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cd00464: SK 
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Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.
Statistics
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PSSM-Id: 238260
View PSSM: cd00464
Aligned: 109 rows
Threshold Bit Score: 98.7819
Threshold Setting Gi: 42524847
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
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Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:ADP binding site [chemical binding site]
Evidence:
  • Structure:1L4U; Mycobacterium tuberculosis shikimate kinase with bound ADP
    View structure with Cn3D

cd00464 is part of a hierarchy of related CD models.
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cd00464 is a member of the superfamily cl17190.
cd00071:GMPKcd00464:SKcd01428:ADKcd01672:TMPKcd01673:dNKcd02019:NKcd02020:CMPKcd02021:GntKcd02022:DPCKcd02023:UMPKcd02024:NRK1cd02025:PanKcd02026:PRKcd02027:APSKcd02028:UMPK_likecd02029:PRK_likecd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
cd00464 Sequence Cluster
cd00464 Sequence Cluster
Sub-family Hierarchy
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 cd00464 Branch
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CD Hierarchy
Sequence Alignment?
Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               ######                                                                  
1KAG_A        6 NIFLVGPMGAGKSTIGRQLaqqlnMEFYDSD-QEIEKRTGa----DVGWVFDle-geEGFRDREek-------------- 65
1L4U_A        4 KAVLVGLPGSGKSTIGRRLakalgVGLLDTD-VAIEQRTGr----SIADIFAtd-geQEFRRIEed-------------- 63
gi 46446517  27 SVALIGLPLCGKTTWGQWLakkfeYAFIDTD-WLIQQKHPt---lTCREIFQlf-gqSYFRSLErd-------------- 87
gi 20092053   8 NITLIGMAGAGKSTIGKALakrlnYTFIDVD-GIITKRTGm----PLQALIDk----QGDSALIrye------------- 65
gi 46580925  15 CVTIIGMAGAGKTTVGRELarqmdWAHVDTD-SLIEATYG-----TVLQNVAdsmskEAFLDVEa--------------- 73
gi 42527948   2 IIFLIGMSRAGKTETGRALskklkAPFVDTD-SYMEEVYGk----TIRELYKah-geKKFRLKEfeclnkiiekiiekfs 75
gi 12698097  57 NIILMGPPGAGKTTVGRIIgqklgCCVIDVDdDILEKTWNm----SVSEKLQdv-gnEQFLEEEgk-------------- 117
gi 29840481   2 NLFLCGLPAVGKTLLGRALanylsISFFDTD-DLIVSNYDnglysSAGEIFQav-geEAFATLEv--------------- 64
gi 7673958    2 TIILCGLPTSGKSSLGKALakflnLPFYDLD-DLIVSNYSsalysSSAEIYKay-gdQKFSECEa--------------- 64
gi 53755789   6 RIFIVGHHGAGKGLLAKSVaqllgWQFVDAD-LGLESHVGr----HLYEILGsh-gsEAFYECQfd-------------- 65
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                        #          #   
1KAG_A       66 -------vINELTEk------qGIVLATGGGsvksret-rnrlsarGVVVYLETt----iEKQLARTQRdk----kRPLL 123
1L4U_A       64 -------vVRAALAd------hDGVLSLGGGavtspgv--raalagHTVVYLEIs----aAEGVRRTGGnt----vRPLL 120
gi 46446517  88 -------vIDDLKPt------kQVIIATGGGviyndqn-rnalkkyCRLIYLKLs----fSNWKERIFSqt----eLPAY 145
gi 20092053  66 -----eeaILELEQm------dNCIISPGGSvvyseka-mehlkkiSKIVFLDAp----fRSIVRRIPNar----kRGIV 125
gi 46580925  74 -------gIICRIGa------kRAVLSTGGSvvyraea-mrhlaslGPVVYLDVs----lPLILERIARnp----dRGLA 131
gi 42527948  76 scsndknaIYCECEnavhcddvNAIVSTGGGyaeneaiikklkdfpRIILIDTAp-----AEIFYRIKTsaykkgfYPAF 150
gi 12698097 118 -------aVLNFSAs-------GSVISLTGSnpmhdas-mwhlkknGVIVYLDVp----lLDLIHRLKLmk---idRIVG 175
gi 29840481  65 -------eALRSLPr------dNSVTALGGGtimhqea-ydiikhrGTLIYLSLp----vTEIYQRLLK-------RGLP 119
gi 7673958   65 -------rILETLPp------eDALISLGGGtlmyeas-yraiqtrGALVFLSVelpliyERLEKRGLPe------RLKE 124
gi 53755789  66 -------iLKSLCTq------eHIVVTTDSSvvlalkn--cqllrnEMTVFLDVs----tPVQIERTARnsanllpVPSW 126
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
Feature 1                                                      #  
1KAG_A      124 hvetpp-----revleaLANERNPLYEEi--ADVTIRTd-----DQSAKV 161
1L4U_A      121 agpdra------ekyraLMAKRAPLYRRv--ATMRVDTn-----RRNPGA 157
gi 46446517 146 isqeqss----dvslkkLYASRTLIYENw--ADQTIDMn-----GSMNND 184
gi 20092053 126 glrdr--------slkeLFEERLVLYKKy--ADFSIRLk-----GKENVQ 160
gi 46580925 132 iapgq--------tiedLYNERKALYETyqdFTLTADTlt--peECGRAI 171
gi 42527948 151 lgeniknekdaedrffsIYERRIKIYKAl--ASFSINPk-----GLSPDE 193
gi 12698097 176 rnsgt--------smkdLLKFRRQYYKKw--YDARVFCe----sGASPEE 211
gi 29840481 120 erlkht------pnveeILKQRINRMQRv--ANYNFSLnhidlfDERSLL 161
gi 7673958  125 amktk--------plseILTERIDRMKEi--ADYIFPVd-----HVDHSS 159
gi 53755789 127 rdf-----------fdqLHDERDSLYKEv--ATLTVHGd-----DGKLEE 158

Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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Click on image for an interactive view with Cn3D
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D