Conserved Protein Domain Family
mtEFTU_III

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cd03706: mtEFTU_III 
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Domain III of mitochondrial EF-TU (mtEF-TU). mtEF-TU is highly conserved and is 55-60% identical to bacterial EF-TU. The overall structure is similar to that observed in the Escherichia coli and Thermus aquaticus EF-TU. However, compared with that observed in prokaryotic EF-TU the nucleotide-binding domain (domain I) of EF-TUmt is in a different orientation relative to the rest of the structure. Furthermore, domain III is followed by a short 11-amino acid extension that forms one helical turn. This extension seems to be specific to the mitochondrial factors and has not been observed in any of the prokaryotic factors.
Statistics
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PSSM-Id: 58072
View PSSM: cd03706
Aligned: 12 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 23-Aug-2004
Updated: 5-Sep-2006
Structure
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Aligned Rows:
Hierarchy
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cd03706 is part of a hierarchy of related CD models.
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cd01513:Translation_factor_IIIcd03704:eRF3_C_IIIcd03705:EF1_alpha_IIIcd03706:mtEFTU_IIIcd03707:EFTU_IIIcd03708:GTPBP_IIIcd04093:HBS1_C_IIIcd04094:eSelB_IIIcd04095:CysN_NoDQ_III730420525141371118159573033066651885356752675721150241D2E A1XB2 A8992853979446361806580730420525141371118159573033066651885356752675721150241D2E A1XB2 A8992853979446361806580
cd03706 Sequence Cluster
cd03706 Sequence Cluster
Sub-family Hierarchy
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 cd03706 Branch
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1D2E_A      293 QPHQkVEAQVYILTKEEGGRHKPFVSHFMPVMFSLTWDMACRIILppgkeLAMPGEDLKLTLILRQPMILEKGQRFTLRD 372
1XB2_A      304 QPHQkVEAQVYILTKEEGGRHKPFVSHFXPVXFSLTWDXACRIILppgkeLAXPGEDLKLTLILRQPXILEKGQRFTLRD 383
gi 7304205  346 DISNhFEGSMYLLSRAEGGRVKPMLSKYIQQLFSQTWNVPARIDIvpseaMLMPGEHGQVRVTLLRKMVMTPGQAFTIRE 425
gi 7303306  371 KALDqLEAQVYILSKDEGGRTKPFMSFIQLQMFSRTWDCAVQVQIpd-keMVMPGEDTKLILRLIRPMVLEQGQRFTLRD 449
gi 25141371 329 TITNrVKVELYLLSEAENGRKIGIRTGFTDKMYCSTWDQVGRFDMsn--eLLMPGEHTSATVLLMKDMPLRKGMPFTLRE 406
gi 1181595  346 KVTDkVKAQLYVLKESEGGAKTPIANYFSEHVFSLTWDSGASVRIig-kdFVMPGESAEVELSLNSQMFIEPQQRFTIRK 424
gi 39794463 346 RPHQkIQAQVYILSKEEGGRHKPFVSNFLPVMFSLTWDMSCRVTLpankeMVMPGEDTALTLTLRQPMVLEIGQRFTLRD 425
gi 899285   347 KPHQkVEAQVYILSKEEGGRHKPFVSHFMPVMFSLTWDMACRIILppekeLAMPGEDLKFNLILRQPMILEKGQRFTLRD 426
gi 61806580 342 QPHQkIRAQVYILSKEEGGRHKPFFTNFTPIMFSLTWDMACIVELlpgkeMVMPGEDTAVNLILRQPMALDKGQRFTLRD 421
gi 72115024 352 SPHNnFIAQVYILSKDEGGRHKPFTSNFTPIMYSYTWDAAARITLpegkeMVMPGEDTSLEIALKRPMVSEVGQRFTLRD 431
gi 56752675 338 SMHDyVQSQVYMLSKKEGGRTKPFTNNHQFHIFSKSWDCSALLVLpegreMIMPGEDAAVNLHFQKKMALEVGQRFTIRE 417
gi 66518853 351 KANDhLECQVYMLTSAEGGKRKPINNLVQIQMFCKTWDCASQLNLvd-ktLVMPGEDSTIRLKLIRPMVCEKGQRFTLRD 429
                        90
                ....*....|....*
1D2E_A      373 Gn--RTIGTGLVTDT 385
1XB2_A      384 Gn--RTIGTGLVTDT 396
gi 7304205  426 Ng--ATVATGMVTQR 438
gi 7303306  450 Gn--LTLGTGVVTST 462
gi 25141371 407 GsskTTIARGIISDL 421
gi 1181595  425 Ga--KTIGTGVFTDV 437
gi 39794463 426 Gn--RTIGTGLVTEI 438
gi 899285   427 Gn--RTIGTGLVTNT 439
gi 61806580 422 Gn--QTIGTGLVTDI 434
gi 72115024 432 Gr--ITLGTGIITKV 444
gi 56752675 418 Qr-yYSWGTELLVKY 431
gi 66518853 430 Gk--VTIATGVITNI 442
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