Conserved Protein Domain Family
7tmA_mAChR_M4

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cd15298: 7tmA_mAChR_M4 (this model, PSSM-Id:320425 is obsolete and has been replaced by 341344)
muscarinic receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors
Muscarinic receptors regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320425
Aligned: 16 rows
Threshold Bit Score: 430.589
Created: 4-Jul-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to Human M2 muscarinic acetylcholine bound an antagonist (3-quinuclidinyl-benzilate), contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       #
XP_002200150  43 VFIATVTGSLSLVTVVGNILVMLSIKVNRQLQtvNNYFLFSLACADLIIGVFSMNLYTVYIIKGYWPLGaVVCDLWLALD 122 zebra finch
P17200        43 VFIATVTGSLSLVTVVGNILVMLSIKVNRQLQtvNNYFLFSLACADLIIGVFSMNLYTVYIIKGYWPLGaVVCDLWLALD 122 chicken
P30544        34 IFIATVTGSLSLVTVVGNILVMLSIKVNRQLQtvNNYFLFSLACADLIIGVFSMNLYSLYIIKGYWPLGpIVCDLWLALD 113 African clawed ...
P08173        33 VFIATVTGSLSLVTVVGNILVMLSIKVNRQLQtvNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGaVVCDLWLALD 112 human
XP_002755204  33 VFIATVTGSLSLVTVVGNILVMLSIKVNRQLQtvNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGaVVCDLWLALD 112 white-tufted-ea...
XP_002821870  33 VFIATVTGSLSLVTVVGNILVMLSIKVNRQLQtvNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGaVVCDLWLALD 112 Sumatran orangutan
NP_001181484  33 VFIATVTGSLSLVTVVGNILVMLSIKVNRQLQtvNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGaVVCDLWLALD 112 Rhesus monkey
NP_001185865  32 VFIATVTGSLSLVTVVGNVLVMLSIKVNRQLQtvNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGaVVCDLWLALD 111 rabbit
EOB05439      43 VFIATVTGSLSLVTVVGNILVMLSIKVNRQLQtvNNYFLFSLACADLIIGVFSMNLYTVYIIKGYWPLGaVVCDLWLALD 122 mallard
AAI19776      32 VFIATVTGSLSLVTVVGNILVMLSIKVNRQLQtvNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGaVVCDLWLALD 111 human
Feature 1        #  ##                                              #                            
XP_002200150 123 YVVSNASVMNLLIISFDRYFCVTKPltYPARRtTKMAGLMIAAAWILSFILWAPAILFWQFIVGKRTVPERECYIQflSN 202 zebra finch
P17200       123 YVVSNASVMNLLIISFDRYFCVTKPltYPARRtTKMAGLMIAAAWILSFILWAPAILFWQFIVGKRTVHERECYIQflSN 202 chicken
P30544       114 YVVSNASVMNLLIISLERXFCVTKPltYPARRtTKMAGLMIAAAWLLSFELWAPAILFWQFIVGQRTVPSGECYIQflSN 193 African clawed ...
P08173       113 YVVSNASVMNLLIISFDRYFCVTKPltYPARRtTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQflSN 192 human
XP_002755204 113 YVVSNASVMNLLIISFDRYFCVTKPltYPARRtTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQflSN 192 white-tufted-ea...
XP_002821870 113 YVVSNASVMNLLIISFDRYFCVTKPltYPARRtTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQflSN 192 Sumatran orangutan
NP_001181484 113 YVVSNASVMNLLIISFDRYFCVTKPltYPARRtTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQflSN 192 Rhesus monkey
NP_001185865 112 YVVSNASVMNLLIISFDRYFCVTKPltYPARRtTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQflSN 191 rabbit
EOB05439     123 YVVSNASVMNLLIISFDRYFCVTKPltYPARRtTKMAGLMIAAAWILSFILWAPAILFWQFIVGKRTVPEGECYIQflSN 202 mallard
AAI19776     112 YVVSNASVMNLLIISFDRYFCVTKPltYPARRtTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQflSN 191 human
Feature 1           #  ##  ##                                                                    
XP_002200150 203 PAVTFGTAIAAFYLPVVIMTVLYIHISLASrsrvrrhkpesrkerkakslrflkgpvvkqnnnnspkravevkeevrngk 282 zebra finch
P17200       203 PAVTFGTAIAAFYLPVVIMTVLYIHISLASrsrvrrhkpesrkerkgkslsffkappvkqnnnnspkravevkeevrngk 282 chicken
P30544       194 PAVTFGTAIAAFYLPVVIMTILYIHISLASrsrvrrhcpetrqekkkpissmksllikqtknipkqdagdkvvekkngvs 273 African clawed ...
P08173       193 PAVTFGTAIAAFYLPVVIMTVLYIHISLASrsrvhkhrpegpkekkaktlaflksplmkqsvkkpppgeaareelrngkl 272 human
XP_002755204 193 PAVTFGTAIAAFYLPVVIMTVLYIHISLASrsrvhkhrpegpkekkaktlaflksplmkhsvkkpppreaareelrngkl 272 white-tufted-ea...
