25295807 2 KMCCPPIQVSLPVYGWGTLIGHfclrlfFSYTIQMlRESFGNNEEVSRVALKAMEYTSDHINSRDDVPFKLAFDHRVVEE 81 Caenorhabditis ele... 7494809 -------------------------------------------------------------------------------- Caenorhabditis ele... 1169959 1 ---MQHIFAFFCTGFLGAVVGAn-----FPNNIQI-GGLFPNQQSQEHAAFRFALSQLTE-----P--PKLLPQIDIVNI 64 human 1346142 1 MRIISRQIVLLFSGFWGLAMGA------FPSSVQI-GGLFIRNTDQEYTAFRLAIFLHNTAPNASEAPFNLVPHVDNIET 73 human 1169961 8 GQSVLRAVFFLVLGLLGHSHGG------FPNTISI-GGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDS 80 human 1169961 8 GQSVLRAVFFLVLGLLGHSHGG------FPNTISI-GGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDS 80 human 23831146 1 MQKIMHISVLLSPVLWGLIFGV------SSNSIQI-GGLFPRGADQEYSAFRVGMVQFST--S--E--FRLTPHIDNLEV 67 human
25295807 82 gaAVSWNMVNAVCDELKEGAMALLSSVDGKGREGIRGVSDALEMPLVSLTAlsnddhqQQQFGNLFEVSVRPPISELLAD 161 Caenorhabditis ele... 7494809 -------------------------------------------------------------------------------- Caenorhabditis ele... 1169959 65 --SDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSF-------PVDTSNQFVLQLRPELQDALIS 135 human 1346142 74 --ANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSF-------PTEGESQFVLQLRPSLRGALLS 144 human 1169961 81 --SNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSF-------PTDADVQFVIQMRPALKGAILS 151 human 1169961 81 --SNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSF-------PTDADVQFVIQMRPALKGAILS 151 human 23831146 68 --ANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSF-------PTDGTHPFVIQMRPDLKGALLS 138 human
25295807 162 FIVHKGWGEVLVLIDPVHASLHLPSLWRHLRTRtNTSVKASMFDLPADEKQfeaYLMQFNMMRNNETNRILIDCASPKRL 241 Caenorhabditis ele... 7494809 1 ------------------------------------------------------------MLTLRPVN-VIVDLEGSYRT 19 Caenorhabditis ele... 1169959 136 IIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEK-NWQVTAVNILTTTEEG----YRMLFQDLEKKKERLVVVDCESERLN 210 human 1346142 145 LLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQN-GWHVSAICVENFNDVS----YRQLLEELDRRQEKKFVIDCEIERLQ 219 human 1169961 152 LLGHYKWEKFVYLYDTERGFSILQAIMEAAVQN-NWQVTARSVGNIKDVQE---FRRIIEEMDRRQEKRYLIDCEVERIN 227 human 1169961 152 LLGHYKWEKFVYLYDTERGFSILQAIMEAAVQN-NWQVTARSVGNIKDVQE---FRRIIEEMDRRQEKRYLIDCEVERIN 227 human 23831146 139 LIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEK-KWQVTAINVGNINNDKKdemYRSLFQDLELKKERRVILDCERDKVN 217 human
25295807 242 KKLLINIRSAQFNqANYHYVLANYDFLPYDQEMFQNGNINISGFNIINKDG---REYWSLKKHLKTSSSLGGG--DDVSV 316 Caenorhabditis ele... 7494809 20 RAFLRALEESVLVkKEYHYVFSNFDVDETDLSGFHFSLINITIFRIFDKNN---KKFLKTRAEFHDVYRGGFSntDSIPT 96 Caenorhabditis ele... 1169959 211 AILGQIIKLEKNG-IGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDtipAKIMQQWKNSDARDHTRVDw-KRPKY 288 human 1346142 220 NILEQIVSVGKHV-KGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTpmvTKLMDRWKKLDQREYPGSE--TPPKY 296 human 1169961 228 TILEQVVILGKHS-RGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENpmvQQFIQRWVRLDEREFPEAKn-APLKY 305 human 1169961 228 TILEQVVILGKHS-RGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENpmvQQFIQRWVRLDEREFPEAKn-APLKY 305 human 23831146 218 DIVDQVITIGKHV-KGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDslvSKFIERWSTLEEKEYPGAHt-TTIKY 295 human
