Conserved Protein Domain Family
7tmA_MrgprX-like

?
cd15106: 7tmA_MrgprX-like 
primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors
The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.
Statistics
?
PSSM-Id: 320234
Aligned: 7 rows
Threshold Bit Score: 379.482
Created: 26-Dec-2013
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracellular surface of its receptor.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                           #  ##               ######
Q96LB2     28 LSLTVLTCIVSLVGLTGNAVVLWLLGCRMRrnaFSIYILNLAAADFLFLSGRLIYSLLSFISIPHTIS-----KILYPVM 102 human
EHA99477   42 LIPDFLIIIIGLVGLPGNAVVIYLLGCRMRrntISVYILNLAASDFLVLCCHCFGSLLIVIRPFHHLYig-isFILINIA 120 naked mole-rat
Q96LA9     28 LSFTVLTCIISLVGLTGNAVVLWLLGYRMRrnaVSIYILNLAAADFLFLSFQIIRLPLRLINISHLIR-----KILVSVM 102 human
Q96LB0     28 LSFTGLTCIVSLVALTGNAVVLWLLGCRMRrnaVSIYILNLVAADFLFLSGHIICSPLRLINIRHPIS-----KILSPVM 102 human
Q96LB1     31 LIPVFLILFIALVGLVGNGFVLWLLGFRMRrnaFSVYVLSLAGADFLFLCFQIINCLVYLSNFFCSISin-fpSFFTTVM 109 human
ELR52836   43 MTLFVLTAIIALGGLAGNAVVLWLLGFHLHa--FTVYILNLAAADFLCLCCQVIDSLEALIACCSASSi---pSFFTSVM 117 Bos grunniens mutus
Q8R4G1     27 LTLSFLVPIITLLGLAGNTIVLWLLGFRMRrkaISVYVLNLSLADSFFLCCHFIDSLMRIMNFYGIYAhklskEILGNAA 106 Norway rat
Feature 1      ##  #                                          # #####                      #  
Q96LB2    103 MFSYFAGLSFLSAVSTERCLSVLWPIWYRCHRpTHLSAVVCVLLWALSLLRSILEWMLCgflfsgaDSAWCqtsDFITVA 182 human
EHA99477  121 LIPYIAGLSTLSAISMERCLSVLWPIWYRCHRpRHTSAIVCTLLWALSLLLNILEWNYSgflyeffSSIWWknfDFIVTA 200 naked mole-rat
Q96LA9    103 TFPYFTGLSMLSAISTERCLSVLWPIWYRCRRpTHLSAVVCVLLWGLSLLFSMLEWRFCdflfsgaDSSWCetsDFIPVA 182 human
Q96LB0    103 TFPYFIGLSMLSAISTERCLSILWPIWYHCRRpRYLSSVMCVLLWALSLLRSILEWMFCdflfsgaNSVWCetsDFITIA 182 human
Q96LB1    110 TCAYLAGLSMLSTVSTERCLSVLWPIWYRCRRpRHLSAVVCVLLWALSLLLSILEGKFCgflfsdgDSGWCqtfDFITAA 189 human
ELR52836  118 TFAYLAGLSLLSAISTERCVSVLCPVWYRCHRpTHLSAIVCTVLWALALLLSILEGKYCgflltdfSHLWCqvfDFIAAG 197 Bos grunniens mutus
Q8R4G1    107 IIPYISGLSILSAISTERCLSVLWPIWYHCHRpRNMSAIICVLIWVLSFLMGILDWFFSgfl-getHHHLWknvDFIVTA 185 Norway rat
Feature 1     ### ### ##                                    #  ## ##  #          ## ###  #  ##
Q96LB2    183 WLIFLCVVLCGSSLVLLIRILCGSrkIPLTRLYVTILLTVLVFLLCGLPFGIQFFLFlwihvdrevlFCHVHLVSIFLSA 262 human
EHA99477  201 WLIFLFLTLSGSSLTLVVRILCGSrrMPVTRLYVTILFTVLVFLICALPFGLFWFLLlwlpitlpdfSCYFYIATTVLSC 280 naked mole-rat
Q96LA9    183 WLIFLCVVLCVSSLVLLVRILCGSrkMPLTRLYVTILLTVLVFLLCGLPFGILGALIyrmhlnlevlYCHVYLVCMSLSS 262 human
Q96LB0    183 WLVFLCVVLCGSSLVLLVRILCGSrkMPLTRLYVTILLTVLVFLLCGLPFGIQWALFsrihldwkvlFCHVHLVSIFLSA 262 human
Q96LB1    190 WLIFLFMVLCGSSLALLVRILCGSrgLPLTRLYLTILLTVLVFLLCGLPFGIQWFLIlwiwkdsdvlFCHIHPVSVVLSS 269 human
ELR52836  198 WMMFLFGLLAGSSLALLLRILFKSqyIQLTRLYVTVGLTVLAFLLCGLPYGILWFLLiwiqddlfaiPCHNCLVVFGLSC 277 Bos grunniens mutus
Q8R4G1    186 FLIFLFMLLFGSSLALLVRILCGSrrKPLSRLYVTISLTVMVYLICGLPLGLYLFLLywfgihlhypFCHIYQVTVLLSC 265 Norway rat
Feature 1                                              
Q96LB2    263 LNSSANPIIYFFVGSFRQRQNrq----nLKLVLQRALQDAS 299 human
EHA99477  281 VNSCANPIIYFFIGSFRQQHQt------LKLVLQRALQDSY 315 naked mole-rat
Q96LA9    263 LNSSANPIIYFFVGSFRQRQNrq----nLKLVLQRALQDKP 299 human
Q96LB0    263 LNSSANPIIYFFVGSFRQRQNrq----nLKLVLQRALQDTP 299 human
Q96LB1    270 LNSSANPIIYFFVGSFRKQWRlqq--piLKLALQRALQDIA 308 human
ELR52836  278 INSSINPIIYFFVGSFRQRQTkkrgrqtLKVVLQRALEDIS 318 Bos grunniens mutus
Q8R4G1    266 VNSSANPIIYFLVGSFRHRKKhr----sLKMVLKRALEETP 302 Norway rat

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap