Conserved Protein Domain Family
SGNH_hydrolase_YpmR_like

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cd04506: SGNH_hydrolase_YpmR_like 
Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid. This subfamily contains sequences similar to Bacillus YpmR.
Statistics
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PSSM-Id: 58525
View PSSM: cd04506
Aligned: 22 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 2-Oct-2006
Updated: 9-Mar-2011
Structure
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Aligned Rows:
Hierarchy
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Display:
 
Feature 1:active site [active site]
Evidence:
  • Citation:PMID 7773790
  • Comment:the active site resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases
  • Comment:the histidine side chain may be oriented by a backbone oxygen or by an acidic sidechain

cd04506 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00229:SGNH_hydrolasecd01820:PAF_acetylesterase_likecd01821:Rhamnogalacturan_acetylesterase_likecd01822:Lysophospholipase_L1_likecd01823:SEST_likecd01824:Phospholipase_B_likecd01825:SGNH_hydrolase_peri1cd01826:acyloxyacyl_hydrolase_likecd01827:sialate_O-acetylesterase_like1cd01828:sialate_O-acetylesterase_like2cd01829:SGNH_hydrolase_peri2cd01830:XynE_likecd01831:Endoglucanase_E_likecd01832:SGNH_hydrolase_like_1cd01833:XynB_likecd01834:SGNH_hydrolase_like_2cd01835:SGNH_hydrolase_like_3cd01836:FeeA_FeeB_likecd01837:SGNH_plant_lipase_likecd01838:Isoamyl_acetate_hydrolase_likecd01839:SGNH_arylesterase_likecd01840:SGNH_hydrolase_yrhL_likecd01841:NnaC_likecd01842:SGNH_hydrolase_like_5cd01844:SGNH_hydrolase_like_6cd01846:fatty_acyltransferase_likecd01847:Triacylglycerol_lipase_likecd04501:SGNH_hydrolase_like_4cd04502:SGNH_hydrolase_like_7cd04506:SGNH_hydrolase_YpmR_like68056198890966984278457556420177164132001502608389098754173093889100601564203041641447715675396300240004886501923023631488707616251380381428609909616916816080428271358231005046805619889096698427845755642017716413200150260838909875417309388910060156420304164144771567539630024000488650192302363148870761625138038142860990961691681608042827135823100504
cd04506 Sequence Cluster
cd04506 Sequence Cluster
Sub-family Hierarchy
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 cd04506 Branch
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #                                       #                                
gi 89100601  52 HVVSVGDSLTEGVGDSTGRGgylpyleeqleqekgvsqteflNFGVKGNRTDQLLKKLkssevr-saiseaDLVIITIGG 130
gi 68056198  53 TYVALGDSLTRGVGASNGNSyaaivgrklv---kkdrverfqNLAVSGARTEDLLKQLkqkevr-rtlsqaKVISVTIGG 128
gi 42784575  57 QIVSLGDSLTRGVGDKEGIGyigrmkedlq--kdykqkvaltNLAVSGAKMPDLLKQIessgaq-ysikqaDVIVLTIGG 133
