2BIW,3NPE,5J53


Conserved Protein Domain Family
RPE65
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pfam03055: RPE65 (this model, PSSM-Id:335198 is obsolete and has been replaced by 460788)
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Retinal pigment epithelial membrane protein
This family represents a retinal pigment epithelial membrane receptor which is abundantly expressed in retinal pigment epithelium, and binds plasma retinal binding protein. The family also includes the sequence related neoxanthin cleavage enzyme in plants and lignostilbene-alpha,beta-dioxygenase in bacteria.
Links
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Statistics
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PSSM-Id: 335198
Aligned: 554 rows
Threshold Bit Score: 197.034
Created: 22-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2BIW_A        29 QEWdYWvE--Dv--E-GSIPPDLQGTLYR-------NGPGllei---------gdrPLK-------HPFDGDGMVTAFKF 80  Synechocystis s...
XP_007280168  32 PETtTE----TqctTaGTWPSWLKGTFIR-------IGPGrftvplsedgskpraiIQ--------HFFDGLGMLHKFRM 92  Colletotrichum ...
EGU72483      32 pETpKE----VeckLgGTWPTWVHGSFLRyfiqnilIGVGrftiplsedgskpravVQ--------HLFDGLGLLHKFRM 99  Fusarium oxyspo...
EPB91835      45 PEVqDPv---VlqlQsGQIPSWLNGIMYR-------IGPGrfniqqnd-----------gstfsirHAFDGLPFMHRFEV 103 Mucor circinell...
EIE76803      41 ntpecqdRitLekvS-GQLPSWLNGVMYR-------VGPGvfnikqkn-----------gitytirHAFDGLPMVHRFQL 101 Rhizopus delema...
EPB86031      25 PSVeSP----VtlkLdGQIPSWVNGVMYR-------SGSGrynvlldn-----------gdtfhigHPFDGLAMLHRFEI 82  Mucor circinell...
EIE87137      74 TDSkQV----VdleVdGQLPDWLASEHYT-------IGPGtydvkytrkieidgilQSAtatftlgHWFDA--------- 133 Rhizopus delema...
XP_007855575  51 PEQrVPvD--Lt-iK-GEIPSWLSGVLYR-------TGPGtyrip------sfkdhSRVvd---iqHWFDGLSMNHRFEI 110 Moniliophthora ...
EPT00520      18 VEQpTPvD--Lv-lH-GDFPPWLSGVLYR-------TGPGtynip------stgdpSKVte---ihHWFDGVAMHHRFEI 77  Fomitopsis pini...
XP_007334202  17 SPQhEPvL--Lp-vK-GRIPSWLSGSLYR-------TGPGqfrihptstantdaspKPEvs---vsHWFDGLGMNHQFKI 82  Agaricus bispor...

2BIW_A        81 p--------GdgrVHFQSKFvRTQGYVEEQKAGK----------------------------------------MIYrg- 111 Synechocystis s...
XP_007280168  93 ld------gN---VHYTSRYtSEGVV---RRAKRdgylstnvfglnpntp--------lkytqdpcsallgaqqSLYlpn 152 Colletotrichum ...
EGU72483     100 tq------gR---VFYMSRYtHEGVV---RRAYEdgyllttrmglnantp--------lkdaqdpcstllgaqqSLYvpt 159 Fusarium oxyspo...
EPB91835     104 ngs-------tqtLKYNSRMlAKSLE---TEIKNksfkgliffghipemtfpqwlyn----------------------- 150 Mucor circinell...
EIE76803     102 ngs-------tqtVTYNSRHtAKSLE---KEISSgadkglvffghvpevsfltwlin----------------------- 148 Rhizopus delema...
EPB86031      83 sge-------tqsVKYNSRHtSHGVE---RRIGQrdptlltfgpdpcktifgriqsvyhhiskfganaalqendAEF--- 149 Mucor circinell...
EIE87137     134 ------------------------------DHHGyapnfp---------------------------------------- 143 Rhizopus delema...
XP_007855575 111 hpg----gqR---VSYRSRK-ASEDYERQISEHGkipgiafgqqp------------------dicqsifrkffTVFqqm 164 Moniliophthora ...
EPT00520      78 lpatpergpR---VVYRSHK-GAPDLEQRIADAGeypkalfafaqrhr-------------aadpcanlfqkffTTFasl 140 Fomitopsis pini...
XP_007334202  83 tsk--------geVYYSNRS-SSDGRIDYIQQTGrtpgstfgnqq------------------dpckelfkkffTTYvph 135 Agaricus bispor...

