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pfam00270: DEAD 
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DEAD/DEAH box helicase
Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolizm, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Statistics
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PSSM-Id: 249732
View PSSM: pfam00270
Aligned: 182 rows
Threshold Bit Score: 58.4132
Threshold Setting Gi: 2506763
Created: 28-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam00270 is a member of the superfamily cl17251.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RRM_A        29 SKIQERALPLLLhnP-PRN-MI--------AQSQSGTGKTAAFSLTMLTRVnPedASpQAICLAPSRELARQTLEVV--- 95
gi 3914610   233 TRDQQNAIKEIQ-----ND-LTssiackrlIIGDVGCGKTMVILA---SMVlty--pnKTLLMAPTSILAKQLYNEA--- 298
gi 132252    270 TGAQARVVAEIE-----RD-MAldvpmmrlVQGDVGSGKTLVAALAALRAIah---gkQVALMAPTELLAEQHANNF--- 337
gi 3914635   272 TVDQKRVITEIT-----QD-LEreepmarlIQGDVGSGKTLVAFFSCLKIIeq---ggQVALLAPTELLARQHADTA--- 339
gi 3914638   407 TQAQQRVVNEIL-----QD-LNkpspmnrlVQGDVGSGKTVVGVFAILAALqg---gyQAALMAPTEVLAEQHYQKL--- 474
gi 3914611   258 TNAQSRVLREIT-----AD-MSspyrmnrlLQGDVGSGKTAVAAIALYAAIls---gyQGALMVPTEILAEQHADSL--- 325
gi 3914614   362 TRAQERAIKEIL-----ED-LSrdvpmnrlLQGDVGSGKTIVAILTSLAVVks---gyQVAVMVPTEILAHQHYKKF--- 429
gi 13432220  289 TEGQ-REVRDVL-----SDgLAatrplnrlLQGEVGSGKTIVAVLAMLQMIda---gyQCVLLAPTEVLAAQHLLSI--- 356
gi 82010680 1161 SRSNAIVVCNRIahGsDSKhFL--------VRGNVGSGKSTAIPRYLS----D--KG-KVLVLEPTRPLTENVCQQLqne 1225
gi 8247947  1192 TRNTASAVSHQIahNeHKD-II--------LMGAVGSGKSTGLPTNLC----K--FG-GVLLLEPTRPLAENVTKQMrgs 1255
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RRM_A        96 QEMGKFtKIT-----------SQLIVPDSFEKN----KQI---N--AQVIVGTPGTVLDLMRRklmqlQK-IKIFVLDEA 154
gi 3914610   299 LKFLPP-YF------------EVELLLGGSYKKrsnhLFEt--I--THVVIGTQALLFDKRD------LNeFALVITDEQ 355
gi 132252    338 RNWFAP-LGI-----------EVGWLAGKQKGKarlaQQEaiaSgqVQMIVGTHAIFQEQVQ------FNgLALVIIDEQ 399
gi 3914635   340 ARLLAP-IGI-----------RLAFLTGNVKSEgrayLLEalvAgeINLVVGTHALFSKSVR------YHdLRLVIIDEQ 401
gi 3914638   475 VSWFNL-LYL-----------PVELLTGSTKTAkrreIHAqlsTgqLPLLVGTHALIQETVN------FQrLGLVVIDEQ 536
gi 3914611   326 VSLFEK-WDV-----------SVALLTSSVKGKrrkeLLErlaAgeIDILVGTHALIQDEVE------FKaLSLVITDEQ 387
gi 3914614   430 SEMLKD-YGV-----------NVALLTGSLTPSqkksVYKhvkEgnIHVLVGTHALIQDKVE------FKnLGYVIIDEQ 491
gi 13432220  357 RDVLGP-LGMgcqlggaenatQVALLTGSMTMAqkkkVRAdifSgqTGIVIGTHALLQDAIE------FHnLGMVVVDEQ 429
gi 82010680 1226 PWCLDPtMQM-----------RGKSIFGSTP-----------------ITIMTTGFALHLFANnv-erLSeFKFIIFDEC 1276
gi 8247947  1256 PFFASPtLRM-----------RNLSTFGSSP-----------------ITVMTTGFALHFFANnv-keFDrYQFIIFDEF 1306
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
3RRM_A       155 DNMLDQq-GLGDQCIR------VKRFlpkdTQ-LVLFSATFA-DAVRQY 194
gi 3914610   356 HRFGT---KQRYQLEKma---sSKGN----KPhSLQFSATPIpRTLALA 394
gi 132252    400 HRFGV---HQRLALWEkg---qQQGF----HPhQLIMTATPIpRTLAMT 438
gi 3914635   402 HRFGV---LQRSALIQkgregnPQGK----TPhIIMMSATPIpRTLALS 443
gi 3914638   537 HRFGV---QQRAKLLAk-----GNA------PhVLSMTATPIpRTLALT 571
gi 3914611   388 HRFGV---EQRKKLRN------K-GQ----DPdVLFMTATPIpRTLAIT 422
gi 3914614   492 HRFGV---MQRKLLLEk-----GKGL----YPhCLVMSATPIpRTLALS 528
gi 13432220  430 HRFGV---EQRDQLRTk----aRTGI----MPhLLVMTATPIpRTVALT 467
gi 82010680 1277 HVVDSNamAFSCLLEE------YKYN----GK-IISVSATPPgGSEFQT 1314
gi 8247947  1307 HVLDSNaiAFRNLCHE------YSYN----GK-IIKVSATPPgRECDLT 1344
Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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