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cd00156: REC 
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Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; contains a phosphoacceptor site that is phosphorylated by histidine kinase homologs; usually found N-terminal to a DNA binding effector domain; forms homodimers
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Statistics
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PSSM-Id: 238088
View PSSM: cd00156
Aligned: 307 rows
Threshold Bit Score: 40.2517
Threshold Setting Gi: 7477508
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
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Hierarchy
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Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:acidic pocket
  • Structure:coordinates Mg2+ needed for phosphorylation
    - View structure with Cn3D
  • Comment:Pro directs side chain of Lys towards the active site
  • Comment:Lys forms a salt-bridge with the putative phosphorylation site
  • Comment:Asn, Ser, Val implicated in the activation process
  • Citation:PMID 9878437
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cd00156 is part of a hierarchy of related CD models.
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cd00156 is a member of the superfamily cl17736.
cd00156:REC1TMY 1176639136346459217451409871717507171148217114701174405171148074759477324141A2O A75310687531057753105675310654655871273177449508185457711363511352713633692564260166119916174381364139581307581308212736674707287482844748284074828427482838748284374430491A04 A40037474430461731319744304574430447443041170636174430427481836140618417023212070774430511367667479080744304074430397443038121420193473467977281169032394388266552116968239946251071013220274430475678865389927481734107311061365482496677294729421207062120411212070574852887470113744302474430157443011216052517088842317696747078574708497469666143969748283674839551B00 A1172480130120742907273080574290681055347813465439909488603846619411743366857245437777144547740441474440207443029744406574440477444043742906717058507444063744406425073741747435744406611610565440917475948212676174440445862031175624742907417311357444059730156742907774440697470857742907674707581119215742906917297832500750250074174290717444032157569013552918343751723888729232748187174440356968660417621742907025982755848281301262500753115110725007427444054609370048552125007443913255129158162104528170813858511411125076072443260744404511769937444040744405874511827777657443012744301074430131172507212041512803637470841747083774430141723332135175074692867469285747022474440317470856747046417546427470859221364925995702598024747076374483927302737469287744839174483937448394117250658558611766981DC7 A1DC8 A11685534171661FSP 7443025222633574430233CHY 235376721208036288897493238138164950523401240049107555521208022292999410314716212871DCF A74708557470852250738211706467477508149830522180941903400730744747085274290777489870126221074708557444070113628973074574899089397242073556250075525007541708886116848511516025073802507377162128517088831731161461403221809574708457444053747594612054641031465849265476657449424744942274494251705889250074099470162352978746535074708581350837318316074043991DCK B1202011202002145517585040221365012849525980251299571183994818829515725073751136292120407266789625679738806217546429502312374817733642160529108401721605301TMY 1176639136346459217451409871717507171148217114701174405171148074759477324141A2O A75310687531057753105675310654655871273177449508185457711363511352713633692564260166119916174381364139581307581308212736674707287482844748284074828427482838748284374430491A04 A40037474430461731319744304574430447443041170636174430427481836140618417023212070774430511367667479080744304074430397443038121420193473467977281169032394388266552116968239946251071013220274430475678865389927481734107311061365482496677294729421207062120411212070574852887470113744302474430157443011216052517088842317696747078574708497469666143969748283674839551B00 A1172480130120742907273080574290681055347813465439909488603846619411743366857245437777144547740441474440207443029744406574440477444043742906717058507444063744406425073741747435744406611610565440917475948212676174440445862031175624742907417311357444059730156742907774440697470857742907674707581119215742906917297832500750250074174290717444032157569013552918343751723888729232748187174440356968660417621742907025982755848281301262500753115110725007427444054609370048552125007443913255129158162104528170813858511411125076072443260744404511769937444040744405874511827777657443012744301074430131172507212041512803637470841747083774430141723332135175074692867469285747022474440317470856747046417546427470859221364925995702598024747076374483927302737469287744839174483937448394117250658558611766981DC7 A1DC8 A11685534171661FSP 7443025222633574430233CHY 235376721208036288897493238138164950523401240049107555521208022292999410314716212871DCF A74708557470852250738211706467477508149830522180941903400730744747085274290777489870126221074708557444070113628973074574899089397242073556250075525007541708886116848511516025073802507377162128517088831731161461403221809574708457444053747594612054641031465849265476657449424744942274494251705889250074099470162352978746535074708581350837318316074043991DCK B120201120200214551758504022136501284952598025129957118399481882951572507375113629212040726678962567973880621754642950231237481773364216052910840172160530
cd00156 Sequence Cluster
cd00156 Sequence Cluster
Sub-family Hierarchy
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CD Hierarchy
Sequence Alignment?
