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cd01949: GGDEF 
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Diguanylate-cyclase (DGC) or GGDEF domain
Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.
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BioAssay Targets and Results
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CID: 6804
AID: 1811
GI: 56966618
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CID:6804AID:1811GI:56966618
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Experimentally measured binding affinity data derived from PDB
Chemical Name: guanylic acid
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Statistics
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PSSM-Id: 143635
View PSSM: cd01949
Aligned: 825 rows
Threshold Bit Score: 39.0769
Threshold Setting Gi: 144898329
Created: 13-Dec-2003
Updated: 17-Jan-2013
Structure
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Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:the active site is formed at the diguanylate cyclase dimerization interface
  • Structure:1W25: Response regulator PleD in complex with Cyclic Di-GMP
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cd01949 is part of a hierarchy of related CD models.
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cd01949 is a member of the superfamily cl11967.
cd01949:GGDEFcd07302:CHDcd07556:Nucleotidyl_cyc_III2066847592140425201560661530351160399979202212770319826177815614796344971221961954572070855469120112342524511214039892344958413768113611762112698690920708619420708401624375805289015903993360619826339621231729156001521961931603768024821243179212317501754835339995914198262721196195529912018303999677119619512516523782735989333594381158016481147731721486560821889967031866852973449641917134034196178955156058741560662415605926157644515425219823999675818942490389093894269910942167393111858177320708607120708466521733723221733723817240051589588142528080512461611831054215727334091201909242141839120423613429941115615598208087012070838702070857321448983581677307631830994720708433015644336156437321564394021733612215002016615642917282116082698789124372162288982571580011115601453343303253024914115894105282104272066018298330982820708493315605636167730790214038699156147972437499583644174282114761573739843026412015595535207086565243724302070852072070864642293226230996593999605528853238345581493455789490022874193078679156443424589924345576083455677989095154114563157242156287127917920708540120708632620708631720708623320708433620708606137676011159185090289009702070857381W25 A2V0N A17229908912027883247759139934712155983732698882221403605016820341013471467156412292437590489092428195522611637614638879780915965900335925391583758834101840211077523449891621229884273612262124217315807849891081897353878591775551193222243543085661559536719762662027382451399966541596655215891183159184564341053461205532361961938813410539214489815011477742689094043207083839887043133BRE A2421522819619344322298467193222397243725153993667819826320019619189717231091163322362698996021233187222987533449864777543222193076781196193400155947645430235537676477288682234252719114022851156009351564228321232762324773642837906828379379289007802070855241564136519615757933929221580600527361790252942215641042156072288207084004288542002699016550122121194307175231005502736153516982828815918462215918487413470977500853791599019781223044430577826144898172206602029334153511449010672886848914489837977165235144899939344964881350664017548555584270775124448314490026514489888577918291302481113999564439933598836432461448999341559956317133360196176126196182927243746042124311619619500015600635302498617848454221108215175493181754903415299577830262524427797741583209768909457015801891208075513999613920708429320708625020708628416376329920708570739933860168186556207085601183097861500173502070844387877828215893919243717411877801661529951923445202915640673543023152070854352890103134558378300187351275112191676258522736122524376026345573291798801456419998205374177543096792119608773247261214897550224372790399334473449888228900464288968661754847527383111345568299593120437676764230988148252400328296141651835165183415902723830250015773614332122385146198730344970334140861019619292228871350198262314273665972111369934498023341023431245143731560563115606404156004881560021013476242891083321561553329829276158277461580549317229798222991551961916093247240119826124222298454211958261196248193124516000407872982736168688704648273791751651984213476852512469621347190719825425215918627621403875415807290118593438193782538211960692269899013767820014631179841019471542986442070840111573706545008550619826155036596182655361465788241580663415807957206602907206601586206601953317476711573648141482708951564453212451578914489738221301364526989277717260642736563613473025155960441449009131591851092140292761347368439937227399352212737750513488231124514355461989353449703720660229346202755211960773150777771407952888324729834057212341095498161976257631448986451580663831283061347444816533745008388515601713540425191580529810416197721733574639998445399