Conserved Protein Domain Family
DEAD

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pfam00270: DEAD 
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DEAD/DEAH box helicase
Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolizm, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Statistics
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PSSM-Id: 278688
View PSSM: pfam00270
Aligned: 182 rows
Threshold Bit Score: 63.4075
Threshold Setting Gi: 2506763
Created: 14-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam00270 is a member of the superfamily cl21455.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A         49 TEI-QKQTIGLAL-QGK-DVLGAAKTGSGKTLAFLVPVLEALyr------lqWt------STDGLGVLIISPTRELAYQT 113
gi 75539318   245 WPAqHLLGKADVL-KGE-SAIVQMPTSAGKTKATELILRSAFl-----------------AERVSLAIIIAPLRTLCHEI 305
gi 75318295   507 NRV-QSKVYGTALfKAD-NILLCAPTGAGKTNVAVLTILHQLg--------lNmnpggtfNHGNYKIVYVAPMKALVAEV 576
gi 158518649 1328 NPV-QTQIFHTLYhTDC-NVLLGAPTGSGKTVAAELAIFRVFn-----------------KYPTSKAVYIAPLKALVRER 1388
gi 18202096  1136 NAV-QTQFFHTIYhTDT-NIFVGAPTGSGKTMAAELATWRALh-----------------NYPKSKVVYIAPMKALVKER 1196
gi 75318295  1353 NPV-QTQVFTVLYnTSD-NVVVAAPTGSGKTICAEFAILRNHl--------eG-------PDSAMRVVYIAPLEAIAKEQ 1415
4BGD_A        908 NKI-QSQVFESLYnSND-SVFVGSGKGTGKTAMAELALLNHW------------------RQNKGRAVYINPSGEKIDFL 967
gi 207344888  134 NPM-QTMTFYTLYnTNE-NAFVGSPTGSGKTIVAELAIWHAFk-----------------TFPGKKIVYIAPMKALVRER 194
gi 148696231  448 NRI-QSKLYRAALeTDE-NLLLCAPTGAGKTNVALMCMLREIg--------kHinmdgtiNVDDFKIIYIAPMRSLVQEM 517
gi 207345780  499 NPI-QSKVFHAAF-EGDsNMLICAPTGSGKTNIALLTVLKALshhynpktkkL-------NLSAFKIVYIAPLKALVQEQ 569
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A        114 FEVLRKVGKN----HDFSAGLIIGGKDLKHEAERIn--N-INILVCTPGRLLQHMd----ETVSfhATDLQMLVLDEADR 182
gi 75539318   306 KNSLVEAFHNeptkVD-EL-----SDALQTDFEIAellGhQQILVVTPEKLLYVLrhapeL-----AAHIGLLVFDEGHQ 374
gi 75318295   577 VDSLSQRLKD----FGVTVK-ELSGDQS-LTGQEI---KeTQIIVTTPEKWDIITrk-sgDRTY--TQLVRLLIIDEIHL 644
gi 158518649 1389 MDDWKVRIEEk---LGKKVI-ELTGDVT-PDMKSI---AkADLIVTTPEKWDGVSrs-wqNRNY--VQQVTILIIDEIHL 1457
gi 18202096  1197 VKDWGHRLVEp---MGISMI-ELTGDTN-PDVKAV---TnANIIITTPEKWDGITrs-wkSRKY--VQDVSLIILDEIHL 1265
gi 75318295  1416 FRDWEKKFGKg---LGLRVV-ELTGETL-LDLKLL---EkGQIIISTPEKWDALSrr-wkQRKY--IQQVSLFIVDELHL 1484
4BGD_A        968 LSDWNKRFSHl---AGGKIINKLGNDPS-LNLKLL---AkSHVLLATPVQFELLSrr-wrQRKN--IQSLELMIYDDAHE 1037
gi 207344888  195 VDDWRKKITPv---TGDKVV-ELTGDSL-PDPKDV---HdATIVITTPEKFDGISrn-wqTRKF--VQDVSLIIMDEIHL 263
gi 148696231  518 VGSFGKRLAT----YGITVA-ELTGDHQ-LCKEEI---SaTQIIVCTPEKWDIITrk-ggERTY--TQLVRLIVLDEIHL 585
gi 207345780  570 VREFQRRLAF----LGIKVA-ELTGDSR-LSRKQI---DeTQVLVSTPEKWDITTrn-snNLAI--VELVRLLIIDEIHL 637
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
2PL3_A        183 ILDMGFADTMNAVIENL-------PKKRQ-TLLFSATQTkSVKDL 219
gi 75539318   375 FDSGTRGITYELLLTSLrsm----ipaGTqKVLISAVIS-NAEAV 414
gi 75318295   645 LDDN-RGPVLESIVARTlrqiestKEHIR-LVGLSATLP-NCDDV 686
gi 158518649 1458 LGEE-RGPVLEVIVSRTnfisshtEKPVR-IVGLSTALA-NARDL 1499
gi 18202096  1266 LGSD-RGPVLEMIVSRMnyvasqtNKKVR-VLGLSTAVA-NANDL 1307
gi 75318295  1485 IGGQ-GGQVLEVIVSRMryissqvGNKIR-IVALSTSLA-NAKDL 1526
4BGD_A       1038 ISQGVYGAVYETLISRMifiatqlEKKIR-FVCLSNCLA-NARDF 1080
gi 207344888  264 LASD-RGPILEMIVSRMnyissqtKQPVR-LLGMSTAVS-NAYDM 305
gi 148696231  586 LHDD-RGPVLEALVARAirniemtQEDVR-LIGLSATLP-NYEDV 627
gi 207345780  638 LHDD-RGPVLESIVARTfwaskygQEYPR-IIGLSATLP-NYEDV 679
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