Format: Row Display: Color Bits: Type Selection: 
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##                                                         #         #       
1DCF_A      11 LVMDENg----vSRMVTKGLLVhl-------gCEV-TTVS--SNEECLRVVsh--eHKVVFMDVCMPg--VENYQIALRI 72
1DCK_B       7 HIVDDEe----pVRKSLAFMLTmn-------gFAV-KMHQ--SAEAFLAFApd-vrNGVLVTDLRMPd--MSGVELLRNL 69
gi 113635    4 LIVDDEp----lARERLARLVGqld-----gyRVLePSASn-GEEALTLIDsl--kPDIVLLDIRMPg--LDGLQVAARL 69
gi 113527    4 FICEDDp----kQRENMVTIIKnyimi-eekpMEI-ALATdnPYEVLEQAKnm-ndIGCYFLDIQLSt-dINGIKLGSEI 75
gi 2564260   8 FILEDDl----iQQQYLKKLLLeqksknnwkdIVI-LETAr-PNDIIEAVKsk-pnNNIYFLDIEIHnnfSSGFELAQEI 80
gi 1363369   6 ILCEDQi----tQLNQLETIIQnyilf-htelFNV-EIKTqsPMEVIEYLKkfnpkQGIYFLDIDLEs-sIDGIELAEQI 78
gi 1661199   5 FVLEDDf----lQQGRLETTIAaimkeknwsyKEL-TIFGk-PQQLIDAIPek-gsHQIFFLDIEIKkeeKKGLEVANQI 77
gi 1364139   5 YLLEDDlqqqaiYQQIIANTIMine-----faMTL-TCAAs-DTETLLAAIkd-qqRGLFFLDMEIEdnrQAGLEVATKI 76
gi 1617438   4 LVLEDTi----eHQVRIENVFEeisre-lnleIKA-KVTGk-IHEFKEYVEsd-evNQLYFLDIDIKgeeQKGLEMAQFI 75
gi 581307    5 YLLEDNe----aQRVEYISIIKniimikeydmQLV-VATGd-LQELMNNVMns--kEGLFFLDMEIGeqtQAGLNLADEI 76

                       90       100       110       120       130
               ....*....|....*....|....*....|....*....|....*....|....*..
Feature 1                       #                    #  ##              
1DCF_A      73 HekftkqrhqRPLLVALSGnt-dKSTKEKCms-fGLDGVLLKPVSlDNIRDVLSDLL 127
1DCK_B      70 Gdl-----kiNIPSIVITGhg-dVPMAVEAmk-aGAVDFIEKPFEdTVIIEAIERAS 119
gi 113635   70 Cer-----eaPPAVIFCTAh--dEFALEAFq--vSAVGYLVKPVRsEDLAEALKKAS 117
gi 113527   76 Rkh-----dpVGNIIFVTShselTYLTFVYk--vAAMDFIFKDDP-AELRTRIIDCL 124
gi 2564260  81 Rey-----dpFGWIVFVTTh--sEFLPITFkyklTALDFIDKSLPdQEFENRISECV 130
gi 1363369  79 Ran-----dvQAKIIFVTTh--dEMIPLTLqrrvEALGFVTKDQSlDDYRTEIVELL 128
gi 1661199  78 Rqh-----npSAVIVFVTTq--sEFMPLTFqyqvSALDFIDKSLNpEEFSHRIELAL 127
gi 1364139  77 Rqm-----mpFAQIVFITTh--eELTLLTLerkiAPLDYILKDQTmAEIKRQLIDDL 126
gi 1617438  76 Rqh-----npYAIIVFVTSh--sEFATLTFkykvSALDFIDKDINdNSFKKRVKDCI 125
gi 581307   77 Rqq-----lpCAQIVFITTh--eELSFLTLerriAPLDYILKEQGlDDIKQKIVKDI 126

Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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Click on image for an interactive view with Cn3D
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D