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cd00299: GST_C_family 
Click on image for an interactive view with Cn3D
C-terminal, alpha helical domain of the Glutathione S-transferase family
Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress. In addition, GSTs also show GSH peroxidase activity and are involved in the synthesis of prostaglandins and leukotrienes. This family, also referred to as soluble GSTs, is the largest family of GSH transferases and is only distantly related to the mitochondrial GSTs (GSTK). Soluble GSTs bear no structural similarity to microsomal GSTs (MAPEG family) and display additional activities unique to their group, such as catalyzing thiolysis, reduction and isomerization of certain compounds. The GST fold contains an N-terminal thioredoxin-fold domain and a C-terminal alpha helical domain, with an active site located in a cleft between the two domains. GSH binds to the N-terminal domain while the hydrophobic substrate occupies a pocket in the C-terminal domain. Based on sequence similarity, different classes of GSTs have been identified, which display varying tissue distribution, substrate specificities and additional specific activities. In humans, GSTs display polymorphisms which may influence individual susceptibility to diseases such as cancer, arthritis, allergy and sclerosis. Some GST family members with non-GST functions include glutaredoxin 2, the CLIC subfamily of anion channels, prion protein Ure2p, crystallins, metaxins, stringent starvation protein A, and aminoacyl-tRNA synthetases.
Statistics
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PSSM-Id: 198286
View PSSM: cd00299
Aligned: 134 rows
Threshold Bit Score: 30.5447
Threshold Setting Gi: 15826112
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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dimer interfacesubstrateN-terminal
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:Residues from both N-terminal TRX-fold and C-terminal alpha helical domains form the dimer interface.
  • Comment:Residues contributing to the dimer interface vary among different classes of GSTs.
  • Structure:1A0F; Escherichia coli Class Beta GST dimer; contacts at 3.5A
    View structure with Cn3D
  • Citation:PMID 9680481
  • Structure:1OYJ; Oryza sativa Class Tau GST dimer; contacts at 3.5A
    View structure with Cn3D

cd00299 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00299 is a member of the superfamily cl02776.
cd00299:GST_C_familycd03177:GST_C_Delta_Epsiloncd03178:GST_C_Ure2p_likecd03180:GST_C_2cd03181:GST_C_EF1Bgamma_likecd03182:GST_C_GTT2_likecd03183:GST_C_Thetacd03184:GST_C_Omegacd03185:GST_C_Taucd03186:GST_C_SspAcd03187:GST_C_Phicd03188:GST_C_Betacd03189:GST_C_GTT1_likecd03190:GST_C_Omega_likecd03191:GST_C_Zetacd03192:GST_C_Sigma_likecd03193:GST_C_Metaxincd03194:GST_C_3cd03195:GST_C_4cd03196:GST_C_5cd03197:GST_C_mPGES2cd03198:GST_C_CLICcd03199:GST_C_GRX2cd03200:GST_C_AIMP2cd03201:GST_C_DHARcd03202:GST_C_etherase_LigEcd03203:GST_C_Lambdacd03204:GST_C_GDAP1_likecd03205:GST_C_6cd03206:GST_C_7cd03207:GST_C_8cd03208:GST_C_Alphacd03209:GST_C_Mucd03210:GST_C_Picd03211:GST_C_Metaxin2cd03212:GST_C_Metaxin1_3cd10289:GST_C_AaRS_likecd10290:GST_C_MetRS_N_fungicd10291:GST_C_YfcG_likecd10292:GST_C_YghU_likecd10293:GST_C_Ure2pcd10294:GST_C_ValRS_Ncd10295:GST_C_Sigmacd10296:GST_C_CLIC4cd10297:GST_C_CLIC5cd10298:GST_C_CLIC2cd10299:GST_C_CLIC3cd10300:GST_C_CLIC1cd10301:GST_C_CLIC6cd10302:GST_C_GDAP1L1cd10303:GST_C_GDAP1cd10304:GST_C_Arc1p_N_likecd10305:GST_C_AIMP3cd10306:GST_C_GluRS_Ncd10307:GST_C_MetRS_Ncd10308:GST_C_eEF1b_likecd10309:GST_C_GluProRS_Ncd10310:GST_C_CysRS_Ncd10424:GST_C_92HSN A2557117862545815565030296745201428502878131568410462388828443LXT A34498512167563680298291325312960357995002077459551174271371864762568359232332283555827376526127214421742974330249900335970931714641017431686434498761297537826253998324226939600158041338364925617074751656477462291614453134212582099651712698707711938624656676924254462395890528131267343423016482483305011613174011631216091402098835343264045031826791302621950673264125863231362481143271161542466683072968412544700822099666851448987511542523268359460111792695583858473307728720273830031499266991507410632719336213476551179832323043919909041951413472368326475587712817581572188166852458675249816752426932395728681288233239573068128823668468261A0F