Conserved Protein Domain Family
MYSc_Myo7

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cd01381: MYSc_Myo7 
class VII myosin, motor domain
These monomeric myosins have been associated with functions in sensory systems such as vision and hearing. Mammalian myosin VII has a tail with 2 MyTH4 domains, 2 FERM domains, and a SH3 domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Statistics
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PSSM-Id: 276832
Aligned: 27 rows
Threshold Bit Score: 964.024
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Aligned Rows:
  next features
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                    #########                                         
Q13402      79 AGILRNLLIRYRDH---LIYTYTGSILVAVNPYQLLSIYSPEHIRQYTNK-KIGEMPPHIFAIADNCYFNMKRN------ 148  human
AAF34810    80 YTILRNLQNRYAKQ---LIYTYTGSMLVAINPYQILPIYTNREIQLYRNK-SLAELPPHIFAISDNAFQRLQRL------ 149  fruit fly
CAF97644   101 AGLLRNLMLRYKQG---VIYTYIGSVLVAVNPYQDFPIYTSEQVKLYQGG-NLEELPPHIYALAESCYSRMTRHlqnqcc 176  spotted green pu...
EAT39611    78 YAILRNLIVRYRQK---QIYTYTGSMLVAINPYEILPIYTFNEINLYRER-KIGDLPPHIFAIGDSAYQEMRRD------ 147  yellow fever mos...
EDO45563    78 AGILRNLLIRYRAN---KIYTYVGSVLVAVNPYCSFPIYGTAYISRYQKAvNATDLPPHIYATGEMSFAMMKRE------ 148  starlet sea anemone
EFA03648    80 YAILRNLHKRYRSK---NIYTYIGSMLVAINPYEVLPIYTNALIKEYRNK-KLNELPPHIFAIGDNSYVDMKTS------ 149  red flour beetle
ADY39973    77 AGILRNLFVRYKEK---LIYTYTGSILVAVNPYMDLPIYTAEQIRLYRNR-RIGELPPHIFAISDNAYTNMRKN------ 146  pig roundworm
EGD80527    80 AGILRNLQIRYNDPegcKLYTYTGSILVAVNPYQALDIYDGSHMETYKNT-KIGDLPPHIFAIADAAYTMMRRD------ 152  Salpingoeca sp. ...
EHJ66585    78 YTILRNLHIRYKQQ---LIYTYTGSMLIAINPYEILPIYTMDQIHFYQDN-NIGDIPPHIFAIGNNSYKELLET------ 147  monarch butterfly
EJW85906    71 AALLRNLFVRYNNK---LIYTYVGSVLIAVNPNTPLPIYSIEQIRLYRNR-RIGELPPHIFAIANSAYCNMKSS------ 140  agent of lymphat...
Feature 1                        ########                                      ###########     
Q13402     149 ---------SRDQCCIISGESGAGKTESTKLILQFLAAISGq--HSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGKYI 217  human
AAF34810   150 ---------KENQCVVISGESGAGKTESTKLILQYLAAISGk--HSWIEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYI 218  fruit fly
CAF97644   177 iirsvpcdgGRNASFLPSGESGAGKTESTKLILRYLAAVSSemsKRRVERLVLESNPILEAFGNAKTTRNDNSSRFGKYL 256  spotted green pu...
EAT39611   148 ---------GRDQCIVISGESGAGKTESTKLILQYLAATSGk--HSWIEQQIIESNPIMEAFGNAKTVRNDNSSRFGKYI 216  yellow fever mos...
EDO45563   149 ---------KHNQCVVISGESGAGKTESTKFILQYLTAVSGr--HSTIEEQILDANPILEAFGNAKTIRNDNSSRFGKYI 217  starlet sea anemone
EFA03648   150 ---------RKDQCVVISGESGAGKTESTKLILQYLASTSGq--HSWIEQQILEANPIMEAFGNAKTVRNDNSSRFGKYI 218  red flour beetle
ADY39973   147 ---------CRNQCLIISGESGAGKTETTKLVLQFLATVSGq--HSWIEQQVLEANPIMEAFGNAKTIRNDNSSRFGKYI 215  pig roundworm
EGD80527   153 ---------KRNQCCVISGESGAGKTETTKLVLQFLAAVSGq--HSWIEQQILEANPIMEAFGNAKTIRNDNSSRFGKYI 221  Salpingoeca sp. ...
