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Entrez CDD Structure Protein Help
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cd02156: nt_trans 
Click on image for an interactive view with Cn3D
nt_trans (nucleotidyl transferase) This superfamily includes the class I amino-acyl tRNA synthetases, pantothenate synthetase (PanC), ATP sulfurylase, and the cytidylyltransferases, all of which have a conserved dinucleotide-binding domain.
Statistics
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PSSM-Id: 28823
View PSSM: cd02156
Aligned: 915 rows
Created: 7-Mar-2002
Updated: 5-Jan-2006
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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Feature Residues: 33-36,186-189. -Click on image for an interactive view with Cn3D
Feature 1: active site
Evidence:
  • Comment:residues which were generally conserved in the active site based on multiple structure evidences (using 3.5A).
  • Structure:1I6M_A; TrpRS bound to Tryptophanyl-5'AMP using 3.5A
    View structure with Cn3D
  • Comment:Includes ATP binding sites (HIGH and KMSKS motifs)

cd02156 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd02156 is a member of the superfamily cl00015.
cd00395:Tyr_Trp_RS_corecd00418:GlxRS_corecd00517:ATPScd00560:PanCcd00668:Ile_Leu_Val_MetRS_corecd00671:ArgRS_corecd00672:CysRS_corecd00674:LysRS_core_class_Icd00802:class_I_aaRS_corecd00805:TyrRS_corecd00806:TrpRS_corecd00807:Gln_GluRS_non_corecd00808:GluRS_corecd00812:LeuRS_corecd00814:MetRS_corecd00817:ValRS_corecd00818:IleRS_corecd02039:cytidylyltransferase_likecd02064:Flavokinase_Ccd02156:nt_transcd02158:PanC_ATPScd02163:PPAT_acd02164:PPAT_CoAScd02165:NMNATcd02166:NMNAT_Archaeacd02167:NMNAT_NadRcd02168:NMNAT_Nudixcd02169:Citrate_lyase_ligasecd02170:cytidylyltransferasecd02171:G3P_Cytidylyltransferasecd02172:RfaE_Ncd02173:ECTcd02174:CCT1A8H  6094407738827925010302500939525009363250093752500940662261895860602500937017116401431863415020809334170752135848319115319305805313122902234786511351165292462052348358814424467250094071F4L A250094043247376131229112500936425009397250103425009365312290573882781264403625009343250093961711639191123782017833232414515391507234785759347859091223064919074889214287603915073609440829830946738828125009409250093791831150531087940250093541FFY A135115962261812507434134768166226709171163425010111017719324665024767880427884149190754382501012312289866478228928379157910201JZS A21220556293462161351343122901250101328881130730870246685433478380319074910622618289283836094404892836417116352501068157912983122909125853466226199284934451608122012585358158977841GAX A1347119734540861622619625010673915080609441758606912585357135118113518417116551223064713511791264417715292509288282251907419215620829175106612501065191147312135567525074381H3N A25010283217158015791045691998013514221355409135144135116325010292507435302467825076082361273531232866919982691997714285783321715751351401711638135141622671021429196244967891521756769199813122899312290832171571691997839158681442394814916942144239401EUQ A345415542209619623489563273799481907475513511703478550212643524113871293241630825074361138715922096197252932772924682376743481351041751100717116262136294621751193234906881907404020043025292486791G59 A668601417380509122309423031616913510617116273031618330316163622617013511502500974135107301731803247491924418705668602425074281911443732403878622617133285170668598822654288246653212505898929348157236194933031617630316177303161814033775668599330316275352129462500977303161733334350303163392500979668600430316178303163413334355303161729664593157902301IRX B300206638928369622618428493029278086793183557244187033183169318316889283806226186278057452310802489283681LI7 A6226168342227521138715468316826831685212640202126402528493314234649022500966683168331228841538399054902421264002683168425074271138714922257061315448831351147244187012885617528436794201416414972706135162117308401750979719173375115283391043351919922218683168665994746094392683168124418697303161642126401028493283212640261H3E A498099113519311745543024675622620425010761JIJ A4TS1 A135198212203077705710157893121676860813511856226208265542511335767415828956141952281347033513511831351184368746160944196226205235083721J1U A31229121579105525010781460182416081625236129351N3L A21357223281756631917365254903715840133183174324159661I6M A20178125250094173439597932141199803980680398072706464622620321362967246661511561476325009454250094292780482828493653250094512500944226553910315447511351182417845391507960944182965532862262002500943479946923454166721672854167633152501073250094312017813831229102500943011745532830230925010743096253766363881907485320178122201781332017812728950279201781391F7U A373821223822206135169250104820178140282778202017833121431831767435723822190767435016127589391506460944121IQ0 A1580755276743437674354238222022501049333436233343592382219123822192160814231351172250104631544216285147762261922347450026554064158287143521485429655291767435224214388622619323822203238222111351171285725711IHO A11720079978473296117973017305412643468272625184552819730173019444856741343177524215214428511504312348844587856446112024432802011133982273802733249119744462709134317784452270624638093246381052463810330248104455203561428565320139170444590981MOP A1459500828493030730270246380949978482445666684325105144279895436308604458184244379638444581451V8F A81346231723042824638102170956921399457813461781346253244393622299993239578163752137513431776246380913017311645198800249874332265534345565632934971634540294446089384452488444398822332411953386214642949885440089364461520944444057436675754458353943834088443206424463674644509192813462625090869230159553823489144247326537131214252692153713870282113521JEE A198616231I2D A1956978055663197388241296540381336213338648407388232738823742557691445650267388233738823473882397388238331504401JHD A738823121673691738822918313467158996254140869670538524667044922992020178315380145242850293474285282026030017542422565616249824150121498965524574024320543094636794089918310128624949128212136681768717183688115673170488662362837789458337217293777636251409034764056754283742437945071910723425270301EJ2 A156781781M8J A1HYB A1M8K C1M8G A1M8F A1F9A A1F9A F244185771072012410720129200925283058047824418578145903751831321930580481107203621072036814423765305804857060613910720131107201283521222537521229567513151580741515807935567075352124144450085678676763791LW7 A73010715607353669658552625084223128339557365011567396923023386713645151B6T A1QJC B26991799294278625124662640063042542935396820612584691883226291234557028141945337115128784691985803935214194502488482024876416956416718294278782965364047779379537564924657994358220679846920371892375710836783017281811706405372876848862368715427671O6B A294278461TFU A56964142518925777136988184692046242298629427812679880142942779829427697509546651OD6 A8469199294277722942782129427884679279436685707371547793293769456251422133240402375204161VLH F395747452942784829427874315630163156301739649520540409001347090748870380315630154886589850842942324765438469193425268835404090114194507294277265404090329427730557376092942795623002617583371438469191156057976696531753799635572350541GZU C11245472507592911NUP A5075205847228809628577014721643268356350455519723413920243079895572819255959796411523863759031747206745507511645834807107201274610204029150132425685611072037329251261564689646812584571752255310773191K4K A1K4K D291426233752526750120245313402335646005825008829542972541KAM A1KAQ F5642105738258126569634051419496621759288141949611590363438257939230036883999830023024093382580454887046262512889488653902500883228476477715408465723367721759284217593033409849946199723107201113410182835214590512464396793413571545714141949644614108952006323296538953024837653757569537969365371879817546912740237254757497721759289518915723825811568548412712784951072012021232047335970114886396623474941465803636767569310720107425272533247537466855309425251691072012113959723265539723409851973662473315414661072012215828806474591115402053071894335107201145750527157018571711506631072011842560977503651913226189919704467242135552167285767919607679379256854937968552747714813123439624138258073369558464885602848850