A1N2A B496113942PMT D3752648551596605174278297413689832469909344957442DSA A601026913542825429783150084488161272031743033252428688566960842737627333599663538027152301475427382286564783122110846870731934774586671F2E D67237032X64 A33597483523081926805692554633212134710977567491850914091335973112737761415073887566798672NTO A5380462478067772399413081612578021230874780664577127825537680040780608925667794713421392335974817072967777459958632569993LQ7 A1347191033595940134245197746512427380461150738897746434542524938150751485667876623011072273829707804819334496619500836955645915877464476780469047806776427375884134741261626415478063404731924503021551612707562946451212317247806309616422827500834445230772449612166213401363668445816685070467516695710199956254621916127318660444265667788326989197273669412890127249610538710390822738081139937163668475192623686632623721141BYE D1AXD B220224001138545769578973627561815041567144191109601262361403152431611385463231977381138547511385479113854831BX9 A6784844656550673417093164163922941947322830573860956764915515218641341468022265416986378113537515098080826646835506691G6Y B1JZR A1HQO B66846589675255953995701366849014509492054678676496456835025659468471336496549693C8E A5573870113471927260221591219130607158335408323454491679046243GX0 A1336265650086064375239412162232946114316861366281612667317983306171304703359746820977251273832443752391573541179164605279564773441932223542421605546915783710833331347413870729655566983174252353954294869148554583116251768668439356681356466819057325082811591173766824103281202753668000193M3M A3M8N A37528091293606780151398807073348934497230161986670163793414167644763152980765332993485259416865293395465251789481330821711182677458118593257332307636717346491493769293309935841702938771559823187301486158340002307825614162632681529817882623732783263259701NHY A255715395544232302310811132335949642712385667952388809984964775767540786242823740320583677496466724964809249648770684882306848818914923779725457279649528311668447726752227636503732134049323092986362088795708377020511916544969758555838991191662863033615640502219599832767508835188743913214623941107346211984148291191641892366451215436752397910301104565782211216463132122814640918425012528123284311129838985368054524201215915654359930721010830718776738760613245171223201680332812055123250788872257146785675950012644177135117921105439327286779543114392987144973251809202191150133027825451680119619010128511678893830012137766850715679046343029046747101343014554645214550752014552819730267759872939968128987740256207166512333595205174279973263191101559800926988624288710092212674823347769375255194961214027379509161268825372306678060799735411801972845631559708734495649707319282124506450086133566962281OYJ D446879650082481230922552VO4 A152209052397843037359347736278029419948136246511521830153749405113854891GWC C46276333665287229822621138550511385527314332224256552231433207113855173143322311385503200674231138551913877559240303511138542599572625574108687788603001727141714810567806499684210567804647892075957901056780811385453105678101138552311385455113855074468798136998571138549311385509113854516128717823978432113855338957003980393113854455197056468299217113854392159363146404433118907493ERF A2738309416764789313470767163759715254473471376766574691578424373147170727771565434051347587956695475161268311612632739934646134732401507508224376169632574843LXZ A3PR8 A707332893CBU A174290305380487845657241344998285220928713470376622897861YY7 B161311195380397928893983553729170256821895542986933LYP A3MDK A77163830783643663LYK A5858238250086031156777835670760023016069326696819148259824564773471148001311637922571584244543121150061707413393000235873043212602982914771485565213263863691507629113476762154250697352140221624519657806321127381813296532742456588081194896739950632174270948870576524371612469162062547843354842874525442403350083711158337866890932223267970552378069442269411012887153342524614254283431118590277254293117134240378364931611456929325441976030238243234496541335945231710567982943411252995326382228724914961224118359995031549781831079602266769710707323132255558723200383618712065077465379254438897566770551529944122179769391637600272269533708880064314530002531518050326077808825745573612721942322515418580398163BBY