Conserved Protein Domain Family
catalase

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cd00328: catalase 
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Catalase heme-binding enzyme
Catalase is a ubiquitous enzyme found in both prokaryotes and eukaryotes, which is involved in the protection of cells from the toxic effects of peroxides. It catalyzes the conversion of hydrogen peroxide to water and molecular oxygen. Catalases also utilize hydrogen peroxide to oxidize various substrates such as alcohol or phenols. Most catalases exist as tetramers of 65KD subunits containing a protoheme IX group buried deep inside the structure. In eukaryotic cells, catalases are located in peroxisomes.
Statistics
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PSSM-Id: 163705
View PSSM: cd00328
Aligned: 7 rows
Threshold Bit Score: 400.684
Threshold Setting Gi: 115706
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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Display:
 
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding pocket [chemical binding site]
Evidence:
  • Structure:1GGE_A: Escherichia coli catalase HPII binds heme, contacts calculated at 4A.
    View structure with Cn3D
  • Comment:these residues are conserved in all heme-catalases
  • Structure:1A4E: Saccharomyces cerevisiae catalase A binds heme, contacts calculated at 4A
    View structure with Cn3D
  • Citation:PMID 9931255

cd00328 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00328 is a member of the superfamily cl09506.
cd00328:catalasecd08150:catalase_likecd08151:AOScd08152:y4iL_likecd08153:srpA_likecd08154:catalase_clade_1cd08155:catalase_clade_2cd08156:catalase_clade_3cd08157:catalase_fungal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
cd00328 Sequence Cluster
cd00328 Sequence Cluster
Sub-family Hierarchy
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 cd00328 Branch
 Whole Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #                                      #                                 
1GGE_A     121 RIPERIVHARGSAAHGYFQPYkSLSdiTKADFLSDpNKITPVFVRFSTVQGGAGSADTVRDIRGFATKFYTEEGIFDLVG 200
1DGF_A      64 RIPERVVHAKGAGAFGYFEVThDITkySKAKVFEHiGKKTPIAVRFSTVAGESGSADTVRDPRGFAVKFYTEDGNWDLVG 143
1A4E_A      49 NIPQRNPHAHGSGAFGYFEVTdDITdiCGSAMFSKiGKRTKCLTRFSTVGGDKGSADTVRDPRGFATKFYTEEGNLDWVY 128
1M7S_A      45 RIPERVVHARGTGVKGEFTASaDISdlSKATVFKS-GEKTPVFVRFSSVVHGNHSPETLRDPHGFATKFYTADGNWDLVG 123
gi 115706   54 EAVERAAHAAAAAAFGAFVARgDWTa-SAAAAFQA-AGKQIAFMAAFSTVAGAKGSATVRDADAFAAKFASAAALQELVG 131
3EJ6_A      64 RIPERVVHARGAGAHGIFTSYgDWSniTAASFLGAkDKQTPVFVRFSTVAGSRGSADTARDVHGFATRFYTDEGNFDIVG 143
gi 3023452  57 RVPERAVHARGTGAHGTFLSYeDWSnlTAASFLSAeGKFTPEMTRFSTVSGARGSADTARDVHGFATRFYVDEGNFDIVG 136
                       90       100       110       120       130       140       150       160
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1      #    #         #                                                                
1GGE_A     201 NNTPIFFIQD--AHKFPDFVHAV--KPEPHWAIPqgqsaHDTFWDYVSL--QPETLHNVMWAMS-DRGIPRSYRTMEGFG 273
1DGF_A     144 NNTPIFFIRD--PILFPSFIHSQ--KRNPQTHLKd----PDMVWDFWSL--RPESLHQVSFLFS-DRGIPDGHRHMNGYG 212
1A4E_A     129 NNTPVFFIRD--PSKFPHFIHTQ--KRNPQTNLRd----ADMFWDFLTTpeNQVAIHQVMILFS-DRGTPANYRSMHGYS 199
1M7S_A     124 NNFPTFFIRD--AIKFPDMVHAF--KPDPRTNLDn----DSRRFDFFSH--VPEATRTLTLLYS-NEGTPAGYRFMDGNG 192
gi 115706  132 NNSPISFFIF--DLLFAAILFASkaKAANQAAFA-----AAAELAAESLfvRLPSLHQVSFFALaGFAAVAAHRHMNGYG 204
3EJ6_A     144 NNIPVFFIQD--AIRFPDLIHSV--KPSPDNEVPqaataHDSAWDFFSS--QPSALHTLFWAMS-GNGIPRSYRHMDGFG 216
gi 3023452 137 NNIPVFFIWDviIEPTLMALHAQ--KPNPRFHLPrgqqdPNRISDNLTA--RGDSLAQGSQISS-ERGSPKAYSNTEPNK 211
                      170       180       190       200       210       220       230       240
