Conserved Protein Domain Family
Cyt-b5

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pfam00173: Cyt-b5 
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Cytochrome b5-like Heme/Steroid binding domain
This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.
Statistics
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PSSM-Id: 249651
View PSSM: pfam00173
Aligned: 210 rows
Threshold Bit Score: 35.6368
Threshold Setting Gi: 122065155
Created: 28-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam00173 is a member of the superfamily cl02041.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1SOX_B          7 YTREEVGRHRs--PEERVWVTHGTDVFDVTD-FVELHPGG--------------PDKILLAAGGALEPFWa--------- 60
gi 449081265  247 YSWDQVAKLE-------NYMVIDGYVLNMSP-YLSFNPTAvegdev--dsiirhVLSNQTGSGKDATRLF---------- 306
gi 166203133  413 FTWDDIKNSS------RNLVVYSGHVLDLDL-LHWFNDTQvtyparfkelrdknTAGNQAIRGRDITHAF---------- 475
gi 148887356  408 FTWADIRNNS------RNLFVYSGNVLDLDL-LFWFNRDQvniprrfeelrdknNAANRAIRGRDATRTF---------- 470
gi 122065155  403 VSLQWNNVTD----PARNLAVYRGSVLDLNR-LNNLTTGLsypel-----ydtlKRRNDSWAGRDVTSAV---------- 462
gi 74582634   304 YNWTDI--HE----PGTSLMVFNGNVLDLSR-LRYLTPNIplpiq-----iaqiVGPGSAFIGRDATYWL---------- 361
gi 6648047     47 RTLSKFNGHD----DEKIFIAIRGKVYDCTRgRQFYGPSG----------------PYTNFAGHDASRGLalnsfdldvi 106
gi 74871543    83 FTVKELRQYDgtqPDGRVLVAVNGSVYDVSKgRRFYGPGG----------------PYATFAGRDASRNLatfsvvsidk 146
gi 91206848  1291 VRRADMENLL---LDGSRCIILAGYVCDLSG-YNCESETL--------------RSVLDSGLGKDLTAEM---------- 1342
gi 341941077 1211 IRKADLENHN---KDGGFWTVIDGKVYGIKD-FQTQSLTG--------------NSILAQFAGEDPVVAL---------- 1262
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
1SOX_B         61 ----------------LYAVHGePHVLELLQQ-YKVGELS 83
gi 449081265  307 ----------------FNRQVP-QDAVGCMKArYVAGRID 329
gi 166203133  476 -----------------QSSKD-KQIAECFEEiIKVGSVD 497
gi 148887356  471 -----------------MASGD-RQIAECFEDiIKVGTVD 492
gi 122065155  463 -----------------MRQRL-EREFQCLEQiTRVGFID 484
gi 74582634   362 ----------------STTADR-LKLGKCLTDiLKVGVVD 384
gi 6648047    107 kdwdqpidplddltkeQIDALD-EWQEHFENKyPCIGTLI 145
gi 74871543   147 d----eyddlsdlsavEMDSVR-EWEMQFKEKyELVGKLL 181
gi 91206848  1343 ----------------SSQVHR-TAMEHILEH-HKLGKYM 1364
gi 341941077 1263 -----------------EAALQfEDTQESMHA-FCVGQYL 1284
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