7506319 1 MKSKRRDDIVQFCRENTLLVMTMFSVFLGVVLGFGLRPLN----LSQETLQLINFPGEIFMQVLKMMILPLIFSSLISGe 76 Caenorhabditis elegans 7296173 18 DAPVELTGYRRWLSENLMLLVTLSGVLLGVILGLSLRPLN----LHGDSIMLISYPGELFMRVLKLMILPLVISSLIAG- 92 fruit fly 7297508 3 RPKQDGGKFKAFMQENVLTMATVIGVFVGGLIGFIIKNSTg--eWSKREIMYISFPGEIFLRMLKCLIVPLLVSSITSA- 79 fruit fly 7447031 17 HVRSPTNKMAKLSKENLLLLFTVLGVVVGIGLGFSLRDPSk--aWSKRHLSYLRFPGDLFVQMLKMLILPMIMSSIITS- 93 Caenorhabditis elegans 3023678 1 ----------MGMKKDLLLVLTIESVVLGVVLGFVIRPFN----PSNDTISLIGFPGEIFMQIVEMMILPLIMSSVISa- 65 Caenorhabditis elegans 17537407 4 ASKKSVSRWTSWLTKNMLLLMTMAGIVMGVIIGGVLRTAD----PSPDVIRYVGFPGELFMNMLKAMVLPLIAASIVSG- 78 Caenorhabditis elegans 1352332 3 KPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSn---LSTLEKFYFAFPGEILMRMLKLIILPLIISSMITG- 78 human 1173365 27 TAAGRARRCAGFLRRQALVLLTVSGVLAGAGLGAALRGl----sLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSG- 101 human 21542389 37 GYCGSRDQVRRCLRANLLVLLTVVAVVAGVALGLGVSGAGgalaLGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGG- 115 human 3023686 2 VPHTILARGRDVCRRNGLLILSVLSVIVGCLLGFFLRTRR----LSPQEISYFQFPGELLMRMLKMMILPLVFSSLMSG- 76 human
7506319 77 lklkqlqafevqksvtLAQMDAKESGQMGASTVLYYLSTAVLATILGIFLVTVIHPGDPSIKGTDISEAPSDG-----NV 151 Caenorhabditis elegans 7296173 93 ----------------SASLNAKMNGKIALRTLVYFASTSFFNAALGIALVLLIHPGNPDLHNADDRSTDRR------AV 150 fruit fly 7297508 80 ----------------IGGLDLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQGAKIVETQTESIDKAs----KV 139 fruit fly 7447031 94 ----------------LASLDSGTAGRLGMVSMIYYTLTTFFAVFLGIVLVSVIKPGKWTTTNIEDLVGHVKTtp--cVA 155 Caenorhabditis elegans 3023678 66 ----------------LAQVRARDARRIGIVTIIYYMITTFLATFTGIILVSSIHPGDPELIHELGEGTLENT-----AL 124 Caenorhabditis elegans 17537407 79 ----------------LSQLDGKTSGRLGSRAVMYYAITTTHAVILGIIVVSIIQPGDPTIKQKMGYDKEGEAa----NV 138 Caenorhabditis elegans 1352332 79 ----------------VAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTP------EV 136 human 1173365 102 ----------------AASLDASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSgpppvPK 165 human 21542389 116 ----------------AASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINAS-VGAAGSaenapSK 178 human 3023686 77 ----------------LASLDAKTSSRLGVLTVAYYLWTTFMAVIVGIFMVSIIHPGSAAQK-ETTEQSGKP------IM 133 human
7506319 152 SPLDTFLDLVRNMFPENIIQATFERMQTTYVAIRp---KiASKNGTSGNIIVKR-------------------------- 202 Caenorhabditis elegans 7296173 151 NLLDSLLDLGRNVFPDNLFQASIQQAHTVYLPKP----SiLHVFNETMNDTLASgseaqrlsed------------lted 214 fruit fly 7297508 140 LTPDTLMDLVRNMFTDNIIQSTMFQHRTEIYENT----S-ISPAQPMENWEFKS-------------------------- 188 fruit fly 7447031 156 TAVDTIIDLMKSCFPENLIEATFRSQKICLKFFN----G--TTEIPPEIAMTMSpeqraq-------------------- 209 Caenorhabditis elegans 3023678 125 STLDTFLDQIRNMFPENIIQATFQQVQTEYMPIKpsrvRnATSMNMTSEVLHKQ-------------------------- 178 Caenorhabditis elegans 17537407 139 