7299064 4 KEEPVTPAPSPTEEGMANIGSAgagdqpqtsgnntnvKIVIIGAGMAGLSAANHLL--QNGCDDFLILEARGRVGGRIVS 81 fruit fly 7293950 1 -----MSACSEPTTFSKTKETA---------------KIVIIGAGASGVAAATKLL--EQGFKNVLLFEAEDRIGGRINT 58 fruit fly 23093238 1 -----MSSASLR-LLSKTRQTA---------------RIVIVGAGSAGIAAATRLL--DLGFRNVLLLEAEDRIGGRVHT 57 fruit fly 7295017 1 --------------MEKCRASS---------------RIIIIGAGVSGIAAATRLL--QNNFQNVQILEAEDRIGGRINT 49 fruit fly 19922014 1 ------------MSGAQRNQDR---------------KIVVIGAGASGVACATKLL--ELGFQNVLVVEAEDRLGGRIHT 51 fruit fly 15233671 1 ----------------MAKKAR----------------IVIIGAGMAGLTAANKLYtsSNNTFELSVVEGGSRIGGRINT 48 thale cress 17561442 1 MHWLIIFFLLGKCDGLFMQENA---------------SIAIIGAGFAGLRAAQRFE---ELGIVYTIFEGSDRIGGRVYS 62 Caenorhabditis elegans 17558184 4 SVRIVLIVIIGCGITVQKESEKgdss--------ikpSIAIVGAGISGLSTARRLI--ELGIDDFDIYEGLDRIGGRIHA 73 Caenorhabditis elegans 17560136 5 SVEPSNSWRYAIGKHLFSLRNCltnfc------ifkvKVCIIGAGLAGLRSAIHFE---QVGIDYTIFEGSNRIGGRVYP 75 Caenorhabditis elegans 23097272 1 --------MESTGSVGEAPGGP---------------RVLVVGGGIAGLGAAQRLCg-HSAFPHLRVLEATARAGGRIRS 56 human 9506693 4 CESSGDSADDPLSRGLRRRGQP---------------RVVVIGAGLAGLAAAKALL--EQGFTDVTVLEASSHIGGRVQS 66 human
7299064 82 IPLSNNqKIELGANWIHG-VLGNPIFELAVQHG----------------LVSVVNVPKPHKVVA--TTEDGHQVPFNILQ 142 fruit fly 7293950 59 ILFANS-LIDLGAQWCHG-EEGNVVYEKVK-------------------DLDVLDRTGDYVVHF--IRSNKEILTDVHNK 115 fruit fly 23093238 58 IPFADN-VVDLGAQWCHG-EKGNVVYDKVK-------------------DLNLLEVTEPHYETFrcVRSNKEVLPDDLAD 116 fruit fly 7295017 50 VYFGDN-VIDLGAQWCHG-KQQNCVYDMVK-------------------DMGILHETGDYYSPIkrVRSNKEVVPHELAC 108 fruit fly 19922014 52 IPFADN-VIDLGAQWCHG-ERDNIVYELTRKQ-----------------DEELLESTGPVYENYecVRSNGDVVPEEVSS 112 fruit fly 15233671 49 SEFSSE-KIEMGATWIHG-IGGSPVYRIAKETGslvsdepwecmdstidKAKTFAEGGFEIEPSivESISGLFTALMELA 126 thale cress 17561442 63 FPYQNG-YLQFGAEYING--EDNDIYEIVE--------------------RKNLLSTSETDKDEfeTMVYGKPVHDTFHN 119 Caenorhabditis elegans 17558184 74 IPYKDG-FLQMGAQFING--AQNPLYKIANRLG-----------------LLADVVSDTAHVDNahFAFGNQNVQEKDIK 133 Caenorhabditis elegans 17560136 76 FEYQDG-YLHFGAEYVNG--VDNEVYNLVEKYDlf------------dkTKPRTDDLWMLDQDNsiTLVNGHLVPKKILD 140 Caenorhabditis elegans 23097272 57 ERCFGG-VVEVGAHWIHGpSRGNPVFQLAAEYGllgek-------elsqENQLVETGGHVGLPSvsYASSGASVSLQLVA 128 human 9506693 67 VKLGHA-TFELGATWIHG-SHGNPIYHLAEANGlleettd---gersvgRISLYSKNGVACYLTnhGRRIPKDVVEEFSD 141 human
