Conserved Protein Domain Family
Arl4_Arl7
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cd04152: Arl4_Arl7 
Arf-like 4 (Arl4) and 7 (Arl7) GTPases
Arl4 (Arf-like 4) is highly expressed in testicular germ cells, and is found in the nucleus and nucleolus. In mice, Arl4 is developmentally expressed during embryogenesis, and a role in somite formation and central nervous system differentiation has been proposed. Arl7 has been identified as the only Arf/Arl protein to be induced by agonists of liver X-receptor and retinoid X-receptor and by cholesterol loading in human macrophages. Arl7 is proposed to play a role in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Older literature suggests that Arl6 is a part of the Arl4/Arl7 subfamily, but analyses based on more recent sequence data place Arl6 in its own subfamily.
Links
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Statistics
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PSSM-Id: 206719
Aligned: 9 rows
Threshold Bit Score: 309.809
Created: 1-Sep-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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  next features
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Comment:Based on alignment to Arl2
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                #######              ##                           #                  
AAH77817   18 FQSLHIAILGLDCAGKTTVLYRLQFNEFVNTVPTKGFNAEKIKVALGNSKt-VTFHFWDVGGQEKLRPLWKSYTRCTDGI 96  African clawed frog
NP_005728  11 FQSLHIVMLGLDSAGKTTVLYRLKFNEFVNTVPTIGFNTEKIKLSNGTAKg-ISCHFWDVGGQEKLRPLWKSYSRCTDGI 89  human
NP_955938  18 FQSLHVVVIGLDSSGKTSLLYRLKLKEFVETIPTKGFNTEKIKVPVGNGRa-ITFQAWDVGGQEKLRPLWKSYTRRTDGM 96  zebrafish
AAF59368   22 QATLHVVMLGLDSAGKTTALYRLKFDQYLNTVPTIGFNCEKVQCTLGKAKg-VHFLVWDVGGQEKLRPLWRSYTRCTDGI 100 fruit fly
AAH63973   18 FQALHIVILGLDCAGKTTVLYRLRFNEFVNTVPTKGFNTEKIKVNLGPKSrtATFHFWDVGGQEKLRPLWRSYTRCADGL 97  zebrafish
NP_997625  18 FQSFHIVILGLDCAGKTTVLYRLQFNEFVNTVPTKGFNTEKIKVTLGNSKt-VTFHFWDVGGQEKLRPLWKSYTRCTDGI 96  human
AAH75129   11 FQSLHIVMLGLDSAGKTTVLYRLKFNEFVNTVPTIGFNTERIRLSNGAAKg-ISCHFWDVGGQEKLRPLWKSYSRCTDGI 89  African clawed frog
AAH93202   11 FQSLHIVMLGLDSAGKTTVLYRLKFNEFVNTVPTIGFNTEKIKLSNGTAKg-ISCHFWDVGGQEKLRPLWKSYSRCTDGI 89  zebrafish
CAG06532   19 LHPLHVVVIGLDSAGKTSLLYRLKLREFVETIPTKGFNTETVRVAVGSSRs-VSFQVWDVGGQEKLRPLWKSYTRRTDGL 97  Tetraodon nigrovir...

Feature 1                                          ## #                                       
AAH77817   97 VFVVDSVDTERMEEAKTELHKITKISENQGVPVLIVANKQDLRNSLTLSEVEKLLALNEFgs------------------ 158 African clawed frog
NP_005728  90 IYVVDSVDVDRLEEAKTELHKVTKFAENQGTPLLVIANKQDLPKSLPVAEIEKQLALHELip------------------ 151 human
NP_955938  97 VFVVDSTEVERMEEAKVELHKITRTSENQGVPVLVLANKQDLPVALPVSDVEKVLAVHELsa------------------ 158 zebrafish
AAF59368  101 LFVIDSVDTERMEEAKMELMRTAKCPDNQGVPVLILANKQDLPNACGAMELEKLLGLNELynpvpnismpsssdssptin 180 fruit fly
AAH63973   98 VFVVDSVDAERMEEAKTELHKITRLQENLGVPVLVVANKQDLRSALPLSEVEQMLALNELgs------------------ 159 zebrafish
NP_997625  97 VFVVDSVDVERMEEAKTELHKITRISENQGVPVLIVANKQDLRNSLSLSEIEKLLAMGELss------------------ 158 human
AAH75129   90 IYVVDSVDSDRLEEAKTELHKVTKFAENLGTPLLVIANKQDLPKSLAVTEIERQLALQELsp------------------ 151 African clawed frog
AAH93202   90 IYVVDSVDVDRLEEAKTELHKVTKFAENQGTPLLVIANKQDLPKSLTVSEIEKHLALHELsp------------------ 151 zebrafish
CAG06532   98 VFVVDSAEMERMEEARVELHKITRTSENQGVPVLVLANKQDLGSAVSVGEVEKLLSLHELga------------------ 159 Tetraodon nigrovir...

Feature 1                                                                                     
AAH77817      --------------------------------------------------------------------------------     African clawed frog
NP_005728     --------------------------------------------------------------------------------     human
NP_955938     --------------------------------------------------------------------------------     zebrafish
AAF59368  181 ligcrvsnqsitdksleekkeshlhssmihikpaleskdhnstlsggaltafiypqshnnsavldqknpqdvkngfhnkk 260 fruit fly
AAH63973      --------------------------------------------------------------------------------     zebrafish
NP_997625     --------------------------------------------------------------------------------     human
AAH75129      --------------------------------------------------------------------------------     African clawed frog
AAH93202      --------------------------------------------------------------------------------     zebrafish
CAG06532      --------------------------------------------------------------------------------     Tetraodon nigrovir...

Feature 1                        ###                              
AAH77817  159 ----------sTPWHLQATCAIIGDGLREGIEKLYEMIIKRRKMlrqqKKKR 200 African clawed frog
NP_005728 152 ----------aTTYHVQPACAIIGEGLTEGMDKLYEMILKRRKSlk-qKKKR 192 human
NP_955938 159 ----------sTLHHVQGCSAVDGQGLQLGLEKLYDMILKRKKMvrlsKKKR 200 zebrafish
AAF59368  261 mnrsssnsvqfRGWYIQPTCAITGEGLQEGLDALYDMILKRRKIn--kSNKR 310 fruit fly
AAH63973  160 ----------hTPWHLQPACAIIGEGLQEGLERLHTMIIKRRKMmrqqKRKR 201 zebrafish
NP_997625 159 ----------sTPWHLQPTCAIIGDGLKEGLEKLHDMIIKRRKMlrqqKKKR 200 human
AAH75129  152 ----------sTPYHVQPACAIIGEGLTEGMDKLYEMILKRRKTl--kKKKK 191 African clawed frog
AAH93202  152 ----------sTTYHVQPACAIIGEGLHEGMDKLYEMIVKRRKSlk-qKKKR 192 zebrafish
CAG06532  160 ----------yTLHHAQGCSALDGRGLQAGLEKLHQMILKRRKMmkhsRNRR 201 Tetraodon nigroviridis

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