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cl09099: P-loop_NTPase Superfamily 
P-loop containing Nucleoside Triphosphate Hydrolases
Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.
Links
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Taxonomy: root
PubMed: 1018 links
Book:
Protein: Related Protein
Related Structure
Statistics
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Accession: cl09099
PSSM Id: 214148
Name: P-loop_NTPase
Created: 8-Feb-2008
Updated: 29-Oct-2012
Superfamily
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Curated CD Hierarchy
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cd00267::ABC_ATPase: root of the domain hierarchy. Click the red icon to see the complete information for this domain model.
cd00046::DEXDc: root of the domain hierarchy. Click the red icon to see the complete information for this domain model.
cd00079::HELICc: single member domain hierarchy. Click the red icon to see the complete information for this domain model.
cd00227::CPT: single member domain hierarchy. Click the red icon to see the complete information for this domain model.
cd01120::RecA-like_NTPases: root of the domain hierarchy. Click the red icon to see the complete information for this domain model.
cd02019::NK: root of the domain hierarchy. Click the red icon to see the complete information for this domain model.
cd01983::Fer4_NifH: root of the domain hierarchy. Click the red icon to see the complete information for this domain model.
cd00009::AAA: single member domain hierarchy. Click the red icon to see the complete information for this domain model.
cd00882::Ras_like_GTPase: root of the domain hierarchy. Click the red icon to see the complete information for this domain model.
cd09639::Cas3_I: single member domain hierarchy. Click the red icon to see the complete information for this domain model.
cd09673::Cas3_Cas2_I-F: single member domain hierarchy. Click the red icon to see the complete information for this domain model.
cd09696::Cas3_I: single member domain hierarchy. Click the red icon to see the complete information for this domain model.
cd09708::Csf4_U: single member domain hierarchy. Click the red icon to see the complete information for this domain model.
cd09710::Cas3_I-D: single member domain hierarchy. Click the red icon to see the complete information for this domain model.
cd01849::YlqF_related_GTPase: root of the domain hierarchy. Click the red icon to see the complete information for this domain model.
Imported CD
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Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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