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pfam00069: Pkinase 
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Protein kinase domain
Statistics
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PSSM-Id: 249558
View PSSM: pfam00069
Aligned: 54 rows
Threshold Bit Score: 199.01
Threshold Setting Gi: 123515
Created: 28-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:

pfam00069 is classified as a model that may span more than one domain.
pfam00069 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4AGU_B         5 YEKIGKIGEGSYGVVFKCRNRDTGQiVAIKKFLESEDDPVIKKIal------rEIRMLKQL-K--HPNLVNLLEVFRR-- 73
2X9E_A        14 YSILKQIGSGGSSKVFQVLNEKKQI-YAIKYVNLEEADNQTLDSyr------nEIAYLNKL-QqhSDKIIRLYDYEIT-- 83
gi 134968    191 LVQLGKIGAGNSGTVVKALHVPDSKiVAKKTIPVEQNNSTIINQlv------rELSIVKNVkP--HENIITFYGAYYNqh 262
gi 417302    221 IETLGILGEGAGGSVSKCKLKNGSKiFALKVINTLNTDPEYQKQif------rELQFNRSF-Q--SEYIVRYYGMFTDd- 290
gi 115194     66 LEVVRHLGEGNGGAVSLVKHRNI---FMARKTVYVGSDSKLQKQil------rELGVLHHC-R--SPYIVGFYGAFQY-- 131
gi 417818    620 YANLVKIGQGASGGVYTAYEIGTNVsVAIKQMNLEKQPKKELIIn--------EILVMKGS-K--HPNIVNFIDSYVL-- 686
gi 341940540  25 YHLKQVIGRGSYGVVYKAINKHTDQvVAIKEVVYENDEELNDIMa--------EISLLKNL-N--HNNIVKYHGFIRK-- 91
gi 115195    394 WIRGALIGSGSFGQVYLGMNASSGElMAVKQVILDSVSESKDRHaklldalagEIALLQEL-S--HEHIVQYLGSNLN-- 468
gi 125616    191 FTIHGALTPGSEGCVFDSSHPDYPQrVIVKAGWYTSTSH--------------EARLLRRL-D--HPAILPLLDLHVV-- 251
gi 125620     53 FEVLQPLQSGSEGRVFVARRPGEADtVVLKVGQKPSTLM--------------EGMLLQRL-S--HDNVMRMKQMLAR-- 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4AGU_B        74 -KRRLHLVFEYCDHtVLHELDR-------------YQRGVPEHLVKSITWQTLQAVNFCHK-HNCIHRDVKPENILITKH 138
2X9E_A        84 -DQYIYMVMECGNI-DLNSWLK-------------KKKSIDPWERKSYWKNMLEAVHTIHQ-HGIVHSDLKPANFLIV-D 146
gi 134968    263 iNNEIIILMEYSDCgSLDKILSvykrfvqrgtvssKKTWFNELTISKIAYGVLNGLDHLYRqYKIIHRDIKPSNVLINSK 342
gi 417302    291 eNSSIYIAMEYMGGrSLDaiyk---------nlleRGGRISEKVLGKIAEAVLRGLSYLHE-KKVIHRDIKPQNILLNEN 360
gi 115194    132 -KNNISLCMEYMDCgSLDAILR-------------EGGPIPLDILGKIINSMVKGLIYLYNvLHIIHRDLKPSNVVVNSR 197
gi 417818    687 -KGDLWVIMEYMEGgSLTDVVT--------------HCILTEGQIGAVCRETLSGLEFLHS-KGVLHRDIKSDNILLSME 750
gi 341940540  92 -SYELYILLEYCANgSLRRLISr------------SSTGLSENESKTYVTQTLLGLKYLHG-EGVIHRDIKAANILLSAD 157
gi 115195    469 -SDHLNIFLEYVPGgSVAGLLT-------------MYGSFEETLVKNFIKQTLKGLEYLHS-RGIVHRDIKGANILVDNK 533
gi 125616    252 -SGVTCLVLPKYQA-DLYTYLSr------------RLNPLGRPQIAAVSRQLLSAVDYIHR-QGIIHRDIKTENIFINTP 316
gi 125620    114 -GPATCLVLPHFRC-DLYSYLTm------------RDGPLDMRDAGCVIRAVLRGLAYLHG-MRIMHRDVKAENIFLEDV 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4AGU_B       139 SVIKLCDFGFArl------lTGPSDYYDDEVATRWYRSPELlv----------gDTQYGPPVDVWAIGCVFAELLSGVPL 202
