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cd03486: MutL_Trans_MLH3 
MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. MLH1 forms heterodimers with MLH3. The MLH1-MLH3 complex plays a role in meiosis. A role for hMLH1-hMLH3 in DNA mismatch repair (MMR) has not been established. It has been suggested that hMLH3 may be a low risk gene for colorectal cancer; however there is little evidence to support it having a role in classical HNPCC.
Links
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Statistics
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PSSM-Id: 239568
View PSSM: cd03486
Aligned: 12 rows
Threshold Bit Score: 145.537
Threshold Setting Gi: 49655430
Created: 21-Feb-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
Hierarchy
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Display:
 
ATP binding
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:By similarity to Escherichia coli MutL.
  • Comment:conserved Lys residue from the transducer domain interacts with the gamma-phosphate of bound nucleotide.

cd03486 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd03486 is a member of the superfamily cl02783.
cd00329:TopoII_MutL_Transcd00782:MutL_Transcd00822:TopoII_Trans_DNA_gyrasecd00823:TopoIIB_Transcd03481:TopoIIA_Trans_ScTopoIIAcd03482:MutL_Trans_MutLcd03483:MutL_Trans_MLH1cd03484:MutL_Trans_hPMS_2_likecd03485:MutL_Trans_hPMS_1_likecd03486:MutL_Trans_MLH34723020249115413620031575074850072007107668103335025840049655430495287454498007763250935030537347230202491154136200315750748500720071076681033350258400496554304952874544980077632509350305373
cd03486 Sequence Cluster
cd03486 Sequence Cluster
Sub-family Hierarchy
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 cd03486 Branch
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 47230202  205 SIYHRFVQIHSlsr-aqNLGEINfth---------qqfSVVGYVGReg---hyNNCLQFLYVNERLLLk-TRVHKLINCL 270
gi 49115413  136 DVRSRFCQIYGlpr-sqKLCEIQhkv---------kefDMWGYISCea---hyNKRMQYLYVNKRLVLk-TKLHQLIDFL 201
gi 66810333  249 SFLSYFKHFYGqem-mnKLEYVTsenynnttnnnsssyYLSGYLSSphkkghpNKSFQYIYLNNRIVLn-TKLHRHVNQL 326
gi 62003157  206 DVCSRFCQIYGlgk-sqKLREISfky---------kefELSGYISSea---hyNKNMQFLFVNKRLVLr-TKLHKLIDFL 271
gi 72007107   82 SIVQTFGYLFGkdv-adCLKEVNhir---------tifNVSGFIGSts---frNKSLQFVYVNGRLVLk-TKIHKLINEL 147
gi 50748500  285 DVYSRFCQIYGlgr-sqKLREIKhks---------ggfEISGYISSeg---hyNKNMQFLYVNRRLVLk-TRLHKLIDFL 350
gi 50258400  218 SALDVFKTLYGgal-vqSVQKIKvta---------gkrKVDGFISIsg---dvSKAHQHLYINNYPIDr-GDVHTAIAKK 283
gi 49655430  241 RYATIFKSIYGhsl-lsEYETVRanf---------qdyKLDGIIGLfp---sqSKAFQYIFVNQRPLLisNEDSKYLNKI 307
gi 49528745  240 PIHNAFIRVYGhvvpdpSIKIVKlsf---------reyNITGLISNcq---vrSKSFQFVFVNGRRYSn-SEFLGKINRI 306
gi 6325093   233 QMSQVLRNVFGaiippdMLKKVSlkf---------neyQIEGIISKmp---vgLKDLQFIYINGRRYAd-SAFQGYVDSL 299
gi 44980077  226 TLMAVLMCCLGpvvaakDLQYVSaky---------qdiEVQGVISTvg---vpSKDYQFIYINKRRYEd-KRFIFGFNKL 292
gi 50305373  216 QLDTCFHNIFGeilprkQLKFVSasf---------kshTVKGIVSInp---iqSKDYQYIFINGRKYSd-SRFFSAVNKL 282
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                     #  
gi 47230202  271 LRkp-----------sSINQKndspersvgs--------------pkhkrsqdlHGVYILNIKCCYSEYDVCL-EPAKTL 324
gi 49115413  202 LRk------------eSSICKpkninvgksss------------pgrsrscqelHGIFVINIYCHYSEYDVCF-EPAKTL 256
gi 66810333  327 YQkyrlf-----natrKANANvskiak---------------------kevidsNPIFILFLRCSQLEYERSYePSSKTF 380
gi 62003157  272 LRk------------eSIICKpkngptsrqmn-----------sslrhrstpelYGIYVINVQCQFCEYDVCM-EPAKTL 327
gi 72007107  148 LSn-------------SLVTKskgknqdtalgytmksnaasstcqpspggnqveYGIFVLNITCPRSEYDITL-DPSKTL 213
gi 50748500  351 LRk------------eSVICKaksvpaskqgss----------spgrlrcgpelYGIFVLNVTCAYSDYDVSL-EPTKTL 407
gi 50258400  284 FAs-------------SKFANlasagqhdededy-------hpsgrrsprrlerYPVYVLNVTLSAGELDVSY-EPQKGV 342
gi 49655430  308 FVtanfg-----gmltSTASNislspskvspn------------kqytsksfsrFPVFIINIQCPIIIEDLFQ-DPSKSI 369
gi 49528745  307 FDq-------------STFATnavekdtr-----------------lgkrsarsYPLFVIKIDGPAHVQDLIQ-STSKDI 355
gi 6325093   300 FQaqdfgekgmsllktKSVGKpy-----------------------------rsHPVFILDVRCPQTIDDLLQ-DPAKKI 349
gi 44980077  293 FR--------------SARYKednmlaast---------------rggqqaysgYPVYLLVCKGPPSISDLLQ-NPSKVI 342
gi 50305373  283 FQs------------tKYVEKnwdsysvk-----------------svgspysaYPLFIIGCEVPLEISDLIQ-DPGKTI 332
                        170       180
                 ....*....|....*....|..
Feature 1                              
gi 47230202  325 IEFkdWDGVMACVEEAVKTFLK 346
gi 49115413  257 IEFkdWDTVLHCVEEGTRAFLK 278
gi 66810333  381 LEFndWKKPLAEIQNVLTKFLT 402
gi 62003157  328 IEFqnWDTLLFCIQEGVKMFLK 349
gi 72007107  214 IEFrdWEGAVTCVHELVTSFLH 235
gi 50748500  408 IEFqnWDVLLACVEEGVKMFLK 429
gi 50258400  343 LGYkdIESLKTMLLAVVDEFLR 364
gi 49655430  370 YYSnhMKLILNMLRNVFSSFLL 391
gi 49528745  356 IHLsdGKLINILILKVIYSFLK 377
gi 6325093   350 VKPshIRTIEPLIVKTIRSFLT 371
gi 44980077  343 ENLeyGRVLQPLLCQVAKSFLR 364
gi 50305373  333 FQSgtLKTLCPLILNVMSSFLK 354

Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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