NCBI CDD Logo
?
pfam00122: E1-E2_ATPase 
E1-E2 ATPase
Statistics
?
PSSM-Id: 249606
View PSSM: pfam00122
Aligned: 126 rows
Threshold Bit Score: 88.0095
Threshold Setting Gi: 154420326
Created: 28-Mar-2013
Updated: 4-Apr-2013
Structure
?
Aligned Rows:
pfam00122 is a member of the superfamily cl02811.
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123496234  102 TILAVVLLNGVLGFAQESRAEQALAALEAms-apS-ARVLRD---G-----------EQRM---------------V-PT 149
gi 74543549   144 FIVSLILTGSYVESLVKAKASDAGNRLLSli-peTvHLVSDG---------------GIVD---------------I-ES 191
gi 156845346  229 PLAFVITVTMLKEATDDIQRRSRDKELNN-----ElYEVLQ----------------KDGQ---------------V-TS 271
gi 119720385   66 ILLATVWFSTLSESISEHQARARVDYLRSlekdvVaHKLVGD---------------RVVD---------------V-RS 114
gi 317478660   72 ILFVTLLFANFAEAIAEARGKAQADSLRKtr-eeTpAKVLVD---G-----------KIHT---------------V-SS 120
gi 94311315   206 MLITFLLIGRLIEIHARQESGLAVQALRSla-peTaTKLTSA---Gge--------kAEST---------------V-LL 257
gi 126666412  213 MLITFQLIARLLDTSVRRRASEVIRRYLQdv-peLvTVKASD---------------GKLE---------------TrLA 261
gi 347836259  300 LLVTLVMVGRLVTSLARQRAVESI-SIESlq-psTaILIDSN---Sd----------SLNE---------------I-DA 348
gi 154286430  524 LLITLILLGRLMAAWVRRKAQNAI-KLGTsq-qkSaLVVRKA---Sp----------KNNPdasaflglgdnqpelI-DS 587
gi 119491134  603 FLTLFILAGRFMEAYSKARTGDAVASLGKlr-psEaILVEKStpiDqtgsgesssleSQQR---------------I-AV 665
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123496234  150 PELVPGDLLLLEEGDTIAADARVV--Es--I--ALRAAESALTGES-------TAASKDpaplad--------------- 201
gi 74543549   192 SKISPENLVEVRPGETVPVDGIVE--R---G--SADVDSSMITGES-------LPITVN--------------------- 236
gi 156845346  272 KDLRVGDLIRLKKGSRVPADSVLLqtSevtG--EAFIKTDQLDGETdwklriaPPITQSlqeseliekttinasppeksi 349
gi 119720385  115 SELVPGDVVVVGEGEYVPRDGYVL--E---G--IAYVDESMLTGES-------EPVEKK--------------------- 159
gi 317478660  121 SRLKKGDYFICEAGDTIPADGEIV--E---G--LASIDESAITGES-------APVIREag------------------- 167
gi 94311315   258 AELAPGDTVLIRANERIAVDGIVV--A---G--QSAVDLSLLQGES-------APRSVQ--------------------- 302
gi 126666412  262 KDVSAGERIFLQAGDQLALDGNVF--R---G--HGQADLSMLTGEH-------LPQSLG--------------------- 306
gi 347836259  349 RLLQYGDVFVVSPDSSVATDGTVI--S---G--ISDVDESMITGEA-------TLVAKQ--------------------- 393
gi 154286430  588 SLLHYGDIIQGKASENIVTDGIVV--S---G--SAEIDEAHITGEH-------EPVVRS--------------------- 632
gi 119491134  666 DLLEIGDVVSIPHGASPPADGVII------GpnIYQFDESSLTGES-------KWVQKS--------------------- 711
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123496234  202 --------------evgigdRTNMVFSGTAIA-AGRGRAVVTGTGRATEIGRIAASLqATEEapTPLQKELDrvGKLLga 266