A257093011707297707806319516089705330031388318747737531740582934498479335921561930770762380277121530063077128247310877379730161532311808710333284917562039806840279211810060911840396026079799026083223772954883156332093246967672383820712791314240301660429837521461171337061713083523221685757901150788163314761713379856750304336325602229392829654147502535801347035678060451150744875667977717428005156012561EEM A3LFL A55957304551543874990439850749765278191094712300854311256465182477295080300888527295079546408047295076664998071072805372027721565505334656742429467223473393062332429017329634215373387413553197312863370511052242865341220180168039123466631456678664743170681713404033240019336346607238184278184463759112021347143917429615496110477836393946915352597140043994091057230605675387807100670275911194759112072698874832598312925941849630439285212673434184514982126727803254450714255264306241764654160900008710383871499081475971233825449168188705982119503895945005584691637612751270811911663791793455114562710304408965117920705890928391199448011197762371529976153267962158711940925399730990409454297539532327378222253999944783629783028798909041690917431814114775416300865915121604840260222962319794840839457131583342551145702282545049232544702761491865642542943551485565609449865033632634116073038871247453364114833240236159903279723819093386118714992806714558872883949965114769929543088491194760911499079957127919426996260659711991157376885269104647294141894905775941489760932544678881G7O A3IR4 A2961169292702622462422396105803990132669526956543043325186309300716893170721783523071593786342301156244127207791567758023802083625854495422502423432526804629478863518802600649612825597121915430989231518023890579331301108868298709630323449194224015302326793626567077726685181367524139376772601489786741FW1 A5074852856541153499030771563813347299183307213189290992292720066596681632138752947105607733206742521914472301891E6B A12173629420155775495981138548711385465113854853NIV A77164934712781292889812646916270262273255174273941581872181176188212248247977736224919307873283643830574344133016295383265635502V6K A1342530878049287134712238879803571737422344964272231093273752203993772911133647566773213LG6 A6752287756459828782121031RK4 B1129829641K0N A32728677142744541491182592AHE A2D2Z A1181015874989910237681767826176323341679030067686238372885126325443118083880301625462470862455592530941054774472080233FY7 A38511628224072927495223413132247603132209652912399252608081332R4V A2PER A4990299171895359225709414472262151984273982211047412912310841960062872912310822211165792YV7 A3214793672YV9 A3214778436247148129841261255918300324506320281924212265514197590405153518717473687116787748168003076302767666302802115168056121286288515675691947086881468118895678971550750403260835453260835200307194092321468529241254620242247676225708682721685937293722316967488170579264242017245228331531953989211563646035571608538569475327290719495227263187418776779622377810207217664115636089824169426824201715415654212238769173245136333169695501960048311984315962211192037299205157014431242247449910777627354095127381776226554361204354866850323399689956751706966849028573192650256715714146637080352038566821712824497080351971414350681267455235246438767105235246652352460219131045670770058329005832943616784572738296013423832591173626081781626083045356680046502555362HQT A2HSN B2HRK B5029146325458669945198487503110595055204919034584223885023311544074129773648025563627618405465168023384159129986239614066322694288289619715320593169296423074710176212UZ8 A118086431317419787148231139260782772196008373242005261221126095156394163194114040247623161571159361582936673071842461565433001984169433251851153010959003201630022215045872420107252464946630720043732278935115608948371030102191155681700899733093130262HRA A2HRK A3023087695030218923888323430879941516985266823861430716178429932366959047220882189217812291223150198425469196001647294953077325192530301099654115435896148910610304708430280649515948678129642335532646049623960709011538399216961564125948100530931487828120771032508159915608979584998002320164647299470285298707516221502201126444054873504431418823472150057200553424185918130327414222400884132507906628120405311835783814552138841402773132376162458672132278698845549259221486518303304987224050868169646833472132542191264543288734261680244983169662553227832732700061572420223743320274463287871582537451171404302234785909147905173147898905260825349376821472142876015829735131237441268130193716545581V40 D2VCQ A3EE2 A1PD2 23204175324500876243361342711342601342681342611GSQ A76789751345961732PGT A13GS B1GSY B2GSR B2126365167677962212636524630882604604816046048322094809664728651TU8 D12174517563170721128641Q4J B6792277639936941174300941626502666767413710037963H1N A46518245542879266225491403627171M0U B1M0U A66534655323306631170107716362613514020315591154953292634536838495329126671050411541857283135682720713296512113559624387685164345571YQ1 B38768533878379643430464343032736391387621118056502ON5 A2WS2 A1ZL9 B1TW9 H31044412388017522911255668487920338923175693812HNL A72113637668233196682095966814384668284516681064072012790721109851GSF A1K3Y B1PL1 B1TDI B1496420681ML6 B491698161B48 B1VF4 A249510766910972119624787716798061GUL A5235483429056288254261781720518451XWK C4GTU H2AB6 D2GST A3GTU D163323511GSU B1C72 D34539117470761158071386625558274628361UA5 A2FHE B3ISO A604185041984896951011500215914092342856443358592WB9 A1OE8 B1U3I A22643241Z9H D6289877229179467507573821242975451984363022046618711679258316802479720302734195999088221123923720447662417514672420238059107834830719785122571015830880074638791193011038953251863893649670221501424326437938299471554621759322618558827140797762176797681272261262893010692181485545711542523961624541491347656110954904150740952221481593043919981637423123993740029653600320988629221797875618267931222092680315842489031740527932640559116379697830715486246203998712779073264312621493755063IC8 A174287855055445967526059780605933LJR B1LJR A2C3Q A2C3N A1393791145382479410536466836626047227658479376223341657747207577739956932154158821541590559772135597721521627590228326706656443828381612720048971158748627209020966806675668008417755170911385461404940111833911692401PN9 B1JLV A3EIN A3F6F A1947426141JLW B3F6D A3G7J A1451779332278498211596148214350074639180420386063242247327170806872996007299606195166072283812836067878930177068144953542154158615767448730088854552413121700327971V2A D2129646521541592214350013123825531R5A A23171095165554155646217667513960239789864321469134170032789157114237215415842IL3 A5597721118158596181586021815860074275399412234207291847730259818158604730393858808517302612667708472148337273026211170115284357413582502321881347302619730262073026187303338181586065579409451011512298253735834288116116602301123946201479134738904252086616127869994633554309758161263249948906163292891713293256750758159028003332395827238331433860670500847113PPU A496470015722978841605834088225654963471005992250108751579109122930067567685977465135675393223M1G A38233687163323324961264071278845171331815197157172012955233082936680821166801707255263545632390663215936684649450545773332397027238342633633233338607802501143366815759712824142982760672942612HSN A2557117862545815565030296745201428502878131568410462388828443LXT A34498512167563680298291325312960357995002077459551174271371864762568359232332283555827376526127214421742974330249900335970931714641017431686434498761297537826253998324226939600158041338364925617074751656477462291614453134212582099651712698707711938624656676924254462395890528131267343423016482483305011613174011631216091402098835343264045031826791302621950673264125863231362481143271161542466683072968412544700822099666851448987511542523268359460111792695583858473307728720273830031499266991507410632719336213476551179832323043919909041951413472368326475587712817581572188166852458675249816752426932395728681288233239573068128823668468261A0F A1N2A B496113942PMT D3752648551596605174278297413689832469909344957442DSA A601026913542825429783150084488161272031743033252428688566960842737627333599663538027152301475427382286564783122110846870731934774586671F2E D67237032X64 A33597483523081926805692554633212134710977567491850914091335973112737761415073887566798672NTO A5380462478067772399413081612578021230874780664577127825537680040780608925667794713421392335974817072967777459958632569993LQ7 A1347191033595940134245197746512427380461150738897746434542524938150751485667876623011072273829707804819334496619500836955645915877464476780469047806776427375884134741261626415478063404731924503021551612707562946451212317247806309616422827500834445230772449612166213401363668445816685070467516695710199956254621916127318660444265667788326989197273669412890127249610538710390822738081139937163668475192623686632623721141BYE