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                      
1GGE_A     274 IHTFRLINAEGKATFVRFHWKPLAGKASLVWDEAQKLTGrdpDFHRRELWEAIEAGDFPEYELGFQLIPEEDEFKFDFDL 353
1DGF_A     213 SHTFKLVNANGEAVYCKFHYKTDQGIKNLSVEDAARLSQedpDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNP 292
1A4E_A     200 GHTYKWSNKNGDWHYVQVHIKTDQGIKNLTIEEATKIAGsnpDYCQQDLFEAIQNGNYPSWTVYIQTMTERDAKKLPFSV 279
1M7S_A     193 VHAYKLVNAKGEVHYVKFHWKSLQGIKNLDPKEVAQVQSkdySHLTNDLVGAIKKGDFPKWDLYVQVLKPEELAKFDFDP 272
gi 115706  205 SHTFKLVAKDGSVYCSKFWYKADQGQAAEVWKDAEEVAAedvDYFRDLNFQAEAAGRYPLWELASQVMTFSDFEIDPFNE 284
3EJ6_A     217 IHTFRLVTEDGKSKLVKWHWKTKQGKAALVWEEAQVLAGknaDFHRQDLWDAIESGNAPSWELAVQLIDEDKAQAYGFDL 296
gi 3023452 212 HRSFRLVTDNGKQFQCSNHWQPLQGFIDLGVEEAWRFPEegeGYVAENLFESIELLTVGDEELEIQSMSFNNDLRERFNS 291
                      250       260       270       280       290       300       310       320
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                          #   #       
1GGE_A     354 LDPTKLIPEelvPVQRVGKMVLNRNPDNFFAENEQAAFHPGHIVP---GLDFTN--------DPLLQGRLFSYTDTQISR 422
1DGF_A     293 FDLTKVWPHkdyPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPP---GIEASP--------DKMLQGRLFAYPDTHRHR 361
1A4E_A     280 FDLTKVWPQgqfPLRRVGKIVLNENPLNFFAQVEQAAFAPSTTVP---YQEASA--------DPVLQARLFSYADAHRYR 348
1M7S_A     273 LDATKIWPDv--PEKKIGQMVLNKNVDNFFQETEQVAMAPANLVP---GIEPSE--------DRLLQGRVFSYADTQMYR 339
gi 115706  285 NIPTKVVPResvPLIVDAELLLNRNPLNMFAEVEQVFMDVAAASKgadEVEDPLiqrqfayiDTHLSELTASYGIPVCRP 364
3EJ6_A     297 LDPTKFLPEefaPLQVLGEMTLNRNPMNYFAETEQISFQPGHIVR---GVDFTE--------DPLLQGRLYSYLDTQLNR 365
gi 3023452 292 SEVTKSSVVrlvPLITQGKLVFNKNIQMLFNEVIGAMFQPGHIVR---GVDFTE--------DPLLQGRLFSYLDTQLNR 360
                      330       340       350       360       370       380       390       400
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                      
1GGE_A     423 Lg-----------GPNFHEIPINRPT-CPYHNF---QRDGMHRMGIDtn----paNYEPNSindnwpretppgpkrggfe 483
1DGF_A     362 L------------GPNYLHIPVNCPYrARVANY---QRDGPMCMQDNqgg---apNYYPNSfgapeqqpsalehsi---- 419
1A4E_A     349 L------------GPNFHQIPVNCPYaSKFFNPa--IRDGPMNVNGNfgs---epTYLANDksytyiqqdrpiqqhqe-- 409
1M7S_A     340 L------------GANGLSLPVNQPK-VAVNNG---NQDGALNTGHTts----gvNYEPSRleprpaddkarysel---- 395
gi 115706  365 YatvlndqedgarYDDVQDVLVIAPN-AFSASAvevQIPAAAAFNLAa-------ARVAAAgdvrvn------------- 423
3EJ6_A     366 Hr-----------GPNFEQLPINRPV-SGVHNN---HRDGQGQAWIHkn----ihHYSPSYlnkgypaqanqtvgrgfft 426
gi 3023452 361 H------------GPNIQQLGFNRPPrAPIHNN---NRDGAGEMIDLppfasfveTQEWGAkdikqtavgqnkfdqehr- 424
                      410       420       430       440       450       460       470       480
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                      
1GGE_A     484 syqervegnkvrerspsfgEYYSHPRLFWLsq--tPFEQRHIVDGFSFELSKv-vRPYIRERVVDQLAHIDLTLAQAVAK 560
1DGF_A     420 -----qysgevrrfntandDNVTQVRAFYVnv-lnEEQRKRLCENIAGHLKDa--QIFIQKKAVKNFTEVHPDYGSHIQA 491
1A4E_A     410 --vwngpaipyhwatspgdVDFVQARNLYRvlgkqPGQQKNLAYNIGIHVEGa--CPQIQQRVYDMFARVDKGLSEAIKK 485
1M7S_A     396 -----plsgttqqakitreQNFKQAGDLYRsy--sAKEKTDLVQKFGESLADt--LTESKNIMLSYLYKEDPNYGTRVAE 466
gi 115706  424 --------------avveaDQRKQSRQFWAsd--vNAQKKRLVDAFRMEVASa-vSASIQVDVTVEFSFVAAAAAARIAA 486
3EJ6_A     427 tpgrtasgvlnrelsatfdDHYTQPRLFFNsl--tPVEQQFVINAIRFEASHv-tNEQVKKNVLEQLNKISNDVAKRVAV 503
gi 3023452 425 --fshwkfgvngfvhtrndDNVTHARGFFTap--eRGQQKKRVAAFDRMFTVvglSVDGQQANSDQYADFDAAAGKKVAK 500

               ..
Feature 1        
1GGE_A     561 NL 562
1DGF_A     492 LL 493
1A4E_A     486 VA 487
1M7S_A     467 VA 468
gi 115706  487 AV 488
3EJ6_A     504 AL 505
gi 3023452 501 AI 502

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Conserved site includes 7 residues -Click on image for an interactive view with Cn3D