967561589172619307800421404368353804085198253204273822244771681033595684138789562124138129830487211960636512417371588950431747795156407221596461237675710250670216125149273813422917150815918612913473973784847421560084554309631273623353993762333603636399360851448981302736108720708596354302563214036618207083962212325501923621822349999220708411117548233118588681917931852736781587118233345573533455788434556560345574072070848682070850012070839973455657420708490420708534820708633634557175207085761207083971207084756207083920207085896207086151207086195207084045207086123183092271982627152070847914657843971726101207085673156419362437404219618705915805776214038423140253901564274327358578156008511591861872738123542525647207085309212199022437214915598454208081429120400011107504539997035697802939997160144898329207085176159647051589595926987880288721285430282228898528282114302126389992437377018942582742528226134727681613000719618933819826251121243539243722192437203245441313376782541347176713473015192359514198261599528412591976259311982612891449001362123364154308632341015492070858255124405327360006542931734252757824375060158948461589484424373140273612391095745615808001201409592047896583768041615643920156410802889772727362612543083302610844824374297289754042736769012451497121733555441409745198261748196191474198253401140250691596661723500704140230451612490839933844158056322124141541407781399362824657917626990374193222304198252430198264295540221053359622017548474161195983993604916264252159185329134736121798780339934859235007283767666315300955015918461821404503216820341516703778715606095324737223247636339998060399343711205566961559796734498028336020903EZU A24217301156411985011960715918504550086421206603322156426922735839322298701465790501903400273613271591845972124321514489893233592585207084507205374857282114141637644082119565982736760515641384341050433410504419070379324713791205531021529960452123136050120026273622093768031115641117134709251140478591982629411589392489094058207086182163849321344955462698730114489784122298593172326661932224421448982242111478615601603109574531095740914022333159184666114564388156416072735896321263899527467446217332936302654349449825328875454158918652851425214038916212422383410155015889298888002362437238520660201615641601273617482890003920708604143788453767968727367989144899082144897986576657289009242736594820708591720708497021403843216767795399368532070859122070851453455723720708649234557573207085557542969013024845742528225335934482437321421229717543026642421540415896780164145261680109219322221920708532620708395232473997156399652437593534556843425229504252232628899140207085403890936351559952819619567019619621419826291916636404019617904489107874262480445645940977919843775432238909450832471539198261749114154898144897254134745022699006328899662214029554376811461347672513474053144898061344965981976260813449626714489922020708560528900331887996995430915617547151171326379120010450122807149908192124515977114772070114564780273589062437368724251273109899932399974111449013492124136415918468620140964289004112736694915601316335955801449009282736259489098814243737311560169224375348871229122066847592140425201560661530351160399979202212770319826177815614796344971221961954572070855469120112342524511214039892344958413768113611762112698690920708619420708401624375805289015903993360619826339621231729156001521961931603768024821243179212317501754835339995914198262721196195529912018303999677119619512516523782735989333594381158016481147731721486560821889967031866852973449641917134034196178955156058741560662415605926157644515425219823999675818942490389093894269910942167393111858177320708607120708466521733723221733723817240051589588142528080512461611831054215727334091201909242141839120423613429941115615598208087012070838702070857321448983581677307631830994720708433015644336156437321564394021733612215002016615642917282116082698789124372162288982571580011115601453343303253024914115894105282104272066018298330982820708493315605636167730790214038699156147972437499583644174282114761573739843026412015595535207086565243724302070852072070864642293226230996593999605528853238345581493455789490022874193078679156443424589924345576083455677989095154114563157242156287127917920708540120708632620708631720708623320708433620708606137676011159185090289009702070857381W25 A2V0N A17229908912027883247759139934712155983732698882221403605016820341013471467156412292437590489092428195522611637614638879780915965900335925391583758834101840211077523449891621229884273612262124217315807849891081897353878591775551193222243543085661559536719762662027382451399966541596655215891183159184564341053461205532361961938813410539214489815011477742689094043207083839887043133BRE