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pfam00147: Fibrinogen_C 
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Fibrinogen beta and gamma chains, C-terminal globular domain
Statistics
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PSSM-Id: 249628
View PSSM: pfam00147
Aligned: 11 rows
Threshold Bit Score: 318.609
Threshold Setting Gi: 120092
Created: 28-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:

pfam00147 is a member of the superfamily cl00085.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2FFD_B         59 SGKECEEIIRK--GGETS---EMYLIQPDSSV-KPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATnt 132
gi 124106312  225 SGKECEEIIRK--GGETS---EMYLIQPDTSS-KPYRVYCDMKTENGGWTVIQNRQDGSVDFGRKWDPYKKGFGNIATne 298
gi 1346006    214 SGKECEKIIRN--EGETS---EMYLIQPEDSS-KPYRVYCDMKTEKGGWTVIQNRQDGSVDFGRKWDPYKQGFGNIATna 287
1M1J_E        212 SGRECEDIYRK--GGETS---EMYIIQPDPFT-TPYRVYCDMETDNGGWTLIQNRQDGSVNFGRAWDEYKRGFGNIAKsg 285
gi 120159     202 IYKDCSDHYVL--GRRSS---GAYRVTPDHRN-SSFEVYCDMETMGGGWTVLQARLDGSTNFTREWKDYKAGFGNLER-- 273
gi 120092      66 YPRDCYDILQS--CSGQSppsGQYYIQPDGGN--LIKVYCDMETDEGGWTVFQRRIDGTINFYRSWSYYQTGFGNLN--- 138
gi 290457668 4071 FPRDCGEEMQN--GAGAS---RTSTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNIS--- 4142
gi 281185495 1980 FPKDCSQAMLN--GDTTS---GLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRR--- 2051
gi 135584    1587 YPKDCSQALLN--GEVTS---GLYTIYLNGDRtQPLQVFCDMAEDGGGWIVFLRRQNGKEDFYRNWKNYVAGFGDPK--- 1658
gi 462084     400 EYIDCLDVLQRrpGGKAS---GLYEVRPRGAK-RALTVHCEQDTDGGGWTLVQQREDGSLNFNRSFSAYREGFGTVDGsg 475
gi 120140     173 TGRDCQDVANK--GAKES---GLYFIRPLKA--KQFLVYCEIDGSGNGWTVFQKRLDGSLDFKKNWIQYKEGFGHLSPtg 245
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2FFD_B        133 dgknycglpGEYWLGNDKISQLTRMG--PTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRG-TAGNALMdga 209
gi 124106312  299 dtkkycglpGEYWLGNDKISQLTRIG--PTELLIEMEDWKGDKVKAHYGGFTVQTEANKYQVSVNKYKG-TAGNALMega 375
gi 1346006    288 egkkycgvpGEYWLGNDRISQLTNMG--PTKLLIEMEDWKGDKVTALYEGFTVQNEANKYQLSVSKYKG-TAGNALIega 364
1M1J_E        286 gkk-ycdtpGEYWLGNDKISQLTKIG--PTKVLIEMEDWNGDKVSALYGGFTIHNEGNKYQLSVSNYKG-NAGNALMega 361
gi 120159     274 ----------EFWLGNDKIHLLTKSK--EMILRIDLEDFNGLTLYALYDQFYVANEFLKYRLHIGNYNG-TAGDALR--- 337
gi 120092     139 ---------TEFWLGNDNIHYLTSQG--DYELRVELNNTLGNHYYAKYNKFRIGDSFSEYLLVLGAYSG----------- 196
gi 290457668 4143 ---------GEFWLGNEALHSLTQAG--DYSMRVDLRAG-DEAVFAQYDSFHVDSAAEYYRLHLEGYHG----------- 4199
