Conserved Protein Domain Family
GAL4

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cd00067: GAL4 
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GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations
Links
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Statistics
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PSSM-Id: 238023
View PSSM: cd00067
Aligned: 118 rows
Threshold Bit Score: 31.865
Threshold Setting Gi: 159164869
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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Zn2+ bindingDNA binding
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn2+ binding site [ion binding site]
Evidence:

cd00067 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00067 is a member of the superfamily cl00068.
cd00067:GAL41PYI A13078411734397021392170561941857258648280628611359660136260901351343109983781CLD  1D66 A6324483586293495995413624754182757347493505749350614581734158237931168367315025211359280749374573187231502551271835373138413176713175711595549136340045854441708905495995067150974996624113592811174472828347292907492096749070417306321297335856511296311073094163249567319451203898312835374928943ALC A12043559632072914279690113594416324736632474663232965497607490705147009014194797135197610303236586367171802514285695116919711289949169445586323257170888813674738501327801306250173814056563229747317481HWT C16944579135170817232193929345749303613516727290571730692731287549625111399901176484173088258635413165311689271729888126217452032474930391271825974915496320629250174040713152808662134679460942687493181170617717061765438021PYI A13078411734397021392170561941857258648280628611359660136260901351343109983781CLD  1D66 A6324483586293495995413624754182757347493505749350614581734158237931168367315025211359280749374573187231502551271835373138413176713175711595549136340045854441708905495995067150974996624113592811174472828347292907492096749070417306321297335856511296311073094163249567319451203898312835374928943ALC A12043559632072914279690113594416324736632474663232965497607490705147009014194797135197610303236586367171802514285695116919711289949169445586323257170888813674738501327801306250173814056563229747317481HWT C1694457913517081723219392934574930361351672729057173069273128754962511139990117648417308825863541316531168927172988812621745203247493039127182597491549632062925017404071315280866213467946094268749318117061771706176543802
cd00067 Sequence Cluster
cd00067 Sequence Cluster
Sub-family Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
Feature 1            #  #      #                #  #        #   
3ALC_A        9 RQNHSCDPCRKGKRRCDApenrneanengwvSCSNCKRWN--KDCTFN 54
1HWT_C        5 RIPLSCTICRKRKVKCDKlr----------pHCQQCTKTGvaHLCHYM 42
gi 16944558  15 KSRKGCETCKRRHIRCDEsf----------pQCRNCTKHK--IRCPYN 50
gi 6323257   39 KSKTGCDNCKRRRVKCDEgk----------pFCKKCTNMK--LDCVYS 74
gi 14285695  50 RSRTGCYTCRLRRKKCDEgs----------pMCTACKHLG--LCCEYK 85
gi 7493039   16 RSRYGCLICRSMRKKCDEvh----------pQCGRCLKAG--KQCIWK 51
gi 11289949  86 KSRRGCFTCKRRRVKCSEkl----------pECDNCTRIG--LICEYP 121
gi 1708888  154 YSRNGCSECKRRRMKCDEtk----------pTCWQCARLN--RQCVYV 189
gi 1169197  313 RSRMGCLTCRQRKKRCCEtr----------pRCTECTRLR--LNCTWP 348
gi 136747    12 YSKHGCITCKIRKKRCSEdk----------pVCRDCRRLS--FPCIYI 47

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Conserved site includes 6 residues -Click on image for an interactive view with Cn3D