Conserved Protein Domain Family
MYSc

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cd00124: MYSc 
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Myosin motor domain superfamily
Myosin motor domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Statistics
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PSSM-Id: 276950
View PSSM: cd00124
Aligned: 152 rows
Threshold Bit Score: 281.402
Threshold Setting Gi: 323456521
Created: 5-Feb-2015
Updated: 5-Feb-2015
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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Display:
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Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:the residues of the P-loop wrap around the triphosphate region of the nucleotide and the N-terminal region forms the binding pocket for the nucleotide
  • Structure:1D1C: Dictyostelium discoideum myosin S1DC (motor domain fragment) complexed with MgADP-BeFx, contacts at 4A
    View structure with Cn3D
  • Structure:1MMN: Dictyostelium discoideum myosin II binds AMPPNP, contacts at 4A
    View structure with Cn3D
  • Citation:PMID 9305951
  • Structure:1JWY: Dictyostelium discoideum myosin II binds ADP, contacts at 4A
    View structure with Cn3D
  • Structure:1QVI: Argopecten irradians myosin S1 binds MgADP.VO4, contacts at 4A
    View structure with Cn3D
  • Structure:1B7T: Argopecten irradians myosin S1 binds MgADP contacts at 4A
    View structure with Cn3D
  • Structure:1BR1: Gallus gallus smooth muscle myosin binds MgADP.Alf4, contacts at 4A
    View structure with Cn3D
  • Citation:PMID 9741621
  • Structure:4DB1: Human Myosin S1DC (beta isoform) binds Mn-AMP-PNP, contacts at 4A
    View structure with Cn3D
  • Structure:1LKX: Dictyostelium discoideum class I myosin, MyoE, binds to MgADP.VO4,contacts at 4A
    View structure with Cn3D
  • Structure:1OE9; Gallus gallus myosin V binds a sulfate ion
    View structure with Cn3D

cd00124 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00124 is a member of the superfamily cl22853.
cd00106:KISccd00124:MYSccd01363:Motor_domaincd01364:KISc_BimC_Eg5cd01365:KISc_KIF1A_KIF1Bcd01366:KISc_C_terminalcd01367:KISc_KIF2_likecd01368:KISc_KIF23_likecd01369:KISc_KHC_KIF5cd01370:KISc_KIP3_likecd01371:KISc_KIF3cd01372:KISc_KIF4cd01373:KISc_KLP2_likecd01374:KISc_CENP_Ecd01375:KISc_KIF9_likecd01376:KISc_KID_likecd01377:MYSc_class_IIcd01378:MYSc_Myo1cd01379:MYSc_Myo3cd01380:MYSc_Myo5cd01381:MYSc_Myo7cd01382:MYSc_Myo6cd01383:MYSc_Myo8cd01384:MYSc_Myo11cd01385:MYSc_Myo9cd01386:MYSc_Myo18cd01387:MYSc_Myo15cd14872:MYSc_Myo4cd14873:MYSc_Myo10cd14874:MYSc_Myo12cd14875:MYSc_Myo13cd14876:MYSc_Myo14cd14878:MYSc_Myo16cd14879:MYSc_Myo17cd14880:MYSc_Myo19cd14881:MYSc_Myo20cd14882:MYSc_Myo21cd14883:MYSc_Myo22cd14884:MYSc_Myo23cd14886:MYSc_Myo25cd14887:MYSc_Myo26cd14888:MYSc_Myo27cd14889:MYSc_Myo28cd14890:MYSc_Myo29cd14891:MYSc_Myo30cd14892:MYSc_Myo31cd14893:MYSc_Myo32cd14894:MYSc_Myo33cd14895:MYSc_Myo34cd14896:MYSc_Myo35cd14897:MYSc_Myo36cd14898:MYSc_Myo37cd14899:MYSc_Myo38cd14900:MYSc_Myo39cd14901:MYSc_Myo40cd14902:MYSc_Myo41cd14903:MYSc_Myo42cd14904:MYSc_Myo43cd14905:MYSc_Myo44cd14906:MYSc_Myo45cd14907:MYSc_Myo46cd14908:MYSc_Myo47cd14909:MYSc_Myh1_insects_crustaceanscd14910:MYSc_Myh1_mammalscd14911:MYSc_Myh2_insects_molluskscd14912:MYSc_Myh2_mammalscd14913:MYSc_Myh3cd14915:MYSc_Myh4cd14916:MYSc_Myh6cd14917:MYSc_Myh7cd14918:MYSc_Myh8cd14919:MYSc_Myh9cd14920:MYSc_Myh10cd14921:MYSc_Myh11cd14923:MYSc_Myh13cd14927:MYSc_Myh7bcd14929:MYSc_Myh15_mammalscd14930:MYSc_Myh14_mammalscd14932:MYSc_Myh18cd14934:MYSc_Myh16cd14937:MYSc_Myo24Acd14938:MYSc_Myo24Bcd15896:MYSc_Myh19336372944393244437443918024402221456353241115521720344449545992521724021388583932747019325215820378129628132885859534232075647258855639257555240188531140512136838450182551101155318798128545298690549482667121007464456812348053943648747753657634700068317094414025672095155080963547224219139916765121158260911940377545308685944930084740792100848591963115707349532877249932876947652158208540905057144954934633636661652172876938974686939060170039321625852730006239258713055491041233638477039259386140222624939322913535323878938858045035805790838450028332345652153073795529870918657098847156805192856802154156602624757032994569880587057447625226210005334867569732518969738386444133202964130824573239292736834187462230935777632449963127000477254667527030720622030717138733201765821250938332054469919568250320544701909945931088711543214785512155023273576312474059647661905883213320201023227886553071880813072134515682572401088841281678636733576234791939137891579631579641579661579682458248224582484739202392142886232016575874860417604713006681908133301318125987842696979219688575265548507609677306422602651640537184879326995656120141291529131730718980331237687635763157321251849432145600740597021119058198732450004739390503731323610940740874843209232929421184621771271489215951521124223121473153557548044408986615372659461244871131488866006636340203020818186828736372898951282566052848926656428041123496