SAAQKFLDLFRNAFPENIMRATFSQVQTNYINQT-------HSNGATHEVLHTG-------------------------- 185 Caenorhabditis elegans 1352332 137 STVDAMLDLIRNMFPENLVQACFQQYKTKREEVK----P---PSDPEMNMTEESftavmttais------------knkt 197 human 1173365 166 ETVDSFLDLARNLFPSNLVVAAFRTYATDYKVVT----QnSSSGNVTHEKIPIG-------------------------- 215 human 21542389 179 EVLDSFLDLARNIFPSNLVSAAFRSYSTTYE-------ErNITG--TRVKVPVG-------------------------- 223 human 3023686 134 SSADALLDLIRNMFPANLVEATFKQYRTKTTPVV----K--SPKVAPEEAPPRRiliygvqeengshvqnfaldltpppe 207 human
7506319 203 -----SIGMTKGMNILGIIVFCTGFGIVISQLGERARIVVDFFVILDAVIMRWVVTLMWFAPLGITCLICGNLLELDDIS 277 Caenorhabditis elegans 7296173 215 vvlvrDIQYRSGTNTLGIVFFCLVFGTFLGTIGQKGQVVVDFFAAIFEVIMKMVTCVMWLTPVGISSVIAGKILSVGDLG 294 fruit fly 7297508 189 -------AQREGSNVLGLVMFSVILGTTIGRMREKGQLLQDFFTTLSEAMMTITSWVIWISPLGVAFLIAAKIIEMESIA 261 fruit fly 7447031 210 ftevpEKIVSDGMNILGLVVFSVALGIVIGVIGEDGKPMKNFFKSLEACSMKLIGWVIIYSPVGITFLIAAQIVGMKDPG 289 Caenorhabditis elegans 3023678 179 -----TLTYTNEMNVLGLIVFCSGFGIILSILGDQARLMINFFIVLDAIIMRWISALMWCYPIGILSLVCKNIIDIDNLT 253 Caenorhabditis elegans 17537407 186 -------YVD-GMNVLGIIVFCIVMGLVVSRIGEEAKALANLFHALDVVITRMVMLIMWLGPIGIPSLIAQKMLEVSDLW 257 Caenorhabditis elegans 1352332 198 keykiVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWE 277 human 1173365 216 -------TEIEGMNILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDII 288 human 21542389 224 -------QEVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVG 296 human 3023686 208 vvyksEPGTSDGMNVLGIVFFSATMGIMLGRMGDSGGPLVSFCQCLNESVMKIVAVAVWYFPFGIVFLIAGKILEMDDPR 287 human
7506319 278 DIASVLALYVFTVCAGLILHTIITVPLMYFFITRENPLPIFKGMIQAAVTAFGTASGspknirkltitkndyvGATLPMS 357 Caenorhabditis elegans 7296173 295 LVMSQLMWFIVTVAIGVFIYQFVVMQAIYFVVVRRNPFKFYAGLIQAMLTAFATAST----------------AAALPIT 358 fruit fly 7297508 262 ATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYIAKLSQVLATAFGTGSS----------------SATMPLT 325 fruit fly 7447031 290 QELHRLMGYVITVILGLLIHAFVVIPLLCVVLARRNPIKFVGGMAQALLTALATSSS----------------SATLPLS 353 Caenorhabditis elegans 3023678 254 ETAQALAMYVVTVICGLMIHSLLTLPLLYFLVTKKSPFAFMTGMLQALATAFGTASS----------------GATLPVT 317 Caenorhabditis elegans 17537407 258 LTARMLGLFVFTVILGLAIQAFITLPLIYFIGTRHNPYTFLKGLGQAIMTALGTSSS----------------AASLPVT 321 Caenorhabditis elegans 1352332 278 IFR-KLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSS----------------SATLPVT 340 human 1173365 289 VLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSS----------------SATLPSM 352 human 21542389 297 LLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSS----------------SATLPLM 360 human 3023686 288 AVGKKLGFYSVTVVCGLVLHGLFILPLLYFFITKKNPIVFIRGILQALLIALATSSS----------------SATLPIT 351 human
