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cd00075: HATPase_c 
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Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
Links
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Statistics
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PSSM-Id: 238030
View PSSM: cd00075
Aligned: 483 rows
Threshold Bit Score: 33.7742
Threshold Setting Gi: 6094499
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

cd00075 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00075 is a member of the superfamily cl00075.
cd00075:HATPase_c1A4H  198594791BYQ A60162641236671076758170831417865492178654866015101205321031237261786549317865487178654786016274249536417083372495363113868166225519178656795019928327356846201317865477178654962495706131246113122957131246011312483031229543024756131246261H7S A204550951419494489282401B62 A20455148204551508039787136312302045511020455124204551072045512020455087892822439140821387858319856116204551302045510617091882045512989282142045516420455163111356441EI1 A1708094121889929709854446640333956647525250129666475313550425391572517095846831559403339818273027403340013527162501299462227170809312188740991115294641170146134624174806201172018136383614033401743746674374631264410520532279117474025012976094499135126474813817479282136768173132011843617063607470846747907975312657475955747596421829943425858127840276545111716571278377477506747703317063591GJV A1JM6 A318311746612031831123695005731802747085632532111175625992856574793631L0O A464792134758328791332879063287908134491173690901175728748282574828337482827746931274828317482834748282274828267482829748283674828287482824748283274775401B3Q B7442990150888081205467521130616599439156402507378229300074641091621285372157017380473250075921294061743372511628274692851293528994626874692867470224862312179979120140965742936325066872500766136339603913941250076213632799746970658620441046062507383122297077481671170620474818962507376729184170888321272804104349747596333204642507384130181130188464380173056560937141301853914343130190111340291172496130189126442641730566117249837243462499557548512400792214794625071852499556130192182062631113403262266717492948250076735111307465219213624062136244425067331521397425007611705888152139787428875135250139159671385802014187128278801385884376185124004911717931171792927309310876128597128598128596573203810840171183951738040073222641716717865735201410271170663585587216052974759583041695746377072990174759571202081202061202073184127128494481880585041182546522136492160528177336117733672120409201417323024195747596574678961ID0 A410332932373736258422120819296107511761111723889171078817297841666498748411611743662267071171723703269107554932983663298362126437735437787481385173139612230969298105228959351BXD A752158574678982126373548536328806574765887481839416838116105574816533122321312231474816697429074742907518273032105534873080674698787479049134637418343762854037467522201412622947211259957029519332213649182546574786317479048747813074487937448794157568974487957429079585964216076174708477488992748469440925267484745748495074895382243158285299113523977470844207355674899087493238135083774938037470855134644074708502507379172332925073774106623174337413320466136379377531256746762013638405747083817088867470837149830574696497481384221809415460767470843742907774440701262210749378239550361738041074898707470841746376916797577289902353767747083411362894661951301307470848175464246140327650357469378748167727391337481675730745122297214104596747596174759621176994218299672597922182835391325674759567482821122304741223045724995581401270746757774759682182992410460374708367470849747084574708357470839744295941046097475953485520751501228016517515009368766423387287777533282775130131738800841040191264467617312052808665625679748394825007652145515173803241075537561864556614746300646439323520987429076747085321267627474192748394674839577483954748394774513577470840748395274839497451361745136074839581A4H  198594791BYQ A60162641236671076758170831417865492178654866015101205321031237261786549317865487178654786016274249536417083372495363113868166225519178656795019928327356846201317865477178654962495706131246113122957131246011312483031229543024756131246261H7S A204550951419494489282401B62 A20455148204551508039787136312302045511020455124204551072045512020455087892822439140821387858319856116204551302045510617091882045512989282142045516420455163111356441EI1 A1708094121889929709854446640333956647525250129666475313550425391572517095846831559403339818273027403340013527162501299462227170809312188740991115294641170146134624174806201172018136383614033401743746674374631264410520532279117474025012976094499135126474813817479282136768173132011843617063607470846747907975312657475955747596421829943425858127840276545111716571278377477506747703317063591GJV A1JM6 A318311746612031831123695005731802747085632532111175625992856574793631L0O A464792134758328791332879063287908134491173690901175728748282574828337482827746931274828317482834748282274828267482829748283674828287482824748283274775401B3Q