Conserved Protein Domain Family
Death

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cd01670: Death 
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Death Domain: a protein-protein interaction domain
Death Domains (DDs) are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. Structural analysis of DD-DD complexes show that the domains interact with each other in many different ways. DD-containing proteins serve as adaptors in signaling pathways and they can recruit other proteins into signaling complexes. In mammals, they are prominent components of the programmed cell death (apoptosis) pathway and are found in a number of other signaling pathways. In invertebrates, they are involved in transcriptional regulation of zygotic patterning genes in insect embryogenesis, and are components of the ToII/NF-kappaB pathway, a conserved innate immune pathway in animal cells.
Statistics
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PSSM-Id: 260017
View PSSM: cd01670
Aligned: 157 rows
Threshold Bit Score: 29.1721
Threshold Setting Gi: 93279906
Created: 12-Dec-2003
Updated: 20-Aug-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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Display:
PubMed ReferencesClick to see Conserved Features Help

cd01670 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd01670 is a member of the superfamily cl14633.
cd00045:DEDcd01670:Deathcd01671:CARDcd08304:DDcd08305:Pyrincd08306:Death_FADDcd08307:Death_Pellecd08308:Death_Tubecd08309:Death_IRAKcd08310:Death_NFkB-likecd08311:Death_p75NRcd08312:Death_MyD88cd08313:Death_TNFR1cd08315:Death_TRAILR_DR4_DR5cd08316:Death_FAS_TNFRSF6cd08317:Death_ankcd08318:Death_NMPP84cd08319:Death_RAIDDcd08320:Pyrin_NALPscd08321:Pyrin_ASC-likecd08323:CARD_APAF1cd08324:CARD_NOD1_CARD4cd08325:CARD_CASP1-likecd08326:CARD_CASP9cd08327:CARD_RAIDDcd08329:CARD_BIRC2_BIRC3cd08330:CARD_ASC_NALP1cd08332:CARD_CASP2cd08333:DED_Caspase_8_r1cd08334:DED_Caspase_8_10_r2cd08336:DED_FADDcd08337:DED_c-FLIP_r1cd08338:DED_PEA15cd08339:DED_DEDD-likecd08340:DED_c-FLIP_r2cd08341:DED_Caspase_10_r1cd08775:DED_Caspase-like_r2cd08776:DED_Caspase-like_r1cd08777:Death_RIP1cd08778:Death_TNFRSF21cd08779:Death_PIDDcd08780:Death_TRADDcd08781:Death_UNC5-likecd08782:Death_DAPK1cd08783:Death_MALT1cd08784:Death_DRscd08785:CARD_CARD9-likecd08786:CARD_RIP2_CARD3cd08787:CARD_NOD2_1_CARD15cd08788:CARD_NOD2_2_CARD15cd08789:CARD_IPS-1_RIG-Icd08790:DED_DEDDcd08791:DED_DEDD2cd08792:DED_Caspase_8_10_r1cd08793:Death_IRAK4cd08794:Death_IRAK1cd08795:Death_IRAK2cd08796:Death_IRAK-Mcd08797:Death_NFkB1_p105cd08798:Death_NFkB2_p100cd08799:Death_UNC5Ccd08800:Death_UNC5Acd08801:Death_UNC5Dcd08802:Death_UNC5Bcd08803:Death_ank3cd08804:Death_ank2cd08805:Death_ank1cd08806:CARD_CARD14_CARMA2cd08807:CARD_CARD10_CARMA3cd08808:CARD_CARD11_CARMA1cd08809:CARD_CARD9cd08810:CARD_BCL10cd08811:CARD_IPS1cd08813:DED_Caspase_8_r2cd08814:DED_Caspase_10_r2cd08815:Death_TNFRSF25_DR3cd08816:CARD_RIG-I_r1cd08817:CARD_RIG-I_r2cd08818:CARD_MDA5_r1cd08819:CARD_MDA5_r2cd13785:CARD_BinCARD_like1D2Z A85667908312285532170588733392901571910841733071987954782569143576062733214555801571137711700599393334677653123730752410121371157525902A9I A3MOP G3MOP H7189698118398665347224401231291756296044656477169072608140311984365791D2Z B1D2Z D320542367242009174270013308478249787357617711239792296156545388322793130341650464170057523108876413333468409241598587405978688288551189630339913MOP K3MOP L718953672769478015929005557421462248125693905384085225378149632263685347084520847371WMG A1WMG B3G5B A22035305333058554722361615379255731442351229462767190339930538281591195837863637421278123084016755508429645300044926708113402562421627159260830830269784893443719417321473784405964157158299784270008123478731837357613981357616795540365533080721583600445011603589412D96 A17086183116208114326269472223382DBF A517036153848726081259685252590134604437178207057032615866832926910126640596576717058602417505472316971483707950329109154434101077225323063227957701488410643173735954835159521479031491537926132608021854436848822419987303072013021155335963169695842700121883MOP D3MOP