2X9E_A       147 GMLKLIDFGIAnqm----qpDTTSVVKDSQVGTVNYMPPEAikdmsssrengksKSKISPKSDVWSLGCILYYMTYGKTP 222
gi 134968    343 GQIKLCDFGVSk--------KLINSIADTFVGTSTYMSPERi-----------qGNVYSIKGDVWSLGLMIIELVTGEFP 403
gi 417302    361 GQVKLCDFGVSg--------EAVNSLATTFTGTSFYMAPERi-----------qGQPYSVTSDVWSLGLTILEVANGKFP 421
gi 115194    198 GEIKLCDFGVSg--------ELVNSVAQTFVGTSTYMSPERi-----------rGGKYTVKSDIWSLGISIIELATQELP 258
gi 417818    751 GDIKLTDFGFCaq------iNELNLKRTTMVGTPYWMAPEVv-----------sRKEYGPKVDIWSLGIMIIEMIEGEPP 813
gi 341940540 158 NTVKLADFGVS---------TIVNSSALTLAGTLNWMAPEIl-----------gNRGASTLSDIWSLGATVVEMLTKNPP 217
gi 115195    534 GKIKISDFGISkklelnstsTKTGGARPSFQGSSFWMAPEVv-----------kQTMHTEKTDIWSLGCLVIEMLTSKHP 602
gi 125616    317 EDICLGDFGAAcfv----qgSRSSPFPYGIAGTIDTNAPEVl-----------aGDPYTTTVDIWSAGLVIFETAVHNAS 381
gi 125620    179 DTVCLGDLGAAr-------cNVAAPNFYGLAGTIETNAPEVl-----------aRDRYDTKVDVWGAGVVLFETLA--YP 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4AGU_B       203 WP-GK-----SDVDQLYLIRKTLGDLIPRHQQVFSTnqyfsgvkipdpe------dmeplelkfpnisYPALGLLKGCLH 270
2X9E_A       223 FQ-QI-------INQISKLHAIIDPNHEIEFPDIPE--------------------------------KDLQDVLKCCLK 262
gi 134968    404 LG-GHndtpdGILDLLQRIVNEPSPRLPKDRIYS----------------------------------KEMTDFVNRCCI 448
gi 417302    422 CS-SE-----KMAANIAPFELLMWILTFTPELKDEPesni-------------------------iwsPSFKSFIDYCLK 470
gi 115194    259 WSfSNiddsiGILDLLHCIVQEEPPRLPSSFP------------------------------------EDLRLFVDACLH 302
gi 417818    814 YL-NE-----TPLRALYLIATNGTPKLKEPENLS----------------------------------SSLKKFLDWCLC 853
gi 341940540 218 YH-NL--------TDANIYYAVENDTYYPPSSFS----------------------------------EPLKDFLSKCFV 254
gi 115195    603 YP-NC-----DQMQAIFRIGENILPEFPSNIS------------------------------------SSAIDFLEKTFA 640
gi 125616    382 LF-SAprgpkRGPCDSQITRIIRQAQVHVDEFSPHPesrltsryrsraagnnrppytrpawtryykmdIDVEYLVCKALT 460
gi 125620    239 KT-ITggdepAINGEMHLIDLIRALGVHPEEFPPDTrlrsefvryagthrq---pytqyarvarlglpETGAFLIYKMLT 314
                        330
                 ....*....|....*...
4AGU_B       271 MDPTERLTCEQLLHHPYF 288
2X9E_A       263 RDPKQRISIPELLAHPYV 280
gi 134968    449 KNERERSSIHELLHHDLI 466
gi 417302    471 KDSRERPSPRQMINHPWI 488
gi 115194    303 KDPTLRASPQQLCAMPYF 320
gi 417818    854 VEPEDRASATELLHDEYI 871
gi 341940540 255 KNMYKRPTADQLLKHVWI 272
gi 115195    641 IDCNLRPTASELLSHPFV 658
gi 125616    461 FDGALRPSAAELLCLPLF 478
gi 125620    315 FDPVRRPSADEILNFGMW 332
Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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