819523576328254832704221481949221505028523574593396082204449330034471569481675188783264376145642754886752329606752271566752213226570097856707660557139823557231839504008026039282180379316039282010945483389584912371059235571570655571831556039282339921729540703353121779830429328266403220842148616204557125534557191183557138031169048198099025809902750400803371059355642820758291339223485072675230207675235412680735755649925567522468066920349265700728567521872419424753822105805057496863057933935121779833428673409399217626283132458340508716283132464283132462283132460710670347106106871061070283132466710610664033460722223552421340724405235598285282374065282210374074088454078481182613357173400598414073961954074248854074100214074103554074230812909966562840951924059648246815993615220594414615211555609887755609887555611265013366175556096732795861816011282646577074676251624453875872964394862185117035857182755560938124059518851562227901088738583576114696658114962125093123214660792155083581905869523403790024059684345284912616329590141637761971637763533264333293264290113264307341637745851675259483264322201675234773264302591637773173264341431637750393264332123264317943201634163264355923264335381637772513264361443264369502621117643251826815307272222987146993251823472399258033976298367484943532507502232886656344080088844080019613466381021893001227353234548063234559563234501183234510345235720063234529532987102703234479513234572242621018633486716563251838345307316462987145743234509302621113475307406486757227915445016875445016895870124435913311196251821655688982995688983035689772735689772776756076907013981455569962046589072433168866148669275148669276149052835622468532816170328161721570412441570412461570412481617843453442451672813404533517077156224683131243611184025902964392331195760671195760701195760693071718583072081203320187153227840262125142812213298242213298261088722542700123274782500263576280314059771761675332193264299972752974015201281815435497920537185471887947108753119628422119628423991011138493977835574983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A4A7F C16620414066805717604649601677683250804571662041411637734143264314473201642618187188831737339575571449855410368187193632172416122145769131243511277571520316411343167013431715134320293419409874L79 A13431669685837391890834661890832062266941774BYF A317373577226693542226723126821101372267230668208248522672306741019509190360006746292861903598591903598573388183291217902907469665519035989819035989919035986019035990519035986119035986419035985612180579912173563519035985812192163574659874746606304425702337466114524980241903599013475958181903599007466113019035989774679586190360002223590255218511702597998871662041421662041441171093134317042698496642382186337854841821527410612774938258908281207275166204143748498974DBQ A4DBR A4DBP A3L9I A2X51 A2V26 A2BKH A2BKI A2VAS A4E7Z A4E7S A122065628750397218211475749118463510116271343171022929794380996101905844926704351555570146855568865144370121221251456130719299227000179935352635135760480232145884042779671332450341156011781417508741719994083939118293245016653132337231637780465144857055307374522620973803251916783251812805307375073251912192621031703486770612987081672991165382994713782987137782620997203486761283251806905307409992991174652991174682209687302399258112209760622209761582174077342209699283976176672209774822209704422399258212174038592209702132209684273234537132994721982987047652620998973251841485307300885307300875307300845307275545709687913011199212621062003486900043251886725307393182621015283011033745680090496751741575681036115679795523486865943486859565679514962620953305307376623251867442620994425307282422621087303486653353251857865307376105642814473895850376707662742738122214850832215027101492076864286729024032211323992180603239903226210771234868831032518207732518157926210321632518227853073854734868096257033735226210328253073150932517970126211171234866986432518486726210940853073313926209631353074082332345519132345730453073188026210254226059048426210302422096814922097669223992580523992581721740260520958333038342176938494953618908320825493953719438441481862507254939539254939541344238825440908874254939551528769621449282063483519307821783301479066611919618081OE9 A1W8J A2DFS A5479672964392343419409831343167340868927719034023529643929312206559113431668947330042948624538745416405953164443684084291277983198416146212506289270010527303387470321461417156220958163777608363743687190585207749829356012573315859801431321941719290383576293843913308213201703691277365597651055976508559765074173355597650940321573150175134825573172289503523287953938858047832876757731076787530774628463961425280629263392515585559355275565160683695698051988218451988293051988224251988217275220738752646165198821907517442251988223551988219151988216951988222729598276259180161221753836472600334214838425202130711012722645636314457850141299336720519832051981384249313308153581166204139479413752732464256264451988219912231997116047951116047953302143081527204288561006144519882198519882201300153643162670727669633197300138780527204778226517133226460320412986125551670502551647457551638301428165722710034801455440661455124312098824215235774724407932731D1C