Conserved Protein Domain Family
DED

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cd00045: DED 
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Death Effector Domain: a protein-protein interaction domain
Death Effector Domains comprise a subfamily of the Death Domain (DD) superfamily. DED-containing proteins include Fas-Associated via Death Domain (FADD), Astrocyte phosphoprotein PEA-15, the initiator caspases (caspase-8 and -10), and FLICE-inhibitory protein (FLIP), among others. These proteins are prominent components of the programmed cell death (apoptosis) pathway. Some members also have non-apoptotic functions such as regulation of insulin signaling (DEDD and PEA15) and cell cycle progression (DEDD). DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and CARD (Caspase activation and recruitment domain). They serve as adaptors in signaling pathways and they can recruit other proteins into signaling complexes.
Statistics
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PSSM-Id: 260016
View PSSM: cd00045
Aligned: 31 rows
Threshold Bit Score: 53.7452
Threshold Setting Gi: 90108829
Created: 1-Nov-2000
Updated: 20-Aug-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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Display:
 
charge triad
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: charge triad [active site], 3 residue positions
Conserved feature residue pattern:[ED] R DClick to see conserved feature residue pattern help
Evidence:
  • Comment:The charge triad is part of a signature motif (E/D-RxDL) that is present in the DED family but not in other families of death domains (DD, CARD or Pyrin).
  • Comment:The charge triad is essential for the function of some DED-containing proteins. In FLIP, it is involved in the interaction with FADD to block apoptosis. In PEA15, the triad is necessary for interaction with ERK MAP kinase.