EHJ66585   148 ---------STNQCIVISGESGAGKTESTKLLLQYLAAASGk--HSWIEQQIQETNPILEAFGNAKTVKNDNSSRFGKYI 216  monarch butterfly
EJW85906   141 ---------NRDQCVFINGESGSGKTESAKLVIQFLATISGq--HSWIEQQVLETNPIIEAFGNAKTTRNDNSSRFGRNI 209  agent of lymphat...
Feature 1                                                                                      
Q13402     218 DIHFNkRGAIEGAKIEQYLLEKSRVCRQAlDERNYHVFYCMLEGMSEDQKKKLGLgqasdyny--lamgncitCEGRVDS 295  human
AAF34810   219 EIRFTpQGAIQGARIQQYLLEKSRIVFQSrDERNYHIFYCMLAGLSTAERERLKLqeqspsqyhylaqggcftLPGRGDA 298  fruit fly
CAF97644   257 EIFFNeEGVIEGARMEQYLLEKSRVCHQAlGERNYHIFYCMLAGITAEEKKALTLsdpgdymf--ltkgsciqCEGRDDA 334  spotted green pu...
EAT39611   217 DVHFNkEGVIGGAKIDQYLLEKSRIVGQNkGERNYHIFYSMLAGLSKEEKKLLELedaskyhy--ltrgqtliCDGRSDA 294  yellow fever mos...
EDO45563   218 DVHFNdSWVIEGAKIDHYLLEQSRIVAQMpNERNYHIFYRMLAGMSPQEKKSLHLthaqdyyy--lsqgncltCEGMDDA 295  starlet sea anemone
EFA03648   219 DIHFNkSGNIEGARIEQYLLEKSRIVSQNdGERNYHIFYSMLAGLSKEEKKRFDLtepdhyvy--lkggrtltCQGRNEA 296  red flour beetle
ADY39973   216 DIHFTgNGAIEGAKIEQYLLEKSRLVSQTlGERNYHIFYCLLAGLSAAEKDELSLtdardyfy--ltqgkmleADGRDDA 293  pig roundworm
EGD80527   222 DISFDeDGAIEGASIEQYLLEKSRLSFQAaDERNYHVFYRLIVGSSAEELSALGLtkcedyay--ltggdcinLPGVDDR 299  Salpingoeca sp. ...
EHJ66585   217 NIYFNqNGVIEGGNIEQYLLEKSRIVMQNkGERNYHIFYSLVTGLSADEKKKLELgrpadyey--lnsgnmltCDGRNDA 294  monarch butterfly
EJW85906   210 DLYFSsNGAIEGARFEHYLLEKSRVVSQAsDERNYHIFYCLLAGLTASEKQELSLsnasdyyy--lnqgdaveVEGRNDS 287  agent of lymphat...
Feature 1                                                                                      
Q13402     296 QEYANIRSAMKVLMFtDTENWEISKLLAAILHLGNLQYEARTFENldacevlfspslATAASLLEVNp------------ 363  human
AAF34810   299 KDFADIRAAMKVLSFkPEEVWSILSLLAAILHLGNLRFTATEVANlataeiddtpnlQRVAQLLGIPi------------ 366  fruit fly
CAF97644   335 AIYKHVRSAMELFFS-ESQCQEIFRLLAAILHLGNICFEGNTRDNletchvskskhfSIAASVLEVSsslwwpfwfsplf 413  spotted green pu...
EAT39611   295 GEFADVRAAMKMLSFtDRDIWSVLSLLAAILHLGNIKYKATVVQNmdavevndnvnvSRICNLLGFAk------------ 362  yellow fever mos...