25295807 317 EAAVGHDAMLVTWHGFAKCLQANds-lfHGTFRhrrffnRGFPGiycdplsDRSHPNrpFSSFEHGKTIGVAFRNMKIgh 395 Caenorhabditis ele... 7494809 97 AAAFAHDAILVAGKALQIAMNEHgkgifDKSFVrhqlfnRGRKGlycrpheDQTE-SrqFETFEHGKKIAEAIKKVVLtd 175 Caenorhabditis ele... 1169959 289 TSALTYDGVKVMAEAFQSLRRQR-----IDISR------RGnAG-------DCLANP--AVPWGQGIDIQRALQQVRF-- 346 human 1346142 297 TSALTYDGVLVMAETFRSLRRQK-----IDISR------RGkSG-------DCLANP--AAPWGQGIDMERTLKQVRI-- 354 human 1169961 306 TSALTHDAILVIAEAFRYLRRQR-----VDVSR------RGsAG-------DCLANP--AVPWSQGIDIERALKMVQV-- 363 human 1169961 306 TSALTHDAILVIAEAFRYLRRQR-----VDVSR------RGsAG-------DCLANP--AVPWSQGIDIERALKMVQV-- 363 human 23831146 296 TSALTYDAVQVMTEAFRNLRKQR-----IEISR------RGnAG-------DCLANP--AVPWGQGVEIERALKQVQV-- 353 human
25295807 396 kEGtLTGNIEFDRF-GNRKNFDVSIVDLVSNTkatfnSKEVLAWRQGVGFFSNRTVAqHSRKSQNDHKDNQVIVLTNLVA 474 Caenorhabditis ele... 7494809 176 kDGtLTGRIQFDKVtGKRTNFSAEIVEIKPGVnslnsIWERFQWAEGEGFLLG-----GERYVQEKKKDSSQTRKGILPS 250 Caenorhabditis ele... 1169959 347 -EG-LTGNVQFNEK-GRRTNYTLHVIEMKHDS-----IRKIGYWNEDDKFVPAATDA-QAGGDNSSVQNRTYIVTTILED 417 human 1346142 355 -QG-LTGNVQFDHY-GRRVNYTMDVFELKSTG-----PRKVGYWNDMDKLVLIQDVP-TLGNDTAAIENRTVVVTTIMES 425 human 1169961 364 -QG-MTGNIQFDTY-GRRTNYTIDVYEMKVSG-----SRKAGYWNEYERFVPFSDQ--QISNDSASSENRTIVVTTILES 433 human 1169961 364 -QG-MTGNIQFDTY-GRRTNYTIDVYEMKVSG-----SRKAGYWNEYERFVPFSDQ--QISNDSASSENRTIVVTTILES 433 human 23831146 354 -EG-LSGNIKFDQN-GKRINYTINIMELKTNG-----PRKIGYWSEVDKMVVTLTEL-PSGNDTSGLENKTVVVTTILES 424 human
25295807 475 PFVMIKREclemanLTECQGNNKFEGFCIDLLKLLADKIEEfNYEIKLGTkasEKIlrivfyklfqAGSKQADGS-WDGM 553 Caenorhabditis ele... 7494809 251 KPWQLRfnv---vtVL--VKP--FEGYCIDLLNLLAKNITGfEYDVFIs----DGNk---------YGSRQADGS-WDGM 309 Caenorhabditis ele... 1169959 418 PYVMLKKN------ANQFEGNDRYEGYCVELAAEIAKHVGY-SYRLEIVS---DGK----------YGARDPDTKaWNGM 477 human 1346142 426 PYVMYKKN------HEMFEGNDKYEGYCVDLASEIAKHIGI-KYKIAIVP---DGK----------YGARDADTKiWNGM 485 human 1169961 434 PYVMYKKN------HEQLEGNERYEGYCVDLAYEIAKHVRI-KYKLSIVG---DGK----------YGARDPETKiWNGM 493 human 1169961 434 PYVMYKKN------HEQLEGNERYEGYCVDLAYEIAKHVRI-KYKLSIVG---DGK----------YGARDPETKiWNGM 493 human 23831146 425 PYVMMKKN------HEMLEGNERYEGYCVDLAAEIAKHCGF-KYKLTIVG---DGK----------YGARDADTKiWNGM 484 human
25295807 554 IGELLSGRAHAVVASLTINQERERVVDFSKPFMTTGISIMIKKPDKQEFSVFSFMQPLSTEIWMYIIFAYIGVSVVIFLV 633 Caenorhabditis ele... 7494809 310 IGYLLNETADVAVAPLTITQERERAVDFSKPFMTTGISIMIKKPEKQEFNIFSFMEPLGMTIWIFTLSSYFGVSLTIFLV 389 Caenorhabditis ele... 1169959 478 VGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLV 557 human 1346142 486 VGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLV 565 human 1169961 494 VGELVYGRADIAVAPLTITLVREEVIDFSKPLMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLV 573 human 1169961 494 VGELVYGRADIAVAPLTITLVREEVIDFSKPLMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLV 573 human 23831146 485 VGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLV 564 human
25295807 634 SRFSPYEWRVEETs---RGGFT----ISNDFSVYNCLWFTLAAFMQQGTDILPRSISGRIASSAWWFFTMIIVSSYTANL 706 Caenorhabditis ele... 7494809 390 SWFSPYEKRIEFK----RGEFT----VTNEFTLYNSLWFTLAAFMQQGTDILPRAVSGRIASSCWWFFTLIIVSSYTANL 461 Caenorhabditis ele... 1169959 558 SRFSPYEWHSEef---eEGRDQttsdQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANL 634 human 1346142 566 SRFSPYEWHTEep---eDGKEGpsdqPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANL 642 human 1169961 574 SRFSPYEWHLEDNneepRDPQSpp-dPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANL 652 human 1169961 574 SRFSPYEWHLEDNneepRDPQSpp-dPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANL 652 human 23831146 565 SRFSPYEWHTEef---eDGRETqsseSTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANL 641 human