371610996706853999256544132566771019657601289002685971378454302591107201192229872117229975567514073324104733863727338650397238281433862001140380449853804644423649655653502851391911539571005670496461153997571940741014502580694626606321444503060915028783744985097116114491258522357254101750987330580471125853141265316749522270537338657201733645550974567532636682666570834856716646195646630856471212674774262213625828566182509424832893292213458574622880268352350528099131433688668040855026062312643330276970076220435150752297230927873217243919074770649184252788237324051727100313123482162236194005465804746229809653038646835077611611449496522954644150549647379125853144952227053733865567532631750987322136258509424832893292270834856716646195652125123619400564663086682666556471212462298091655449520092353315630093156302948477580571603872465860255238270720406063236350549522272522190002514340939589394343656115093464742554653461007675101266950305731462298652924569468350701156065642983785334133205242471368181137685436011N1D A4690985869937304156729064620071727380533296540166792455571083244685525856854942856752220222953186696350653796251183121014565804910640451157899426821150926219352009401613814134159215427060709114601966159180645358506564721015402033515829019718945744745930316743796687998615611406571681726968056572411455701718934482718711510715670801726554380222952816792064037519786171339855376460256751037338626373386182979939175091915510177822231003265696398950842952156057184644639228476590683049404252301415639873425265494876601056679723161249566820571213476810682469224690697866857474710828651MRZ B48854843537156263454070973541272816321162148144816343257234593537302025647795671838108588183266964163463082845841719156417122425206002167243315616770251662502965373848861379273639725646023775207957375245941560352654296957537574625008331871364500995080652006966344990257227089512449466800287568177934242161486798669462424968715445266793127750954473302491373247528968263812413261562960619438234051156099236823274942525592583375316816603610175029160787305641980242782897283776936819505262514172283786642302357048869686228923150590668488659501590097762464258230990577366280231544324714824571083888216730832347341634762574212306125379585668270735715417722726232251892664685620302738259159802563488505096458736461984672080783649474573679164781814534515024779282109651A8H  6094407738827925010302500939525009363250093752500940662261895860602500937017116401431863415020809334170752135848319115319305805313122902234786511351165292462052348358814424467250094071F4L A250094043247376131229112500936425009397250103425009365312290573882781264403625009343250093961711639191123782017833232414515391507234785759347859091223064919074889214287603915073609440829830946738828125009409250093791831150531087940250093541FFY A135115962261812507434134768166226709171163425010111017719324665024767880427884149190754382501012312289866478228928379157910201JZS A21220556293462161351343122901250101328881130730870246685433478380319074910622618289283836094404892836417116352501068157912983122909125853466226199284934451608122012585358158977841GAX A1347119734540861622619625010673915080609441758606912585357135118113518417116551223064713511791264417715292509288282251907419215620829175106612501065191147312135567525074381H3N A25010283217158015791045691998013514221355409135144135116325010292507435302467825076082361273531232866919982691997714285783321715751351401711638135141622671021429196244967891521756769199813122899312290832171571691997839158681442394814916942144239401EUQ A345415542209619623489563273799481907475513511703478550212643524113871293241630825074361138715922096197252932772924682376743481351041751100717116262136294621751193234906881907404020043025292486791G59 A668601417380509122309423031616913510617116273031618330316163622617013511502500974135107301731803247491924418705668602425074281911443732403878622617133285170668598822654288246653212505898929348157236194933031617630316177303161814033775668599330316275352129462500977303161733334350303163392500979668600430316178303163413334355303161729664593157902301IRX