3KVT


Conserved Protein Domain Family
BTB_2
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pfam02214: BTB_2 (this model, PSSM-Id:366986 is obsolete and has been replaced by 426665)
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BTB/POZ domain
In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerisation of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.
Links
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Statistics
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PSSM-Id: 366986
Aligned: 35 rows
Threshold Bit Score: 95.3475
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3KVT_A   7 VIINVGGIRHETYKATLKkiPATRLSRLTEG-MLNYDPVLNEYFFDRHPGVFAQIINYYRS---GKLHYPtDVCGPLFEE 82  California sea hare
O70479  30 VQLNVGGSLYYTTVRALTr-HDTMLKAMFSGrMEVLTDKEGWILIDRCGKHFGTILNYLRDd-tITLPQS-RQEIQELMA 106 house mouse
O16706   5 VQLDVGGTIFKTSKSTLTk-FNGFLKIMLESdIGLKIDESGSIFIDRSPKHFDLILNFMRDg-dVVLPSC-ELTVKELLA 81  Caenorhabditis elegans
P91564   5 IKLDVGGTIFKTSKDTLTk-FHSFFKTMLECkTGPKIEKTGCIFIDRSPKHFELILNLMRDg-dLPLPED-ERELRELMA 81  Caenorhabditis elegans
O16711   8 IRLNIGGTIFETSKSTLTk-FDGFFKTLLETdIPIQKDDSNCIFIDRSPRHFEKILNYLRDgadVDLLPEsEKEVREILK 86  Caenorhabditis elegans
O16612   6 VKLNVGGTVFETLKSTLTk-HDGFFKALIETdVPAEKDDSNCFFIDRSPKHFETVLNYMRSg-dVVLPDS-KKDMLELKK 82  Caenorhabditis elegans
O16613   8 VKLNVGGTVFVTLKSTLTk-HHGIFKALVKTeMPAEDGDS--FFIDRSPKHFETVLNYIRSg-dVDLPDS-ENELKELKR 82  Caenorhabditis elegans
O16708  99 VNLNVGGKPFATLKTTLQk-FEGNLKELPE--IQGESLPTARIFIDRPYKHFETILNFLRDg-dVILPES-MESLKELLH 173 Caenorhabditis elegans
O16630   2 IRLDVGGRKFSTNRSTLTk-FDGYFRKLPKLkDESSTTTR--IVIDRSPKHFETVLNFMRDg-sVDLPES-LKHLRQLLR 76  Caenorhabditis elegans
P91557   6 IKLNVGGKEFSTTEATLTk-FEGYFKQKLKTrGKIWQTT---LFIDRSPTHFEIILNFMRDg-kVDLPET-LKELMPIFR 79  Caenorhabditis elegans

3KVT_A  83 ELEFWGLDSNqVEPC 97  California sea hare
O70479 107 EAKYYLIQGL-VSTC 120 house mouse
O16706  82 EAQFYLLDEL-IELC 95  Caenorhabditis elegans
P91564  82 EAQFYWLDGL-VLMC 95  Caenorhabditis elegans
O16711  87 EAQFYLLEGL-MELC 100 Caenorhabditis elegans
O16612  83 EAEYYLLSNL-AKLC 96  Caenorhabditis elegans
O16613  83 EAEYYSLEKL-ATLC 96  Caenorhabditis elegans
O16708 174 EAILYKLSGL-SEKC 187 Caenorhabditis elegans
O16630  77 EAIFYGLEKL-IECC 90  Caenorhabditis elegans
P91557  80 ETEYYTLASL-VEQC 93  Caenorhabditis elegans
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