3U65,4DI3


Conserved Protein Domain Family
PBP2_TRAP_Tp0957_like

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cd13670: PBP2_TRAP_Tp0957_like 
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Uncharacterized substrate-binding protein of the Tripartite ATP-independent Periplasmic transporter family; the type 2 periplasmic-binding protein fold.
This subfamily includes the putative periplasmic substrate-binding protein Tp0957 from Treponema pallidum, which is similar to TRAP transport systems such as SiaP (a sialic acid binding virulence factor) and TeaA (an ectoine binding protein). TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process and a smaller membrane of unknown function. The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Statistics
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PSSM-Id: 270388
Aligned: 38 rows
Threshold Bit Score: 308.747
Created: 21-Aug-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:putative chemical substrate binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
3U65_B     11 VLKIASIAparsiWETELKKLSAEWSEitgGLVSMKFYDmsslGGEREGIRKLKSsrpgqaapLDGAVFsclglSELAPD 90  Treponema pallidum...
AEF81079   36 EVKIASPVpkdspWGRTLDRMAVEWAKitnNQVRMRVLHggteGGEGKMLLSLSSn------tIQAAVFtsfgiSAINPR 109 Treponema azotonut...
EFW37121   27 TLKIATVAparspWEIELKKLAQEWNRitkGQVSVRFYDmivlGGEKAGVQKLRSarpgqpapMDGAIFsslglHELEPK 106 Treponema phageden...
ADK81365   25 TVKIGSIApagspWDQTLKEIAADWEElsdGRLSIKIYAggiaGDEEAMIRKMRVg------qLDGVVLtsiglDIISPD 98  Spirochaeta smarag...
AEE17332   33 TVKIASVApvrspWDTEQKLLAQKWSKlsgGSVTMQFFStsalGGESGVIQKMRAvrpgqrspLDGAVFtsvgfSEFAPE 112 Treponema brennabo...
AEF83688   20 TIKLATQVpastpWGAALNRMAAEWAAatnGQVRLQIYPngtqGNEADMLQKLNMn------vIQAAVFtsfglNRIAPE 93  Treponema primitia...
ADN02975   20 TIKVASLApvgtpWDDALREVAQKWAElsnGEVEMKIYPggiaGDEIDVIRKMRLg------qLQGAVLtsvglNKIHPD 93  Spirochaeta thermo...
YP_286776  26 QLRIGTLApknslYHRQLMELGEAWRTaqgGTAKYLVYPdgsqGGETDMVRRMRIg------qLQGGLLsvvglREIEPS 99  Dechloromonas arom...
YP_846785  33 VIKMATLApqgseWHQVLQEMGAAWQKashGKVAFRLYPggvaGDDTDVVRKMRLg------tLNAGLLtisglSDIDRG 106 Syntrophobacter fu...
EDY82611   34 MIRITTLApkdssFDKSLRKMGQEWKDttgGQVNLVVFSggvqGGETAMIDRMRVn------qTQAALIsgvglSEIDPG 107 Verrucomicrobiae b...
Feature 1                                                                         # #         
3U65_B     91 SGiytlsVPFLIQNEKDLERVlhelrEDLDRPFRAAGFRVITWTNAGWLSFYTRapyaslGQLKKQTIALSsldsSVLGT 170 Treponema pallidum...
AEF81079  110 VMtl--sAPFLIRTDSELNAVlpqiqPELEAQINQTDYVMVAWSKVGWVNIFSKdpvfvpDDLKRQKIATNgd-aDDLNV 186 Treponema azotonut...
EFW37121  107 SGiytlsLPFLIKSQKELDLVlktygKDIEDPIANAGFQLITWSNVGWLSFYTKesyrtlKELKSIKLSLSgmdsPILSN 186 Treponema phageden...
ADK81365   99 LFim--sLPRIIRSADEYDYLvpkmePTFDKIVSEKGYKLITWTMAGWVKFFSTkpvvipDDLKRLRLGIIpg-qEGMER 175 Spirochaeta smarag...
AEE17332  113 SNmltlcMPFLFRSQDEVDLIletfsDRIEKTVSEQGFVLLGWFNIGWAYFFTKepvrtpEELKKLKLVVGgitsPALGA 192 Treponema brennabo...
AEF83688   94 FLtl--sCPFLIRSNAEMDLVfanlkPELEAKVSAQGLYPLAIVKGGWIKIFSKspvfvpADLKRQRVGSDpq-ePAMTQ 170 Treponema primitia...
