Conserved Protein Domain Family
Integrin_beta

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pfam00362: Integrin_beta 
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Integrin, beta chain
Integrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer. The sequences repeats have been trimmed due to an overlap with EGF.
Statistics
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PSSM-Id: 278776
View PSSM: pfam00362
Aligned: 132 rows
Threshold Bit Score: 400.75
Threshold Setting Gi: 597794282
Created: 11-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam00362 is a member of the superfamily cl00057.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4UM9_B        30 TCEDCLLIgPQCAWCAQENFTHps-gvGERCDTPAnllAKGCQLNfIE--N-PV--S--QV-EILKNKP---LSvgrqKn 97
gi 122067717  33 TCVECLDAdYDCAWCTDENYGm----yKHRCMTFDdlvASNCSKSqIE--T-NDyfS--KL-EVEENRP---LL----D- 94
gi 74799383   38 NCIECLDAdKDCAWCTDELYDm----rKSRCMTKHellESKCNALkIE--T-NDdyS--FL-QIGKNEP---HR----D- 99
gi 307203961  39 SCENCLEAsSACAWCSDWTYSNst-hgKPRCNVPErlrAFGCPAAeIR--TaPP--G--SL-ELLANED---FQ----Dv 103
gi 170035229  33 TCIECLDTdYACAWCTDESYGMy----KSRCMTLDdlrANNCSESgIEtnF-NF--S--KL-DIVQNDPprdFD----Re 98
gi 328786925  37 TCENCLQAsSSCAWCSDWFYSNst-igRPRCNVPErlkEFGCSPEkIH--TtPL--E--SM-TLLEDSD---FQ----Dm 101
gi 568249885  40 nyyDCLDAdEQCAWCTDELYEMr----KYRCMHEEkllASNCSASkIL--T-ND--NyqFI-ETLLNEP---HR----Df 102
gi 315133297  36 SCSECMGIrPACSWCSADEFDDtkegpGFRCAPSSvllARGCPQSsIE--D-VE--S--VL--LDHGVP---LDq---As 100
gi 405971672  24 rCGDCL-InDGCGWCKDSEFSFp------RCAPINqltDNGC--VaVI--K-RK--E--HVvQLLQNDE---FS----Dg 80
gi 357623485  27 TCHNCIRDaNKCVWCDSHKFNDt------KCKSAAeqlENWCPHT-II--N-PK--S--VV-KVITNND---FS----Se 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4UM9_B        98 --S--S-----D--IVQIAPQSLILKLRPGGA-QTLQVHVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLSKEMSK 165
gi 122067717  95 -----YdreklG--ATQIRPQRLKIHLGKLES-HSFKFTYKPAKNYPLDLYYLMDLTWSMKDDRDTLINMGDQLAKALAN 166
gi 74799383  100 -----FdsqqlE--AVQIMPQKMNLRLGKLGS-RTISFKYKPAKNYPLDMYYLMDLTWSMRDDKATLESMGSQLALALAN 171
gi 307203961 104 --S--N-----DraPVQLRPQRLRLRIRPHTS-QELTLQYRPAKNYPLDLYYLMDLTWSMKDDKETLVGLGCRMANTLGT 173
gi 170035229  99 --R--L-----E--AVQISPQRIKMKLG------------KPAKHYPLDLYYLMDLTWSMKDDRDTLVNMGDQLAKALAN 155
gi 328786925 102 eaD--H-----T--PIQLRPQRVNIRIPPYSK-MTIPIRYRLAKNYPLDLYYLMDLTWSMKDDKETLVSLGGDMSRRIGK 171
gi 568249885 103 deK--M-----Q--AIQISPQKVRFVLGKLAA-RTVTVTYKPAKNYPLDMYYLMDLTWSMRDDKANLEKMGSELALALAN 172
gi 315133297 101 --L--T-----E--DIQLTPRSQSVKVRPGGT-MMVNFTFQSISDYPVDLYFLTDLSYTMIDDLETVSRLTNDIVLTMRN 168
