Conserved Protein Domain Family
CCP

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cd00033: CCP 
Click on image for an interactive view with Cn3D
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.
Links
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BioAssay Targets and Results
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CID: 5288251
AID: 107967
GI: 124318
IC50: 0.003µM
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Effective concentration required against phosphorylation of Mammary gland factor/STAT5
Target Name: Interleukin-2 receptor subunit alpha
Chemical Name: 1py2
IC50: 0.003µM
CID: 5288251
AID: 241068
GI: 124317
IC50: 0.06µM
more
Inhibitory concentration against interleukin-2 binding
Target Name: Interleukin-2 receptor subunit alpha
Chemical Name: 1py2
IC50: 0.06µM
CID: 11490653
AID: 241068
GI: 124317
IC50: 0.6µM
more
Inhibitory concentration against interleukin-2 binding
Target Name: Interleukin-2 receptor subunit alpha
Chemical Name: CHEMBL182704
IC50: 0.6µM
Statistics
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PSSM-Id: 153056
View PSSM: cd00033
Aligned: 287 rows
Threshold Bit Score: 27.8124
Threshold Setting Gi: 124316
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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receptor-ligand
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:receptor-ligand interactions
Evidence:
  • Comment:ligation of CR2 by C3d-bound antigens on the surface of a B cell enhances the induction of the IgG response.
  • Structure:1GHQ_B; CR2-C3d interface
    View structure with Cn3D

cd00033 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00033 is a member of the superfamily cl00043.
cd00033:CCP1CKL A101898912431612431766855281243181161312013777610857181375331166099629556116131116131201377761161311312420711972111972111613111613220137776543981116132543981119721116131201377761197211085718750067675006767500676750067675006777500677750067675006767500677750067675006777500676750067675006767500676137490117027575074232665149629556108571810857187507422117027575036641170275738783675043531GHQ B1184035170896417182531VVC  117315117310595982117315416625249379241673324937924616651718253231558543826250619625061961QUB A231558750742311702751152047387859198601401152051156761166091152132493794101597019167211166101173101166107504353137490969091116126584908101597021337853913233391564216851171176795168511775074221165915849083913233101597016851177497949126181266458134643513464361085718167958410189891708964249895896295562498958738783613530907507422126434941C1Z A46152811731018192011731559598211731011731516851175853981HFH  1197217294591197217294591HFI  119721729459116131201377761173101345942249379624937951161311197211GHQ B117316461665170925524976532497654249765561749031085718134594224937952493797116131750742312431611395481345942249379524937961916721249379124937921161311161312665141085718171825396295563946507503664394650182024951152132493794129830129832129831117315249379126651417089642493791249379246166524937922493793249379424957231ELV A115204135220319860140543983131242071085718585398168511772927281685117749794972927287507423729272875074237503664749794975036641E5G A224647713459422493795249379624937912493792266514117310348269116131108571811731011731545046499628005116131201377761139548113954811395481139548126178126179134643411707601346438117076013464381346439126181134643513464362664581261812664581346436117076013464381261812664581346435134643612618126645813464351261821346438117076013464381346439126182117076013464384625001346437137488249895975074231161312013777675036647503664984515205530374979491CKL A101898912431612431766855281243181161312013777610857181375331166099629556116131116131201377761161311312420711972111972111613111613220137776543981116132543981119721116131201377761197211085718750067675006767500676750067675006777500677750067675006767500677750067675006777500676750067675006767500676137490117027575074232665149629556108571810857187507422117027575036641170275738783675043531GHQ B1184035170896417182531VVC  117315117310595982117315416625249379241673324937924616651718253231558543826250619625061961QUB A231558750742311702751152047387859198601401152051156761166091152132493794101597019167211166101173101166107504353137490969091116126584908101597021337853913233391564216851171176795168511775074221165915849083913233101597016851177497949126181266458134643513464361085718167958410189891708964249895896295562498958738783613530907507422126434941C1Z A46152811731018192011731559598211731011731516851175853981HFH  1197217294591197217294591HFI  119721729459116131201377761173101345942249379624937951161311197211GHQ B117316461665170925524976532497654249765561749031085718134594224937952493797116131750742312431611395481345942249379524937961916721249379124937921161311161312665141085718171825396295563946507503664394650182024951152132493794129830129832129831117315249379126651417089642493791249379246166524937922493793249379424957231ELV A115204135220319860140543983131242071085718585398168511772927281685117749794972927287507423729272875074237503664749794975036641E5G A22464771345942249379524937962493791249379226651411731034826911613110857181173101173154504649962800511613120137776113954811395481139548113954812617812617913464341170760134643811707601346438134643912618113464351346436266458126181266458134643611707601346438126181266458134643513464361261812664581346435126182134643811707601346438134643912618211707601346438462500134643713748824989597507423116131201377767503664750366498451520553037497949
cd00033 Sequence Cluster
cd00033 Sequence Cluster
Sub-family Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1                    #                      #                                    
1CKL_A        1 CEEPPTFe---AMELigkp---kpyYEIGERVDYKCKK--GYFYipplaTHTICDr----NHTWLPvsddaCY 61
1GHQ_B       72 CPEPIVP----GGYKirg----stpYRHGDSVTFACKT--NFSMng--nKSVWCQa----NNMWGPtrlptCV 128
1GHQ_B        4 CGSPPPIl---NGRIsyy----stpIAVGTVIRYSCSG--TFRLig--eKSLLCItkdkvDGTWDKpa-pkCE 64
gi 266514    23 CPTRNQYvsvkYVNLtny----sgpYPNGTTLHVTCRE--GYAKrp--vQTVTCV-----NGNWTVpk--kCQ 80
gi 1085718  870 CTLTAVPd---NVRMtpraa-lknqMRKGQKLKFACTDr-RDTLlg--kAEVECLd----NGKWSYpf-ptCG 930
gi 1085718  807 CEIGVMPt---HVSVvglpp-gtktIKAGQKLQLQCDN--AQPVdr--pAEIECLq----TGEWNAaf-paCG 866
gi 1176795 1169 CSSLNLNl---NSTTrptsseikdsYSVGEKIYHICEKdySFEIalqplKIYQCLn----GGAWSGtp-ekCV 1233
gi 1685117  411 CETPSVP----SGSFvig-----ydYNVHSKIQYNCDP--GHIMdg--tPVLECLd----SGEWSAda-pyCE 465
gi 1718253   25 CSQKTLI----GYRLkmsr---dgdIAVGETVELRCRS--GYTTya-rnITATCLq----GGTWSEpt-atCN 82
gi 7387836  142 CPLLPSDs--qVQEVrn-------pPDNPQTIDYSCSP--GFKLkg--mARISCLp----NGQWSNfp-pkCI 196

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