Conserved Protein Domain Family
WW

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cd00201: WW 
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Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.
Links
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Statistics
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PSSM-Id: 238122
View PSSM: cd00201
Aligned: 134 rows
Threshold Bit Score: 29.8034
Threshold Setting Gi: 12230059
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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binding pocket
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:binding pocket
Evidence:

cd00201 is part of a hierarchy of related CD models.
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cd00201 is a member of the superfamily cl00157.
cd00201:WW1I5H W1709250117168266804761619793315928476117542472999167504875159284767503507178656251K5R A11754241175422730684391581838758417306843915818117168212643803505933317865625668047617510413750504792571956855417675569266831247299954730684391581866804762224585668047650593331265271711716821709250152317512662159117168217092501EG3 A1337739830467161453042375076451152851417863044137749592257483749245774917171641609590552201043469674937927484306331928275076459257195115285141222962312229651748762472931667662464154261121F8A B175377291264401711695567492279126558562739197312791510443046152925751169228458946611994766503195775081359055220750350775109451199476611753617487624950644311994195729288072933107509730117058613959396139593944966251302372160059486005948905538072961531E0L A86560031523091646567274920774656721703572572975472989251753805313531141353114273163790552447295860632541074920771522092111753611199419533419809055244729892512230059175380531E0M A1176535136764431I5H W1709250117168266804761619793315928476117542472999167504875159284767503507178656251K5R A11754241175422730684391581838758417306843915818117168212643803505933317865625668047617510413750504792571956855417675569266831247299954730684391581866804762224585668047650593331265271711716821709250152317512662159117168217092501EG3 A1337739830467161453042375076451152851417863044137749592257483749245774917171641609590552201043469674937927484306331928275076459257195115285141222962312229651748762472931667662464154261121F8A B175377291264401711695567492279126558562739197312791510443046152925751169228458946611994766503195775081359055220750350775109451199476611753617487624950644311994195729288072933107509730117058613959396139593944966251302372160059486005948905538072961531E0L A86560031523091646567274920774656721703572572975472989251753805313531141353114273163790552447295860632541074920771522092111753611199419533419809055244729892512230059175380531E0M A117653513676443
cd00201 Sequence Cluster
cd00201 Sequence Cluster
Sub-family Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30
                ....*....|....*....|....*....|..
Feature 1                      #          #     
1F8A_B       12 PPGWEKRMSRssGRVYYFNhITNASQWERPSG 43
gi 1175361   92 NDSWVVVFTKk-NRYFFHNlKSHESYWEPPLE 122
gi 1176535   99 LNGWFEYETDv-GRTFFFNkETGKSQWIPPRF 129
gi 4589466  284 ATPWRELVDEasGAPFFFNvETGDTTWELPAA 315
gi 6005948  125 KGRWVEGITSe-GYHYYYDlISGASQWEKPEG 155
gi 7292880 2015 PPAWNWQVTSd-GDIYYYNlRERISQWEPPSP 2045
gi 7298925  114 PEIWVETKAEd-GRSYYYHaVTRETTWSRPDG 144
gi 7487624  240 KEEWIETFDEasGHKYFYNtRTHVSQWEPPAS 271
gi 9055380  126 KGGWVEGVTAd-GHCYYYDlITGASQWEKPEG 156
gi 9506443  533 GTPWCVVWTGd-ERVFFYNpTTRLSMWDRPDD 563

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Click on image for an interactive view with Cn3D
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D