gi 405971672  81 --GpgL-----E--PVQIKPQRIKIRLTPNSQlRNVMVFYKIAKNFPLDLYFLNDPSYTMRQLTSSLNLLANDIANDIAT 151
gi 357623485  85 --R--G-----K--VIHMKPQQIQINIRPGDV-IDFDFSFRKAQNYPVDLYFLLDGSASMASVKNEIVKQTESIYQMMKS 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4UM9_B       166 LTSNFRLGFGSFVEKPVSPFVKTTPEEIANPCSSip---yfCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGG 242
gi 122067717 167 LTENYRLGFGSFIDKPIMPFIQTEEDRVRNPCSTer---dvCEPTYGFRHRLEITKNIDRFIEKLKTSNVSANLDNLEGG 243
gi 74799383  172 LTANYQLGFGSFADKPAFPFIQSEPHRLQNPCYSen---dqCEPTYGFKHRLKITRDIDSFIAQVKESNVTGNVDNLEAG 248
gi 307203961 174 FTTNFRLGFGSYADKPLMPYIF--PGHEENPCKSeh---afCTPLYSFWHHLELTDNIPRFIHEVNYSSVTGNVDNLEGG 248
gi 170035229 156 LTENYRLGFGSFIDKPIMPFMQTEAHRQANPCISer---evCEPTYGFRHRLQITKNTDKFIEKLKTSNVSANLDNLEGG 232
gi 328786925 172 FTNKYRLGFGSYADKPVMPYI--LPGHEKNPCVSeh---avCSSIYSYWHHLRLTDDIQRFITKVNNSLVTGNADNLEGA 246
gi 568249885 173 LTANYRLGFGSFADKPAMPFIQSEPHRLANPCYSen---eqCEPTYGFRHRLRISSDIDSFIEQVKQSNVTGNIDNLEAG 249
gi 315133297 169 VTKKLQMGFGAFVDKPVFPFVVPTPEYLRNPCLNvgtknlhCDPPFLYKHILSLTDNFEEFREKTKVARPSGNLDSPEGG 248
gi 405971672 152 LTTDFTFGLGTSMDKVVSPFTRQDPKYLATPCGTts---ipCDFPYSFIHRQSLTNDITAFTNAVRGVNTTGNQDIVEGL 228
gi 357623485 153 MTDNVYLGMGSFVDKNLLPFTNVl----------------nSTNTYSFRNRLKLINDPEAFKKTINDTAFGYNYDEQEGT 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4UM9_B       243 FDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVCPNDGLCHL-------DSKNEYSM---STVLEYPTI 312
gi 122067717 244 LDALMQVLVCDDRIGWGKNTRKIVILATNGLMHMAGDGKLAGITERNDKECHL-------SAEGEYTG---TLTYDYPSL 313
gi 74799383  249 LDALMQVLVCEKQIGWGSNTRKIVIVATDGWLHMAGDGLLAGIVEENDKQCHL-------DSDGNFVD---ALKYDYPSL 318
gi 307203961 249 LDGVVQAIVCTQQVGWAHQARKLMLLATDGFLHFAGEGKLGGVVHRPDFQCHV-------DENGQYSL---AKEYDYPSL 318
gi 170035229 233 LDALMQVLVCGDRIGWGENTRKIVILATNGYLHMAGDGLLAGITERNDKQCHL-------SQEGEYTG---TLQYDYPSL 302
gi 328786925 247 LDGIVQTIVCTEQVGWEHQARKIILVVTDGHLHFAGDGKLGGIVKRQDFKCHL-------DERQQYFL---ASEFDYASL 316
gi 568249885 250 LDALMQVLVCEKQIGWGSNTRKIVVIATDSLLHMAGDGLLAGIIRDNDKQCHL-------SDDGNFVQ---ELQYDYPSL 319
gi 315133297 249 MDALLQVARCSEAIGWRAGARKIVLFASDGGFHLAGDGRIAGLILPPPTTCQLtyqadrfNSSLKYLGwhnSDQTDYPSV 328
gi 405971672 229 LDGLMQVMVCGDRIGWRKKSRRMVIYATDINFHHAGDGRVAGILQPNDGLCHL-------DSNGKYTM---AEVQDYPSV 298
gi 357623485 217 LDALAQVIVCKEQIGWREESRKIILVFTGASFHAASDGIFGGVVEPYDGKCYL-------END-VYSK---ETVMDYPSV 285
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4UM9_B       313 GQLIDKLVQNNVLLIFAVTQE-----QVHLYENYAKLI-P-G--ATVGLLQKDSGNILQLIISAYEELRSEVELEvL-GD 382