D1AXD B220224001138545769578973627561815041567144191109601262361403152431611385463231977381138547511385479113854831BX9 A6784844656550673417093164163922941947322830573860956764915515218641341468022265416986378113537515098080826646835506691G6Y B1JZR A1HQO B66846589675255953995701366849014509492054678676496456835025659468471336496549693C8E A5573870113471927260221591219130607158335408323454491679046243GX0 A1336265650086064375239412162232946114316861366281612667317983306171304703359746820977251273832443752391573541179164605279564773441932223542421605546915783710833331347413870729655566983174252353954294869148554583116251768668439356681356466819057325082811591173766824103281202753668000193M3M A3M8N A37528091293606780151398807073348934497230161986670163793414167644763152980765332993485259416865293395465251789481330821711182677458118593257332307636717346491493769293309935841702938771559823187301486158340002307825614162632681529817882623732783263259701NHY A255715395544232302310811132335949642712385667952388809984964775767540786242823740320583677496466724964809249648770684882306848818914923779725457279649528311668447726752227636503732134049323092986362088795708377020511916544969758555838991191662863033615640502219599832767508835188743913214623941107346211984148291191641892366451215436752397910301104565782211216463132122814640918425012528123284311129838985368054524201215915654359930721010830718776738760613245171223201680332812055123250788872257146785675950012644177135117921105439327286779543114392987144973251809202191150133027825451680119619010128511678893830012137766850715679046343029046747101343014554645214550752014552819730267759872939968128987740256207166512333595205174279973263191101559800926988624288710092212674823347769375255194961214027379509161268825372306678060799735411801972845631559708734495649707319282124506450086133566962281OYJ D446879650082481230922552VO4 A152209052397843037359347736278029419948136246511521830153749405113854891GWC C46276333665287229822621138550511385527314332224256552231433207113855173143322311385503200674231138551913877559240303511138542599572625574108687788603001727141714810567806499684210567804647892075957901056780811385453105678101138552311385455113855074468798136998571138549311385509113854516128717823978432113855338957003980393113854455197056468299217113854392159363146404433118907493ERF A2738309416764789313470767163759715254473471376766574691578424373147170727771565434051347587956695475161268311612632739934646134732401507508224376169632574843LXZ A3PR8 A707332893CBU A174290305380487845657241344998285220928713470376622897861YY7 B161311195380397928893983553729170256821895542986933LYP A3MDK A77163830783643663LYK A5858238250086031156777835670760023016069326696819148259824564773471148001311637922571584244543121150061707413393000235873043212602982914771485565213263863691507629113476762154250697352140221624519657806321127381813296532742456588081194896739950632174270948870576524371612469162062547843354842874525442403350083711158337866890932223267970552378069442269411012887153342524614254283431118590277254293117134240378364931611456929325441976030238243234496541335945231710567982943411252995326382228724914961224118359995031549781831079602266769710707323132255558723200383618712065077465379254438897566770551529944122179769391637600272269533708880064314530002531518050326077808825745573612721942322515418580398163BBY A257093011707297707806319516089705330031388318747737531740582934498479335921561930770762380277121530063077128247310877379730161532311808710333284917562039806840279211810060911840396026079799026083223772954883156332093246967672383820712791314240301660429837521461171337061713083523221685757901150788163314761713379856750304336325602229392829654147502535801347035678060451150744875667977717428005156012561EEM A3LFL