFK---------------------------------------------------------------- 219
gi 38503240   255 MLASHVFGSFWYLISIERKDRcwreacakiqncthaylycsptgednrlflng------scplidpeeitnstvfnfgif 328
gi 81886460   451 AVVVYLYTVVAFNLFRKFYNKse--------------------------------------------------------- 473
gi 74893161  1316 TIIVYCYTVIAFNFFRKFYVSeeddv------------------------------------------------------ 1341
gi 82227439  4889 AVVVYLYTVVAFNFFRKFYNKsed-------------------------------------------------------- 4912
gi 74893945   334 TIIVYIYTVIAFNFFRKFYVQeedde------------------------------------------------------ 359
gi 74764518  2455 LILVYMFSIIGYMFFRNDFIVdvtdndidwdtiqkhinqriesyvttslsvkknsvedtcemgvdcteedssnlynvvds 2534
gi 44888998  2541 LILVYLFSIIGYMFFKDDFLVsvdfeeqdnapppsvpltlsvpvsgds----------------csapddlgncqaakev 2604
gi 313104120 2448 LILVYLFSIVGYLFFKDDFILevdrlpnetavpetgeslandflysdv---------------crvetgenctspapkee 2512
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
3LUT_B        354 ----------RDSQFPSIPDAFWWAVVSMTTVGYGDMVP-----------TTIGGKIVG-SLCAIAGVLTIALPVPVI 409
gi 75075040   220 --------------LSRHSKGLQILG---QTL---KASM------------RELGLLIF-FLFIGVILFSSAVYFAEV 264
gi 38503240   329 adalqsgvveSRDFPKKFFYCFWWGLRNLSAL---GQNLkt--------sAFEGEIIFA-IVICISGLVLFALLIGNM 394
gi 81886460   474 --------dgDTPDMKCDDMLTCYMFHMYVGVRAGGGIGdeied-pagdeYEIYRIIFDiTFFFFVIVILLAIIQGLI 542
gi 74893161  1342 ------vdqkCHDMLTCFVFHLYKGVRAGGGIGDEIEAPdg-------deYELYRIIFDiTFFFFIIVILLAIIQGLI 1406
gi 82227439  4913 -------edePDMKCDDMMTCYLFHM-YVGVRAGGGIGDeiedp--agdeYELYRVVFDiTFFFFVIVILLAIIQGLI 4980
gi 74893945   360 ------vnrnCHDMLTCFVFNLYKGVRAGGGIGDELEPPdg-------ddSEVYRIIFDiSFFFFIIVILLAILQGLI 424
gi 74764518  2535 itkevmveveDAKEEACSTLLMCIVTSLNHGLRSGGGIGdilrapsnkenLFAARVIYDlLFFFVVIIIVLNLIFGVI 2612
gi 44888998  2605 appsagggevKERSCDSLVMCIVTTL--NQGLRNGGGIGdilrapsskegLFVARVIYDlLFFFIVIIIVLNLIFGVI 2680
gi 313104120 2513 llpaeeteqdKEHTCETLLMCIVTVL--SHGLRSGGGVGdvlrkpskeepLFAARVIYDlLFFFMVIIIVLNLIFGVI 2588
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