A2421522819619344322298467193222397243725153993667819826320019619189717231091163322362698996021233187222987533449864777543222193076781196193400155947645430235537676477288682234252719114022851156009351564228321232762324773642837906828379379289007802070855241564136519615757933929221580600527361790252942215641042156072288207084004288542002699016550122121194307175231005502736153516982828815918462215918487413470977500853791599019781223044430577826144898172206602029334153511449010672886848914489837977165235144899939344964881350664017548555584270775124448314490026514489888577918291302481113999564439933598836432461448999341559956317133360196176126196182927243746042124311619619500015600635302498617848454221108215175493181754903415299577830262524427797741583209768909457015801891208075513999613920708429320708625020708628416376329920708570739933860168186556207085601183097861500173502070844387877828215893919243717411877801661529951923445202915640673543023152070854352890103134558378300187351275112191676258522736122524376026345573291798801456419998205374177543096792119608773247261214897550224372790399334473449888228900464288968661754847527383111345568299593120437676764230988148252400328296141651835165183415902723830250015773614332122385146198730344970334140861019619292228871350198262314273665972111369934498023341023431245143731560563115606404156004881560021013476242891083321561553329829276158277461580549317229798222991551961916093247240119826124222298454211958261196248193124516000407872982736168688704648273791751651984213476852512469621347190719825425215918627621403875415807290118593438193782538211960692269899013767820014631179841019471542986442070840111573706545008550619826155036596182655361465788241580663415807957206602907206601586206601953317476711573648141482708951564453212451578914489738221301364526989277717260642736563613473025155960441449009131591851092140292761347368439937227399352212737750513488231124514355461989353449703720660229346202755211960773150777771407952888324729834057212341095498161976257631448986451580663831283061347444816533745008388515601713540425191580529810416197721733574639998445399967561589172619307800421404368353804085198253204273822244771681033595684138789562124138129830487211960636512417371588950431747795156407221596461237675710250670216125149273813422917150815918612913473973784847421560084554309631273623353993762333603636399360851448981302736108720708596354302563214036618207083962212325501923621822349999220708411117548233118588681917931852736781587118233345573533455788434556560345574072070848682070850012070839973455657420708490420708534820708633634557175207085761207083971207084756207083920207085896207086151207086195207084045207086123183092271982627152070847914657843971726101207085673156419362437404219618705915805776214038423140253901564274327358578156008511591861872738123542525647207085309212199022437214915598454208081429120400011107504539997035697802939997160144898329207085176159647051589595926987880288721285430282228898528282114302126389992437377018942582742528226134727681613000719618933819826251121243539243722192437203245441313376782541347176713473015192359514198261599528412591976259311982612891449001362123364154308632341015492070858255124405327360006542931734252757824375060158948461589484424373140273612391095745615808001201409592047896583768041615643920156410802889772727362612543083302610844824374297289754042736769012451497121733555441409745198261748196191474198253401140250691596661723500704140230451612490839933844158056322124141541407781399362824657917626990374193222304198252430198264295540221053359622017548474161195983993604916264252159185329134736121798780339934859235007283767666315300955015918461821404503216820341516703778715606095324737223247636339998060399343711205566961559796734498028336020903EZU A2421730115641198501196071591850455008642120660332215642692273583932229870146579050190340027361327159184597212432151448989323359258520708450720537485728211414163764408211956598273676051564138434105043341050441907037932471379120553102152996045212313605012002627362209376803111564111713470925114047859198262941158939248909405820708618216384932134495546269873011448978412229859317232666193222442144898224211147861560160310957453109574091402233315918466611456438815641607273589632126389952746744621733293630265434944982532887545415891865285142521403891621242238341015501588929888800236243723852066020161564160127361748289000392070860414378845376796872736798914489908214489798657665728900924273659482070859172070849702140384321676779539936853207085912207085145345572372070864923455757320708555754296901302484574252822533593448243732142122971754302664242154041589678016414526168010921932222192070853262070839523247399715639965243759353455684342522950425223262889914020708540389093635155995281961956701961962141982629191663640401961790448910787426248044564594097791984377543223890945083247153919826174911415489814489725413474502269900632889966221402955437681146134767251347405314489806134496598197626081344962671448992202070856052890033188799699543091561754715117132637912001045012280714990819212451597711477207011456478027358906243736872425127310989993239997411144901349212413641591846862014096428900411273669491560131633595580144900928273625948909881424373731156016922437534887122912
cd01949 Sequence Cluster
cd01949 Sequence Cluster
Sub-family Hierarchy
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 cd01949 Branch
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CD Hierarchy
Sequence Alignment?