2BIW_A       112 ---------------vfGsq-pAggwlktifdlrlkNIANTNITy--------------------------wGDRLLALW 149 Synechocystis s...
XP_007280168 153 g-------------------------------ymepDEINVNVVprrgmhlppddn----phskgpeakdpaTEEVLVQT 197 Colletotrichum ...
EGU72483     160 g-------------------------------yaepDSVNMNVQprrgmhlpndkn----pysrgtqsanpaTEEILVHT 204 Fusarium oxyspo...
EPB91835     151 --------------fyvrfnnlilspkprhdgrpdgQSVGVTVTpnfplpa--------------rikkadgENVLVSKT 202 Mucor circinell...
EIE76803     149 --------------wivrlnnlvlrpkpihltkpdgRSVGVTVTpnytlpar------------vsmnndlsKKSLVAKT 202 Rhizopus delema...
EPB86031     150 ------------------------------------DMVNVTVTpnfplgad------------leqetgvkRGEALVVK 181 Mucor circinell...
EIE87137     144 -------------------------------aglfkTHPNQTMLikflnngkkpkpdrvpcnqrimtqvpglDGRLFTQN 192 Rhizopus delema...
XP_007855575 165 rspp------tssgspsG----A--------------NVQVTLTpdmpgwgaiter-----lpelkqhqhsgPQYLVAKT 215 Moniliophthora ...
EPT00520     141 gevlkamsgrdgehddeT----T-------------DNVSVTLTpdmpgvftgee------ekatsgearkgPKVIVAKT 197 Fomitopsis pini...
XP_007334202 136 sdn---------phtpsQpgrdM-------------ENVSVTLTpnipglsshd---------ntksssatgLRYIVAAT 184 Agaricus bispor...

2BIW_A       150 -EGGQPHRLEPSNLATIGLDDLggilaegQ-PL---------SAHPRIDpa--------sTfdggqpCYVTFS-Ikssls 209 Synechocystis s...
XP_007280168 198 -DFNLLQVCDARTLEPKRMLTYa------QiDPelsg--ygiCSHPPKDrtrgltfn--ylidpekgIMSVFAlNiaskp 266 Colletotrichum ...
EGU72483     205 -DWNLLQICDARTLEPKRLLNYm------DiDPelag--tgsCAHPPHDrkrgltfn---ylidgsgVLFVFAlDvgsnp 272 Fusarium oxyspo...
EPB91835     203 -DANVLQKIHAETLEPqnifnytsy--------darikgqlsAAHHQYDpntkeifnf-alttgpvpRLVVFStTea--- 269 Mucor circinell...
EIE76803     203 -DANVLQKLHAETLVPeiifsykny--------dphlngpfsAAHHQFDpetneifnf-slhlfpksKMTVFKtSke--- 269 Rhizopus delema...
EPB86031     182 rDANTLQVVDPETLKPLKMFtyahvsk--------klqgqlcASHHQYDeetdeyinf-mvklgpfpTFQTFSlGpylps 252 Mucor circinell...
EIE87137     193 -FANHIQELDPFDLTPTQVQTWd------EiNAdfkg--yssSPNGQVDpetgeyinftmeigyrttRYHFFSiSnqe-- 261 Rhizopus delema...
XP_007855575 216 -DADGLQLVDPISLEPLAVATY-------K-TLdprldgqlsAAHSCRDkeanefynytcKlggrfpTYKVFRiKgdn-- 284 Moniliophthora ...
EPT00520     198 -DANVLQLLEPSTLAPLKCITY-------E-NIdprlsgqlsAAHACRDaetgdfynfvaEvsa-ktTYKIFKiRgdd-- 265 Fomitopsis pini...
XP_007334202 185 -DSNWLQILDPETLEPLEITTY-------A-RIdprlaghlsAAHSCRDpstgehfnyvqKfgstssSYKVFRaTpsrnp 255 Agaricus bispor...