7506319 358 MQCLEDHCGVDRRISRFVLPLGSTINMDGNALYEAVAVIFIAQLNNVQLSLAEVLTVSITATIASIGLGSVP-AGLVSIL 436 Caenorhabditis elegans 7296173 359 FRCMNEKLKVDPRITRFVLPIGCNINMDGTALYIAVASIFIAQMSGMVLGFGELLTVLLTSTAASMSSASVPsAALVLLL 438 fruit fly 7297508 326 IKCLD-NMGIDPRVTRFVIPVGATINMDGTALYEAVAALFIAQYREMSYSFGTIVAVSITATAASIGAAGIPqAGLVTMV 404 fruit fly 7447031 354 IKCCEENNKVDPRVTRFVLPLGATINMDGTALYEAVAAIYISQCYGNDLSLGEVVLVSLTATLASIGAAGIPqAGIVTMI 433 Caenorhabditis elegans 3023678 318 FRALEENLKIDRRVTRFVLPLGATITMDGTALYEAVAVIFIAQLHNIKLSLMDLVTISITTTVASIGSGSVP-AGLDTIV 396 Caenorhabditis elegans 17537407 322 FRCLNK-LGIDPRVTKFVLPVGAMVNMDGTALYEATASIFIAQMNGLELSIGQIVTVSITATLASIGAASIPsAGLVTML 400 Caenorhabditis elegans 1352332 341 FRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPqAGLVTMV 420 human 1173365 353 MKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPaGGVLTIA 432 human 21542389 361 MKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAAGIPaGGVLTLA 440 human 3023686 352 FKCLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITGTAASIGAAGIPqAGLVTMV 431 human
7506319 437 LILNTVGLPVRDVSMLFTVDWLLDRVRTAVNVLGDAFAASMVQHLLQKKLDQADARHdyktelkgeielLKSAATSRRPs 516 Caenorhabditis elegans 7296173 439 VVLTAIDAPVQDVTLLFAVDWFVDRIRTTNNMLGDCYTAAVVEELSRKELMALDAASv----------nYQDMPAGTPNg 508 fruit fly 7297508 405 MVLDTVGLEPKDVSLIIAVDWLLDRFRTTINVMCDALGTILVNHLSKND--------------------LASVDRLN--- 461 fruit fly 7447031 434 MVLIAIGLPTNLFILIFPVDFMLDRLRTTVNVHGDSIATAVIERLCEDQ---------------------LQKDTHT--- 489 Caenorhabditis elegans 3023678 397 IVLTTVGLPAKDLSLLLTVDWLLDRIRTSVNVLGDSFGAGIIHHLTRSSLLEADTDElirqir-edidiLNNPHQDTLPi 475 Caenorhabditis elegans 17537407 401 IVLTALGLPANDISLILAVDWFLDRLRTSVNVIGDALGCGFVHHICADHLNADVAeae---------knHAVVEAHG--- 468 Caenorhabditis elegans 1352332 421 IVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKE--------------------LEQMDVSSEVn 480 human 1173365 433 IILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILH-HLNQKATKKGEQE------------LAEVKVEA--- 496 human 21542389 441 IILEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDRTESRSTEPE------------LIQVKSELPL- 507 human 3023686 432 IVLTSVGLPTDDITLIIGVDWALDRFRTMINVLGDALAAGIMAHICRKDFARDTGTEkllpce-tkpvsLQEIVAAQQNg 510 human
7506319 517 ftmseaskelFLTHANTAGNSRIGSRIGSrrPSSTNLHLSWRNNNIEPPY 566 Caenorhabditis elegans 7296173 509 hghghghhdgGLLEGQTELETSSKCVMTMtdSVVVDISAVMNNVNLQQEH 558 fruit fly 7297508 462 -------------------AEPHELL-----ELGPNGHEMKE-------- 479 fruit fly 7447031 490 --------------------KHLE--------E---NDEQVKFI------ 502 Caenorhabditis elegans 3023678 476 shh---svqsTIQNTQNAMQAPHVYSKSAraSFAPIPNEEERKALLKESI 522 Caenorhabditis elegans 17537407 469 ---------------VNFDELEKECE------QENNNQKQIEQV------ 491 Caenorhabditis elegans 1352332 481 ivnpfalestILDNEDSDTKKSYVNG-----GFAVDKSDTIS-FTQTSQF 524 human 1173365 497 ----------IPNCKSEEETSPLVTHQNP----AGPVASAPELESKESVL 532 human 21542389 508 ----------DPLPVPTEEGNPLLKHYR------GPAGDATVASEKESVM 541 human 3023686 511 cvksvaeaseLTLGPTCPHHVPVQVERDEelPAASLNHCTIQISELETNV 560 human
Jiyao W et al.(2023). "The conserved domain database in 2023.",