7299064 143 EIYEAYVCFLRRCDEYFLCqys----ppPDIHSVGEHINY---EIEIYLS-GVQDPK-------EKRLKQSIFNCLLKRE 207 fruit fly 7293950 116 ALTELTNAFEVPG---------------EHEGSVGDAFN----AYWKEN--IHQLVPn------DKTIAKEAQDCLKKVI 168 fruit fly 23093238 117 QLKTIAD-MSIPDRQAELL---------DFEGSLGDYINM---KYWKE---LAKLPPi------DRTIAEEFLEVFHKFE 174 fruit fly 7295017 109 RIHDIAV-KSMPSGP---H---------PVVGSFGTHLTQ---TFWRKI--ESELPQv------NRDVASEALNTFAKHE 164 fruit fly 19922014 113 RLKAIVG-DSLVTRQLELR---------HCSGSLGSYLTN---KFYDTLR-RPENSDi------DAEVASEFFVNYQKFE 172 fruit fly 15233671 127 QGKEISQSDADLSRLAHIYetatrvcskGSSTSVGSFLKSgfdAYWDSISnGGEEGVkgygkwsRKSLEEAIFTMFSNTQ 206 thale cress 17561442 120 IWNRFEITTMAKLEK--------------DAANKGISMNS----------------------------VPQRIDFYFEEF 157 Caenorhabditis elegans 17558184 134 TFLDFTSKLDPKYRS--IAk--------HDEKTARRYTFKeifTLDYMHFlKSQNFTd------QQTNVFDSLARSFRSY 197 Caenorhabditis elegans 17560136 141 KFNDYIRYLNVALYEKSIK---------INQLSVENEINN---QFIEFLRdVPEN---------DHEIYESLINVYKNYF 199 Caenorhabditis elegans 23097272 129 EMATLFYGLIDQTREFLHAa-------eTPVPSVGEYLKK---EIGQHVAgWTEDEE-------TRKLKLAVLNSFFNLE 191 human 9506693 142 LYNEVYNLTQEFFRHDKPVn-------aESQNSVGVFTRE---EVRNRIRnDPDDPEa------TKRLKLAMIQQYLKVE 205 human
7299064 208 TCITGCNNMDEVDLLELGSYTELQG---GNIVLPTGYSSILRPLGAQIAKQSILTKcpvkkiHWKRKKTFTGLETVDENs 284 fruit fly 7293950 169 CSMDACDNLSELSYRNFRNFAIAGGd-qNLSWRQKGYWKFLSVLLNSSDNQPGDQGi-----LKGHVHLNKRIAKINWE- 241 fruit fly 23093238 175 ASVEAADHLFEVSGKGHLEYWLCEGe-lLLNWKDKGYKRFLKLLMKAPEDQSEDLGi-----LKDHVRLNRRIAEINWK- 247 fruit fly 7295017 165 SSIIGADNLFEVSVREHIEYHECDGd-kLLHWGTKGYRRFLRLLMKVSADTPEELGl-----LEGRIQLDMKVIKIELA- 237 fruit fly 19922014 173 NSVEASDTLEQVSGRGYLDYWECEGd-iLLNWKDKGYVELLRLLMR-SRELNVEHGv-----LEQRLLLGTRVVKINWNr 245 fruit fly 15233671 207 RTYTSADELSTLDFAAESEYQMFPG---EEITIAKGYLSVIHHLASVLPQGVIQLN-------------R-KVTKIEWQ- 268 thale cress 17561442 158 KNITGLDPDEAIVFEKMLKIYKNQF---QIEWSASAEDLCLKNFNTWDSGVDSEAT----------------LNNMGFK- 217 Caenorhabditis elegans 17558184 198 WEFEWAADWSTLSVHVLKEWNDYGPeceSFATNKIGFKAILDDIAAPIPRKAFNFN--------------SRVENINLDs 263 Caenorhabditis elegans 17560136 200 QTEWSS-PVGELSLSNLSIWDDGTEeedSAVLNKQGFYEILKDFRSKIPAGNIRLN--------------CEVINVKEE- 263 Caenorhabditis elegans 23097272 192 CCVSGTHSMDLVALAPFGEYTVLPG---LDCTFSKGYQGLTNCMMAALPEDTVVFEk-----PVKTIHWNGSFQEAAFPg 263 human 9506693 206 SCESSSHSMDEVSLSAFGEWTEIPG---AHHIIPSGFMRVVELLAEGIPAHVIQLGkpvrciHWDQASARPRGPEIEPRg 282 human