B300206638928369622618428493029278086793183557244187033183169318316889283806226186278057452310802489283681LI7 A6226168342227521138715468316826831685212640202126402528493314234649022500966683168331228841538399054902421264002683168425074271138714922257061315448831351147244187012885617528436794201416414972706135162117308401750979719173375115283391043351919922218683168665994746094392683168124418697303161642126401028493283212640261H3E A498099113519311745543024675622620425010761JIJ A4TS1 A135198212203077705710157893121676860813511856226208265542511335767415828956141952281347033513511831351184368746160944196226205235083721J1U A31229121579105525010781460182416081625236129351N3L A21357223281756631917365254903715840133183174324159661I6M A20178125250094173439597932141199803980680398072706464622620321362967246661511561476325009454250094292780482828493653250094512500944226553910315447511351182417845391507960944182965532862262002500943479946923454166721672854167633152501073250094312017813831229102500943011745532830230925010743096253766363881907485320178122201781332017812728950279201781391F7U A373821223822206135169250104820178140282778202017833121431831767435723822190767435016127589391506460944121IQ0 A1580755276743437674354238222022501049333436233343592382219123822192160814231351172250104631544216285147762261922347450026554064158287143521485429655291767435224214388622619323822203238222111351171285725711IHO A11720079978473296117973017305412643468272625184552819730173019444856741343177524215214428511504312348844587856446112024432802011133982273802733249119744462709134317784452270624638093246381052463810330248104455203561428565320139170444590981MOP A1459500828493030730270246380949978482445666684325105144279895436308604458184244379638444581451V8F A81346231723042824638102170956921399457813461781346253244393622299993239578163752137513431776246380913017311645198800249874332265534345565632934971634540294446089384452488444398822332411953386214642949885440089364461520944444057436675754458353943834088443206424463674644509192813462625090869230159553823489144247326537131214252692153713870282113521JEE A198616231I2D A1956978055663197388241296540381336213338648407388232738823742557691445650267388233738823473882397388238331504401JHD A738823121673691738822918313467158996254140869670538524667044922992020178315380145242850293474285282026030017542422565616249824150121498965524574024320543094636794089918310128624949128212136681768717183688115673170488662362837789458337217293777636251409034764056754283742437945071910723425270301EJ2 A156781781M8J A1HYB A1M8K C1M8G A1M8F A1F9A A1F9A F244185771072012410720129200925283058047824418578145903751831321930580481107203621072036814423765305804857060613910720131107201283521222537521229567513151580741515807935567075352124144450085678676763791LW7 A73010715607353669658552625084223128339557365011567396923023386713645151B6T A1QJC B26991799294278625124662640063042542935396820612584691883226291234557028141945337115128784691985803935214194502488482024876416956416718294278782965364047779379537564924657994358220679846920371892375710836783017281811706405372876848862368715427671O6B A294278461TFU A56964142518925777136988184692046242298629427812679880142942779829427697509546651OD6 A8469199294277722942782129427884679279436685707371547793293769456251422133240402375204161VLH F395747452942784829427874315630163156301739649520540409001347090748870380315630154886589850842942324765438469193425268835404090114194507294277265404090329427730557376092942795623002617583371438469191156057976696531753799635572350541GZU C11245472507592911NUP A5075205847228809628577014721643268356350455519723413920243079895572819255959796411523863759031747206745507511645834807107201274610204029150132425685611072037329251261564689646812584571752255310773191K4K A1K4K D291426233752526750120245313402335646005825008829542972541KAM A1KAQ F5642105738258126569634051419496621759288141949611590363438257939230036883999830023024093382580454887046262512889488653902500883228476477715408465723367721759284217593033409849946199723107201113410182835214590512464396793413571545714141949644614108952006323296538953024837653757569537969365371879817546912740237254757497721759289518915723825811568548412712784951072012021232047335970114886396623474941465803636767569310720107425272533247537466855309425251691072012113959723265539723409851973662473315414661072012215828806474591115402053071894335107201145750527157018571711506631072011842560977503651913226189919704467242135552167285767919607679379256854937968552747714813123439624138258073369558464885602848850371610996706853999256544132566771019657601289002685971378454302591107201192229872117229975567514073324104733863727338650397238281433862001140380449853804644423649655653502851391911539571005670496461153997571940741014502580694626606321444503060915028783744985097116114491258522357254101750987330580471125853141265316749522270537338657201733645550974567532636682666570834856716646195646630856471212674774262213625828566182509424832893292213458574622880268352350528099131433688668040855026062312643330276970076220435150752297230927873217243919074770649184252788237324051727100313123482162236194005465804746229809653038646835077611611449496522954644150549647379125853144952227053733865567532631750987322136258509424832893292270834856716646195652125123619400564663086682666556471212462298091655449520092353315630093156302948477580571603872465860255238270720406063236350549522272522190002514340939589394343656115093464742554653461007675101266950305731462298652924569468350701156065642983785334133205242471368181137685436011N1D A4690985869937304156729064620071727380533296540166792455571083244685525856854942856752220222953186696350653796251183121014565804910640451157899426821150926219352009401613814134159215427060709114601966159180645358506564721015402033515829019718945744745930316743796687998615611406571681726968056572411455701718934482718711510715670801726554380222952816792064037519786171339855376460256751037338626373386182979939175091915510177822231003265696398950842952156057184644639228476590683049404252301415639873425265494876601056679723161249566820571213476810682469224690697866857474710828651MRZ B4885484353715626345407097354127281632116214814481634325723459353730202564779567183810858818326696416346308284584171915641712242520600216724331561677025166250296537384886137927363972564602377520795737524594156035265429695753757462500833187136450099508065200696634499025722708951244946680028756817793424216148679866946242496871544526679312775095447330249137324752896826381241326156296061943823405115609923682327494252559258337531681660361017502916078730564198024278289728377693681950526251417228378664230235704886968622892315059066848865950159009776246425823099057736628023154432471482457108388821673083234734163476257421230612537958566827073571541772272623225189266468562030273825915980256348850509645873646198467208078364947457367916478181453451502477928210965
cd02156 Sequence Cluster
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cd02156 Sequence Cluster
Sub-family Hierarchy
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CD Hierarchy
Sequence Alignment?
Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 ####                                                                  
1IHO_A       24 VALVPTMGnLHDGHMKlVDEAKara---------dvVVVSIFVNpmqfdrpe---------------------------- 66
1F7U_A      149 FSSPNIAKpFHAGHLRsTIIGGflanlyeklgweviRMNYLGDWgkqfgllavgferygneealvkdpihhlfdvyvrin 228
1I6M_A        5 FSGIQPSGvITIGNYIgALRQFvelq------heynCYFCIVDQhaitvwqd---------------------------- 50
1IQ0_A      109 HTSVNPNKeLHVGHLRnIALGDaiarilayagrevlVLNYIDDTgrqaaetlfalrhygltwdgkekydhfagrayvr-- 186
1IRX_B       25 ESGITPSGyVHVGNFReLFTAYivghalrdkgyevrHIHMWDDYdrfrkvprnvpqewkdylgm---------------- 88
1LI7_A       27 VCGITVYDlCHIGHGRtFVAFDvvarylrflgyklkYVRNITDIddkiikranen------------------------- 81
gi 1351172  110 SVSANPTGrIHLGHVRiAFFGDvlnnlakllgyttvCEYWVNDYgqqarvfsfsvyqslqlkkniaiqqhpdgysgivid 189
gi 20178122  77 YTGRGPSGpMHIGHIIpFFATKwlqek-----fgvnLYIQITDDekflfkenl--------------------------- 124
gi 20178127  76 YTGRGPSGpVHIGHMVpWILLKwfsdk-----fgleVYFQITDDekfyddpem--------------------------- 123
