Conserved Protein Domain Family
WD40

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cd00200: WD40 
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WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Statistics
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PSSM-Id: 238121
View PSSM: cd00200
Aligned: 90 rows
Threshold Bit Score: 141.318
Threshold Setting Gi: 3183237
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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structural
Conserved site includes 40 residues -Click on image for an interactive view with Cn3D
Feature 1:structural tetrad
Evidence:
  • Comment:[GAS]-H-X(3)-[VI]-X-[SAC][VLI]-X-[FWLIVY]-X(2-30)-[LIV][AVLI][ST][GA][SG]-X-D-X-[TS]-[IVL][KR][VLI]-[WFY]-[DN]
  • Comment:a hydrogen-bonding network
  • Comment:a hallmark of WD40-repeat blades
  • Comment:forms a stable propeller-like platform

cd00200 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00200 is a member of the superfamily cl02567.
cd00200:WD401JV2 A46269274797557509863318323724949053123032749376324988384827056925725717228371176045749205475101583122853632344124949173023853302385130238462494906249490717302313023856116986773043130251253122638391581431226233122636749371654975263232513024893250647631230583123058302512230233076857755749206231217391TBG A2TRC B13461061346107302385430238451730217116985931221361346108600589431231763123159312314346184874971071ERJ A24949011175392134672950321597486097749352931223171170675748637675129863915881116881517056813122986402854731832893122851312285273007711707941170794302421975070181351791475798863204733122601312295274923201JV2 A46269274797557509863318323724949053123032749376324988384827056925725717228371176045749205475101583122853632344124949173023853302385130238462494906249490717302313023856116986773043130251253122638391581431226233122636749371654975263232513024893250647631230583123058302512230233076857755749206231217391TBG A2TRC B13461061346107302385430238451730217116985931221361346108600589431231763123159312314346184874971071ERJ A2494901117539213467295032159748609774935293122317117067574863767512986391588111688151705681312298640285473183289312285131228527300771170794117079430242197507018135179147579886320473312260131229527492320
cd00200 Sequence Cluster
cd00200 Sequence Cluster
Sub-family Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #                            #              #     ##              ##  
1TBG_A       47 TRRTLr---gHl------AK-IYAMHWGtd----srLLVSASq-----------DGKLIIWDSy--------tTNKVHAI 93
1JV2_A        7 SPAEYs----Gpe----gSYfGFAVDFFvpsassrmFLLVGApkanttqpgiveGGQVLKCDWss-------tRRCQPIE 71
gi 2498838    8 SHIEEn---aHq------AD-IYSLNVVa------gNLWSASg-----------DSKIKKWSIgdaehslveeIDTPHKL 60
gi 6857755  941 KTGQIdy--lPe------AQ-VSCCCLSph----leYVAFGDe-----------DGAIKIIELpnnr---vfsSGVGHKK 993
gi 2494905   87 YTRAIlp-psYlnsfsneDW-VSSLDVGdg----skHIISGSy-----------DGIVRTWDLsgn----vqkQYSGHSG 145
gi 7509863  662 NHDAHd---vHad---keGF-LTAVALSnd-----dKYAACGt----------nNGIVALWDLevcq--cvftTIQNKGD 717
gi 3123032  312 PARTLk---gHn------KL-VTSLAFDta----skALYSGSy-----------DGVILQWNLetgi--avpiAGTGHTS 364
gi 462692    36 FLTLVdkfnpHts----pHG-ISSICWSsn----nnFLVTASs-----------SGDKIVVSSc--------kCKPVPLL 87
gi 3183237   13 FFGVIa---sSg-----cNI-LGQPSSSaks---vgRAIVGG------------LESVLEWDLk---------TGQLLSK 59
gi 3025122   41 LERQFt---gSd------VA-INRIHFSpd----gqFLLTAAa-----------DGVGTLWTKege----mlgQLQGQKP 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                             #                 #     ##                