2BIW_A       210 stltlleldpQgkllrqk---------tetfpgFAFIHDFAITPHYAIFLQNNVTlnglpyLF--------GlrGAGECV 272 Synechocystis s...
XP_007280168 267 aslf---------------------wktplpckPCYIHSLAMTDKYVVFIRNPVQm-----DVs------dTtkPMSDML 314 Colletotrichum ...
EGU72483     273 valv---------------------wksplpcrPCYTHALAMTDKYVVFVRNPVHl-----DLs------dTtkGFADMM 320 Fusarium oxyspo...
EPB91835     270 --------gkVtiladfth------rtdkspiqAPYIHSLWLTENYVIIPESPMVlkdrg-------anmlMngSFLSSI 328 Mucor circinell...
EIE76803     270 --------gqTtllaeithr-----kgdhsefrASYIHSFYLTKNYVIIPESPLVygdqg-------lnslLqgAVLSSM 329 Rhizopus delema...
EPB86031     253 ppgekeampapeprlhqpiwrhlgawktmealkPSYIHSFSMTKNYIIIPNFPYYysfgg-------lsaiYysSAYQTF 325 Mucor circinell...
EIE87137     262 --------pkGhpitt------------iwnapTGWVNGFALTPNYIVMVIHPMLa-----NSgav--rfaWneSVLDSF 314 Rhizopus delema...
XP_007855575 285 --------kvDvlaei-------------kdapASYLHSFAMTSKYVILAVWQAHi-----TGygmsilynQ--NIAQSI 336 Moniliophthora ...
EPT00520     266 -------gkvDvlania-----------ekeapPSYIHAITMTDRFVVLCVWQAHi-----KQfglslvltH--NIADAI 320 Fomitopsis pini...
XP_007334202 256 g----ekakvDiladi-------------tdapMAYIHSFAMTKKYVVLSVWQSDy-----GQnglavfknK--NALSSI 311 Agaricus bispor...

2BIW_A       273 --QFHPDKPAQIILVPRD-----GgeIk--RIPv-----qAGF-VFHHANAFeengkiildsicynslpqvdtd------ 331 Synechocystis s...
XP_007280168 315 --QFEPNTPTQFYVLNKNd----GrhVatya------qkdGFM-FFHSVNGYdyvdrqtgavnihidlcsyeetypsys- 380 Colletotrichum ...
EGU72483     321 --VCEHDSPTEFYILDKSd----GkhVaty-------qvnNFY-FFHIGNAYdyidpktgdvnihvdivsyreehypym- 385 Fusarium oxyspo...
EPB91835     329 --SWVKDAPTYCHVIARHpvqqkEglVasi-------pvnPGFfTFHVANAFetkdnsgetiltldcasfsdgdimhqlh 399 Mucor circinell...
EIE76803     330 --HWIDQAPLYFHVIHRNe----GglVasi--------paPAFyTFHVANAFeevsldgelllhldssafsdgdiiyqvq 395 Rhizopus delema...
EPB86031     326 --YWDETRHTLFHVIDRHt-----------GHHvatyeadPCF-SFHTANAWdedvelpggrkerviymdycmyentdiv 391 Mucor circinell...
EIE87137     315 --TFYPSEPTLFYVISRVd----KevIacyRSN-------ACF-SLNQVNAYedvhgnvtvdmvcyeddtivhrfa---- 376 Rhizopus delema...
XP_007855575 337 dkKWNPKMNSLFYIIDKAs----GgvvakyETP-------PFF-CFHQLNAFddpvtddiildmsvyedhsvidsly--- 401 Moniliophthora ...
EPT00520     321 dkTWHPEKPSIFYVVDRHd----GglvakyKTD-------AFY-AFHYINAFddpdtgdvvidisvypdtsvidrly--- 385 Fomitopsis pini...
XP_007334202 312 q-KWNPNRDALFYVISREr----GgvvakyKAP-------TFF-SFHTINAYetpskvdpskdditidiatyetnavldm 378 Agaricus bispor...

2BIW_A       332 ----------------------------gdfrstnfdnldpgqlwrftidP---------------------------AA 356 Synechocystis s...
XP_007280168 381 ------------------------eyslsnivdparpfqdgtlvryemagVdnadpsrigrv------------------ 418 Colletotrichum ...
EGU72483     386 ------------------------dysisnlldpkkplqngtlvryqmdsVnkadpakicrg------------------ 423 Fusarium oxyspo...
EPB91835     400 sfgtphr--------kgpaaekaaqttlngisyppqqqsgfgdlvryklnLdqsttlsi--------------------- 450 Mucor circinell...
EIE76803     396 nfggtf----------lqddlslkrtkfhgftfppaqqvsfghltrhtlnLnqrtavfa--------------------- 444 Rhizopus delema...
EPB86031     392 dasfelgktptgkldldlvqparyvfdkntahkeehqiapsqfrryrlgqVpvakpgadtwtpswsnafsnltkfnkrRV 471 Mucor circinell...
EIE87137     377 --------------------------tekmrdadmerlpssevrrfvlanPrheankiyldnnsyipsaisvtsrigtVW 430 Rhizopus delema...
XP_007855575 402 --------------------------lnrlrnltaenpmlmgrarrfrlsNv---------------------------- 427 Moniliophthora ...
EPT00520     386 --------------------------ldtlrnpgvlenpwmgqarryrltDp---------------------------- 411 Fomitopsis pini...
XP_007334202 379 -----------------------lyldhmrvvdptgksieipqarryilsNil--------------------------- 408 Agaricus bispor...

2BIW_A       357 ATV----EKQLM--------VS--------RCC-----------EFPVVH-PQQVGRP-YRYVYM----------GAAHH 393 Synechocystis s...
XP_007280168 419 ---------------------------------tvaasipgmacELPRIAkVASMDPN-YRYVYC----------TAGNG 454 Colletotrichum ...
EGU72483     424 ---------------------------------svasaiaglpcELPRVSkPASMDPN-YRYTYG----------ISGIG 459 Fusarium oxyspo...
EPB91835     451 -------------------------------------dtlaknvEFPRFN-QDYALKKkNRFVYG----------CQLQG 482 Mucor circinell...
EIE76803     445 -------------------------------------htlaeniEFPRFH-QELIGKP-YKFVYG----------CRVLD 475 Rhizopus delema...
EPB86031     472 ASYavigHDL----------------------------------EMPRFN-PRYNMKP-YRFCWGvcesrhapsyASGSV 515 Mucor circinell...
EIE87137     431 NYVtgqaGQPENa--------TgsagwhawMPVvkyeriseatlELPQVN-PLYKMRK-YSFAYG----------LGNTG 490 Rhizopus delema...
XP_007855575 428 -------TSPSSttriat------veftlpQSEs---------iELPTIN-PAKYHRP-YRYAYG----------INKLD 473 Moniliophthora ...
EPT00520     412 -------TKATApgksktpvLYaktdftlpQSVa---------vELPTLA-PGKHHHT-YRYTYG----------ITRKP 463 Fomitopsis pini...
XP_007334202 409 ------sTTTINsdtkslptNPaelaf------------tfsniELPTIH-PSFYYSH-YRYAYG----------THRAE 458 Agaricus bispor...