A1JWY A3MNQ A2JHR A2XEL A1YV3 A2AKA A1D0X A1340478503MYH X2Y0R X2Y9E X1W9L A1W9K A1MMA A1FMV A1MMD A1G8X A1MMN A1MMG A1LVK A1W9J A1W9I A2XO8 A13272546127758492875518509134402973122840855532840944517300923023070034032164383875113831561148723575240574066020163853055124643241119034710123885131912643253460990404657969173580580194725844383925758533885821214308124075017548905531398155110035245529168241521409021200168319074177510120702429965852523780548378755459325661565682886591BR1 A1BR2 A1I84 S3DTP B3J04 A3915778453840601093221346644126723207131248751312487913432177275297445572761092091583920915861195743121195743131700269401561209012964734061945080134316762007069150510675148664975241982716241982718344236890149028757187469439282158051351694452444727176417414042432108581169642445190339288667730504109181214328479903485099885548271874109030814328673597115296964195813431706263370452633705327807325335989646853310774184809109734611149052999215274129355568234365192532367460087367460090380784231431894051432105645440895602417406838557293722124492124502124514538267913928704134316721196104561486785061482238781839856684911791634852708443290979641092857871151983293360261486907931486907944088214504088214551490560341622871274447057273343876039645256116284394116284396119592244119592245119592247119592249224831241327478526296477596417406848616659955359612667788294363801582566501943883983555636273834081556981236134316713442505661797802374180977114326446205371802122135145160425231351703509417515715296487363300795444127759453826934174068324174140364174140404319052274321120003807881353849471945382589372870381038014765509247262136269353478589338494719828277520381744553196557601205376745284730374109017795515026293485111774328712023485208765514920734328430444109173503132301655133881615795311417901572480157248224762816247628186247180562471820261245147320544370320544374386768643402534579193910415194145421357612190212512229478345912270011484321465459427788343922991025150354719839753600448813201690561637792053264274681905877134QBD A245846922458469428136509524584704157892245847023867697162458470015789128136509924584716219990777245847102458471424584712110825729386769714386769710386769708386769712245847062857423924584696190615926108878533571778023167881574478250665270011842641654451641654466212507227307190725307212786183979376321476143127737325661397478875334188324183699693836996958369969732449991732449998939391213155584154205829470586830498719861552292980232292984531B7T A1QVI A1DFK A1DFL A1KK7 A1277732367884976535817598135375512EC6 A14081922OS8 A14081944059728184059750563I5G A35335156035335156432528803533515623154395521890077821890077845665535811610442572157003583330443986194187006525248957455560933515556966395557029232813498804447242815716375743190801953825991946597252911971681885933663132357393174189826575555174990426875548089265484473384990426835839788427345997404109204855739038255569474005642279643173734112752991359904567111959664415321751211959664235171423014586447114867418920582919714903087821193846143210146247211780410930490657594253551507010296439498150010558166997692296491471440897199261245016537185428224044393453821094DB1 A179508120536721154961691195865552010675898330491214834249929727413867117505581029648359575054114126352320557414861259878441259878431659739903556931551277488393807149063941304170818859641741804668187155714870436418795691831737358229702411958655915610490835569315421952443190717312774118665951019161830242046754774381739656055235274209220834058991487043671916223442590243915779112769545083883613431711119850721251757455348449898645311961040615612031916597398828135141029647668641035271941035272341035272741035273344089594312775569812344447121551220655661537926491490529653075488943517016274318940714321056674103527214103527313272646645128803371221320841200342325182395048088091106247813225100491244869591486784854447121504318940662964766504408959453517016213637406513272646712MYS A1M8Q A2W4A M1343217513466377392119267189167742160801068792081098927594321056624318940681159471741221320863517016244808811110611903119610410224471840355568250355753766304170718903455866911961041411961041515394579019438256235556824912213208518930358735170162271143152739202361486784841879565252816040962964766163296639861343171630722305153791586194388796750558122612450633056328423555682523557537687505411612635259811594717812213208855741490750564821425023120583042820583043612595260016597399213431707157954424444712153263342277392119182524274187956263205830438305632844413866917505581175054115126352470750564807505648115727973117805671848088151097314971155270821196104122266941763363729443932444374439180244022214563532411155217203444495459925217240213885839327470193252158203781296281328858595342320756472588556392575552401885311405121368384501825511011553187981285452986905494826671210074644568123480539436487477536576347000683170944140256720951550809635472