A55957304551543874990439850749765278191094712300854311256465182477295080300888527295079546408047295076664998071072805372027721565505334656742429467223473393062332429017329634215373387413553197312863370511052242865341220180168039123466631456678664743170681713404033240019336346607238184278184463759112021347143917429615496110477836393946915352597140043994091057230605675387807100670275911194759112072698874832598312925941849630439285212673434184514982126727803254450714255264306241764654160900008710383871499081475971233825449168188705982119503895945005584691637612751270811911663791793455114562710304408965117920705890928391199448011197762371529976153267962158711940925399730990409454297539532327378222253999944783629783028798909041690917431814114775416300865915121604840260222962319794840839457131583342551145702282545049232544702761491865642542943551485565609449865033632634116073038871247453364114833240236159903279723819093386118714992806714558872883949965114769929543088491194760911499079957127919426996260659711991157376885269104647294141894905775941489760932544678881G7O A3IR4 A2961169292702622462422396105803990132669526956543043325186309300716893170721783523071593786342301156244127207791567758023802083625854495422502423432526804629478863518802600649612825597121915430989231518023890579331301108868298709630323449194224015302326793626567077726685181367524139376772601489786741FW1 A5074852856541153499030771563813347299183307213189290992292720066596681632138752947105607733206742521914472301891E6B A12173629420155775495981138548711385465113854853NIV A77164934712781292889812646916270262273255174273941581872181176188212248247977736224919307873283643830574344133016295383265635502V6K A1342530878049287134712238879803571737422344964272231093273752203993772911133647566773213LG6 A6752287756459828782121031RK4 B1129829641K0N A32728677142744541491182592AHE A2D2Z A1181015874989910237681767826176323341679030067686238372885126325443118083880301625462470862455592530941054774472080233FY7 A38511628224072927495223413132247603132209652912399252608081332R4V A2PER A4990299171895359225709414472262151984273982211047412912310841960062872912310822211165792YV7 A3214793672YV9 A3214778436247148129841261255918300324506320281924212265514197590405153518717473687116787748168003076302767666302802115168056121286288515675691947086881468118895678971550750403260835453260835200307194092321468529241254620242247676225708682721685937293722316967488170579264242017245228331531953989211563646035571608538569475327290719495227263187418776779622377810207217664115636089824169426824201715415654212238769173245136333169695501960048311984315962211192037299205157014431242247449910777627354095127381776226554361204354866850323399689956751706966849028573192650256715714146637080352038566821712824497080351971414350681267455235246438767105235246652352460219131045670770058329005832943616784572738296013423832591173626081781626083045356680046502555362HQT A2HSN B2HRK B5029146325458669945198487503110595055204919034584223885023311544074129773648025563627618405465168023384159129986239614066322694288289619715320593169296423074710176212UZ8 A118086431317419787148231139260782772196008373242005261221126095156394163194114040247623161571159361582936673071842461565433001984169433251851153010959003201630022215045872420107252464946630720043732278935115608948371030102191155681700899733093130262HRA A2HRK A3023087695030218923888323430879941516985266823861430716178429932366959047220882189217812291223150198425469196001647294953077325192530301099654115435896148910610304708430280649515948678129642335532646049623960709011538399216961564125948100530931487828120771032508159915608979584998002320164647299470285298707516221502201126444054873504431418823472150057200553424185918130327414222400884132507906628120405311835783814552138841402773132376162458672132278698845549259221486518303304987224050868169646833472132542191264543288734261680244983169662553227832732700061572420223743320274463287871582537451171404302234785909147905173147898905260825349376821472142876015829735131237441268130193716545581V40 D2VCQ A3EE2 A1PD2 23204175324500876243361342711342601342681342611GSQ A76789751345961732PGT A13GS B1GSY B2GSR B2126365167677962212636524630882604604816046048322094809664728651TU8 D12174517563170721128641Q4J B6792277639936941174300941626502666767413710037963H1N A46518245542879266225491403627171M0U B1M0U A66534655323306631170107716362613514020315591154953292634536838495329126671050411541857283135682720713296512113559624387685164345571YQ1 B38768533878379643430464343032736391387621118056502ON5 A2WS2 A1ZL9 B1TW9 H31044412388017522911255668487920338923175693812HNL A72113637668233196682095966814384668284516681064072012790721109851GSF A1K3Y B1PL1 B1TDI B1496420681ML6 B491698161B48 