F7189660654038162292630827292630829849935907098079619438812814640378222927733844368860872011756824683754059755064527551793333989844190693384042515044527551812292747653137570592292916802292917201563933283214775012700048561571167872G7R A546481651482302824722145260098655115963751NGR A57592181281556064949558524841895296492IB1 A2697849473214752004437243264059540132680541954059707482912779994059643471WXP A46596672052139086328227872608298293132261544437349014059647431571677594782575382700123323071744383214640752411664831959966692292931231905895232YQF A47226452311822472117834D8O A1109530744949959625705106144927777815623028647211441161979451947690801984621951936907512700044883214784432633596811571361042700045962420245111610820851700645702154968312125175044059586693583418613508545523583390281960044264091064719813931960134501905819431960157081905794601905804431905799811905891441905793381905819391960058531905843801960026251905819421905819451905789381905806391905804441960172171960172151905806391905786271960151151905801212292790022292803602292946652292790022292736632292758372292980472292756662292983472292736442292898222292717772292882982292775752292877342292723362292912782292893922292930952292876732292934472292781243462309672292941942607857382292879532292879542292935694059788601905806321ICH A531336061686934711195919513343287594494868384722157821351530846249736313104273313104032194208247431922090342187128351703106444731840188594911064477028875517162951875465958209483508169449267682148231155313226621DDF A3EZQ A3EZQ C60151303517094903421870566015131993164248349954647606688156717314110811193223648236463975524044986852960446184059680272607886882292745362608255242292910042292746222292807132292736272292832762292806493426027453833581482351984720945129604466619033760144373447226082333834730934126083464522929619925474940422929274055239660388597557478253794910926927302611215490066254910936388597553321474251188595096094511483505270150416163156364778156208648156398128156395161156392128242009981156401105156400971156226190229299462198418006405955657405955658229287232229270721316995505316995494119624719718947231483562671959995062292962843EZQ B2GF5 A3EZQ D1FAD A46403853118091445149409596126343438462512841895217932257165944639754416881451322928173214774434328415925222929619522929229719600896322928780211760706122928707744368337240597136573008071220559871571254401700479261582861353123794153320179913214788753214788762OF5 H2OF5 J2OF5 K2OF5 L472245274492744874059772493006696944492734832608325343583371574437190544437307742607829942OF5 E2OF5 A2OF5 B2OF5 F718969375440063447209428308324671148234700260788101720532872608140612292907012608142372292983521198849164319151822813495691667967702960446264659859211984171172292816894437318444059575212292990751D2Z A85667908312285532170588733392901571910841733071987954782569143576062733214555801571137711700599393334677653123730752410121371157525902A9I A3MOP G3MOP H7189698118398665347224401231291756296044656477169072608140311984365791D2Z B1D2Z D320542367242009174270013308478249787357617711239792296156545388322793130341650464170057523108876413333468409241598587405978688288551189630339913MOP K3MOP L718953672769478015929005557421462248125693905384085225378149632263685347084520847371WMG A1WMG B3G5B A22035305333058554722361615379255731442351229462767190339930538281591195837863637421278123084016755508429645300044926708113402562421627159260830830269784893443719417321473784405964157158299784270008123478731837357613981357616795540365533080721583600445011603589412D96 A17086183116208114326269472223382DBF A517036153848726081259685252590134604437178207057032615866832926910126640596576717058602417505472316971483707950329109154434101077225323063227957701488410643173735954835159521479031491537926132608021854436848822419987303072013021155335963169695842700121883MOP D3MOP F7189660654038162292630827292630829849935907098079619438812814640378222927733844368860872011756824683754059755064527551793333989844190693384042515044527551812292747653137570592292916802292917201563933283214775012700048561571167872G7R A546481651482302824722145260098655115963751NGR A57592181281556064949558524841895296492IB1 