242191399167651211582609119403775453086859449300847407921008485919631157073495328772499328769476521582085409050571449549346336366616521728769389746869390601700393216258527300062392587130554910412336384770392593861402226249393229135353238789388580450358057908384500283323456521530737955298709186570988471568051928568021541566026247570329945698805870574476252262100053348675697325189697383864441332029641308245732392927368341874622309357776324499631270004772546675270307206220307171387332017658212509383320544699195682503205447019099459310887115432147855121550232735763124740596476619058832133202010232278865530718808130721345156825724010888412816786367335762347919391378915796315796415796615796824582482245824847392023921428862320165758748604176047130066819081333013181259878426969792196885752655485076096773064226026516405371848793269956561201412915291317307189803312376876357631573212518494321456007405970211190581987324500047393905037313236109407408748432092329294211846217712714892159515211242231214731535575480444089866153726594612448711314888660066363402030208181868287363728989512825660528489266564280411234968195235763282548327042214819492215050285235745933960822044493300344715694816751887832643761456427548867523296067522715667522132265700978567076605571398235572318395040080260392821803793160392820109454833895849123710592355715706555718315560392823399217295407033531217798304293282664032208421486162045571255345571911835571380311690481980990258099027504008033710593556428207582913392234850726752302076752354126807357556499255675224680669203492657007285675218724194247538221058050574968630579339351217798334286734093992176262831324583405087162831324642831324622831324607106703471061068710610702831324667106106640334607222235524213407244052355982852823740652822103740740884540784811826133571734005984140739619540742488540741002140741035540742308129099665628409519240596482468159936152205944146152115556098877556098875556112650133661755560967327958618160112826465770746762516244538758729643948621851170358571827555609381240595188515622279010887385835761146966581149621250931232146607921550835819058695234037900240596843452849126163295901416377619716377635332643332932642901132643073416377458516752594832643222016752347732643025916377731732643414316377503932643321232643179432016341632643559232643353816377725132643614432643695026211176432518268153072722229871469932518234723992580339762983674849435325075022328866563440800888440800196134663810218930012273532345480632345595632345011832345103452357200632345295329871027032344795132345722426210186334867165632518383453073164629871457432345093026211134753074064867572279154450168754450168958701244359133111962518216556889829956889830356897727356897727767560769070139814555699620465890724331688661486692751486692761490528356224685328161703281617215704124415704124615704124816178434534424516728134045335170771562246831312436111840259029643923311957606711957607011957606930717185830720812033201871532278402621251428122132982422132982610887225427001232747825002635762803140597717616753321932642999727529740152012818154354979205371854718879471087531196284221196284239910111384939778355749830130507685380876952380876953699655835170002017433133278060094409037804835235374722994014790185922927714132643048251448491346001821934194098499442374659598002292783357486709312209825512209555042778832532146890540596334544370043074961657747883445601200833244999111826679243419409864722801515622474032643495769842461088753862700072003576096984025919774703216421147783325511388145481211454811155529008619554016329643923520582920881872884449279558175079853244999461088800072700023563214550654277919155561167905144859393072014993320185842700096383214677793576308944059669103264359013201666313201629557502522111358977288299953250866922812013343288765544407894924408048141LKX A4A7F C16620414066805717604649601677683250804571662041411637734143264314473201642618187188831737339575571449855410368187193632172416122145769131243511277571520316411343167013431715134320293419409874L79 A13431669685837391890834661890832062266941774BYF A317373577226693542226723126821101372267230668208248522672306741019509190360006746292861903598591903598573388183291217902907469665519035989819035989919035986019035990519035986119035986419035985612180579912173563519035985812192163574659874746606304425702337466114524980241903599013475958181903599007466113019035989774679586190360002223590255218511702597998871662041421662041441171093134317042698496642382186337854841821527410612774938258908281207275166204143748498974DBQ A4DBR A4DBP A3L9I A2X51 A2V26 A2BKH A2BKI A2VAS A4E7Z A4E7S