4XB3,5BN7


Conserved Protein Domain Family
Alpha-amylase

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pfam00128: Alpha-amylase 
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Alpha amylase, catalytic domain
Alpha amylase is classified as family 13 of the glycosyl hydrolases. The structure is an 8 stranded alpha/beta barrel containing the active site, interrupted by a ~70 a.a. calcium-binding domain protruding between beta strand 3 and alpha helix 3, and a carboxyl-terminal Greek key beta-barrel domain.
Statistics
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PSSM-Id: 395077
Aligned: 18 rows
Threshold Bit Score: 312.754
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4XB3_A         28 GDLKGITSKLD--YLQKLGVMAIWLSPVYD-----------SPMDDNGYDIANYEAIADIFGNMADMDNLLTQAKMRGIK 94   Streptococcus...
P0CW41         37 GDMKGIASKLE--YIKELGTDAIWISPFYD-----------SPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMK 103  Saccharomyces...
P07190         45 GDLNGVTEKLQ--YLKDIGFTGTWLSPIFK-----------SPMVDFGYDISDFYQIHPEYGTMEDFERMIAKAKEVGIK 111  fruit fly
P07192         46 GDLIGITQQLP--YLKEIGITATWLSPIFT-----------SPMADFGYDVADLKGIDPIFGTMEDFEALLARAKELDIK 112  fruit fly
P13080         44 GDLDGVTEKLK--YLKDIGMDGVWLSPIFS-----------SPMADFGYDISNFREIQTEYGDLDAFQRLSDKCKQLGLH 110  yellow fever ...
5BN7_A        179 GDLDGISEKLP--YLKKLGVTALYLNPVFK-----------AP-SVHKYDTEDYRHVDPQFGGDGALLRLRHNTQQLGMR 244  Escherichia c...
Q5L242        173 GDLQGIIDHLD--YLADLGITGIYLTPIFR-----------AP-SNHKYDTADYFEIDPHFGDKETLKTLVKRCHEKGIR 238  Geobacillus k...
Q8R907        169 GDLQGIIDKID--YLKELGINAIYLTPIFL-----------SP-STHKYDTTDYYTIDPHFGDTEKAKELVRKCHDNGIK 234  Caldanaerobac...
Q9KZ11         99 GDLKGLTERLD--YIKGLGTTSIWMAPIFKnqpvq-gtgkdASAGYHGYWITDFTQVDPHFGTNKDLKNLISKAHAKGMK 175  Streptomyces ...
WP_012819102   79 GDWQGIINKINdgYLTGMGVTAIWISQPVEniysvinysgvNNTAYHGYWARDFKKTNPAYGTIADFQNLIAAAHAKNIK 158  Paenibacillus...
4XB3_A         95 IIMDLVVNHTSDEHAW-----------FIEAREHPDSS--ERDYYIW---------------CDQPNDLES------IFG 140  Streptococcus...
P0CW41        104 FITDLVINHCSSEHEW-----------FKESRSSKTNP--KRDWFFWrppkgy----daegkPIPPNNWRS------YFG 160  Saccharomyces...
P07190        112 IILDFVPNHSSTENEW-----------FTKSVD-SDPV--YKDFYIWhdgkin----netgeREPPSNWNS------EFR 167  fruit fly
P07192        113 IILDFVPNHTSDECDW-----------FIRSAA-GEEE--YKDFYVWhtgkv------vngiRQPPTNWVS------VFR 166  fruit fly
P13080        111 LILDFVPNHTSDQHEY-----------FKKSVQ-KDET--YKDFYVWhpgvh-----gpnntKVPPSNWIS------VFR 165  yellow fever ...
5BN7_A        245 LVLDGVFNHSGDSHAW-----------FDRHNRGTG-----GACHN------------------PESPWR---------D 281  Escherichia c...
Q5L242        239 VMLDAVFNHCGYEFGP-----------FQDVLKNGA----ASRYKDWfh------------iREFPLQT----------- 280  Geobacillus k...
Q8R907        235 VIFDAVFNHCGYDFFA-----------FQDVVK--NGP--KSKYWDWfn------------vYEWPIKTH---------- 277  Caldanaerobac...