EDO45563   296 YEYDVIRKAMTALWFtEEETQFIFRSIAAVLHLGNISFEAKMEDNieacdvmnpetvAAAADLLQVPk------------ 363  starlet sea anemone
EFA03648   297 NEFTDIRGAMKVLNFtDKEANDIFQLLAAILHLGNLKFKAGTASNtesseiqdataaDKIARLLGSNk------------ 364  red flour beetle
ADY39973   294 ADLAEMRSAMKVLMFkDAEIWKIFRILAALLHIGNIKYNATILNNmeateikdktgvSRVAKLLQVDe------------ 361  pig roundworm
EGD80527   300 EEWGGIRGAMKVLGFtEEEQWNIFRLVAAFLHMGNTEFEESEVNNmmaaevvnmdavESACKLFQCDa------------ 367  Salpingoeca sp. ...
EHJ66585   295 LEFSDIKSAFKVLNFdDNDVNDLFSLLAAILHLGNLKFKSINVNNmdssevtdsinaNRIASLLGVTk------------ 362  monarch butterfly
EJW85906   288 ADLAEIRSSMKVLMFkDSEIWSIFKILAAILHAGNIKYIAKSVNNveaveirdtfeiERVAELLSINk------------ 355  agent of lymphat...
Feature 1                                                                                      
Q13402     364 ---------------PDLMSCLTSRTLITRGETVStpLSREQALDVRDAFVKGIYGRLFVWIVDKINAAIYKPPSQdvkn 428  human
AAF34810   367 ---------------SALNAALTQRTIFVHGEHVTtsLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQ---- 427  fruit fly
CAF97644   414 ytqtspyacslqvrkSLLESSLTSRSIMTMTESVSkpLSAAQASDCRDAFVKAIYDKLFIWIVGKINSVIYRNLAKspks 493  spotted green pu...
EAT39611   363 ---------------NALVHALTRRTRIAQGERVVsqISKEQALEARDAFVKAIYGKIFIMIVDKINSAIYKSSPK---- 423  yellow fever mos...
EDO45563   364 ---------------EHMEEAFTRKSTFAEGEMIYspVSVERATDIRDAFVKGLYSKVFIWIVNKINSSIYKPRGKddts 428  starlet sea anemone
EFA03648   365 ---------------FDLGEALTKKTIFAHGDKVIstLSQEQASESRHAFVKGIYGKLFIMIIEKINSAIYQPKGA---- 425  red flour beetle
ADY39973   362 ---------------RSLVNALTTRSLITRNERVVscLSAEQSLDIRDALVKGIYGRLFLHIINRINDAIYRPRKDg--h 424  pig roundworm
EGD80527   368 ---------------EAMADALTTQTTVTRGETIVkqLDNEKATDVRDAFVKQVYGRIFVWIVDKINSTISKQSKRs--a 430  Salpingoeca sp. ...
EHJ66585   363 ---------------NKLCEALTRKSLIAHGEKIIsnLSASAAVDGRDALVKAIYGHIFEFIVEMINKTLHKDHELt--- 424  monarch butterfly
EJW85906   356 ---------------ELLVNALIRRSMMIGVERVVsyLSAEETVNVRDIFVKAIYHRLFLHIVEKINGTMNGVRKEe--s 418  agent of lymphat...
Feature 1              ######                                                                  
Q13402     429 SRRSIGLLDIFGFENFAvNSFEQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQDALDMIAnKPMNIIS 508  human
AAF34810   428 PMNSIGVLDIFGFENFDnNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGmKPMNLMS 507  fruit fly
CAF97644   494 SPLSIGLLDIFGFENFYrNSFEQLFINFANEKLQQFFVGHIFKREQEEYRREGVAWTSVRFHDNQDVLDLLAlKACNLLS 573  spotted green pu...