A122065628750397218211475749118463510116271343171022929794380996101905844926704351555570146855568865144370121221251456130719299227000179935352635135760480232145884042779671332450341156011781417508741719994083939118293245016653132337231637780465144857055307374522620973803251916783251812805307375073251912192621031703486770612987081672991165382994713782987137782620997203486761283251806905307409992991174652991174682209687302399258112209760622209761582174077342209699283976176672209774822209704422399258212174038592209702132209684273234537132994721982987047652620998973251841485307300885307300875307300845307275545709687913011199212621062003486900043251886725307393182621015283011033745680090496751741575681036115679795523486865943486859565679514962620953305307376623251867442620994425307282422621087303486653353251857865307376105642814473895850376707662742738122214850832215027101492076864286729024032211323992180603239903226210771234868831032518207732518157926210321632518227853073854734868096257033735226210328253073150932517970126211171234866986432518486726210940853073313926209631353074082332345519132345730453073188026210254226059048426210302422096814922097669223992580523992581721740260520958333038342176938494953618908320825493953719438441481862507254939539254939541344238825440908874254939551528769621449282063483519307821783301479066611919618081OE9 A1W8J A2DFS A5479672964392343419409831343167340868927719034023529643929312206559113431668947330042948624538745416405953164443684084291277983198416146212506289270010527303387470321461417156220958163777608363743687190585207749829356012573315859801431321941719290383576293843913308213201703691277365597651055976508559765074173355597650940321573150175134825573172289503523287953938858047832876757731076787530774628463961425280629263392515585559355275565160683695698051988218451988293051988224251988217275220738752646165198821907517442251988223551988219151988216951988222729598276259180161221753836472600334214838425202130711012722645636314457850141299336720519832051981384249313308153581166204139479413752732464256264451988219912231997116047951116047953302143081527204288561006144519882198519882201300153643162670727669633197300138780527204778226517133226460320412986125551670502551647457551638301428165722710034801455440661455124312098824215235774724407932731D1C A1JWY A3MNQ A2JHR A2XEL A1YV3 A2AKA A1D0X A1340478503MYH X2Y0R X2Y9E X1W9L A1W9K A1MMA A1FMV A1MMD A1G8X A1MMN A1MMG A1LVK A1W9J A1W9I A2XO8 A13272546127758492875518509134402973122840855532840944517300923023070034032164383875113831561148723575240574066020163853055124643241119034710123885131912643253460990404657969173580580194725844383925758533885821214308124075017548905531398155110035245529168241521409021200168319074177510120702429965852523780548378755459325661565682886591BR1 A1BR2 A1I84 S3DTP B3J04 A3915778453840601093221346644126723207131248751312487913432177275297445572761092091583920915861195743121195743131700269401561209012964734061945080134316762007069150510675148664975241982716241982718344236890149028757187469439282158051351694452444727176417414042432108581169642445190339288667730504109181214328479903485099885548271874109030814328673597115296964195813431706263370452633705327807325335989646853310774184809109734611149052999215274129355568234365192532367460087367460090380784231431894051432105645440895602417406838557293722124492124502124514538267913928704134316721196104561486785061482238781839856684911791634852708443290979641092857871151983293360261486907931486907944088214504088214551490560341622871274447057273343876039645256116284394116284396119592244119592245119592247119592249224831241327478526296477596417406848616659955359612667788294363801582566501943883983555636273834081556981236134316713442505661797802374180977114326446205371802122135145160425231351703509417515715296487363300795444127759453826934174068324174140364174140404319052274321120003807881353849471945382589372870381038014765509247262136269353478589338494719828277520381744553196557601205376745284730374109017795515026293485111774328712023485208765514920734328430444109173503132301655133881615795311417901572480157248224762816247628186247180562471820261245147320544370320544374386768643402534579193910415194145421357612190212512229478345912270011484321465459427788343922991025150354719839753600448813201690561637792053264274681905877134QBD A245846922458469428136509524584704157892245847023867697162458470015789128136509924584716219990777245847102458471424584712110825729386769714386769710386769708386769712245847062857423924584696190615926108878533571778023167881574478250665270011842641654451641654466212507227307190725307212786183979376321476143127737325661397478875334188324183699693836996958369969732449991732449998939391213155584154205829470586830498719861552292980232292984531B7T A1QVI A1DFK A1DFL A1KK7 A1277732367884976535817598135375512EC6 A14081922OS8 A14081944059728184059750563I5G A35335156035335156432528803533515623154395521890077821890077845665535811610442572157003583330443986194187006525248957455560933515556966395557029232813498804447242815716375743190801953825991946597252911971681885933663132357393174189826575555174990426875548089265484473384990426835839788427345997404109204855739038255569474005642279643173734112752991359904567111959664415321751211959664235171423014586447114867418920582919714903087821193846143210146247211780410930490657594253551507010296439498150010558166997692296491471440897199261245016537185428224044393453821094DB1 A179508120536721154961691195865552010675898330491214834249929727413867117505581029648359575054114126352320557414861259878441259878431659739903556931551277488393807149063941304170818859641741804668187155714870436418795691831737358229702411958655915610490835569315421952443190717312774118665951019161830242046754774381739656055235274209220834058991487043671916223442590243915779112769545083883613431711119850721251757455348449898645311961040615612031916597398828135141029647668641035271941035272341035272741035273344089594312775569812344447121551220655661537926491490529653075488943517016274318940714321056674103527214103527313272646645128803371221320841200342325182395048088091106247813225100491244869591486784854447121504318940662964766504408959453517016213637406513272646712MYS A1M8Q A2W4A M134321751346637739211926718916774216080106879208109892759432105662431894068115947174122132086351701624480881111061190311961041022447184035556825035575376630417071890345586691196104141196104151539457901943825623555682491221320851893035873517016227114315273920236148678484187956525281604096296476616329663986134317163072230515379158619438879675055812261245063305632842355568252355753768750541161263525981159471781221320885574149075056482142502312058304282058304361259526001659739921343170715795442444471215326334227739211918252427418795626320583043830563284441386691750558117505411512635247075056480750564811572797311780567184808815109731497115527082119610412226694176
cd00124 Sequence Cluster
cd00124 Sequence Cluster
Sub-family Hierarchy
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 cd00124 Branch
 Whole Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                       ##         #                      
2MYS_A        100 PAVLYNLXERyaa----------------wmiYTYSGL---FCVTVNPyxw---lpvYNPXVVLAYrgkkrq-------- 149
gi 308245732   13 AGIAQNLHERfkngqtyvrktivivevstaifQTKASN---VLVFVNDfnk---speNSSNDLEQQsst----------- 75
gi 270004772  166 DAVMKCLQARfna----------------snfYTNVGP---ILLCVNPyr-----dvGNPLTLNSTrgla---------- 211
gi 336372944   28 DIIVSCLRERfmsd---------------nvyTSIGSS---ALVAINPhky---vpsNADSVLQKYaadyrdtse----- 81
gi 332020102  382 DVILDELRDRlrr----------------geyHTFIGD---ILLILNPnee---ndiYGVHHHAKYqcksrs-------- 431
1D1C_A        100 PAVFHNLRVRynq----------------dliYTYSGL---FLVAVNPfkr---ipiYTQEMVDIFkgrrrn-------- 149
gi 323456521  138 NFGLLQMQRRs--------------------gPRAAGArddAGGAAKPryr----tpGADRRKGRFpppagdaa------ 187
gi 320165758   35 SVIATALQRRfaa----------------qqySTWAAE---SLVVVNPfsd---atgYTNAAIAVGrnkplskraialqq 92
gi 530737955  336 PTVLHVLQKRfle----------------grlHTWVGSsasMLVALHSfga----ppTPPSTTNASgia----------- 384
gi 383864441   28 EMIIDFLLERlqh----------------gqiYTWIGS---VLLTINPnneistshlYNLSEFDKYlnssea-------- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                              ########                                   
2MYS_A        150 ------eapphIFSISDNAYQFMLtdrenq--silitGESGAGKTVNTXRVIQYFATIaasgekkkee------------ 209
gi 308245732   76 --------kcyISGVARSALDRISsmssna-esivlgGESGSGKSYNAFQAFKYLTAQpks------------------- 127
gi 270004772  212 -------lspqLNRVVQEAVRQQSetgypq--aiilsGTSGSGKSHASMLLLRQLFAVagggp----------------- 265
gi 336372944   82 ---hraplpphIFQLANNAYYHMRrtsqdq--sillsGETGSGKSENRRLAIKTLLELsvsnpg---------------- 140
gi 332020102  432 ------dnaphIYSVADSAFQDVMlneelq--hillaGESNSGKTTNMLHLVEHLMFLgkgl------------------ 485
1D1C_A        150 ------evaphIFAISDVAYRSMLddrqnq--sllitGESGAGKTENTKKVIQYLASVagrnqa---------------- 205
gi 323456521  188 ----eaeqphlYDAVADAVRRAFElrapq---llsfvGESGSGKSESAKLALEFAAIAfgdpsflgvaaagpttsrlggd 260
gi 320165758   93 gglcrsggkpsVAAAAEQALRSALqsgesg--lvvmrGQAGSGKSRAAEAVISHLIRRcatp------------------ 152
gi 530737955  385 ---------psLAAIAQAAFDALLqdarnq--viivsGESGAGKTTAATRLLAALTKHh--------------------- 432
gi 383864441   81 -----vsgvphIYTVAARAHYSLTrelgrncqviiisGATGTGKTFNACKCLEFLSRInknemlaf-------------- 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                   ##     ####           
2MYS_A        210 ---------------------------------qsgkmqgtlEDQIIsANPLLEAFGNAXtvrndNSSRFGXFIRIHfga 256
gi 308245732  128 ---------------------------------------kitNKHSNaIQSVFKSFGCAKtlkndEATRYGCSIDLLykr 168
gi 270004772  266 --------------------------------------etdaFKHLAaAFTVLRSLGSAKtatnsESSRIGQFIEVQvtd 307
gi 336372944  141 ------------------------------------kkgsklAGQVPaAEFVIESFGNARtlfnpNASRFGKYTELQftd 184
gi 332020102  486 ---------------------------------------hdtGARVLqAIKIIHAFTNAGtplnaDSTRCILQTQTTfgs 526
1D1C_A        206 ------------------------------------ngsgvlEQQILqANPILEAFGNAKttrnnNSSRFGKFIEIQfnn 249
gi 323456521  261 alvaarrddatqawaaplgraanplffsgpeargfsssqaraAKKLLsTPTLVEAFSCARsgrnaNASRGATMYRLAvrp 340
gi 320165758  153 --------------------------------------ridyAKRMEqVEIVFAAFCNARtpnnpDSTRVARFTDISftn 194
gi 530737955  433 ------------------------------------------GSMGLgAHAALAAFGHAKtprndRSSRFAKLVTLHvdp 470
gi 383864441  142 ----------------------------------qgdytyniVLRIMdACRLISAFTTACterneVSSRHGQLVCLHykg 187
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
2MYS_A        257 ----tgkLASADIETYllexsr-----vtfqlpAERSYHIFYQIMsnx---xpELIDMllittnpydyhyv--------- 315
gi 308245732  169 -----niLTGLNLKYTvpleapr----visqkpGERNFNVFYEVYhgl---ndEMKAKfgikglqkffyin--------- 227
gi 270004772  308 -----gaLYRTKIHCYfldqtr-----virplpGEKNYHIFYQMLagl---saEERSKlnleghtpatlryl-------- 366
gi 336372944  185 ----kgrLCGIKTLDYylernr-----vagapsGERNFHIFYYLVaga---taEERQHlhlldktnyrylgsr------- 245
gi 332020102  527 ----tgkASGAIFWLYqlekwr-----vstrdrNQANFHVFYYFY--------DDLEAtenlksyflpsgrklrylritd 589
1D1C_A        250 ----agfISGASIQSYlleksr-----vvfqseTERNYHIFYQLLaga---taEEKKAlhlagpesfnyln--------- 308
gi 323456521  341 gprrealVAGGSCEIYglevarvarspgdaegaADGNFHALHWLAg-------GVESPseraalrlrdardkagyrll-- 411
gi 320165758  195 r---thsQAGASVHIYlldtwrv----adtfafREHNFHIFYYMVv-------GMGAKlpgralashistfry------- 253
gi 530737955  471 s---trsVVGASTTCYllekar-----vvrqgtGDSNYLIFYQLLcsqraadyGLTPFgvgdyaylthh----------- 531
gi 383864441  188 -----stISGATINSFllers--------rvtrGSNNFQIFYQMMfgm---ssTELESynlstdecydil---------- 241
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
2MYS_A        316 ------segeitvpsiddqEELMATDSAIDILGfsaDEXTAIYXLTGAVMHYGNlkfxqxqree-----------qaepd 378
gi 308245732  228 -------qgnsteniqidvNHFKTLEDALHVLGfsdDHCISIYKIICTILHIGNiyfrtkrnpnve-------ndvveig 293
gi 270004772  367 ------qhgdtrqdlaedsSRFQTWKTCLGILG---IPFLDVVRVLAAVLLLGNvqfldgkgle------------vdvk 425
gi 336372944  246 ----gaiaprqnavrdddaNRFDQLKVALKSIGlskRHVAQTCQLVAAILHLGNleftvdrsrne---------daavvr 312
gi 332020102  590 kniekkrafkvrsdpqnnvIKFKELTEYFKFMDm-eEYCDTIWKILAAILILGEirfvegnnge------------aeld 656
1D1C_A        309 ------qsgcvdikgvsdsEEFKITRQAMDIVGfsqEEQMSIFKIIAGILHLGNikfekgageg------------avlk 370
gi 323456521  412 datddaaadwaalsaaygvVARDGDAKSKRPTGvrdSFAEGVAGLLAAILALGDvefgggdeaky----------retaa 481
gi 320165758  254 ----lhqdahtqnsldvaaFRFRELTSALEALGipaSEQDEVFAVLAAILYLGElkfvpseaagtgsassialaridnea 329
gi 530737955  532 ---------vevdrdtvafGALDATLDALRAVEi--LDVDWLLGVVAAILHLGNlvfvsdnetg-----------snvan 589
gi 383864441  242 -------stvdcnkikyfqNSFQDTSKALDILGftsDQKRNIFQVLALLLHMGNikfiqsgetc-----------tidin 303
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
2MYS_A        379 gtevaDXAAYLmglnsAELLKALCYPRVgvgnea-------------vtxgetVSEVHNSVGALAXAVYEXMFLWMVIRI 445
gi 308245732  294 nmsevKWVAFLlevefDQLLNFLLPKSEdgt-------------------tidLNAALDNRDSFAMMIYEELFKWVLNRI 354
gi 270004772  426 gdtelNAVAGLlgvsgAALFRGLTTRTHnargql-------------vksvcdANMSNMTRDCLAKALYCRTVATIVRRA 492
gi 336372944  313 nvdilDVVSEFlgvqpSALEAALSYKTKmvkkel-------------ctvfldPDGASDNRDDLAKTLYSLLFAWLNEHI 379
gi 332020102  657 dneiaNRVAELlglnsKKFIWALINYCLvvkgsv-------------vrkkhtCEEAKEARDVLANTLYQRLVDWIINII 723
1D1C_A        371 dktalNAASTVfgvnpSVLEKALMEPRIlagrdl-------------vaqhlnVEKSSSSRDALVKALYGRLFLWLVKKI 437
gi 323456521  482 sktraADAAELlgvdgGVLRDAFLCRVLdvasgassa-------gvgkrvparPSDAETARDGLIKALYGRLVTWVVKRA 554
gi 320165758  330 gtvpsSLIASLlhiqrQRLDDILLFAPAssaapsaagaamaarsaanslrpmtVEQCSANRDGIARSLYERLVAWILYRV 409
gi 530737955  590 saallAAATHLrv-psDALRDALCVTVLtigskle-----------rqcmphgPERAASAAAAMAKALYVRLFEYIVTCC 657
gi 383864441  304 dkksmKALKSTcalssLTEEAVIELLTTilinpqstwrk----htpyhrylvtVDACRSRLHSIIRHMYELLFHWILNHT 379
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                         ######          
2MYS_A        446 NQQLdtk-----------------------------------------------qpRQYFIGVLDIAGFEIFdf-----n 473
gi 308245732  355 GLHLkc------------------------------------------------plHTGVISILDHYGFEKYnn-----n 381
gi 270004772  493 NSLKrlgstlgtlssdsnesvhnqaevtsqhastvngstnagsksmaalnnavrhaTDGFIGILDMFGFEDPkp-----s 567
gi 336372944  380 NQRLcr------------------------------------------------ddFDTFIGLFDLPGPQNMtsr---pn 408
gi 332020102  724 NYKLsmtr--------------------------------------------slygDKYSISILDHFGFECFsi-----n 754
1D1C_A        438 NNVLcq------------------------------------------------erKAYFIGVLDISGFEIFkv-----n 464
gi 323456521  555 SGECrea-----------------------------------------------arAPSDVYVLDACGFDDAakgaggrn 587
gi 320165758  410 NATIaprpqr-----------------------------------------pddreKVLSVGVFDMFGFAAPnm-----c 443
gi 530737955  658 NASVga------------------------------------------------spDALRLSVLDVVGFESLpl-----n 684
gi 383864441  380 NNALcvk-----------------------------------------------heFFQWLGVLDIFGFESFdk-----n 407
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
2MYS_A        474 SFEQLCINFTNEXLQQFFNHHMFVLEQEEYxxEGIEWEfidf--gmdlAACIELIex--pmGIFSILEEECmfp-----k 544
gi 308245732  382 GVEEFLINSVNERIENLFVKHSFHDQLLDYakDGISVDykvps-sienGKTVELLfkk-pyGLLPLLNDECkfp-----k 454
gi 270004772  568 QLEHLCINLCAETMQHFYNTHIFKSSIESCrdEGINCEvevd--yvdnVPCIDLIssl-rtGLLSMLDVECsir------ 638
gi 336372944  409 SLDQFCINFANERLQSFTQKRLFESHVDEYtnEGISRFvptvp-yfdnSECVRLLqnk-pgGLIHIMDDQArrah----k 482
gi 332020102  755 RLEQLLVNTINEQIQYYYNQRVFAWEMQEQeeEDIPIQqlrf--ydnkEAVDQLMnk--rdGLFHIIDDASrq------- 823
1D1C_A        465 SFEQLCINYTNEKLQQFFNHHMFKLEQEEYlkEKINWTfidf--gldsQATIDLIdgrqppGILALLDEQSvfp-----n 537
