Conserved Protein Domain Family
SPT_ssu-like
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pfam11779: SPT_ssu-like (this model, PSSM-Id:371720 is obsolete and has been replaced by 463347)
Small subunit of serine palmitoyltransferase-like
Serine palmitoyltransferase (SPT) catalyzes the first committed step in sphingolipid biosynthesis. In mammals, two small subunits of serine palmitoyltransferase, ssSPTa and ssSPTb, substantially enhance the activity of SPT, conferring full enzyme activity upon it. The 2 ssSPT isoforms share a conserved hydrophobic central domain, which is predicted to reside in the membrane.
Links
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Statistics
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PSSM-Id: 371720
Aligned: 65 rows
Threshold Bit Score: 43.7027
Created: 2-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EMR61671          19 RWLRLKQYQIEVTFGVYMFTPVEKFVF------------WSVVFLLFGLFAIACILY----LPQHIVFI 71  Eutypa lata UCREL1
JCVI:AT2G30942.1   2 NWVQRKIYLYNVTFGLYMLDWWERYLF------------NSLVLILMWFILYNGSRY----FSELCKRh 54  thale cress
ELU43916         232 RFLWRRQIWFESTFALSMLEPWEKILIsesscsaadaeeLALIF-VWSLFITGAVRY----LPNHISTM 295 Rhizoctonia solani AG-...
EJD37753          26 RFFWAQRMRFECSYALSMLEPWEKILV------------LGLLFALWYSVVTGAVKY----LPHHIDFl 78  Auricularia subglabra ...
1_pfamImport       1 NKIKRLKLALEATTAMNMLEPFEYYAM------------YTVILLLFFLALYGCYWF----LPSHLRHL 53 
XP_016295125      81 RNLFRTYWNIEGTFVLSMLEAWEVFLV------------ICVFITLTLLLCYTVVHY----LPRHASEV 133 Kalmanozyma brasiliens...
KIS70990          80 RTLFRAYWNIEGTFVLSMLEVWEVFLV------------IVVFCLLTLLLWYSLIHY----FPRHAQQV 132 Ustilago maydis 521
SAM75609          83 RKLFRAYWNVEATFVLSMLEAWEVFLV------------IMVFLTLTLLLWYSAYHY----FPRHAREV 135 Ustilago bromivora
XP_015645222       5 NWVSRKIHLYNVTMGLYMLDWWERCLF------------NMMVLILLWFVCFNGSRFasdvFDSHLKAR 61  Japanese rice
BAJ87090          15 NWVGRKIHLYNVNIGLYMLDWWERYLF------------NTLMLCLLWYILRYLTGF----FQSNLETI 67  domesticated barley
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