2BIW_A       394 Stg-----------------naPL-QAILKVDLesgtetlrsFAPh-------------------------gF-AGEPIF 429 Synechocystis s...
XP_007280168 455 SpspgtavpigrlgnglkvvqaAFfGSLAKSDW---------KTGtfkrwq----------------pdngeScPCEPVF 509 Colletotrichum ...
EGU72483     460 AsapgtevpigrlsnglgavhpTVyGSLFKSDW---------KTGlfklwt----------------psngeScPTEPIF 514 Fusarium oxyspo...
EPB91835     483 Ftekk-----------------detGGLIKVDLtgqsgpl--------------------------tfyeegFnCSEPIF 519 Mucor circinell...
EIE76803     476 Dkr---------------------sTGLAKVDVsnqsvi---------------------------qhqesgYaYSEPIF 507 Rhizopus delema...
EPB86031     516 V------------------------NGLIKLDLnnvylgpntdqn-----------------ssakiwdepgcsCAEPIF 554 Mucor circinell...
EIE87137     491 Nsk--------------------mwDSIIKLDV---------NNStvvasw----------------heancY-PSEAQF 524 Rhizopus delema...
XP_007855575 474 Pra-----------------hhTFaDRIIKLDM---------ENIdnghkv---------------wgipgyT-PSEPIF 511 Moniliophthora ...
EPT00520     464 Tcd-----------------gpILsDGIIKFDM---------RAAaevasasrdalegkedeyakfwripdvT-PSEPIF 516 Fomitopsis pini...
XP_007334202 459 Rha-----------------pgVFtDKIVKLDM---------ESQtektw-----------------gaegyT-TGEPIF 494 Agaricus bispor...

2BIW_A       430 V--Prpg----gvaEDDGWLLCLIYka----dLHRSELVILDAQDITApaIATLKLKhHIPYPL-HGSWA 488 Synechocystis sp. PCC 6803
XP_007280168 510 VqrPgt------tdEDDGIVLTIVIdr----egTHSILIGLDGQTFEE--VARADMPqVYALGP-HGSFV 566 Colletotrichum gloeospori...
EGU72483     515 IqrPga------teEDDGIVITITInr----egTHSILVGLDGKTFKE--VARADMPqVYALGP-HGSFV 571 Fusarium oxysporum Fo5176
EPB91835     520 V--Pspt----gtkEDDGVLLSLVNn------fDCCYFIVFDASNLKE--LARVKIGqFIAVTF-HGSYV 574 Mucor circinelloides f. c...
EIE76803     508 V--Phpq----aksEDDGVLLSLANh------tECCYLVILNAMDMKE--LARFKIGqFTAITF-HGSFV 562 Rhizopus delemar RA 99-880
EPB86031     555 I--Pnpd----gqdEDDGVVMSIVNttlq-dgsESCFLLILDACSFTE--IARTTIGaFNAVTL-HGSFV 614 Mucor circinelloides f. c...
EIE87137     525 IpkPkdqaaekdeeEDSGVLISVVMda----arNTSFLLVLNAQDLSV--IAKSQLNkLIPLSFaHGSYr 588 Rhizopus delemar RA 99-880
XP_007855575 512 VprPga------kdEDDGVVLSVVLdg----dRRKSLLIVLDAKDMKE--CARAEMEtAFPIGF-HGLWS 568 Moniliophthora roreri MCA...
EPT00520     517 AprPsg------tsEDDGVLLSVALdssaekgRGQSALIVVDAKTMQE--VARAELPnVYPFGF-HGVYT 577 Fomitopsis pinicola FP-58...
XP_007334202 495 VprPsndgq-qqqaEDDGVVLSVVLdg----vNQKSMLVVLDAKDMTE--IARAEMDkCIPLGF-HGYYA 556 Agaricus bisporus var. bu...
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