gi 323456521  588 FFDELLHNAAAERHHAYYAETTFSDELKLYddEGLDVSttkfpavqtnADVLDLLlgg-paSLLGTVDASAaal-----g 661
gi 320165758  444 RFQHLSVNMANETLRHLFVETAFGMEQADI--QALNWEplhin-fipnEQCVAFFlgr-psGLLAMIDHASlat-----s 514
gi 530737955  685 GLNQLCINYTNEVFQQKMQSEILAADLALYarEGVAAPsmal---hdhQIVLDLLdkk-pdGILHLLEEQArvm-----r 755
gi 383864441  408 GIEQLCVNYANEKMQQYFIETYVESSRKDLgeEGFIKEnnpl---htiDLYKERLnvi-eeGLFLTLNDAChspvpinis 483
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
2MYS_A        545 atDTSFXNXLydehlgksnnfqkpkpakgkaeaHFSLVHYAGTVDYNisGWLEXNxdPLNETVIGLYQXssvxtlallfa 624
gi 308245732  455 gsHESYLEHCnlnhtdrssf----gkartkermEFGVRHCIGTTWYNvnDFFTRNkrIISFSAVQLLRSsknpiigllve 530
gi 270004772  639 gtAESYVSKIsvqhkhnsrl----fepkpvdprLFGIQHFAGRVVYDatDFLDTNkdVVPDDLVAVFYKhncnfgfathl 714
gi 336372944  483 ktDHSMVEAFgkrwgnhssfk--mgsldragfpTFTVNHFNGPITYSaeGFLERNldALNPDFVSLLRGatnvsdgtegs 560
gi 332020102  824 mqDAQYILERikehkrnt-------hikpvsshEFMIAHYTGKLIYDanEIATKNrdFVPPEMINTMRYslhnavkemft 896
1D1C_A        538 atDNTLITKLhshfskknak----yeeprfsktEFGVTHYAGQVMYEiqDWLEKNkdPLQQDLELCFKDssdnvvtklfn 613
gi 323456521  662 etDARALAAVvaahgaspsf---epgrrqraatSFTVKHTGGDVSYDvhDLLRRArvAAPAAAVAALETstrpfvralfa 738
gi 320165758  515 ttSAGFVSDLdrasgthac-----yvkkagvkpCFGIVHYVGTVFYDaaSCIIVNrdYSLPQFLNLLHDsdsstvqqlgr 589
gi 530737955  756 gsDARLAQQVralgspal--------vaqkspmLFGVRHYAGVVTYSadGLTEGNkdTTAPSFADFFAQstlpatfqalf 827
gi 383864441  484 kiIQLACSNLyngqkkf----------ldakdgNFIIDHYSGPVAYSidDLLSKNtdKVPNEISMIFNAstnkflrtlin 553
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
2MYS_A        625 tyggeae----------------------------------------------------ggggkkggkkkgssfqtvSAL 652
gi 308245732  531 s----------------------------------------------------------------yssntsdmivsqAQF 546
gi 270004772  715 fgselkalysvesvp-------------------------------------rgvsfrisptshtdllngdepvstlTQD 757
gi 336372944  561 gsinpfvkgifsgkaiatqahpknedtivsaqqpikpmrapsmrrkgtvkrmptlregdgderdrddeetsggapcvAGE 640
gi 332020102  897 nkltksgnltivhehcfatkktm--------------------ktkwstlmqessmfrkyntaskgqysqtrkmrtcSST 956
1D1C_A        614 dpn------------------------------------------------------------iasrakkganfitvAAQ 633
gi 323456521  739 ecdvdeaacpwlt-----------------------------------------lgdlaacgavrfvhakeqgrasaIAS 777
gi 320165758  590 iavass------------------------------------------------------gslkmnvrgheaaalnnVGR 615
gi 530737955  828 -------------------------------------------------------------------qaapartrspVAD 840
gi 383864441  554 idee-----------------------------------------------------------qyshtiktcrkrtmLAK 574
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
2MYS_A        653 FRENLNXLMANLRs----------tHPHFVRCIIPNetxtp--------gameHELVLHQLRCn-GVLEGIRICRkGFPS 713
gi 308245732  547 ILRGAQDIADKINg----------sHTNFVRCIKSNnerqp--------kkfdIPLVNRQIKNl-LLAELLSFRIkGYPV 607
gi 270004772  758 FHTRLDNLLRTLVh----------aRPHFVRCIRSNsqetp--------nrfdRGTVVRQIRSl-QVLETVNLMAgGYPH 818
gi 336372944  641 FRAALDTLFDTVAe----------tQAWYVFCVNPNdsqlp--------nqleGRSVKGQVRSa-GLSEIARRNVnVFEV 701
gi 332020102  957 FRATSLEILKNLAigt------gngGTHFVRCIRSDledap--------hsfyREIVRQQIRAl-AVLDTAKARRrGYPY 1021
1D1C_A        634 YKEQLASLMATLEt----------tNPHFVRCIIPNnkqlp--------akleDKVVLDQLRCn-GVLEGIRITRkGFPN 694
gi 323456521  778 FRSQLDALYGGLSqlgglsrgtgrpLATHVLCTRAApqrlfdkdpelardffePSYVGKQLFDrfAVPEFATLTKiGLRW 857
gi 320165758  616 YRASLRQLINRASs----------qSVSFVHCIGANasgth--------aqfdTSFVQGQVMAm-SLLELTWSRKfGYPG 676
gi 530737955  841 FRTQLAALRQDIAl----------lHPRHVCCITPSrtrat--------atfePLVVLDQLRAa-GVLAAVNLSTtGLAY 901
gi 383864441  575 LKYNIDTLIKELRk----------cDLHYVRCVKPNrltd---------iewdRKEFRKQLASt-GIFDILPLAKcKYPI 634
                         890       900       910       920       930       940       950
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                                                                                       
2MYS_A        714 RVLYADFKQRYRVLnasaipegqfmdskk----------------------asekllgggdvdhtQYAFGHTX-VFFX 768
gi 308245732  608 KISKTTFARQYRCLlpgdiamcqnekei-----------------------iqdilqgqgvkyenDFKIGTEY-VFLR 661
gi 270004772  819 RMRFKAFNARYRLLapfarlhrtdekvtddchl-------------ilqyvvdliskqhntlvstSWALGKRH-IFLS 882
gi 336372944  702 GMTPEEFCDRYKEPmgamgimssdprer------------------------veqcrsplgvserDVVLGNFK-VFLS 754
gi 332020102 1022 RIPFQEFLRRYKFLafdfdetvemtkd--------------------------ncrlllirlkmeGWIIGKSK-IFLK 1072
1D1C_A        695 RIIYADFVKRYYLLapnvprdaedsqka------------------------tdavlkhlnidpeQYRFGITK-IFFR 747
gi 323456521  858 RMPHDRFYAKYAIAarglgvysrafplvvadddagerrerakrlldallcdpglaaeakeaarrgEAQLGRTL-VMLS 934
gi 320165758  677 RYQHDRFLARFGILnrqpvnqsvvpidacralvqrfgl----stahvaqdmvllkladmdkleaaWVRLNKAAlLFQR 750
gi 530737955  902 RVPHAAFFNLYQRLapgardcka---------------------------------llrdlglrsHAQLGASL-VLYD 945
gi 383864441  635 RLHYEKFCERYSKRptettdlnkckli--------------------------lesvvpqreissLVHFGKQL-IFLT 685

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Conserved site includes 23 residues -Click on image for an interactive view with Cn3D