gi 74543549   237 --------------------PGSKVSSGMKDL-NGTIVVRVQAVGPNSTVGKIYSFIkMASSgrTKIQRIADvfSSYFvp 295
gi 156845346  350 hsflgkvavdlsdsisspltIDNTLWANTVVAsSGTCIACVVYTGRDTRQSMNTTKS-SVKT--GLIELEINslSKLLcv 426
gi 119720385  160 --------------------KDDRVIGGTRVV-RGRIRVEIVAEPGKSYIDRLMALIqTAKRpkMKSEVMLSilLGGLsl 218
gi 317478660  168 -------------------gDKSSVTGGTKVL-SDKIKVLVTQQPGESFLDKMIALVeGATRqkTPNEIALTilLAGFtl 227
gi 94311315   303 --------------------PGERVFAGSVNL-RGPLTVHVTAGAGDRRLDVLGLRMlELFGarSSLSETAErfVRILlp 361
gi 126666412  307 --------------------PGGELFAGCQLV-EGELELTVTAIIGQRRIDRLSRSIsALLSrkTTLQRLTDriARILlp 365
gi 347836259  394 --------------------PGSPVVAGSTNH-SGTLKVRLTRLMGDNTIKSIGLMVdEAKSskARFQDMADrvAAYFvp 452
gi 154286430  633 --------------------RKAYVYAGSTII-NGQINYRVTRLVSENTLSIVKRFVsTAASsrTRTLERADlaASYLtp 691
gi 119491134  712 --------------------AGHQVFTGSVNV-GQPVKIKITALGGSSMLDQIINVVrEGQSrrAPLERVADvlTSHFvp 770
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123496234  267 AVVAIAVvigatLVLvehLSALA------------------DLLDVLLLA-VSLAVAAVPEGLTAITTIVLSLGTRRMAE 327
gi 74543549   296 VVLAAAT-----ASF---LFWFFylrs----------igdpYFIETAILSfVSVIVIACPCAIGLAGPITLLIASEGSFE 357
gi 156845346  427 SVFALSI-----LLV---AFAGFhn---------------eDWYIDIMRY-LILFSTIIPVSLRVNLDLAKSVya----- 477
gi 119720385  219 TFLVITA-----SLYfal--------------------rsvGGWADPVLA-VAFLVALMPTTIGGLLPAIGVAGVTRLMA 272
gi 317478660  228 VFVIVCV-----TLI---PMADYtni------------dhpGTYISIAAI-ISLFVCLIPTTIGGLLSAIGIAGMDRALR 286
gi 94311315   362 VVVTASL-----LAF---VHYLWng---------------sSADQALLGA-LSLLVAACPCAVGLAMPLAYAFTCREAAR 417
gi 126666412  366 VIVTAAA-----LAV---VLALFqg---------------vSAPEAAARG-LAVMIISCPCALSLAIPLVITMGHANMIS 421
gi 347836259  453 IILVLTV-----IVF---VVRVGvgkgil------dystttACINAMTYA-ISALIVSCPCAIGLAVPMVLVIAGGVAAK 517
gi 154286430  692 VILAVAC-----IAF---LIWAFvnrfar------nwasteSAVNALTHA-IAILAISCPCALALAVPMVLTVASTVGAK 756
gi 119491134  771 VITLIAI-----LTF---IIWLSlglsgalppdyldtarggWAFWSLEFA-IAVFVVACPCGLALAAPTALFVGGGLAAR 841
                         330
                  ....*....|....
gi 123496234  328 RNVIVRkl-ssVET 340
gi 74543549   358 AGILVKna-gaMDR 370
gi 156845346  478 ---------yqIEH 482
gi 119720385  273 ENIVAKsg-kaVEA 285
gi 317478660  287 ANVITKsg-kaVET 299
gi 94311315   418 RGVLLRds-asVEA 430
gi 126666412  422 RGIVLRdp-aaLEA 434
gi 347836259  518 NGVIFNsa-etIER 530
gi 154286430  757 KGVLFKag-aaLEA 769
gi 119491134  842 HGILVKgggeaFQE 855
Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap