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pfam00001: 7tm_1 
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7 transmembrane receptor (rhodopsin family)
This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.
Links
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Source: pfam
Taxonomy: root
PubMed: 1 link
Protein: Representatives
Related Protein
Related Structure
Architectures
Superfamily: cl10458
Statistics
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PSSM-Id: 109070
View PSSM: pfam00001
Aligned: 65 rows
Created: 29-Sep-2008
Updated: 30-Oct-2008
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam00001 is a member of the superfamily cl10458.
Sequence Alignment?
Format: Row Display: Color Bits: Type Selection:
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2Z73_A      57 YLFTKTKSLQ----TPANMFIINLAFSDFTFSLVNGFPLMTISCFl-----kKWIFGF---AACKVYGFIGGIFGFMSIM 124
gi 400672   58 TIIRIDLHLH----TPMYFFLSMLSTSETVYTLVILPRMLSSLVGm------SQPMSL---AGCATQMFFFVTFGITNCF 124
gi 1171893  47 LLSRLDARLH----TPMYFFLSNLSSLDLAFTTSSVPQMLKNLWGp------DKTISY---GGCVTQLYVFLWLGATECI 113
gi 129091   50 SLVGAHRCLQ----TPMYFFLCNLSFLEIWFTTACVPKTLATFAPr------GGVISL---AGCATQMYFVFSLGCTEYF 116
gi 548414   47 ALISVDLHLQ----TPMYIFLQNLSFTDAAYSTVITPKMLATFLEe------RKTISY---VGCILQYFSFVLLTVTESL 113
gi 462208   28 LAVSSNSHLH----NLMYFFLSNLSFVDICFISTTIPKMLVNIHSq------TKDISY---IECLSQVYFLTTFGGMDNF 94
gi 1174572  47 SVLAGARQGGshtrSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAAl-----fEWHAVDpgcRLCRFMGVVMIFFGLSPLL 121
gi 548476   40 VVLCKSRKEQk--eTTFYTLVCGLAVTDLLGTLLVSPVTIATYMKg------QWPGGQ---PLCEYSTFILLFFSLSGLS 108
gi 417278   61 LAVVRNGNLH----SPMYFFLCSLAAADMLVSLSNSLETIMIAVInsdsltlEDQFIQ---HMDNIFDSMICISLVASIC 133
gi 461697   56 YLILSSHQLRr---KPSYLFIGSLAGADFLASVVFACSFVNFHVF-------HGVDSK---AVFLLKIGSVTMTFTASVG 122
                       90       100       110       120       130       140       150       160
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2Z73_A     125 TMAMISIDRYNVIGRPMAASKKMSHRRAFIMIIFVWLWSVLWAIGPiFGWGAYTLE-GV----LCNCSFDYISrDStt-- 197
gi 400672  125 LLTAMGYDRYVAICNPLRYMVIMNKRLRIQLVLGACSIGLIVAITQvTS-VFRLPFc-ArkvpHFFCDIR---------- 192
gi 1171893 114 LLVVMAFDRYVAVCRPLHYMTVMNPRLCWGLAAISWLGGLGNSVIQsTF-TLQLPFcGHrkvdNFLCEVP---------- 182
gi 129091  117 LLAVMAYDRYLAICLPLRYGGIMTPGLAMRLALGSWLCGFSAITVPaTL-IARLSFcGSrvinHFFCDIS---------- 185
gi 548414  114 LLAVMAYDRYVAICKPLLYPSIMTKAVCWRLVESLYFLAFLNSLVHtSG-LLKLSFcYSnvvnHFFCDIS---------- 182
gi 462208   95 LLTLMACDRYVAICHPLNYTVIMNLQLCALLILMFWLIMFCVSLIHvLLMNELNFSrG------TEIPHFFCE-LA---- 163
gi 1174572 122 LGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPlLGVGRYTVQyP-----GSWCFLTLGA-ESgd-- 193
gi 548476  109 IICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPnMGLGSSRLQyP-----DTWCFIDWTT-NVtaha 182
gi 417278  134 NLLAIAIDRYVTIFYALRYHSIMTVRKALTLIGVIWVCCGICGVMFiIYSESKM---------VIVCLITMFF-AM---- 199
gi 461697  123 SLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPlMGWTCCPRP----------CSELFPL-IP---- 187
                      170       180       190       200       210       220       230       240
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2Z73_A     198 -----rSNILCMFILGFFGPILIIFFCYFNIVMSVSNHEKEMAAMAkrln---------------------akelRKAQA 251
gi 400672  193 ------PVMKLSCIDTTVNEILTLIISVLVLVVPMGLVFISYVLIIs----------------------------TILKI 238
gi 1171893 183 ------AMIKLACGDTSLNEAVLNGVCTFFTVVPVSVILVSYCFIAq----------------------------AVMKI 228
gi 129091  186 ------PWIVLSCTDTQVVELVSFGIAFCVILGSCGITLVSYAYIIt----------------------------TIIKI 231
gi 548414  183 ------PLFQISSSSIAISELLVIISGSLFVMSSIIIILISYVFIIl----------------------------TVVMI 228
gi 462208  164 ------QVLKVANSDTHINNVFMYVVTSLLGLIPMTGILMSYSQIAs----------------------------SLLKM 209
gi 1174572 194 ----vaFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQ----------------------------------QR 235
gi 548476  183 aysymyAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHhaaaaasvasrghpaaspalprlsdfrrrRSFRR 262
gi 417278  200 -------VLLMGTLYIHMFLFARLHVQRIAVLPPAGVVAPQ--------------------------------------- 233
gi 461697  188 ------NDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQdr--------------------------qVPGMA 235
                      250       260       270       280       290       300       310
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
2Z73_A     252 GANAEMRLAKISIVIVSQFLLSWSPYAVVALLAQFGPLEw---------VTPYAAQLPVMFAKASAIHNPMIY 315
gi 400672  239 ASVEGRKKAFATCASHLTVVIVHYSCASIAYLKPKSENT-----------REHDQLISVTYTVITPLLNPVVY 300
gi 1171893 229 RSVEGRRKAFNTCVSHLVVVFLFYGSAIYGYLLPAKSSN-----------QSQGKFISLFYSVVTPMVNPLIY 290
gi 129091  232 PSARGRHRAFSTCSSHLTVVLIWYGSTIFLHVRTSVESS-----------LDLTKAITVLNTIVTPVLNPFIY 293
gi 548414  229 RSKDGKYKAFSTCTSHLMAVSLFHGTVIFMYLRPVKLFS-----------LDTDKIASLFYTVVIPMLNPLIY 290
gi 462208  210 SSSVSKYKAFSTCGSHLCVVSLFYGSATIVYFCSSVLHS-----------THKKMIASLMYTVISPMLNPFIY 271
gi 1174572 236 PRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPamspagqlsrTTEKELLIYLRVATWNQILDPWVY 308
gi 548476  263 IAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSle------reVSKNPDLQAIRIASVNPILDPWIY 329
gi 417278  234 -QHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNpy------ciCYTAHFNTYLVLIMCNSVIDPLIY 299
gi 461697  236 RMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSd---------qVKKAFAFCSMLCLINSMVNPVIY 299
Citing CDD
Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res. 37(D)205-10.
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