B7442990150888081205467521130616599439156402507378229300074641091621285372157017380473250075921294061743372511628274692851293528994626874692867470224862312179979120140965742936325066872500766136339603913941250076213632799746970658620441046062507383122297077481671170620474818962507376729184170888321272804104349747596333204642507384130181130188464380173056560937141301853914343130190111340291172496130189126442641730566117249837243462499557548512400792214794625071852499556130192182062631113403262266717492948250076735111307465219213624062136244425067331521397425007611705888152139787428875135250139159671385802014187128278801385884376185124004911717931171792927309310876128597128598128596573203810840171183951738040073222641716717865735201410271170663585587216052974759583041695746377072990174759571202081202061202073184127128494481880585041182546522136492160528177336117733672120409201417323024195747596574678961ID0 A410332932373736258422120819296107511761111723889171078817297841666498748411611743662267071171723703269107554932983663298362126437735437787481385173139612230969298105228959351BXD A75215857467898212637354853632880657476588748183941683811610557481653312232131223147481669742907474290751827303210553487308067469878747904913463741834376285403746752220141262294721125995702951933221364918254657478631747904874781307448793744879415756897448795742907958596421607617470847748899274846944092526748474574849507489538224315828529911352397747084420735567489908749323813508377493803747085513464407470850250737917233292507377410662317433741332046613637937753125674676201363840574708381708886747083714983057469649748138422180941546076747084374290777444070126221074937823955036173804107489870747084174637691679757728990235376774708341136289466195130130747084817546424614032765035746937874816772739133748167573074512229721410459674759617475962117699421829967259792218283539132567475956748282112230474122304572499558140127074675777475968218299241046037470836747084974708457470835747083974429594104609747595348552075150122801651751500936876642338728777753328277513013173880084104019126446761731205280866562567974839482500765214551517380324107553756186455661474630064643932352098742907674708532126762747419274839467483957748395474839477451357747084074839527483949745136174513607483958
cd00075 Sequence Cluster
cd00075 Sequence Cluster
Sub-family Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #   #  #                                               # # # ##           
1A4H         37 KEIFLRELISNASDALdkirykslsdpkqletepdLFIRITPKpe-----------qkVLEIRDSGIGMtkaelinnlgt 105
gi 7475965  468 FRRILENLLGNAVKHNgk----------------gTEIQVILEqtk---------nhiSLKVKDNGKGMdeetithlfnr 522
gi 1175625   54 DDHALKDLLVNINLIVen----------------rQQIRIDERl-------------iAITVWDRGKGIsetdqqrvfer 104
gi 4104349  140 VRKIIDNLLSNAIKYCden--------------gdVGVNLTPL---------------ALTISNGGAGIakenlsrifdl 190
gi 7492948 1903 IGQMLKSILDNSVKTVn-----------------nGFIRVRAFlagsskkndrdqlqiAFIVEDTREESnaiflanmins 1965
gi 7469706  335 LRQIFQELLTNAQKFAva----------------dSSIVVTLEqceqism--qvkkniKCTFSNQTVAVddnnlqhlfdp 396
gi 2507185 1005 LQQVLADFLLNAVQFTpp----------------sGWVEIKVEpvvkklpggvsvanvDFRVSHPGEGLpedlidqmfd- 1067
gi 1730566  991 LQLVLSDFLLSIVRHAps---------------pdGWVEIRVSpglkliqdgnvfihiQFRMTHPGQGLpsaliedmvr- 1054
gi 6226671  996 LQQVLADLLFCAINHAtttn-----------edekDWVTIKVSrtktrlddgvhlmhfEFRISHSGQGIsealveemt-- 1062
gi 1172498  987 LQLILADLLRNIVNHApf---------------pnSWVGISISpgqelsrdngryihlQFRMIHPGKGLpsemlsdmfe- 1050
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                ####               # #                               ##
1A4H        106 iaksgtkafmealsagadvsmigqfGVGFYSLFLVAd----RVQVISKsnddeqyiwesnaggsftvtldevnerigrGT 181
gi 7475965  523 yy-----------rgtntkdstagtGLGLAIAKELVhlhngTIHVNSRtn---------------------------iGT 564
gi 1175625  105 ly----------tleesrnkafqgsGLGLTITKRLTekmggIISVQSKpy---------------------------eRT 147
gi 4104349  191 --------------yarfdernggfGIGLHIVKTFCdelgfKISCKSKe----------------------------gLT 228
gi 7492948 1966 lnr---------gcndylpmdlsgtALGMSTCLQLCkimggSVSVEVSq----------------------------nNP 2008
gi 7469706  397 fy----------reqwvidsaiagvGLGLTIVRTLIeqlngKISVVGKpsc------------------------qpgQT 442
gi 2507185 1068 ---------------radarvksqeGLGLSICRKLVrlmngEVQYRREg----------------------------eRN 1104
gi 1730566 1055 ----------------ggtrwttqeGVVLHLSQKLVrmmngHVHYVREq----------------------------qKC 1090
gi 6226671 1063 ----------------nksqkwtpeGLAISISCTLIrlmngDVKYTTDa----------------------------gNK 1098
gi 1172498 1051 ----------------trdgwvtpdGLGLKLSRKLLeqmngRVSYVREd----------------------------eRC 1086

                ....*.
Feature 1        #    
1A4H        182 ILRLFL 187
gi 7475965  565 VITILF 570
gi 1175625  148 AFTITL 153
gi 4104349  229 EFMVEF 234
gi 7492948 2009 TFKICY 2014
gi 7469706  443 VITFTL 448
gi 2507185 1105 FFLLQL 1110
gi 1730566 1091 YFLIDL 1096
gi 6226671 1099 CFLVTI 1104
gi 1172498 1087 FFQVDL 1092

Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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Click on image for an interactive view with Cn3D
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D