Conserved Protein Domain Family

cl02512: NTR_like Superfamily 
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NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the domain plays a role in controlling axon branching in neural development, while the common function of these modules in TIMPs appears to be binding to metzincins. A subset of this family is also known as the C345C domain because it occurs as a C-terminal domain in complement C3, C4 and C5. In C5, the domain interacts with various partners during the formation of the membrane attack complex.
Taxonomy: root
PubMed: 60 links
Protein: Related Protein
Related Structure
Accession: cl02512
PSSM Id: 295338
Name: NTR_like
Created: 8-Feb-2008
Updated: 2-Feb-2016
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Curated CD Hierarchy
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CD Hierarchy
Imported CD
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