A2697849473214752004437243264059540132680541954059707482912779994059643471WXP A46596672052139086328227872608298293132261544437349014059647431571677594782575382700123323071744383214640752411664831959966692292931231905895232YQF A47226452311822472117834D8O A1109530744949959625705106144927777815623028647211441161979451947690801984621951936907512700044883214784432633596811571361042700045962420245111610820851700645702154968312125175044059586693583418613508545523583390281960044264091064719813931960134501905819431960157081905794601905804431905799811905891441905793381905819391960058531905843801960026251905819421905819451905789381905806391905804441960172171960172151905806391905786271960151151905801212292790022292803602292946652292790022292736632292758372292980472292756662292983472292736442292898222292717772292882982292775752292877342292723362292912782292893922292930952292876732292934472292781243462309672292941942607857382292879532292879542292935694059788601905806321ICH A531336061686934711195919513343287594494868384722157821351530846249736313104273313104032194208247431922090342187128351703106444731840188594911064477028875517162951875465958209483508169449267682148231155313226621DDF A3EZQ A3EZQ C60151303517094903421870566015131993164248349954647606688156717314110811193223648236463975524044986852960446184059680272607886882292745362608255242292910042292746222292807132292736272292832762292806493426027453833581482351984720945129604466619033760144373447226082333834730934126083464522929619925474940422929274055239660388597557478253794910926927302611215490066254910936388597553321474251188595096094511483505270150416163156364778156208648156398128156395161156392128242009981156401105156400971156226190229299462198418006405955657405955658229287232229270721316995505316995494119624719718947231483562671959995062292962843EZQ B2GF5 A3EZQ D1FAD A46403853118091445149409596126343438462512841895217932257165944639754416881451322928173214774434328415925222929619522929229719600896322928780211760706122928707744368337240597136573008071220559871571254401700479261582861353123794153320179913214788753214788762OF5 H2OF5 J2OF5 K2OF5 L472245274492744874059772493006696944492734832608325343583371574437190544437307742607829942OF5 E2OF5 A2OF5 B2OF5 F71896937544006344720942830832467114823470026078810172053287260814061229290701260814237229298352119884916431915182281349569166796770296044626465985921198417117229281689443731844405957521229299075
cd01670 Sequence Cluster
cd01670 Sequence Cluster
Sub-family Hierarchy
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 cd01670 Branch
 Whole Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1D2Z_A         20 VRAQLCAHLdaldVWQQLATAVk-----lYPDQVEQISSQkqr---grSASNEFLNIWGGQyn----hTVQTLFALFKKL 87
1ICH_A         15 TLYAVVENVpp-lRWKEFVKRLg-----lSDHEIDRLELQngr--clrEAQYSMLATWRRRtpr-reaTLELLGRVLRDM 85
gi 18859509   203 DQQRFAAHVg--rDWKRVGRALqkncralKGPAIDNLAYEyere-glyEQAYQLLGRFIQSegr--saKLSRLISALEET 277
gi 242009981  804 DLWRISLGIar-rDWRNLGRTLg-----iEEIVLINLEHShqsv-gfrECAYQMLLEWKGRkpk--kcTFGELYSALLRE 874
gi 229287232 2596 RLYQVSRAVg--eEWTRLGQELg-----lNRTVLDNISGEyryirqdtQQAFQMLKAWRTKtphgplhYLPQLEETLQNM 2668
gi 316995505   11 FIFKMSSSIg--tYWVTLGRALg-----iKDSVLEMLDKEnpk---viDKAYAMLKHWTAKnt---naTIDELKIVLMEL 77
gi 316995494   11 NRYLFSRSVg--iDWKDLGRCLq-----iLDSYLDVIDIEskn---ccDKAYQMLTKWTEKen----pSLNELKNALQTM 76
gi 321478876  114 AFAQVSEGIq--nDWRNLARQLt------LAEFDIANIQAstsn-dqqLAASEMLDLFRRRrsh--rdLVRELVTALRAI 182
gi 405968027   16 ILRRVSPYIv--rQWKEVCRELg-----vPETELLEIETTsysk-kisTLAYRGLCLWFEQmgk--laTKEKLISVLKKN 85
gi 229270721  372 LLTKLSCRLg--sDWRRLGAAMg-----iPQSRLDSIQAGysn---aiQRACKVLTVWMGEgdhglphDLKQLETVLRDM 441
                          90
                  ....*....|.
1D2Z_A         88 kl-hNAMRLIK 97
1ICH_A         86 dl-lGCLEDIE 95
gi 18859509   278 kmtsMAEIMLG 288
gi 242009981  875 km-vSVAKFMV 884
gi 229287232 2669 gk-pDLAAAVQ 2678
gi 316995505   78 er-nDLKKEVE 87
gi 316995494   77 ek-nDLMKTLE 86
gi 321478876  183 kr-fSLAAKVD 192
gi 405968027   86 gl-rRAEEEVE 95
gi 229270721  442 dr-aDLLDIVK 451
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