Q9KZ11        176 VFFDVITNHTADVVDYeeksydylskgAFPYLTKDGQPfdDADYADGerrfprvdsgsfprtPTVPAAKKNlkvpswLND 255  Streptomyces ...
WP_012819102  159 VIIDFAPNHTSPASS------------DQPSFAENGKL--YNNGTLLg-------------gYTGDTQNLFh-----HNG 206  Paenibacillus...
4XB3_A        141 GSAWQY---DDKSDQYYLHFFSKKQPDLNWENANLRQKIYD----MMNFWIDKG--IGGFRMDVIDMIGKIPAQH----- 206  Streptococcus...
P0CW41        161 GSAWTF---DEKTQEFYLRLFCSTQPDLNWENEDCRKAIYEs---AVGYWLDHG--VDGFRIDVGSLYSKVAGLPdapvi 232  Saccharomyces...
P07190        168 YSAWEW---NEVRQQYYLHQFAIQQADLNYRNPAVVNEMKN----VIRFWLGKG--VSGFRIDAVPYLFEVDLDRynqyp 238  fruit fly
P07192        167 GSMWTW---NEQRQAYYLHQFHAKQPDLNYRNPKVVEAMKD----VLRFWLRKG--AYGFRIDAVPHVYEIPADAdgnwp 237  fruit fly
P13080        166 GSSWEW---NEERQEFYLHQFLKEQPDLNYRNPAVVEEMKN----VLRYWLDRG--VSGFRIDAVPYLFESDIIDgryrn 236  yellow fever ...
5BN7_A        282 WYSFSD---DGTALD---WLGYASLPKLDYQSESLVNEIYRgedsIVRHWLKAPwnMDGWRLDVVHMLGEAGGA------ 349  Escherichia c...
Q5L242        281 EPRPNY---DTFA-------FVPQMPKLNTAHPEVKRYLLD----VATYWIREFd-IDGWRLDVANEIDH---------- 335  Geobacillus k...
Q8R907        278 -PKPTY---ETFGE------NVWRMPKLMTKNPEVQKYLLE----VAEYWIKEVd-IDGWRLDVANEIDH---------- 332  Caldanaerobac...
Q9KZ11        256 PAMYHNrgdSTWAGESATYGDFNGLDDLWTERPEVVGGMEK----IYQRWVEDFa-IDGFRIDTVKHVDM---------- 320  Streptomyces ...
WP_012819102  207 GTDFST---TENGI----YKNLYDLADLNHNNSTVDTYLKD----AIKMWLDLG--IDGIRMDAVKHMPF---------- 263  Paenibacillus...
4XB3_A        207 -------------IVSNGPKLHAYLKEMNAASF----GQHDLLTVGQTWGATPEIAKQYSNPVNHELSMVFQFEHIGLQH 269  Streptococcus...
P0CW41        233 den--skwqlsdpFTMNGPRIHEFHQEMNKFIRnrvkDGREIMTVGEMRHATDETKRLYTSASRHELSELFNFSHTDVGT 310  Saccharomyces...
P07190        239 depltndsvncpdPDDHCYTQHIYTQDMPETIDm---VYQWRELVDEFHVENGGDKRLLMTEAYTSFENIMTYYGNGVRN 315  fruit fly
P07192        238 dep---rneavsdPEDYTYLQHIYTTDQPETLEl---VYAFRDVIEEIDAELGGDDRVLLTEAYSPLEVLMQYYGNGTHL 311  fruit fly
P13080        237 ep----esrttddPENPAYLVHTQTMDQPETYDm---IYQWRAVLDEYSKTDN-RTRIMMTEGYTSLPKIIEFFGNATAN 308  yellow fever ...
5BN7_A        350 --------------RNNMQHVAGITEAAKETQ-------PEAYIVGEHFGDARQWLQADVEDAAMNYR-GFTFPLWGFLA 407  Escherichia c...
Q5L242        336 ------------------QFWREFRQAVKALK-------PDVYILGEIWHDAMPWLRGDQFDAVMNYP------LADAAL 384  Geobacillus k...