gi 122067717 314 EQIYRVLAKSKTAVIFAVTDE-----LKDYYWSMRELM-SeF--ASVGLLQDDSSNILQLVDTGYRDFVKRVEFT-D-DA 383
gi 74799383  319 EQIWRVLLRSKTAVIFAVTEA-----QQAYYRRLSDLM-PeF--TSVGRLQDDSSNIIQLVDEGYREFVKRVEFI-D-NS 388
gi 307203961 319 AEVSRLLQERKVNLIFAVTED-----RRHEYELIADLLkE-H--ARVATLTRNSSNILEIIESSYHDIVSKVVLR-D-NS 388
gi 170035229 303 EEIYRVLVKSKTAVIFAVTDE-----LQDYYRSLNDLMsE-F--TSVGALQDDSSNILQLVNTGYRDFVRKVEFT-D-NS 372
gi 328786925 317 AELSRLLQEHKINLIFAVTRD-----LLDEYEETVKLLrE-K--ARVAILTSDSSNILDIIESSYHQITSKVILK-D-NS 386
gi 568249885 320 EQIWRVLEKTKTAVIFAVTDE-----KQTYYKRLSALV-PeF--TSVGQLQDDSSNIIQLVKDGYREFVNRIMFT-D-DA 389
gi 315133297 329 GEIAQVLTEADISVIFAVDSK-----LHGLYTKLAEFL-P-S--AAVGILTDSSTNIVRLLRDNYDKIVNKAELMaT-YD 398
gi 405971672 299 GQILQKARENNINIIFVIGGAenefiRNNYYDKFATYL-P-GgfNNASELTTDGSNILNIVGSSYRRLRETVKLVmT-KV 375
gi 357623485 286 GIINKLASEDEKIIIFAIDEE-----AKNIYKSLTNFI-T-G--SKVTKYGGD--LIANMLKTVYEEISQNLKLKvNmDA 354
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4UM9_B       383 TEGLNLSFTAI--CNN-G-TL-FQ-H-QKKCSHMKVGDTASFSVTV--NIPHCe----R--RSRHIIIKPVGL-G-D--- 442
gi 122067717 384 PAYIQISYKTD--CGG-IyKT-PQ-P-TSKCDNIEIGKEYDFFVEV--RLLEYpn-raE--SNLTVKIEETLL-SnE--- 448
gi 74799383  389 PDYMQLRYTTD--CAG-LyRE-PQ-P-INRCDNIEIGKEYKFNVEI--HLLEYpkdpsI--TNVTVRIEEKLI-SnE--- 454
gi 307203961 389 TGPLRLEYFSA--CGG-Q-TA-AEsS-TSECDGIQEGHVYEFKVVI--SVDECpr--nEslWKQTVVIDDALA-S-Ea-s 455
gi 170035229 373 PSYLEISYKTD--CGG-M-YT-KP-QlTSKCDNIEIGKEYEFFVEV--RLINYpp--eSv-SNLTVKIEETLI-S-Negv 439
gi 328786925 387 SSPLKMKYFSN--CGK-G-NVsGW-N-IAECDGIEDGKVYDFQVVL--SFDECpk--dEnlWKQTVIIEDALA-S-E--- 451
gi 568249885 390 PDYIQLKYLTD--CGGmY-ET-PQ-P-IYRCSNIETGKEYNIDVEV--RLLDYpkdpsI--SELTIHIEEKLIsN-E--- 455
gi 315133297 399 ADYLEVQVFSK--CND-E-NE-FS-K-KTVCNDHPVGGKIGYQISI--KAKRCfe--gV----KKVTLKMVAL-E-D--- 458
gi 405971672 376 PEELDVEIYSN--CRT-G-RI-LD-K-TNNCTGLTLEKWTNFTLFLfsNMTTCp---dQ--RTVNFTIFPEGL-E-E--- 438
gi 357623485 355 EHRKNFEFFFNpdCYN----A-YR-Q-YEDCEVVHYEEK-HFTGTI--KLLSYie--nD---SVKMDIVFEGI-K-E--- 414
                        490
                 ....*....|....*.
4UM9_B       443 A--LELLVSPE--CNC 454
gi 122067717 449 S--VELEIYIReaCQC 462
gi 74799383  455 A--VELDIDLRtsCNC 468
gi 307203961 456 E--VQIDVELL--CGC 467
gi 170035229 440 E--LEVDLRQA--CQC 451
gi 328786925 452 AskIIIDIELF--CGC 465
gi 568249885 456 A--IELQIQLR--SNC 467
gi 315133297 459 Q--AVLGVQTA--CSC 470
gi 405971672 439 R--VEIEVEHV--CDC 450
gi 357623485 415 K--IELDISIIkrCDC 428
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