EAT39611   424 SRISIGVLDIFGFEQFEtNSFEQLCINFANENLQQFFVKHIFKMEQEEYTREGINWKNIEFIDNQEVLDMVGmKALHIMA 503  yellow fever mos...
EDO45563   429 GRQSIGVLDIFGFEKFDmNSFEQLCINYANENLQQFFVAQIFKNEQEEYDREGIEWNFVTFVDNQEVLDMLAeKPMNFIA 508  starlet sea anemone
EFA03648   426 SKTSIGVLDIFGFENFKvNSFEQLCINYANENLQQFFVQHIFKLEQDYYTKEGINWKNIAFVDNQDVLDMIGmKPMNLMS 505  red flour beetle
ADY39973   425 RRYSIGVLDIFGFENFNtNSFEQLCINFANENLQQFFVRHIFKLEQDEYDAEKISWRQIEFTDNQNVLDLIAqQQMSIMS 504  pig roundworm
EGD80527   431 KRTSIGVLDIFGFENFTqNSFEQLCINFCNENLQQFFVQHIFKLEQLEYDKEGINWSKIDFQDNQPVLDMIAeKPMNILA 510  Salpingoeca sp. ...
EHJ66585   425 SLGSVGILDIFGFEKFEsNSFEQLCINYANENLQQFFVKHIFKLEQEQYQKEGITWTNINYVDNQEILDLIGqKPMNLLA 504  monarch butterfly
EJW85906   419 QNNTISILDIFGFENFVrNSFEQFCINYTNETLHQLFINLMFKMEQSTYDKEQISWGPIEIVDNKEVLNLIAlGPMSIMA 498  agent of lymphat...
Feature 1                                                                                      
Q13402     509 LIDEESKFPKGTDTTMLHKLnsqhk-lnanYIPPKNNHETQFGINHFAGIVYYETQGFLEKNRDTLHGDIIQLVHSSRNK 587  human
AAF34810   508 LIDEESKFPKGTDQTLLEKLhvqhg-nrsiYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNK 586  fruit fly
CAF97644   574 LIDEESQFPKGSDSSMLRKMnqhha-enrnYVASKREGDTDFGIHHFAGAVFYDSRGFLEKNRDAVSLDLIKMVATSPSH 652  spotted green pu...
EAT39611   504 LIDEETRFPKGTDSTMLSKLhsthg-tkriYRKPKYDNVPSFGVQHFAGTVFYSVNGFLEKNRDTFSPDLKELVTKSSNE 582  yellow fever mos...
EDO45563   509 LIDEESRFPQGTDESFLDKLnynhk-dnkhFVRPKSRVQSQFGVVHFAGTVYYDTTGFLDKNRNTFSADLVDLISSSKCN 587  starlet sea anemone
EFA03648   506 LIDEESKFPKGTDFTMLAKLhnths-akknYLKPKSDVTPAFGVQHFAGPVYYDVPGFLEKNRDSFSQDLKQLIQESNNE 584  red flour beetle
ADY39973   505 LIDEESIFPKGTDQTMLNKLhathghndrlYIKPKSDLNKSFGINHFAGVVFYNYKGFLEKNRDTFSSDLQTLIESSKMN 584  pig roundworm
EGD80527   511 LVDEEAKFPKGTDESMLTKLhqhhd-knglYLKPRARSDPTFGICHFAGNVYYHSHGFLDKNRDTFSNDLVGVISDSENQ 589  Salpingoeca sp. ...
EHJ66585   505 LIDEESKFPKGTDLTLLSKLnsnhs-nkqyYTTPKSTHEHRFGVKHFAGDVLYEVKGFLDKNRDMLTADVKDMIYDSNKV 583  monarch butterfly
EJW85906   499 IMDEESVLPKGTDQNMLEKLhvhhgsneglYFKPQSDLDRSFGIAHYAGTVFYHSKGFIDKNRDKFSSDLLELLHASEFR 578  agent of lymphat...
