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cl00281: metallo-dependent_hydrolases Superfamily 
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Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The family includes urease alpha, adenosine deaminase, phosphotriesterase dihydroorotases, allantoinases, hydantoinases, AMP-, adenine and cytosine deaminases, imidazolonepropionase, aryldialkylphosphatase, chlorohydrolases, formylmethanofuran dehydrogenases and others.
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Taxonomy: root
PubMed: 77 links
Book:
Protein: Related Protein
Related Structure
Statistics
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Accession: cl00281
PSSM Id: 260323
Name: metallo-dependent_hydrolases
Created: 8-Feb-2008
Updated: 16-Jan-2014
Superfamily
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Curated CD Hierarchy
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cd00375:Urease_alphacd00443:ADA_AMPDcd00530:PTEcd00854:NagAcd01292:metallo-dependent_hydrolasescd01293:Bact_CDcd01294:DHOasecd01295:AdeCcd01296:Imidazolone-5PHcd01297:D-aminoacylasecd01298:ATZ_TRZ_likecd01299:Met_dep_hydrolase_Acd01300:YtcJ_likecd01301:rDP_likecd01302:Cyclic_amidohydrolasescd01303:GDEasecd01304:FMDH_Acd01305:archeal_chlorohydrolasescd01306:PhnMcd01307:Met_dep_hydrolase_Bcd01308:Isoaspartyl-dipeptidasecd01309:Met_dep_hydrolase_Ccd01310:TatD_DNAsecd01311:PDC_hydrolasecd01312:Met_dep_hydrolase_Dcd01313:Met_dep_hydrolase_Ecd01314:D-HYDcd01315:L-HYD_ALNcd01316:CAD_DHOasecd01317:DHOase_IIacd01318:DHOase_IIbcd01319:AMPDcd01320:ADAcd01321:ADGF
CD Hierarchy
Imported CD
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Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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