1TBG_A       94 plr-----------------sswVMTCAyaps-gnyVACGGl--------------DNICSIYNLktreg---------- 131
1JV2_A       72 fdatgnrdyakddplefkshqwfGASVRskq---dkILACAplyhwrtemkqerepVGTCFLQDGt-------------- 134
gi 2498838   61 gv-------------------hhLATSLde----nvVVSCGf--------------GQDVYVWNPet------------- 90
gi 6857755  994 av-------------------rhIQFTAdg----ktLISSSe--------------DSVIQVWNWqt------------- 1023
gi 2494905  146 pi-------------------raVKYISnt-----rLVSAGn--------------DRTLRLWKTknddlkltsqqqaqe 187
gi 7509863  718 pi--------------------tCIRYSvd----sqYCISGn-------------qAGCILILDAqng------------ 748
gi 3123032  365 s---------------------vTQAVVqg----nkLVSVSv--------------DDTTRFTPLn-------------- 391
gi 462692    88 ela-----------------egqKQTCVdlnstsmyLASGGl--------------NNTVNIWDLksk------------ 124
gi 3183237   60 wkdsd--------------csakVTCIAnf----deMYAVGy--------------ADGSIRLWKdg------------- 94
gi 3025122   92 pm-------------------fnARLSPdr-----qILITTg-------------yDGTIRLWNLqg------------- 121
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                            ##                   #        #     ##                     
1TBG_A      132 nvrvSRELA------------GHtg--yLSCCRFLDd-nQIVTSSg-----DTTCALWDie----------------tgQ 175
1JV2_A      135 ---kTVEYApcrsqdidadgqGFcq--gGFSIDFTKa-dRVLLGGpgsfywQGQLISDQvaeivskyd---pnvysikyN 205
gi 2498838   91 --neFRDLGnn---------aQHps--eCWSSCISPdgqTIAFTSv-----DGRIAVWDnp-----------------sD 135
gi 6857755 1024 ---gDYVFLq-----------AHqe--tVKDFRLLQd-sRLLSWSf-----DGTVKVWNvi----------------tgR 1065
gi 2494905  188 ddddEVNIEdgktl---aileGHka--pVVSIDVSDn-sRILSASy-----DNSIGFWStiykemtvvdpledinnpnnK 256
gi 7509863  749 --gvVRELF------------MHss--eVLSIMSLVh-nKMISCDi-----QGKMVIWElfg--------------dddT 792
gi 3123032  392 ---pPQYAAq-----------GAkldsqPQSVAVAQg-kDIAVVVt-----LNSVVVLQge----------------kvA 435
gi 462692   125 --rlHRSLK------------DHkc--eVTCVAYNWndcYIASGSl-----SGEIILHSvt----------------tnT 167
gi 3183237   95 --elLITLN------------GHks--aVTTMDFDKmgtRLASGSm-----DTDIIVWDiv----------------aeT 137
gi 3025122  122 --elLEEQQ------------PHra--aVADAIFSPd-sQIIVTCs----dDGQTKIFT--------------------R 160
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                    #                                                  
1TBG_A      176 QTTTFt----------------------gHtg------dVMSLSLApd---------------------------trLFV 200
1JV2_A      206 NQLATr----------------------tAqaifddsylGYSVAVGdfng-----------------------dgidDFV 240
gi 2498838  136 CKISEld---------------------tKgk------fGLCIDYSpn----------------------------gRFI 160
gi 6857755 1066 IERDFt----------------------cHqg------tVLSCAISsd---------------------------atKFS 1090
gi 2494905  257 ISTAArkrrkltmkdgtirrraplsllesHta------pVEQVIFDst---------------------------dnTVG 303
gi 7509863  793 PEMVAt----------------------gVk-------pPIFVPPTg-----------------------------rIMV 814
gi 3123032  436 STTAVk----------------------yQp-------tVVRVSVDg-----------------------------sEVA 457
gi 462692   168 SSTPFg-----------------------Hgsk----qpIRHIKYSlfr--------------------------ksLLG 194
gi 3183237  138 GLFRLr----------------------gHkd------qITKLLFItppskntaeetvvdtdidsgdmdvdskssdsFLL 189
gi 3025122  161 QGQEIas--------------------vlKsg------tARNLAYHp-----------------------------qGLL 185
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1       #        #     ##                ##                        #                #   
1TBG_A      201 SGAc-----DASAKLWDvr--egMCRQTFT---GHes---dINAICFFPng----naFATGSd-------------DATC 250
1JV2_A      241 SGVpraartLGMVYIYDgk--nmSSLYNFT---GEqmaayfGFSVAATDingddyadVFIGAplfmdrgsdgklqeVGQV 315