Feature 1                                                                                      
Q13402     588 FIKqifqadvam---gaetrkrsPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMET 664  human
AAF34810   587 YLVdifphemp-----mdtakkqPTLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMET 661  fruit fly
CAF97644   653 VGDllrlpcrp----tadgskqvPTLSGQFRQSLDSLLKALSACQPFFIRCFKPNDKKQPKVFDRNLCMHQLKCFGLMDT 728  spotted green pu...
EAT39611   583 FLVklfgsdda-----ldtskrsITLSLQFRNSLEALMRTLSSCHPYFIRCIKPNELKKPKVIDNALCVRQLRYSGMMET 657  yellow fever mos...
EDO45563   588 FFLnmffkersm---gtetrkrsPTLGVQFRRSLDVLMKTLASCRSFFVRCVKPNNYKKPMEFDRELCWQQLRYSGMLET 664  starlet sea anemone
EFA03648   585 LLKqifaedfq----qetntkrtITLSSQFRSSLDILMKTLNMCHPYFVRCIKPNEEKKPQVFDRTLCCRQLRYSGMMET 660  red flour beetle
ADY39973   585 FLVdlfdgehnfdsvtsiarrkhITIGSQFRKSLDLLISQLSKCEPFFIRCIKPNEMKKPLVFDRDLVCRQLRYSGMMET 664  pig roundworm
EGD80527   590 FLVslfesdmsa---gsetrskkQTLASQFKRSLDALMKTLGACNPYFVRCIKPNEYKKPNMFDRLLCTRQLRYSGMMET 666  Salpingoeca sp. ...
EHJ66585   584 FFKrlfatsfves-qsqsgsrkiISLSYQFKTSLESLMKTLYACHPFFVRCIKPNEVKKPRIFDRALCVRQLRYAGLMET 662  monarch butterfly
EJW85906   579 LLRllfddvynyd-dmsvmrnkhPTVASHFRKLLENLVASLEHKEPFFINCIVPNAIKRPLFMEREIVYKQMSYMSLLEM 657  agent of lymphat...
Feature 1                                                                        
Q13402     665 IRIRRAGYPIRYSFVEFVERYRVLLPGVKPAYKqgdlrgtcqr-maeavlgthDDWQIGKTKIFLK 729  human
AAF34810   662 ARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQcdcrklarq--icevalpadSDRQYGKTKLFLR 725  fruit fly
CAF97644   729 VHIRKLGYPIRHSLEYFLNRYRVLLDRTACDPKtsttaaccea-icrsvirdkDKWKIGKTKIFLK 793  spotted green pufferfish
EAT39611   658 AKIRKAGYAIRHSYHEFVNRYRHLGKNIGPAHKvdcitaskqi-cvlvlaaipDDYQFGKTKIFLK 722  yellow fever mosquito
EDO45563   665 VRIRKSGYAMRHTFEEFVTRYHMLVRDSLRDMSsrdashli-----atsllgqENWKLGTKRIFLK 725  starlet sea anemone
EFA03648   661 AKIRQAGYPIRYTYKDFVDRFRHLGKAIPPSTKgdckqstkk--icetvfqnnEDFQMGHTKLFLK 724  red flour beetle
ADY39973   665 IRIRKAGYPIRHDYKSFVHRYRVLVNGIGPADMvdcytaakk--icetvlgakADFQLGRTKVFLK 728  pig roundworm
EGD80527   667 IRIRRAGYPIRHSFAEFIARYRLLDSSIPPAGSsadkenalklatrvlgeagaADWQAGHTKVFLK 732  Salpingoeca sp. ATCC50818
EHJ66585   663 AKIRQAGYPIRYSYSEFVHRYRLVVPGIPPAEKtdckaagkt---icsqvlhdDDYKLGHTKIFLK 725  monarch butterfly
EJW85906   658 VRIRKSGYPIRYQYQCFVERYRLLVDGIGPLRTincrmasrr--icditlgpeADIRLGKTMIFLK 721  agent of lymphatic filariasis

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