cd00045 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00045 is a member of the superfamily cl14633.
cd00045:DEDcd01670:Deathcd01671:CARDcd08304:DDcd08305:Pyrincd08306:Death_FADDcd08307:Death_Pellecd08308:Death_Tubecd08309:Death_IRAKcd08310:Death_NFkB-likecd08311:Death_p75NRcd08312:Death_MyD88cd08313:Death_TNFR1cd08315:Death_TRAILR_DR4_DR5cd08316:Death_FAS_TNFRSF6cd08317:Death_ankcd08318:Death_NMPP84cd08319:Death_RAIDDcd08320:Pyrin_NALPscd08321:Pyrin_ASC-likecd08323:CARD_APAF1cd08324:CARD_NOD1_CARD4cd08325:CARD_CASP1-likecd08326:CARD_CASP9cd08327:CARD_RAIDDcd08329:CARD_BIRC2_BIRC3cd08330:CARD_ASC_NALP1cd08332:CARD_CASP2cd08333:DED_Caspase_8_r1cd08334:DED_Caspase_8_10_r2cd08336:DED_FADDcd08337:DED_c-FLIP_r1cd08338:DED_PEA15cd08339:DED_DEDD-likecd08340:DED_c-FLIP_r2cd08341:DED_Caspase_10_r1cd08775:DED_Caspase-like_r2cd08776:DED_Caspase-like_r1cd08777:Death_RIP1cd08778:Death_TNFRSF21cd08779:Death_PIDDcd08780:Death_TRADDcd08781:Death_UNC5-likecd08782:Death_DAPK1cd08783:Death_MALT1cd08784:Death_DRscd08785:CARD_CARD9-likecd08786:CARD_RIP2_CARD3cd08787:CARD_NOD2_1_CARD15cd08788:CARD_NOD2_2_CARD15cd08789:CARD_IPS-1_RIG-Icd08790:DED_DEDDcd08791:DED_DEDD2cd08792:DED_Caspase_8_10_r1cd08793:Death_IRAK4cd08794:Death_IRAK1cd08795:Death_IRAK2cd08796:Death_IRAK-Mcd08797:Death_NFkB1_p105cd08798:Death_NFkB2_p100cd08799:Death_UNC5Ccd08800:Death_UNC5Acd08801:Death_UNC5Dcd08802:Death_UNC5Bcd08803:Death_ank3cd08804:Death_ank2cd08805:Death_ank1cd08806:CARD_CARD14_CARMA2cd08807:CARD_CARD10_CARMA3cd08808:CARD_CARD11_CARMA1cd08809:CARD_CARD9cd08810:CARD_BCL10cd08811:CARD_IPS1cd08813:DED_Caspase_8_r2cd08814:DED_Caspase_10_r2cd08815:Death_TNFRSF25_DR3cd08816:CARD_RIG-I_r1cd08817:CARD_RIG-I_r2cd08818:CARD_MDA5_r1cd08819:CARD_MDA5_r2cd13785:CARD_BinCARD_like1N3K A2LS7 A4IZA B4IZ7 B4659631517677962647215443260804559403894701984227081159085282608041412956464312735475472607857442607857082590135222590135222956464314059678152292941922292941922292739822292739852292877772292973802292870461563951611562136121563681501563621082BBZ A2F1S A2BBR A3CL3 A17646695126435473196592732841592544625015719401519224055425453829971496144521895232261105674473265789482960446282264253183265789461572783135213856122364802016723443120328287311320616276199061498324145692999463975574659514304492704884835191951263377492568605152841592582841592564059621313137569785077168714822479619352318379017350540346260831534405955940443701141148230577188585371195775142BBZ A2F1S A2BBR A126435473196592731164879823CL3 A1132061621195906632509057614961445222405542521362764116723443126081962222364802015727831322642531887781182032828712568605153137569782841592564059621312841592584059540152032828737619910126337749126444634659514301108112523265789481105674472960446284436894012292870821A1Z A2GF5 A1A1W A118091445465958905149409596126343438147898837189521793462512842097330761572783111562135951688145132292817322841592524437336071984126101176070614059538522608000452210918342032828712292910872608161101562103211N3K A2LS7 A4IZA B4IZ7 B4659631517677962647215443260804559403894701984227081159085282608041412956464312735475472607857442607857082590135222590135222956464314059678152292941922292941922292739822292739852292877772292973802292870461563951611562136121563681501563621082BBZ A2F1S A2BBR A3CL3 A17646695126435473196592732841592544625015719401519224055425453829971496144521895232261105674473265789482960446282264253183265789461572783135213856122364802016723443120328287311320616276199061498324145692999463975574659514304492704884835191951263377492568605152841592582841592564059621313137569785077168714822479619352318379017350540346260831534405955940443701141148230577188585371195775142BBZ A2F1S A2BBR A126435473196592731164879823CL3 A1132061621195906632509057614961445222405542521362764116723443126081962222364802015727831322642531887781182032828712568605153137569782841592564059621312841592584059540152032828737619910126337749126444634659514301108112523265789481105674472960446284436894012292870821A1Z A2GF5 A1A1W A11809144546595890514940959612634343814789883718952179346251284209733076157278311156213595168814513229281732284159252443733607198412610117607061405953852260800045221091834203282871229291087260816110156210321
cd00045 Sequence Cluster
cd00045 Sequence Cluster
Sub-family Hierarchy
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 cd00045 Branch
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                        #                                                      # #      
1N3K_A          4 YGTLLQDLTNnITLEDLEQLKSACke--dIPSEKSEeittgSAWFSFLESHNKLdkdNLSYIEHIFEISrRPDLLTMVV 80
1A1Z_A          4 FLVLLHSVSSsLSSSELTELKGLClg--rVGKRKLErvqsgLDLFSMLLEQNDLepgHTELLRELLASLrRHDLLRRVD 80
2BBZ_A         96 YRKLMVCVGEeLDSSELRALRLFAcnlnpSLSTALSessrfVELVLALENVGLVspsSVSVLADMLRTLrRLDLCQQLV 174
gi 229294192    6 RHDLFLEISQnLEDDEVRDLRNYVggrklLPSGRIQha-npHQIFNKLQNDGKMkpgDLSLLAELMRKIgRTEYAEEAE 83
gi 229273982    7 LAQLYLKIADnLSSDDVRKLKALLvhdeiLGIAKVEha-epIEIFTMLKNDMIIgegNLGLLVHILRSLgKRRLAEEAE 84
gi 229287046   23 HKQMFVRIEEdLVEDERRSLKGLLyg--rIPAGKLQky-svGDIFRHMERMGQIsatNLEPIAVLMETIhRRDWAIKVR 98
gi 229294192  206 RQDLFLKISRnLLEEELTDLRNYVsg-aeILPARFVqkadaHQIFTQLEKERKLepgDLSLLAGLLTKIgRRDFAERAE 283
gi 229287777    7 LTLLLVKISQsLTVEDVRDLRALIvd--dLGAARVEna-rpLEIFNMLKQDNKIgngDLGFLVQILRSLgKGRLAEEAE 82
gi 229297380    7 RARLYQRINDsLSEEEVRSLRAMLvsdehLGKARVEsa-tpQEMFNMLEDDNKIgkgNLALLVDLLKVLgRAKLAQEAE 84
gi 229273985    7 LAQLYLKISDnLTEDDVRNLRSLLsldeiLGKAKVEka-tpLEIFNMLVDNNTIgkgNLGLLVQILRCLgKGKLANEVE 84

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Conserved site includes 3 residues -Click on image for an interactive view with Cn3D