Conserved Protein Domain Family
NTR_like

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cl02512: NTR_like Superfamily 
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NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the domain plays a role in controlling axon branching in neural development, while the common function of these modules in TIMPs appears to be binding to metzincins. A subset of this family is also known as the C345C domain because it occurs as a C-terminal domain in complement C3, C4 and C5. In C5, the domain interacts with various partners during the formation of the membrane attack complex.
Links
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Taxonomy: root
PubMed: 60 links
Book:
Protein: Related Protein
Related Structure
Statistics
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Accession: cl02512
PSSM Id: 295338
Name: NTR_like
Created: 8-Feb-2008
Updated: 2-Feb-2016
Superfamily
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Curated CD Hierarchy
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cd03523:NTR_likecd03574:NTR_complement_C345Ccd03575:NTR_WFIKKNcd03576:NTR_PCOLCEcd03577:NTR_TIMP_likecd03578:NTR_netrin-4_likecd03579:NTR_netrin-1_likecd03580:NTR_Sfrp1_likecd03581:NTR_Sfrp3_likecd03582:NTR_complement_C5cd03583:NTR_complement_C3cd03584:NTR_complement_C4cd03585:NTR_TIMP
CD Hierarchy
Imported CD
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