Format: Row Display: Color Bits: Type Selection: 
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                      #  ##    #   #                     
1W25_A        289 VTDQLTGLHNRRYMTGQLDSlvkra---tlggdPVSALLIDIDFFKKINDTF-GHDIGDEVLREFALRLASNVra----i 360
gi 42525647   361 AKSNLQGEANFTLNSTTLTQkidniiinmnadeEVYLLYLDIDKFKTINQLW-GYYAGNALIQHIYSMILAHIksfnipe 439
gi 15606615   641 THNVETGLLNKVGFQKVLSPllgk------lssTGALIALDMVGFSRLIKEF-GEEAIKKLLKEIAVRLEKTFrr----g 709
gi 207086194  236 YIDKATKLRNRKYLIDKLPEylkid----atskGGINMMIALSGIIEANEKI-GHQQVDKFFLAIANIFDAHAsny--dn 308
gi 207085546  185 IFDNKFGVYNKRYLMTKIEQevel-----itefKHKSSLIMIELSRELKDSVsNEKAITLMTRTIARLLLKTSrr----s 255
gi 91201123   944 LIDELTMIFNHRYFQIRLVQetlra---erynlPLALILFDIDHFDNYVARK-GEYYGNLVIKKTSGLVKKNTrg----s 1015
gi 207085309  154 SVDALTKASNKMHMTSIIKTnlkkir--dgqikSFSLMYIDVDDFNAFIRAN-GINATDATIKKIAMIIKRSIrd----k 226
gi 91201830   587 VMDEFQGIYNKRYFTELLTKqlava---krrdeNLSLLILGPDNHKATTETYgSNNAGNLLLQQIAGVLSDSVsn----s 659
gi 39996771   154 RIDTLTGVYNRRYLDERLSPeikra---yryerALSLILVGINDFSGITSAH-GHYAGELALKGCADVLAESIrr---di 226
gi 196195125   95 REDHLTGLFNRPHLLGMLERelals---qrhnyTVSILLIEIEDFTQLLDSY-GRHTGEKALRLFADCIREKIre----s 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             # ####                                                                      
1W25_A        361 DLPCRYGGEEFVVIMPd-tALADALRIAERIRMHVSgspftva----hgremlnVTISIGVSATage----gdtPEALLK 431
gi 42525647   440 DSFMHVIGDEFSIFYFg--NEEEVCRFTQTLIDKINseyftw------nekkltISISVGIVNIpki----pqsSQEIIS 507
gi 15606615   710 DIIAKGDGDEFLIFAYplkKKDDVLSLIEKIRQKFSkpltid-------gkkirLSFYIGVVTYpyd----grtFSELYY 778
gi 207086194  309 SIVARMNGTEFSILLPd-cSDKEGINLAKGIYSSCKkiakgf------nldsseTFISLGLYSYnyk-----enIGQLLS 376
gi 207085546  256 DTVAHYGNGVFAMLLKh-tDIPSALKASERLCELVSnsnffl------adreiqLKISIGITDIatl-----ytVEEIVV 323
gi 91201123  1016 DIFIRYGNSTFALLLTn-tIMSSATNLAKRFVSTIHdypflye----evqpmgkITISLGLVEFka------qsPEEFVY 1084
gi 207085309  227 DILAHWHGDKFMISFAq-iSKDELDDTAKAIRDKISkapfg---------lnghLTCSISIVEItsd-----enINTIID 291
gi 91201830   660 DIIARYDKAEFAIIMPa-tFATRALVKADGIRQRVEytgfhdp----asgnqvnITISIGISSFpeh----aseVEPLVT 730
gi 39996771   227 DWLARYDDDRFVVVLPe-tDASGAMILAKRLRIRIAsmalkl------ydkeikVNAAFGVAGFtatqqkegmtPHILLD 299
gi 196195125  167 DLFGRFDGAQFLLVLPh-tNFDDAARMGEGLKALAGnlklsspgtaaqpeeavtVCARIGVASTens----grsLNPLLN 241

                         170
                  ....*....|....*...
Feature 1                           
1W25_A        432 RADEGVYQAKasgrNAVV 449
gi 42525647   508 NAYDACSIAFrkggGCYE 525
gi 15606615   779 RAITAVKEAKrrgaGEVV 796
gi 207086194  377 HSDNALAQAKfsedNIYL 394
gi 207085546  324 SAMDGIEKAYsdkkIDFA 341
gi 91201123  1085 AAEFSLSAAAakgrNRVE 1102
gi 207085309  292 KLQNSIKLSKetnkGSIV 309
gi 91201830   731 LANKAFYKAKndggNRVE 748
gi 39996771   300 KADRSLREALeeggEMIK 317
gi 196195125  242 EADYALYQNRnegrEKTS 259

Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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Conserved site includes 10 residues -Click on image for an interactive view with Cn3D