gi 281185495 2052 ---------EEFWLGLDNLNKITAQG--QYELRVDLRDH-GETAFAVYDKFSVGDAKTRYKLKVEGYSG----------- 2108
gi 135584    1659 ---------DEFWIGLENLHKISSQG--QYELRVDLRDR-GETAYAVYDKFSVGDAKTRYRLRVDGYSG----------- 1715
gi 462084     476 --------hGELWLGLEAMYLLAHED---STMRVELQGWDGAGAHAEYTVT-LRDDSKGYALQVSDYRG-TAGNALVsg- 541
gi 120140     246 t------gnTEFWLGNEKIHLISTQSsiPYVLRIQLEDWNGRTSTADYASFKVTGENDKYRLTYAYFIGgDAGDAFDgyd 319
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2FFD_B        210 sqlmGENRTMTIHNGMFFSTYDRDNDgwltsDPRKQCSKEDGGG---WWYNRCHAANPNGRYYWGGQYTWDmakh-gtdD 285
gi 124106312  376 sqlvGENRTMTIHNGMFFSTYDRDNDgwvttDPRKQCSKEDGGG---WWYNRCHAANPNGRYYWGGLYSWDmskh-gtdD 451
gi 1346006    365 sqlvGENRTMTIHNSMFFSTYDRDNDgwkttDPRKQCSKEDGGG---WWYNRCHAANPNGRYYWGGAYTWDmakh-gtdD 440
1M1J_E        362 sqlyGENRTMTIHNGMYFSTYDRDNDgwlttDPRKQCSKEDGGG---WWYNRCHAANPNGRYYWGGTYSWDmakh-gtdD 437
gi 120159     338 -----FSR-HYNHDLRFFTTPDRDNDr----YPSGNCGLYYSSG---WWFDSCLSANLNGKYYHQKYKGVR--------N 396
gi 120092     197 ----TAGDSLAYHNTMRFSTYDNDND-----VYSINCASHSSYGrgaWWYKSCLLSNLNG-QYYDYSGAPS--------- 257
gi 290457668 4200 ----TAGDSMSYHSGSVFSARDRDPN-----SLLISCAVSYRGA---WWYRNCHYANLNG--LYGSTVDHQ--------- 4256
gi 281185495 2109 ----TAGDSMAYHNGRSFSTFDKDTD-----SAITNCALSYKGA---FWYRNCHRVNLMG--RYGDNNHSQ--------- 2165
gi 135584    1716 ----TAGDSMTYHNGRSFSTFDKDND-----SAITNCALSYKGA---FWYKNCHRVNLMG--RYGDNNHSQ--------- 1772
gi 462084     542 ---vADDPELTSHGGMTFSTYDRDTDkw----sDGSCAEWYGGG---WWINACQAANLNGVYYQGGPYDPRekppyeveN 611
gi 120140     320 fgddSSDKFFTSHNGMQFSTWDSDND-----KYDGNCAEQVGIG---WWMNKCHAGHLNGVYYQGGTYSKTstpn-gydN 390
                         250       260       270
                  ....*....|....*....|....*....|..
2FFD_B        286 GVVWMNWKGS--------WYSMRKMSMKIRPF 309
gi 124106312  452 GVVWMNWKGS--------WYSMRRMSMKIRPV 475
gi 1346006    441 GVVWMNWQGS--------WYSMKKMSMKIRPY 464
1M1J_E        438 GIVWMNWKGS--------WYSMKKMSMKIKPY 461
gi 120159     397 GIFWGTWPGInqaqpggyKSSFKQAKMMIRPK 428
gi 120092     258 -IYWSYLPGD--------NDQIPFAEMKLRNR 280
gi 290457668 4257 GVSWYHWKGF--------EFSVPFTEMKLRPR 4280
gi 281185495 2166 GVNWFHWKGH--------EHSIQFAEMKLRPS 2189
gi 135584    1773 GVNWFHWKGH--------EYSIQFAEMKLRPS 1796
gi 462084     612 GVVWATYRGS--------DYSLKRTAVRFRRV 635
gi 120140     391 GIIWATWKSR--------WYSMKKTTMKIIPL 414
Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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