7299064 285 edehsddsertvtevptgeirgasvesntssncdyPAGNVRIDCEDGRV-FHAAHVICTIPLGVLKN---THRTLFDPVL 360 fruit fly 7293950 242 -----------------------------------GDGELTLRCWNGQF-VSADHVICTVSLGVLRE---KHHKLFVPAL 282 fruit fly 23093238 248 -----------------------------------GADELTVRCWNGEV-ITADHVICTVSLGVLKE---QHPKLFVPAL 288 fruit fly 7295017 238 -----------------------------------CPRKVILRCQDGDY-FEADHVICTVSLGVLQE---QHEKLFVPPL 278 fruit fly 19922014 246 -----------------------------------NDGRVELQMSNGET-CIADHVVVTVSLGVLKD---QHLRLFEPQL 286 fruit fly 15233671 269 -----------------------------------S-NEVKLHFSDGSV-VFADHVIVTVSLGVLKAgieTDAELFSPPL 311 thale cress 17561442 218 ---------------------------------------TILDELTSKV-SKSKMRMLSKVEGLDYT-------GKF--F 248 Caenorhabditis elegans 17558184 264 -----------------------------------NTGKIKLTVSDRAVpTEYDYIIVTSSLGVLKK---YHHKMFTPPL 305 Caenorhabditis elegans 17560136 264 -------------------------------------ENIMVTLKNGEV-LHFDACIVTCSLGYLKK---HHKTLFTPQL 302 Caenorhabditis elegans 23097272 264 -----------------------------------ETFPVSVECEDGDR-FPAHHVIVTVPLGFLRE---HLDTFFDPPL 304 human 9506693 283 egdhnhdtgeggq---------ggeeprggrwdedEQWSVVVECEDCEL-IPADHVIVTVSLGVLKR---QYTSFFRPGL 349 human
7299064 361 PQYKQESIENLMFGTVDKIFLEYERPFLSADISEIMLLWDDDKrdmnssEEELASEAylsKNWFKKIYSFAKVTDT---- 436 fruit fly 7293950 283 PASKIRSIEGLKLGTVNKFYLEFEEQPVPENIREMAFLWLEED------LKELRSGK---YFWLESVCYFHRVDCQp--- 350 fruit fly 23093238 289 PAAKvraieglklgtvdkffleFENPPLPGDWPGFNCLWLKED------LEELRASE---LFWLESVFGFYPVSRQp--- 356 fruit fly 7295017 279 PAAKVNAIRSLTLGTVNKLYLEYEKQPLPDGWVGFFCFWLEED------LIELRKTE---YFWVEGITGVHMITCQp--- 346 fruit fly 19922014 287 PVEKQRAIDGLAFGTVNKIFVEFPEAFWPEDWTGFTMLWRDED------LDDIRGTS---RAWLEDVFGFYRVSYQp--- 354 fruit fly 15233671 312 PDFKSDAIRRLGYGVVNKLFVEMSQRKFPS----LQLVFDRED-------SEFRFVKi--PWWMRRTATITPIHSNs--- 375 thale cress 17561442 249 QSRKMRAIERAGFGSNLKIFLEYEKPWWPLG----TTLRISGK-------IEVNQTT-----LEDDFMVFEPSSWAk--- 309 Caenorhabditis elegans 17558184 306 PRQKIEAIEKIGFGGSCKVFFEWETPFWSNNTYSIAPLPVKGM---------IRDKL---DAFEDETTILQVVDWAp--- 370 Caenorhabditis elegans 17560136 303 TSVKQDAINRMGFGNNLKVFLEYSDSWWNS-LNTILILTHGEN--------------------E-DFMVFQPSSWAe--- 357 Caenorhabditis elegans 23097272 305 PAEKAEAIRKIGFGTNNKIFLEFEEPFWEPDCQLIQLVWEDTSp-----LEDAAPELq--DAWFRKLIGFVVLPAFas-v 376 human 9506693 350 PTEKVAAIHRLGIGTTDKIFLEFEEPFWGPECNSLQFVWEDEA------ESHTLTYPp--ELWYRKICGFDVLYPPeryg 421 human
7299064 437 -LLLGWVSGREAEYMEKLDHEAVAEKCTEILRNFLQD------------------PYVPKPKRCVCTSWKSQDFTGGAYT 497 fruit fly 7293950 351 rLLQGWIIGAHSRYVETISEEQVLEGIMWMFRKFLK-------------------FSVPYPKNFLRSQWQSNPNFRGSYS 411 fruit fly 23093238 357 rILQGWIIGPHARHMETLTEERVLEGLLWLFRKFLP-------------------FETAHPVRMLRTQWHANPNFRGSYT 417 fruit fly 7295017 347 rMLMAWVNGPHGRHMETLSDEKVLEGLYWLFRKFLT-------------------FEIPPPKRFVRSSWFSNPNFRGSWS 