Conserved Protein Domain Family
SGNH_hydrolase_like_6

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cd01844: SGNH_hydrolase_like_6 
SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.
Statistics
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PSSM-Id: 58520
View PSSM: cd01844
Aligned: 13 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 21-Sep-2004
Updated: 9-Mar-2011
Structure
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Aligned Rows:
Hierarchy
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Display:
 
Feature 1:active site [active site]
Evidence:
  • Comment:by similarity to other members of this super-family
  • Comment:the active site resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases
  • Citation:PMID 7773790

cd01844 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00229:SGNH_hydrolasecd01820:PAF_acetylesterase_likecd01821:Rhamnogalacturan_acetylesterase_likecd01822:Lysophospholipase_L1_likecd01823:SEST_likecd01824:Phospholipase_B_likecd01825:SGNH_hydrolase_peri1cd01826:acyloxyacyl_hydrolase_likecd01827:sialate_O-acetylesterase_like1cd01828:sialate_O-acetylesterase_like2cd01829:SGNH_hydrolase_peri2cd01830:XynE_likecd01831:Endoglucanase_E_likecd01832:SGNH_hydrolase_like_1cd01833:XynB_likecd01834:SGNH_hydrolase_like_2cd01835:SGNH_hydrolase_like_3cd01836:FeeA_FeeB_likecd01837:SGNH_plant_lipase_likecd01838:Isoamyl_acetate_hydrolase_likecd01839:SGNH_arylesterase_likecd01840:SGNH_hydrolase_yrhL_likecd01841:NnaC_likecd01842:SGNH_hydrolase_like_5cd01844:SGNH_hydrolase_like_6cd01846:fatty_acyltransferase_likecd01847:Triacylglycerol_lipase_likecd04501:SGNH_hydrolase_like_4cd04502:SGNH_hydrolase_like_7cd04506:SGNH_hydrolase_YpmR_like6448739911996842330893415077444682298931068870633244416387310567679264775371347988711658293409089122024364487399119968423308934150774446822989310688706332444163873105676792647753713479887116582934090891220243
cd01844 Sequence Cluster
cd01844 Sequence Cluster
Sub-family Hierarchy
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 cd01844 Branch
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #                                #                           #           
gi 6448739   173 VWLHHGSSISHGSDAaSPTTTWPALAAslggveLINLGLGGSALldpf-tarAMRDTPADLISVKIGINVVnadv----m 247
gi 32444163  219 PIVFYGTSITHGACAsRPGMVHTAILGrrfdqpVVNLGFSGNGKmdae-vgeFLVQVDAAVYVIDCLPNMNaam------ 291
gi 67926477  185 PIVFYGTSITHGIGAsRAGMTHVAMLGrtfhreVFNLGFSGNGRmepe-vlkFVGELDPAVFVLDCLPNMGaql------ 257
gi 23308934  160 VWINYGSSISHGSVAtAPTKIWPAIVAqsknynLRNFGFGGSAMldpf-marLIRDTPADLITLEIGINIVngdv----m 234
gi 29340908  178 PIVFYGTSILQGGCAnRPGMAHTNIISrrlnreIVNLGFSGNALldye-iaeVMSSVDAGVYVLDFVPNASsdq------ 250
gi 53713479  187 PLVIYGTSIAQGACAsRPGMAWGNILNrklghpVINLGFSGNGKleea-lfdLLSEIDARLYIIDCMPNLAgkeas--av 263
gi 15077444  158 RWVHYGASESQGRGAlSPTRNWTATVAtelgldLTSLAIGAGCYlqpl-fatLLRDLPADLITCMVGMNIYgaralnqft 236
gi 87310567  198 PLVFYGTSIMHGACAsRPGMSITGIVGrrmnrpVINLGFSGNGRleae-vgeFLCELDPAVFIIDCLPNVDgpv------ 270
gi 91199684  174 RWVHHGSSISHCIEAdGPTGTWPVVAAaladteVINLSQAGNALldpy-varTIRDMPADLISLKVGINIValsa----f 248
