1WIN


Conserved Protein Domain Family
SPFH_flotillin

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cd03399: SPFH_flotillin 
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Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
The flotillin (reggie) like proteins are lipid raft-associated. Individual proteins of this SPFH family may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. In addition, microdomains formed from flotillin proteins may be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and interact with a variety of proteins. They may play a role in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and in cancer invasion, and metastasis.
Statistics
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PSSM-Id: 259798
Aligned: 142 rows
Threshold Bit Score: 80.2408
Created: 4-Feb-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1WIN_A      1 GSSGSSGQRISLEIMTLQPRCEDVETA-----EGVALTVTGVAQVKIMTEk-ELLAVACEQFLGkn--vQDIKNVVLQTL 72   house mouse
CAB41272   53 LPVLHKAEVMDISVKTIEITRAGKEGLic--rDNIRADIRISFFVKVNKTaeDVVKVAQAVGTArasdrDTLQELFHAKF 130  Streptomyces coel...
BAC48645   59 LPFIHDYTPVNMNVLPMGIVRSRQDAVit--rDRMRVDIEADFYVRVQATkeAVSIAAATLGRRtm-epERLHALLAGKF 135  Bradyrhizobium ja...
BAC49735   52 MILPIFHSYASVNLKTLRLTVERKEREslitkDRLRVDIVAEFYVRVRPDdeSIALASQTLGALtn-daEALRNQVEAKF 130  Bradyrhizobium ja...
NP_867388  65 IPLIQQYEFMDLTLKSFEIHRQGSEGLic--rDNIRADIKVAFFVRVDKSpeEMKEVAQSIGAKrcselETLRELFDAKF 142  Rhodopirellula ba...
EEF14785   57 LILPILHDYIDINMQSMKVTVARSKSDsfitkDRMRVDITADFYIRVGEDreSISRAAQTLGKKti-dlRELTGLIEGKL 135  Campylobacter rec...
AEH90250   57 FVIPVLHDITPVNMNVLRIEVRREDGLalitrNRMRVDLIAEFFVRVGASreLVAAAAQTLGRRtl-qpDSLRELLEGKF 135  Mesorhizobium sp....
CCK79108   55 LVLPVFHELIPVNMNTLRLEVQRNNEQalitrDRMRVDVAAEFYVRAKPTeeAIASAAQTLGLKtm-npEQLKELVEGKF 133  Desulfobacula tol...
EAQ11929   51 LAIPYFHEINRVNMQTIRMDVVRRGNSalitkDRMRVDVGAEFYASVVPEpeAIARAAQTLGRRtf-qpDELKTLIDGMM 129  Rhodobacterales b...
EIZ79633   64 MVIPVLHELMQVRLTTVKLEVSRLNKDalitlDKLRVDVVGLFHIKVKPDaqSIAAAAQTLGDSvn-saDAVKSLLDGKL 142  Novosphingobium s...
1WIN_A     73 EGHLRSILGTLTVEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVd-YLSSLGKTQTSGPSSG 143  house mouse
CAB41272  131 SEALKTVGKQLDFTDLYTKREELRYRIIEVIGVDLSGYHLEDAAIDYLEQTPLT--QLDPANVLDAQGIRKI 200  Streptomyces coelicolor A...
BAC48645  136 ISAIRSVASEMTLEEMHERRGDYVVRVKTNAAEALAQNGLELESVAITDLDQTDleFFNPSNRFDAEGLTRL 207  Bradyrhizobium japonicum ...
BAC49735  131 VDGLRSVAATMSILELQEKRSDFVKHVQATVESDVKSNGLELESVSLTKLDQTDvkFFNPENFFDAEGLTQL 202  Bradyrhizobium japonicum ...
NP_867388 143 SEALKTVGKQFDFVDLYDQRDKFKEEILKVIGTDLNGYRLDDAAIDYLEQTPLD--MLSPTNILDAEGIKKI 212  Rhodopirellula baltica SH 1
EEF14785  136 IATLRSVASSMEMKELHEKRDEFSSQVKNAIEADLSKNGLQLESVSLTSLDQTAkeFFNENNAFDAEGLTSL 207  Campylobacter rectus RM3267
AEH90250  136 AGALRTVAAQMTLEEMHELRGDYAAKVRRLAEESLAANGLELESVAIVDLDQTSleYFDPSNAFDAEGLTQL 207  Mesorhizobium sp. LMG 24607
CCK79108  134 VDALRAVAAEMAMEELHEQRVDFVQKVQQVVTEDLLKNGLELETVSLTGLDQTSkkHFNPDNAFDAEGLTKL 205  Desulfobacula toluolica Tol2
EAQ11929  130 IDALRTVAAQMTMDELHENRAEFVREVRDILGETLGRYGLQLDSVSLTDFDQTPfnTLDETNAFNAVGMRKL 201  Rhodobacterales bacterium...
EIZ79633  143 VSALRSVAATMTMEHLHANRADFIQKVQEALMTDLDMNGFQLESVSITHFDQTAfeHFNENNAFDAEGLTVL 214  Novosphingobium sp. Rr 2-17
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