407 fruit fly 19922014 355 rILAGWITNESGRHMETLPVDEVQAGVMYLFRRFLR-------------------WKIPDPANFRTSAWYTNDNFRGSYS 415 fruit fly 15233671 376 kVLLSWFAGKEALELEKLTDEEIKDAVMTTISCLTGKevkndtakpltngslnddDEAMKITKVLKSKWGSDPLFRGSYS 455 thale cress 17561442 310 nILVAWVAGNGPMKIAELSDVQLNEIISKHLTTNLKNi-----------------YNIPKIQKIYRHNWITDEFARGSYS 372 Caenorhabditis elegans 17558184 371 nVLSAWYAGRGHQLVDNMSEEELKQRITKLMRDMYND------------------KSIPEPSKIIRTQLTKNELLLGSYS 432 Caenorhabditis elegans 17560136 358 nILLCWIAGSGPKKICDKTDFELKILLDTHLHDQLKNy-----------------LDVKASVKIYRKNWINDEFTLGSYS 420 Caenorhabditis elegans 23097272 377 hVLCGFIAGLESEFMETLSDEEVLLCLTQVLRRVTGN------------------PRLPAPKSVLRSRWHSAPYTRGSYS 438 human 9506693 422 hVLSGWICGEEALVMEKCDDEAVAEICTEMLRQFTGN------------------PNIPKPRRILRSAWGSNPYFRGSYS 483 human
7299064 498 SIPVG-ATQEDIENLAQPLYATPQ-------------------AMKPAIVFAGEHTHSSFYSTVHGAYLSGRTAAQHLLA 557 fruit fly 7293950 412 YYSTY-ADELRTGRTDLASPLVDV-------------------TGRPRIQFAGEASSRNHFSTVHGAIESGWREAERLNE 471 fruit fly 23093238 418 FRSTY-TDALRTGAWDLEAPLQDV-------------------CGRPRLQFAGESTHKHFYSTVHGAVETGWREAERLHL 477 fruit fly 7295017 408 YRGVM-ADERNTGPWDLESPVLGE-------------------DGHLGLLFAGEASSRNHFSTVHGAVEAGYREADRLID 467 fruit fly 19922014 416 YRSMD-TEQLGTGARELSHPLTVVattpekdkdsedeawqqsrCDRPIVQFAGEASSEHYYSTVHGAVEAGWREARRLAQ 494 fruit fly 15233671 456 YVAVG-SSGDDLDAMAEPLPKINKkvgqvn-------ghdqakVHELQVMFAGEATHRTHYSTTHGAYYSGLREANRLLK 527 thale cress 17561442 373 YISEN-TCHSNTDDIKILRDPVLR-------------------NRKPIICFAGEHTDSKMYQTAVGASRSGLREADRIFN 432 Caenorhabditis elegans 17558184 433 YMTQV-QALSHISHSQLAIPVKLE--------------------GRPKVLFAGEATHHRLFQTTIGGYLSGRREADRAVN 491 Caenorhabditis elegans 17560136 421 YLTPGqIVGEDICILAQPVLKDNN--------------------P--VICFAGEHTDSTMYQTTVGAVRSGLREASRISE 478 Caenorhabditis elegans 23097272 439 YVAVG-STGGDLDLLAQPLPADGAg-------------------AQLQILFAGEATHRTFYSTTHGALLSGWREADRLLS 498 human 9506693 484 YTQVG-SSGADVEKLAKPLPYTESs-----------------kTAPMQVLFSGEATHRKYYSTTHGALLSGQREAARLIE 545 human
7299064 558 sdepdeiIMESDGSDL 573 fruit fly 7293950 472 -------FYEGRAAN- 479 fruit fly 23093238 478 -------YYRARTSQL 486 fruit fly 7295017 468 -------HYTSCSVSA 476 fruit fly 19922014 495 -------FYGISVSRS 503 fruit fly 15233671 528 -------HYKCNF--- 533 thale cress 17561442 433 --------YMRST--- 437 Caenorhabditis elegans 17558184 492 dw---fgRWNQTTKLE 504 Caenorhabditis elegans 17560136 479 h------TFEK----- 483 Caenorhabditis elegans 23097272 499 -------LWAPQVQQP 507 human 9506693 546 -------MYRDLFQQG 554 human