gi 20178133  76 YTGRAPSLgMHIGHLIpFIFTKwlqek-----fnanLYIEITDDekymrnpef--------------------------- 123
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1IHO_A       67 -------------------------------------dlaryprtLQEDCEKlnkrkvdlvfapsvkeiypngteth--- 106
1F7U_A      229 kdieeegdsipleqstngkareyfkrmedgdeealkiwkrfrefsIEKYIDTyarlnikydvysgesqvskesmlkaidl 308
1I6M_A       51 --------------------------------------phelrqnIRRLAALylavgidptqatlfiqsevpahaqaawm 92
1IQ0_A      187 ------------lhqdpeyerlqpaieevlhalergelreevnriLLAQMATmhalnarydllvwesdivragllqkala 254
1IRX_B       89 --------------------------pisevpdpwgchesyaehfMRKFEEEveklgievdllyaselykrgeyseeirl 142
1LI7_A       82 ----------------------------------gesfvamvdrmIAEMHKDfdalnilrpdmeprathhiaeiielteq 127
gi 1351172  190 ki------aseienfpvdnlnfeefcktsfldhflvnctqkvlslIKSDLNKihvfidswkfeseivkktnfndlleqlk 263
gi 20178122 125 -------------------------------------tfddtkrwAYDNILDiiavgfdpdktfifqnseftkiyemaip 167
gi 20178127 124 -------------------------------------kleeatnwAYENALDvialgfsperlhliidtkdikplypiav 166
gi 20178133 124 -------------------------------------tldqtrswAYDNILDiiavgfnpdktfifqdteyirnmypitv 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1IHO_A      107 ------------------------------------------------------tyvdvpglstmlegasrpghfrgvsT 132
1F7U_A      309 fkekgl---------------------------------------thedkgavlidltkfnkklgkaivqksdgttlylT 349
1I6M_A       93 lqc---------------------------------------------ivyigelermtqfkeksagkeavsaglltypP 127
1IQ0_A      255 lleqsphvfr-------------------------------pregkyagalvmdaspvipgledpffvllrsngtatyyA 303
1IRX_B      143 afekrdkimeilnkyreiakqpplp--enwwpamvycpehrreaeiiewdggwkvkykcpeghegwvdirsgnvklrwrV 220
1LI7_A      128 liakghayvadngdvmfdvptdptygvlsrqdldqlqagarvdvvddkrnpmdfvlwkmskegepswpspwgagrpgwhI 207
gi 1351172  264 pnsy-------------------------------------------fyqdnalwlkttlygddkdrvlirsdkrasyfG 300
gi 20178122 168 ---------------------------------------------------iakkinfsmakavfgfteqskigmiffpA 196
gi 20178127 167 r--------------------------------------------------vakkltwntvkatfgftdstniglifypS 196
gi 20178133 167 k--------------------------------------------------iakkltfsevratfgldassniglifypA 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1IHO_A      133 IVSKLFnlv----------------------------------qpdIACFgekdfqqlali-----rkmvadmgfdiEIV 173
1F7U_A      350 RDVGAAmdryek----------------------------yhfdkmIYVIasqqdlhaaqff---eilkqmgfewakDLQ 398
1I6M_A      128 LMAADIlly----------------------------------ntdIVPVgedqkqhieltrdlaerfnkrygelftIPE 173
1IQ0_A      304 KDIAFQfwkmgileglrfrpyenpyypglrtsapegeaytpkaeetINVVdvrqshpqalvra--alalagypalaeKAH 381
1IRX_B      221 DWPMRWshf----------------------------------gvdFEPAgkdhlvagssydt--gkeiikevygkeAPL 264
1LI7_A      208 ECSAMNckqlg-------------------------------nhfdIHGGgsdlmfphhene---iaqstcahdgqyVNY 253
gi 1351172  301 TDVAYHleklqr-----------------------------gfdilFNVWgtdheghikrmy---cafdalknttktSLK 348
gi 20178122 197 IQIAPTffer---------------------------------krcLIPAaidqdpywrlq------rdfaeslgyyKTA 237
gi 20178127 197 LQIAVAflptelr---------------------------reatpvLIPCaidqdpyfrla------rdiadalgypKPS 243
gi 20178133 197 LQIAPTmfek---------------------------------krcLIPAgidqdpywrlq------rdiaeslgyyKAA 237
                       330       340
                ....*....|....*....|...
Feature 1                          ####
1IHO_A      174 Gvpimra------kdglalSSRN 190
1F7U_A      399 Hvnfg----------mvqgMSTR 411
1I6M_A      174 AripkvgarimslvdptkkMSKS 196
1IQ0_A      382 Hlayetv------llegrqMSGR 398
1IRX_B      265 Slmyefvg----ikgqkgkMSGS 283
1LI7_A      254 Wmhsgmv------mvdrekMSKS 270
gi 1351172  349 Ifalqlvtl--yknkelvrLSKR 369
gi 20178122 238 Alhskfvps---ltslsgkMSAS 257
gi 20178127 244 Tlyskfim----altgeskMSAS 262
gi 20178133 238 Qihskflpp---ltgpegkMSSS 257

Citing CDD
Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res. 37(D)205-10.
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Feature Residues: 33-36,186-189. -Click on image for an interactive view with Cn3D