Conserved Protein Domain Family
RRM_1

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pfam00076: RRM_1 
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RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.
Statistics
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PSSM-Id: 249565
View PSSM: pfam00076
Aligned: 79 rows
Threshold Bit Score: 41.4413
Threshold Setting Gi: 17380398
Created: 28-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam00076 is a member of the superfamily cl17169.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
2JVO_A        34 LFVRPFPLDVQESELNEIFGPFGPMKEVKILN--------GFAFVEFEEAESAAKAIEEVHG-KSFANQPLE 96
gi 206729905 216 VYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPd------kGYSFVRFNSHESAAHAIVSVNG-TTIEGHVVK 280
gi 76803808  185 VYVKNFTEDFDDEKLKEFFEPYGKITSYKVMSkedg-kskGFGFVAFETTEAAEAAVQALNGkDMGEGKSLY 255
gi 76803808   92 VFIKNLDRAIDNKAIYDTFSAFGNILSCKVATdekg-nskGYGFVHFETEEAANTSIDKVNG-MLLNGKKVY 161
gi 140346    221 VFIINLPYSMNWQSLKDMFKECGHVLRADVELdfng-fsrGFGSVIYPTEDEMIRAIDTFNG-MEVEGRVLE 290
gi 730773    123 VVVSGLPPSGSWQDLKDHMREAGDVCYADVYRd-------GTGVVEFVRKEDMTYAVRKLDN-TKFRSHEGE 186
gi 400605    202 ITMKNLPEGCSWQDLKDLARENSLETTFSSVNtrd---fdGTGALEFPSEEILVEALERLNN-IEFRGSVIT 269
gi 133249    219 LYVANLSWALTSQGLRDAFADQPGFMSAKVIYdrssgrsrGFGFITFSSAEAMNSALDTMNE-VELEGRPLR 289
gi 21542438   33 LYIGGLSPGTDEHSLKDAFSSFNGVTEARVMTnkvtgrsrGYGFVNFISEDSANSAISAMNG-QELNGFNIS 103
gi 133249    116 LYVGNLPFSMTSSQLSEIFAEAGTVANVEIVYdrvtdrsrGFAFVTMGSVEEAKEAIRLFDG-SQVGGRTVK 186
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