ADN02975   94 MItm--aLPLVTRTDEEVSYLlekmgPRWEGLLVQKGFVPVVWQVAGWVNFFTKipaytpDELKKLKLRTYpd-ePEMNQ 170 Spirochaeta thermo...
YP_286776 100 IAal-qnMPLMFKNWEEVDYVrekmrPGMEKKFLDKGFVVLAWGDAGWVRFFSKepavrpDDFKKMKFFAWgs-eVEQQE 177 Dechloromonas arom...
YP_846785 107 ALvv--dVPLAYADYDEMDCVleqmsPQIEKRIEAKGFVLLGWSDAGWVHFFTKspvrtpDDMKKQKMFIWag-dDQYIE 183 Syntrophobacter fu...
EDY82611  108 VAgl-qqIPMMFHTYEELEYVmeklgPKLEERIREKGFVVLSWVDSGWVKIFSKqlletpDDMKKGKLYTWag-dNKQTD 185 Verrucomicrobiae b...
Feature 1                  #                 ##  #                    #                       
3U65_B    171 CFRICGfdIKDAPNaRLAPLLKAGs-IDGFLSVHLFTWATgfYRYISYALDTKICPAVIGMLISDgsw---ariPSRYHD 246 Treponema pallidum...
AEF81079  187 AFKSMGfqMVETDLtDVGTKILSGa-IMAAYQNPAAVAAYqlHKELRNMLSLNLAPFVGGIVMNQvtwkkiadlNPKYPE 265 Treponema azotonut...
EFW37121  187 SFKVSGfnVKDTPItKFAQALKSGg-VSGFLAVHLATWATgfYKDINYALDSRICPIMAGFVISKesw---nkiPAQYQA 262 Treponema phageden...
ADK81365  176 IWKNMGyrVLPVDTiDWLSSLQGGm-IEATFTSPLAAAAYqvFGVANHMLEYPISPLLGALVFSDrsw---kriPESLRI 251 Spirochaeta smarag...
AEE17332  193 AFKTVGfnTEDIPDdKLMQSLKSPngVKGLYTIPMYAYAAryYETLPYVIEAPLCPVMTAFVISEktw---nsiPESYRP 269 Treponema brennabo...
AEF83688  171 AFKSMGyqVTPIDGnRVLIALNGGt-IDAIYGSPIGAAGLqlFGVAKNMASLNLAPFLGSVILNKhtw---dsiPEQYRA 246 Treponema primitia...
ADN02975  171 TFKEFGfhIVPLTQnEVLAGLQTGi-VEAVYAPPVLVATLqwFALAPHYNTLKFAPVVGALVIEErtw---nriPERYRD 246 Spirochaeta thermo...
YP_286776 178 IMKSLGytPVPLETgDILPAIQTGm-INAVPSTPYFALATqiYTTASNMLDLNWAPIVGALVITKkaw---ddlTPEGQV 253 Dechloromonas arom...
YP_846785 184 LWKKAGfnPVPLPStEISTALQTGl-VNAVTSNAQGVVLLqwYKQVNYMSDLKWALFLGGIVVSKptw---ekiPAEMRP 259 Syntrophobacter fu...
EDY82611  186 LLKNMGfrPVPIDAtEVTSSLQTGl-VDIVPLPPFFALATqsYRPAPNMLDIRYTPIVGAIVISEkaw---eriSEEDQA 261 Verrucomicrobiae b...
Feature 1                                                                                
3U65_B    247 AMLQAATRVRQrlannlETLDRECSNNIQKa-GVSIVHLtpqeiQEWRTEFAADVKRIQarlpgmlnMTLYEKIK 320 Treponema pallidum subs...
AEF81079  266 EIMKSTRRIAAeldasmQQTINSAITVMSKg-GLKVNQPssaqaQLWYNEIDKAIPGLLgtt---fdRDTYQKIS 336 Treponema azotonutriciu...
EFW37121  263 PMLAAAEKARKalneslDSSDREYVKKMEQa-GVKMIRLtpqelTEWQKEFNMNIDQVNkslpgafsMPLYKKIQ 336 Treponema phagedenis F0421
ADK81365  252 RLLESAQEHIKplyersTQLEEEAMSIMKEn-GLVVHTLsdqqwELWEEEIARAYSSGLdkd---ysGAVLQEIQ 322 Spirochaeta smaragdinae...
AEE17332  270 ALRAAVKEAEQkfvavqRTSDAENLDLLEAa-GMTRIVLspeetALWERTFSADVSKLTgmknsvidVAFYREIE 343 Treponema brennaborense...
AEF83688  247 DILRITQKFGEeieksmMDLETEAILTMGKh-GLVINDLndrqlQEWYDDMNRVIPTLVdtt---fdRNAYEKIL 317 Treponema primitia ZAS-2
ADN02975  247 PFRRAAAEAAEalndkvKEVDEKALSIMKQh-GLVIHEAtqeeiAQWEAISRKGLARLAgtl---fsREIYEQII 317 Spirochaeta thermophila...
YP_286776 254 AVREAGAKAGVqlrakaRQEVDEAVEAMKKr-GLKVNKPnaeqmQEWITLADNLYPRIRgkm---vqADTFDEVV 324 Dechloromonas aromatica...
YP_846785 260 LLKDAAVKACKrlrefsRRSEPRDIEVLQKh-GVQVVHVdgaalAEWRKLIEGTLQQVRgsy---vpAEPLDAAL 330 Syntrophobacter fumarox...
EDY82611  262 AMMESARRHGRemtlagRAENEEAIQVMKDkwGLQVRESdegvtKAWEAASEEAYSLIRdnt---vpADIFDEVV 333 Verrucomicrobiae bacter...

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