25295807 707 AAFLTLEKMQAPIESVEDLAKQSKIKYGIQGGGSTASFFKYSSVQIYQRMWRYMESq----VPP------------VFVA 770 Caenorhabditis ele... 7494809 462 AAFLTLERMTPPIESVEDLANQNKILYGVNEGGSTAAFFEDSIVPLYKKMWNFMVSttqkqIELekqsitnstsnrIFVS 541 Caenorhabditis ele... 1169959 635 AAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKS-----AEPs-----------VFVR 698 human 1346142 643 AAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRS-----AEPs-----------VFTR 706 human 1169961 653 AAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKS-----AEPs-----------VFTK 716 human 1169961 653 AAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKS-----AEPs-----------VFTK 716 human 23831146 642 AAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRS-----AEPs-----------VFVR 705 human
25295807 771 SYAEGIERVRSHKGRYAFLLEATANEYENTRKPCDTMKVGANLNSIGYGIATPFGS---------DWKDHINLAILALQE 841 Caenorhabditis ele... 7494809 542 SYADGIEKVRTSKGKYAFLLEETTNNYESGRRPCDTMKVGQNLNTLGYGIATKIGNplryvknsvSLRVSLNLAILYLSE 621 Caenorhabditis ele... 1169959 699 TTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGS---------ALRNPVNLAVLKLNE 769 human 1346142 707 TTAEGVARVRKSKGKFAFLLESTMNDNIEQRKPCDTMKVGGNLDSKGYGVATPKGS---------SLRTPVNLAVLKLSE 777 human 1169961 717 TTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGS---------ALGNAVNLAVLKLNE 787 human 1169961 717 TTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGS---------ALGNAVNLAVLKLNE 787 human 23831146 706 TTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGS---------SLRNAVNLAVLKLNE 776 human
25295807 842 RGELKKLENKWWYDRGQCDAGITVDGSS-ASLNLSKVAGIFYILMGGMVISMLAALGEFLYRSRIEARKSN------SNS 914 Caenorhabditis ele... 7494809 622 KGELKKLENKWWYDRGQCDTGTSDGGTS-SSLNLSKVAGIFYILLAGMVLSMCTALVEFLFRKNKENREKE------RNR 694 Caenorhabditis ele... 1169959 770 QGLLDKLKNKWWYDKGECGSGGGDSKDKtSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKgfclipQQS 849 human 1346142 778 AGVLDKLKNKWWYDKGECGPKDSGSKDKtSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMK--------- 848 human 1169961 788 QGLLDKLKNKWWYDKGECGSGGGDSKDKtSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMK--------- 858 human 1169961 788 QGLLDKLKNKWWYDKGECGSGGGDSKDKtSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMK--------- 858 human 23831146 777 QGLLDKLKNKWWYDKGECGSGGGDSKEKtSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMK--------- 847 human
25295807 915 MVAnFAKNLKSALssqlrlsveGGAVAQPgsqSHNAIRRqqvaaflPANEKEAFNNVDRPANTLY 979 Caenorhabditis elegans 7494809 695 MRS--SRPLK------------PGILAS----CERAKQKq------LQNRRTKSEEVSTPRSTLF 735 Caenorhabditis elegans 1169959 850 INEaIRTSTLPRN---------SGAGASSggsGENGRVVsh---dfPKSMQSIPCMSHSSGMPLG 902 human 1346142 849 ----LTFSEAIRN---------KARLSITgsvGENGRVLtp---dcPKAVHTGTAIRQSSGLAVI 897 human 1169961 859 ----LTKNTQNFK---------PAPATNT----QN-----------YATYREGYNVYGTESVKI- 894 human 1169961 859 ----LTKNTQNFK---------PAPATNT----QN-----------YATYREGYNVYGTESVKI- 894 human 23831146 848 ----VAKNAQNIN---------PSSSQNS----QN-----------FATYKEGYNVYGIESVKI- 883 human
Jiyao W et al.(2023). "The conserved domain database in 2023.",