Conserved Protein Domain Family
EF-hand_1

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pfam00036: EF-hand_1 
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EF hand
The EF-hands can be divided into two classes: signaling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typically undergo a calcium-dependent conformational change which opens a target binding site. The latter group is represented by calbindin D9k and do not undergo calcium dependent conformational changes.
Statistics
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PSSM-Id: 249529
View PSSM: pfam00036
Aligned: 893 rows
Threshold Bit Score: 24.7154
Threshold Setting Gi: 242556142
Created: 28-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam00036 is a member of the superfamily cl23489.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20
                ....*....|....*....|....*....
1GJY_D       73 GWRQHFISFDSDRSGTVDPQELqkALTTM 101
1NYA_A      103 VVKGIVGMCDKNADGQINADEFaaWLTAL 131
gi 74763212  60 KVVDQIMKADANGDGYFTLEEFlaF--NL 86
1JFK_A      108 KVAEQVMKADANGDGYITLEEFleF--SL 134
gi 74956561 462 LWTEILQMCDANGDGQISQQEFidFLVKK 490
gi 134762   112 KIKEMIEKADFPNDGKCSLEEFvkMVMNF 140
gi 74967160 176 EINEILEHHDVNKDGKISLDEFkqTRSDE 204
gi 74956597  57 LWDEISAIADDDKDGKISNQEFkdAVKKT 85
gi 74764621  60 TYSEWVKAADKNKDGKVSLPEFleYAEKH 88
gi 66773929 193 VIQEALEEHDKNGDGFVSLEEFlgDYRRD 221
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