gi 2498838  161 VSGh----qTGQLFLISte--tgRLFHVLS---GHts---pVRSVAFSPgs-----tLLAAAg------------dSKMI 211
gi 6857755 1091 STSa-----DKTAKIWSfd--llSPLHELK---GHng---cVRCSAFSLd------gILLATgd-----------dNGEI 1140
gi 2494905  304 YSVs----qDHTIKTWDlv--taRCIDTRT---TSy----sLLSIAQLStl-----nLLACGs------------sARHI 353
gi 7509863  815 GHCsl---sNKEMKIWAfpe-egPPVTRAKl--SHsd---eITCFATSPkg----gnFIATGs------------rDMSL 869
gi 3123032  458 VGAk-----DNSIHIYSlsgttlSEQAVLS---GHrg---fLTAIAYSPdg-----kHFASAd------------qNRDI 509
gi 462692   195 SVSd-----NGVVTLWDvn--sqSSYHTFDs--THka---pASGICFSPvn----elLFVTIg------------lDKRI 246
gi 3183237  190 SVGk-----DSFMKLWDls--iqHCVETHV---DHqg---eIWAMCVSPda----krCLTAGt-------------GSDV 239
gi 3025122  186 IASvs---dSGSLHLINpn---gKIEREIStgqGRin---nVNFSPNGEq-------LLTSGi-------------NGSA 236
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##                                ##                            #         #   
1TBG_A      251 RLFDlra------------dqELMTY----------SHdni---icgITSVSFsks-----grlLLAGYd------DFNC 294
1JV2_A      316 SVSLqras---------gdfqTTKLN----------GFevf---arfGSAIAPlgdldqdgfndIAIAApyggedkKGIV 373
gi 2498838  212 TIYDvls------------gdQVGQLr---------GHaa------wIFAVAFnpv------gdLLLSAd-----vEGKI 253
gi 6857755 1141 RIWNvsd------------gqLLHSCapisveegtaTHgg------wVTDVCFspd------skTLVSA-------GGYL 1189
gi 2494905  354 TLHDprvga-------sskvtQQQLI----------GHkn------fVSSLDTcpe-----neyILCSGs-----hDGTV 400
gi 7509863  870 KIWQidk------------gfLTQVLv---------GHenv----vtCCCISFde--------rLVVSGa-----rDEKI 911
gi 3123032  510 FVWDkasr----------kikVEGWV----------YHna------rVTSLAWnsn-----snnIVTGSl------DSHV 552
gi 462692   247 ILYDtss------------kkLVKTLv---------ADt-------pLTAVDFmpd-----gatLAIGSs------RGKI 287
gi 3183237  240 KVWEisfpddnnftpttkafqQLGTFtr-------qSRd-------rPITLAYdvs-----nryVVFQAh------DRLL 294
gi 3025122  237 KLWN-----------------LAGEL----------IHeykvvptgwVNSAQFypk------geWLATAs-----dDGTI 278
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##                                            ##                      #   #   
1TBG_A      295 NVWDalk--------------------------adRAGVLA-------GHdnrVSCLGVTdd-----gmAVATGSWDs-F 335
1JV2_A      374 YIFNgrstg----------------------lnavPSQILEgqwaarsMPpsfGYSMKGAtdidkngypDLIVGAFGvdR 431
gi 2498838  254 KIWDi-----------------------------dTMECIStq----sETdgaIWAVAWYk-------nGFIVAGADk-S 292
gi 6857755 1190 KWWNvat--------------------------gdSSQTFYt-----nGTn--LKKIHVSpd------fRTYVTVDNlgI 1230
gi 2494905  401 KVWDvrstsp-------------------mytitrEDKSVQk------GVndkVFAVKWAek------vGIISAGQDk-K 448
gi 7509863  912 IVWNvq----------------------------sGDMVCTv------NTtaaITSLSMTgd-----stVVFSTTEDg-W 951
gi 3123032  553 YVWSvse--------------------------psKHIAIKn------AHrggVNAVLWVde------hTVASAGLDc-S 593
gi 462692   288 YQYDlrm-------------------------lksPVKTIS-------AHktsVQCIAFQys------tSLTKASLSk-G 328
gi 3183237  295 EVFRlrssaelekilnrrrrrkksedvsitlkdeyEPFALI-------RTtarASSVAWIpgn---rtpTLVTSLQNn-S 363
gi 3025122  279 RFWQkd---------------------------gqLIYELP-------LVnarLTSLSFSpd-----gkQLAATSSQg-Q 318

                ....*
Feature 1          ##
1TBG_A      336 LKIWN 340
1JV2_A      432 AILYR 436
gi 2498838  293 IRWYR 297
gi 6857755 1231 LYILQ 1235
gi 2494905  449 IQINK 453
gi 7509863  952 VETWS 956
gi 3123032  594 IKTWT 598
gi 462692   329 SSNKA 333
gi 3183237  364 IEVYA 368
gi 3025122  319 VWVFN 323

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Click on image for an interactive view with Cn3D
Conserved site includes 40 residues -Click on image for an interactive view with Cn3D