Q8R907        333 ------------------HFWRKFREVVKNAK-------KDAIIVGEVWHDASPWLRGDQFDSVMNYPFRNAVVDFFAKR 387  Caldanaerobac...
Q9KZ11        321 ------------------EFWTQWATALDAYAAk--kGRDDFFMFGEVYSADTSVTAPYVTQGRLDST--LDFPFQDAAR 378  Streptomyces ...
WP_012819102  264 ------------------GWQKSFMATVNNY--------KPVFTFGEWFLGVNE---VSAENHKFANESGMSLLDFRFAQ 314  Paenibacillus...
4XB3_A        270 KPEAp--KWDYVKELn---VPALKTIFNKWQTELEL--GQGWNSLFWNNHDLPRVLSIWGNTG-Kyr----ekSAKALAI 337  Streptococcus...
P0CW41        311 SPKF---RQNLIPYE----LKDWKVALAELFRYVNG--TDCWSTIYLENHDQPRSITRFGDDSpKnr----viSGKLLSV 377  Saccharomyces...
P07190        316 GSHIpfnFDFLTSINnaskAGEYVEHIKKWMDAMPE---GVYANWVLGNHDNKRVASRFGVQR-----------TDLINI 381  fruit fly
P07192        312 GSQIpfnFELLAKISyssdAYHYSELIHNWLDNMPE---GQVANWVFGNHDQSRIGSRLGADR-----------IDACNM 377  fruit fly
P13080        309 GAQIpfnFEVISNVKknstGADFATYVKRWLDAKP---ANRRSNWVLGNHDNNRLGSRLGENK-----------IDLYNI 374  yellow fever ...
5BN7_A        408 NTDI---SYDPQQID----AQTCMAWMDNYRAGLSHq-QQLRMFNQLDSHDTARFKTLLGRDIa---------RLPLAVV 470  Escherichia c...
Q5L242        385 RFF------AKEEIS----ARQFADIMIRLLHSYPKq-VNEAAFNLLGSHDTPRLLTVCGGDVr---------KVKLLFL 444  Geobacillus k...
Q8R907        388 KIS----------------AVKFNTLITEQLMRHMDs-VNRVMFNLIGSHDTERFLTLANGMVa---------RMKLALV 441  Caldanaerobac...
Q9KZ11        379 AYA-----SQGGS------ARKLAAVFGDDYKYTTDkaNAYEQVTFLGNHDMGRIGTFLKQDApEagdaellkKDRLANE 447  Streptomyces ...
WP_012819102  315 KVRQ---VFRDNTDN----MYGLKSMLEGSAADYLQ---VEDQVTFIDNHDMERFHNNSANRR----------KLEQALA 374  Paenibacillus...
4XB3_A        338 LLHLMRGTPYIYQGEEIGMTNYPfkd-lneLD 368  Streptococcus mutans UA159
P0CW41        378 LLVSLSGTLYVYQGQELGEINFKnwp-iekYE 408  Saccharomyces cerevisiae S288C
P07190        382 LLQTLPGHAVTYNGEELGMTDVWiswedtvDP 413  fruit fly
P07192        378 IILGLPGVSVTYQGEEMGMTDVWiswedtvDP 409  fruit fly
P13080        375 ALQTLPDIAVTYYGEEIGMLDQWipwnetvDP 406  yellow fever mosquito
5BN7_A        471 WLFTWPGVPCIYYGDEVGLDGKN-------DP 495  Escherichia coli K-12
Q5L242        445 FQLTFTGSPCIYYGDEIGMTGGN-------DP 469  Geobacillus kaustophilus
Q8R907        442 FQFTFVGVPYIYYGDEAGMVGGF-------DP 466  Caldanaerobacter subterraneus subsp. tengcongensis
Q9KZ11        448 LMFLSRGNPVIYYGDEQGFTGAGgdkdarqpm 479  Streptomyces coelicolor
WP_012819102  375 FTLTSRGVPAIYYGTEQYMSGGN-------DP 399  Paenibacillus sp. Y412MC10
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