Conserved Protein Domain Family
RhoGAP_MgcRacGAP

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cd04382: RhoGAP_MgcRacGAP 
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.
Statistics
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PSSM-Id: 239847
Aligned: 14 rows
Threshold Bit Score: 263
Created: 14-Apr-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative GTPase interaction site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                 #                                   
Q9H0H5    346 IGEGMladfv-----sqtsPMIPSIVVHCVNEIEqRGLTETGLYRISGCDRtVKELKEKFlrvKTVPLLSKvdDIHAICS 420 human
CAI28919   36 FGTIEkytk------gmksLLVPYFVKNCITEVErRGLEEIGLYRVSGSKNnVENIIKTYr-kKKNADLSKfnDINDITG 108 Leptopilina boulardi
EAT37692  395 KFTGYlsdyt-----pnigPMIPGLIVHCVNEIEtRGLMEEGIYRIPGSEReVRALKEKFlsgKTVPNLASv-DINVLCG 468 yellow fever mosquito
NP_610912 377 KTMTGyvtdf----apsiaPMIPALIVHCVNEIEaRGLTEVGLYRLSSSEReYKALKEQFlrgKATPHLGNt-DIYVLCC 451 fruit fly
XP_319660 360 AGAISclddy----cpsssPRIPALIVHCVSEIEnRGLTEVGLYRLSGSEReVRALKEKFlhgKTIPTLGQi-DVNVLCS 434 Anopheles gambiae ...
XP_969805 402 NGLGVigdyt-----pttpPMVPAILIHCINEIElRGLSEVGLYRVPGSERdVKALKERFlkgKGAPCLNQv-DIPVICG 475 red flour beetle
AAH76756  353 NGPGVladfa-----pampPRVPSLVIQCVNEIEkRGLRERGIYRIPGCDRlVKELRPKLlqgKIKAQHLAkeDIHTVCG 427 African clawed frog
XP_695377 176 HGSSHpneetlesfapstrPRIPSIIVQCVHEIErRGLEEKGIYRVPGGERqVKELREKYlygKGPLMLHKvdEVHAVCG 255 zebrafish
730597    142 IGTKRgclsdy---aprvaPMVPALIVHCVTEIEaRGLQQEGLYRVSSTREkCKRLRRKLlrgKSTPHLGNk-DTHTLCC 217 fruit fly
AAH63983  369 IGEGTlanyv-----sntsPMIPSLVVHCINEIEqRGLHETGLYRVSGSDRvVKDLKEKFlrgKTVPLLSKveDIHAITG 443 zebrafish
Feature 1       #   #                                                                       # 
Q9H0H5    421 LLKDFLRNLKEPLLTfRLNRAFMEAaeit----dednSIAAMYQAVGeLPQANRDTLAFLMIHLQRVAQSPHTKMDVANL 496 human
CAI28919  109 AFKLFLRSMKGRIIDvDLGKELLLAienl-----spnLETELKEIISkLPTPNIQTLAFIILHLQVVSRIPENEMNIHSL 183 Leptopilina boulardi
EAT37692  469 CVKDFLRSLREPLIPtAMWNTFSNAvqai----sakqVQKELYDAIEsLPQPNRDTLAYLVQHFQRIAECKVVKMSLNNL 544 yellow fever mosquito
NP_610912 452 CVKDFLRSLTEPLIPtSQWKDFANAvqnp----dtktAQDMLVKSVKqLPQANRDTLAFLILHFQRIAQCPVVLMPIDNI 527 fruit fly
XP_319660 435 CIKDFLRTLREPLIPnALLGEFSSAvsgatspnggqrMRQQLCQLIErLPAPNRDTLAFLMLHFQRVAQSEAAKMPIDNL 514 Anopheles gambiae ...
XP_969805 476 TVKDFLRGLHEPVITyALWKKFVQAvnaq----dpldIQPALYQAISeLPQPNRDTLAYMILHLQKVAEAKECKMNIGNL 551 red flour beetle
AAH76756  428 ALKEFFRTLQEPLLTySLHATFLDAadil----decdGRAETCQAVHdLPAPNRDTLAFLILHLYRVMQSSECKMDKTNL 503 African clawed frog
XP_695377 256 LLKDFLRKLSEPLITfKLHRTFMEAsema----dedkSVETLLKTIReLPQPNRDTLAFLMLHLQRVMQSPLCQMDLNNL 331 zebrafish
730597    218 CVKDFLRQLVHPLIPiYHRRDFEEAtrhe----drlaVEMAVYLAVLeLHQAHRDTLAYLMLHWQKIAESPAVRMTVNNL 293 fruit fly
AAH63983  444 LLKDFLRNLKEPLLTfRLNRAFMDAaels----dddnSIALMYQNISdLPQPHRDTLAFLIIHLQRVAQSPATKMDITNL 519 zebrafish
Feature 1      ##                         #              
Q9H0H5    497 AKVFGPTIVahavpnpdpvtmlqdIKRQPKVVERLLSLPLEYW 539 human
CAI28919  184 AIVVAPSVFsdigiap--edsveiIQSRIKIFEKLLEIPSDFW 224 Leptopilina boulardi
EAT37692  545 ARVFAPTIVgyssenvdkhamfaeTVIQVNVLEGLFNIPTDYW 587 yellow fever mosquito
NP_610912 528 SLIFGPTIVgystpdpdqhaiyteVFTQKQVMKALLELPVSFW 570 fruit fly
XP_319660 515 ARVFAPTIVgytradldmnemcaeTYVQFSIVQAMLHISTDYW 557 Anopheles gambiae str. PEST
XP_969805 552 AKIFGPTLVgyssdnpnpnnlldeIVQHNMVMEHLLNIPSDYW 594 red flour beetle
AAH76756  504 ARIFGPTLVgysapnpsplmimqdTPRQAKVMSLLLSIPGRFW 546 African clawed frog
XP_695377 332 SRVFGPTIIghamsepspmtimrdTNTQPRVVARLLSFPSDFW 374 zebrafish
730597    294 AVIFAPTLFgdldl------tlenVVTWQRVLKVLLLMPAGFW 330 fruit fly
AAH63983  520 ARVFGPTIVghavsnpepmtilqdTKRQPRVVERLLSLPVEYW 562 zebrafish

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