gi 106887063 184 KLIFYGTSITQGGCAsRPGMAYTNYLArklnlaHCNFGFSGNGLgeyevakmLSEIEQPLLYIIDYEANSGtngr----- 258
gi 68229893  143 RWLAYGDSIVEGWVAsSAGSSWPARLGrrlgldVCNLGYAGAARgeip-saeHLASVPAALISISYGTNCWstiphtael 221
gi 91220243   85 PVIFYGTSITQGGCAsRPGMAHTNIMSrqldidVYNFGFSGNCRmeqp-iaeLISSVEPSLYIIECMPNMIkpel----- 158
gi 88711658  178 PIVVYGTSIAQGACAsRPGMAWTNILSrrfkepVINLGFSGNGRleqe-iieLMTEIHASVYVLDCLPNLSpnekrtkse 256
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 6448739   248 rlrAFGPAVHGFLDTVreghptAPLLVVSPllcpvqedtpgplapdfsglaegrlrfvatgdpaerasgkltlnvirdeL 327
gi 32444163  292 vseKCVPLVKQIRKAKp----nTPIVLVEDrrntnswilpar--------------------------dahhtanhqalQ 341
gi 67926477  258 vteRTAPGVKLLREAHp----nTPILLVEDrniqtgflvear--------------------------rkaneanhaalR 307
gi 23308934  235 rrrGLEAAVDGFINTIrdghptTPIKIVSPfycpihektpgpgafdtssfgsgq--irfiatgepdehgrltlemvrevL 312
gi 29340908  251 iyeKMETFYRILRDKHp----rTPIIFIEDpvfthalfdkki--------------------------aieinkknkavN 300
gi 53713479  264 vyqRTLEGVKKLREKSr-----APILLVEHdgysnefssesa--------------------------eesyrvanaelR 312
gi 15077444  237 yrpNLVGLVRIIRERHp----sTPLVIASHhyspwhdplegd-------------------------gylsltevreqtR 287
gi 87310567  271 vaeKTGPLVLQLRKAHp----eTPILLVEDrtytfapfrqss--------------------------rerhagsraafK 320
gi 91199684  249 rlrTFGPALHGFLDTIrdghpdTPLLLISPvscpaleqvpgpaatgpdgria------algdpadvaggaltltvvraeL 322
gi 106887063 259 mvkSLDDFVHCLRESHk----eVPILVVSRvphmmdfleest--------------------------tslrnslrefqR 308
gi 68229893  222 lraGLDVFLTVVRQGHp----dTPIVVTTPirrpdaettpnr--------------------------vgatlddlrvaM 271
gi 91220243  159 iteRTIPLVKTIRKKNp----dTPIIFVELfkspitllnnki--------------------------rnenkamddalK 208
gi 88711658  257 iqkRITNSVNLLRKEHp----kTPILLVQHagysdglvdisr--------------------------qkvyttlntwmT 306
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                                              #  #                 
gi 6448739   328 SRIVSERAADhe-nLYYLDGRELYGqada---adlPLPDDIHPDAATHRLIGERFAKLA 382
gi 32444163  342 EAYKTLLADGvt-gLHYIAGDELYGtd------gdGATDGSHASDLGFMRQADVFDPVL 393
gi 67926477  308 EAFAALQAEKvp-hIYYLEGANLLGdd------geGTVDGSHPTDLGFMRQAAEFERVL 359
gi 23308934  313 EGFVEKQKDPh---LTYVDGASLYQas------daPLLDNLHPDEASHALIAQRLLKQL 362
gi 29340908  301 SVFKSLKTKGek-nIYIISSEKMLGed------geATVDGIHFTDLGMMRYADLVCPVI 352
gi 53713479  313 KAYETLQKEQvp-tVYYLTKEEIGMpm-------dAMVDGVHSTDLGMQQYADSYRKKI 363
gi 15077444  288 EVVDLLRADGde-nVHYVHGPSLAGpetahlyvepRYTDPLHFNQEGHDLLAAAFQRKL 345
gi 87310567  321 TAFENLQTAGvk-nLHYLPGDDLLGsd------geAATDGSHPNDLGMMRYADAYVPAL 372
gi 91199684  323 ARIAAARQASdp-hLHHLDGRTLLGphe-----adDLGDGLHPTAAAYRRMGRRFAAYA 375
gi 106887063 309 ETVEKFRTLGdn-aIYFLDGYTLWGddf-----deYTVDFIHPTDLGFYFMGKGLEPII 361
gi 68229893  272 ASLVQARIDGgdpsLTLVHGETLLDe--------sLLADGVHPGDDGHAVMADRLEPVL 322
gi 91220243  209 AEYNKMIENDfk-nIFFIETPELADsd------heGTVDAIHFTDLGFQRYADFLVEKL 260
gi 88711658  307 ESYERLLEENvt-gLYMLSKDNIRLsn-------dAFVDGTHPTDLGMQQYADAYEKVL 357

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