B1VF4 A249510766910972119624787716798061GUL A5235483429056288254261781720518451XWK C4GTU H2AB6 D2GST A3GTU D163323511GSU B1C72 D34539117470761158071386625558274628361UA5 A2FHE B3ISO A604185041984896951011500215914092342856443358592WB9 A1OE8 B1U3I A22643241Z9H D6289877229179467507573821242975451984363022046618711679258316802479720302734195999088221123923720447662417514672420238059107834830719785122571015830880074638791193011038953251863893649670221501424326437938299471554621759322618558827140797762176797681272261262893010692181485545711542523961624541491347656110954904150740952221481593043919981637423123993740029653600320988629221797875618267931222092680315842489031740527932640559116379697830715486246203998712779073264312621493755063IC8 A174287855055445967526059780605933LJR B1LJR A2C3Q A2C3N A1393791145382479410536466836626047227658479376223341657747207577739956932154158821541590559772135597721521627590228326706656443828381612720048971158748627209020966806675668008417755170911385461404940111833911692401PN9 B1JLV A3EIN A3F6F A1947426141JLW B3F6D A3G7J A1451779332278498211596148214350074639180420386063242247327170806872996007299606195166072283812836067878930177068144953542154158615767448730088854552413121700327971V2A D2129646521541592214350013123825531R5A A23171095165554155646217667513960239789864321469134170032789157114237215415842IL3 A5597721118158596181586021815860074275399412234207291847730259818158604730393858808517302612667708472148337273026211170115284357413582502321881347302619730262073026187303338181586065579409451011512298253735834288116116602301123946201479134738904252086616127869994633554309758161263249948906163292891713293256750758159028003332395827238331433860670500847113PPU A496470015722978841605834088225654963471005992250108751579109122930067567685977465135675393223M1G A3823368716332332496126407127884517133181519715717201295523308293668082116680170725526354563239066321593668464945054577333239702723834263363323333860780250114336681575971282414298276067294261
cd00299 Sequence Cluster
cd00299 Sequence Cluster
Sub-family Hierarchy
Click to see CD Hierarchy help
CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##  ##  #                                                             #        
1EEM_A      113 QKMILELFSK-VPSLvgsfirsqnk-------------------------------edyaglkeeFRkEFTKLEEVltnk 160
1A0F_A       94 TIEWLNYIATeLHKGftplfrpdtp------------------------------eeykptvraqLEkKLQYVNEAlkde 143
1V40_D       87 VDAIVDTLDD-FMSCfpwaekkqdvk----------------------------eqmfnelltynAPhLMQDLDTYlggr 137
3BBY_A      103 ARQIQAWLRSdLXPIreerptdvvfaga-------------------------kkapltaegkasAEkLFAXAEHLlvlg 157
gi 23016069  91 ARALARSVSAeMHAGfvplrsacpmdl--------------------------aedhpmaeipddVKaDVARIDAIwtec 144
gi 26988748  92 AETLIARNDTtFKAHvnlykyaeryp-----------------------------ehsrehyrqqAEaWLAELEGLlagr 142
gi 32469676 211 RRNIPLADGDpLLLEayqhkivkeeaaas----------------------fvinepqmrtaiskAEqLVTDLDRDlgas 268
gi 72383820 208 LKAMIDANAD-NAELvsayrakiakeqggk--------------------svrhdaalqraardhVAvLLADLDRLlgts 266
gi 71282473  96 HDALCALISIdIDKIlvrdyllefafpkge--------------------nnsirfdvvkevqpkAAaIFAIIEQVlqqe 155
gi 37677260  82 SESVLDWQRS-AFLPlqkigyprwsnmdlpefatqsarqawrmkketdalnfdallqdtpniateVEaLIERAKSVlnld 160
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
Feature 1                                                             
1EEM_A      161 ktt-----ffggnsISMIDYLIWPWFERLeamklne---cvdhtpkLKLWMAAM 206
1A0F_A      144 hw-------icgqrFTIADAYLFTVLRWAyavkln-----leglehIAAFMQRM 185
1V40_D      138 ew-------ligmsVTWADFYWEICSTTLlvfkpdl----ldnhprLVTLRKKV 180
3BBY_A      158 qp-------nlfgeWCIADTDLALXINRLvlhgd-------evperLVDYATFQ 197
gi 23016069 145 rnrfgqggpflfgvFSNADAMYAPVVTRIrtyal-------pvgavSEAYCDAI 191
gi 26988748 143 ay-------lladhPSMADAALLPLMRQFagvepqwf--aeaayprVRSWLEGW 187
gi 32469676 269 tgp-----wlfgdrFTLADLFWAVSLYRFlwlgysgfwkdgagkprVEAYANRL 317
gi 72383820 267 sp------yllgphFSLGDVLWGVNLTRLaylglas---mwkdrpnVIRYVNAL 311
gi 71282473 156 ta-------ltskdFTIADALLAPMLHYIsclpagfd--litdypkVEQYLANV 200
gi 37677260 161 s---------yqhaTLVDEAIVFSILRGFfsaaei------qwdsvVKDWMESV 199

Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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Conserved site includes 6 residues -Click on image for an interactive view with Cn3D