gi 89096698  53 TYIALGDSLTRGVGSSKGEGfvsltgnqlk---ennlveryqNLGIRGARIEDLLEQLeqkevq-rtlkeaKIITITIGG 128
gi 56420304  46 HLVALGDSLTEGVGDGERKGgyvgrlvpllsaedgvrtvtvaNFGKRGRRIAELEPVIhahqa---elgraDMILITIGG 122
gi 56420177  58 DIVALGDSLTRGTGDESGKGyvgymvdelr--rqtdkpirvtNLAIRGLRSDGLLRQLgqpeiq-rqvamaDLIVMTIGG 134
gi 16413200  58 KITALGDSLTYGVGDTEGGGyvrvvenfyk---qkeknvenvNLAISGAKSGQLLKQLeqkevq-nqiksaDVVLMTIGG 133
gi 23100504 102 QIVAVGDSLTQGVGDETEQGgyvgildrti--nstgysaefnNFGKRGNRTDQLLQRLrneqdlidsiqksDIVLVTIGA 179
gi 15026083  63 NILVMGDSLAKGTGDEKGKGfsgyfadyfr--vknnrnvrldNIAVNGDVSNGLLQIVknkdte-nlikksNMIFISIGG 139
gi 1730938   42 VIAAVGDSLTEGVGDPDGKGyvgkvadsirs-dkqvktvdvkNYAVKGNRSDDLLEKLkdkkvq-kgikdaDYVFFTIGG 119
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1       #                                                                               
gi 89100601 131 NDVmkvvrqnfsnlnvsdftgqkaQYEKNLKEIIDtvrsenseTQIALIGLYNPFYkwfsditeisdimdnWNEASREIL 210
gi 68056198 129 NDLfnrgegvanf-nakktaatiaTAQTNLAKTFKilrkenpdAVIFYVGLYNPFRasengqa-fdaivqeWNAKSRTLG 206
gi 42784575 134 NDLfpgweslgki-dletyrpdteTFQNEAKKIIEeirklntdSPIFWLGLYNPFEdvedlkg-ssnividWNASLEKLA 211
gi 89096698 129 NNLfnsgeifsny-seetalgileTEIPNLEKVFKnireinpdAVTLYTGLYNPFKqspdges-fdsiiqkWNESARTLG 206
gi 56420304 123 NDVmnvvrshfldlsrqrfqqateIFADRLDHLLIslrtinpdAVIVLVGLYNPFSttlpnipeindviteWNKASQAVL 202
gi 56420177 135 NDLfqggealkld--rkqlneakrRYVANLDRIFAalrrfnseAVIFAIGLYNPFGdlddakw-tsavvrdWNFASAEVA 211
gi 16413200 134 NDLfrggealddf-ksdaikqaeaSYTNNLKQIYQtirklnpsAPVFHIGLYNPFMslenase-msavaneWNMQSQNLS 211
gi 23100504 180 NDImqvvkenitnldindfqveqvHYEQRLQDIFTeireinpdSYIYLVGIYNPFKnyfeniqeldmivsdWNDTGVSIT 259
gi 15026083 140 NEVskfkfegnvs--aadlkdtenKYLNNVRDIFRlirdnnskCTIVFIGLYNPFGssigtdk--iellnsWNYQTQNII 215
gi 1730938  120 NDLmkilrqnflqltvepfqeaekPYEKRFEKIISeirelndhAELIYVSMYNPFTftlselneingvvtdWNHIAEKEL 199
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
Feature 1                                  #  #                
gi 89100601 211 SRYdytYFVDIKDIFEnka--edLLYTDYFHPNDKGYELIADRVYRQ 255
gi 68056198 207 LKYd-iEIIDTFNLVRdv---krDLSSDQFHPNDSTYEDIANAAILA 249
gi 42784575 212 VNNknvYITPTFDLFQnrg--kdLLYSDHFHPNEIGYTYMADRLVQN 256
gi 89096698 207 LKYg-iQVVDTFNLVIda---krDLSSDVFHPNDTTYQQIADSTYLI 249
gi 56420304 203 SRYdrtIFVDIQDIFIdr---deLLHRDEFHPNAAGYEQMAMRVHEA 246
gi 56420177 212 ARYpniVAVPTFDLFAlhv--ndYLYSDHFHPNAAGYKRIGERVASL 256
gi 16413200 212 QNEkniIYVPTFDLFQqng--aaYLASDKFHPNHAGYQFIGNRVTEV 256
gi 23100504 260 DEYensTFIPIEDLFNdtn-ninLYADDNFHPNYEGYYRIAERVLNY 305
gi 15026083 216 SVDsnaVFIPTYDLFEydt--ekYLTIDNFHPNSSGYKAIAQRIEEV 260
gi 1730938  200 KKDkhaKIVHIEDLFNqksdssrISEEDDFHPNGTGYSLIAKRVYQA 246

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