XP_002821870 193 PAVTFGTAIAAFYLPVVIMTVLYIHISLASrsrvhkhrpegpkekkaktlaflksplmkqsikkpppgeaareelrngkl 272 Sumatran orangutan
NP_001181484 193 PAVTFGTAIAAFYLPVVIMTVLYIHISLASrsrvhkhrpegpkekkaktlaflksplmkqsvkkpppgeaareelrngkl 272 Rhesus monkey
NP_001185865 192 PAVTFGTAIAAFYLPVVIMTVLYIHISLASrsrvhkhrpegqkekkaktlaflksplmkqsvkkpppgeaareelrngkl 271 rabbit
EOB05439     203 PAVTFGTAIAAFYLPVVIMTVLYIHISLASrsrvrrhkpesrkerkgkslsffkaplikqnnnnspkravevkeevrngk 282 mallard
AAI19776     192 PAVTFGTAIAAFYLPVVIMTVLYIHISLASrsrvhkhrpegpkekkaktlaflksplmkqsvkkpppgeaareelrngkl 271 human
Feature 1                                                                                        
XP_002200150 283 vddqpsaqteatghqeeketsnesstvsmtqttkd-----kptaevlpagqgqspakprvnptskwskikivtkqtgtec 357 zebra finch
P17200       283 vddqpsaqteatgqqeeketsnesstvsmtqttkdk---ptteilpagqgqspahprvnptskwskikivtkqtgtesvt 359 chicken
P30544       274 ngkieksmtnlqtaeeketsnesssaslshnppekqplseassgvvlaptqsmpplpakantaskwskikivtkqtgnec 353 African clawed ...
P08173       273 eeapppalpppprpvadkdtsnesssgsatqntke----rpatelstteattpampapplqpralnpasrwskiqivtkq 348 human
XP_002755204 273 eeapppvlpppprpmadkdtsnesssgsatqntke----rpatelstteattpampapplqpralnpaskwskiqivtkq 348 white-tufted-ea...
XP_002821870 273 eeapppalpppprpvadkdtsnesssgsatqntke----rpatelstteattpampapplqpralnpaskwskiqivtkq 348 Sumatran orangutan
NP_001181484 273 eeapppalpppprpmtdkdtsnesssgsatqntke----rpatelstteattpampapslqpralnpaskwskiqivtkq 348 Rhesus monkey
NP_001185865 272 eeapppalpppprpmadkdtsnesssgsatqntke----rpatelstaeattpamsapplqprtlnpaskwskiqivtkq 347 rabbit
EOB05439     283 vddqpsaqteatghqeeketsnesstvsmtqttkdk---ttaeilpagqgqspshprvnptskwskikivtkqtgtecvt 359 mallard
AAI19776     272 eeapppalpppprpvadkdtsnesssgsatqntke----rpatelstteattpampapplqpralnpasrwskiqivtkq 347 human
Feature 1                                                                        #  ##           
XP_002200150 358 vtaieivpaksgasnslansrpvnvarkfasiarsqvrkkrqmaAREKKVTRTIFAILLAFILTWTPYNVMVLINTFCet 437 zebra finch
P17200       360 aieivpakagasdhnslsnsrpanvarkfasiarsqvrkkrqmaAREKKVTRTIFAILLAFILTWTPYNVMVLINTFCet 439 chicken
P30544       354 vtaieivpecaiplpeqannrpvnvarkfasiarnqvrkkrqmaAREKKVTRTIFAILLAFIITWTPYNVMVLINTFCqt 433 African clawed ...
P08173       349 tgnecvtaieivpatpagmrpaanvarkfasiarnqvrkkrqmaARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCqs 428 human
XP_002755204 349 tgnecvtaieivpatpasmrpaanvarkfasiasnqvrkkrqmaARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCqs 428 white-tufted-ea...
XP_002821870 349 tgnecvtaieivpatpagmrpaanvarkfasiarnqvrkkrqmaARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCqs 428 Sumatran orangutan
NP_001181484 349 tgnecvtaieivpatpagmrpaanvarkfasiarnqvrkkrqmaARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCqs 428 Rhesus monkey
NP_001185865 348 tgnecvtaieivpatpagmrpaanvarkfasiarnqvrkkrqmaARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCqs 427 rabbit
EOB05439     360 aieivpakggasehnslsnsrpanvarkfasiarsqvrkkrqmaAREKKVTRTIFAILLAFILTWTPYNVMVLINTFCqt 439 mallard
AAI19776     348 tgnecvtaieivpatpagmrpaanvarkfasiarnqvrkkrqmaARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCqs 427 human
Feature 1                  #  ##                      
XP_002200150 438 CVPETVWSIGYWLCYVNSTINPACYALCNa-tFKKTF 473 zebra finch
P17200       440 CVPETVWSIGYWLCYVNSTINPACYALCNa-tFKKTF 475 chicken
P30544       434 CIPETIWYIGYWLCYVNSTINPACYALCNa-tFKKTF 469 African clawed frog
P08173       429 CIPDTVWSIGYWLCYVNSTINPACYALCNa-tFKKTF 464 human
XP_002755204 429 CIPDTVWSIGYWLCYVNSTINPACYALCKchlLKRPS 465 white-tufted-ear marmoset
XP_002821870 429 CIPDTVWSIGYWLCYVNSTINPACYALCNa-tFKKTF 464 Sumatran orangutan
NP_001181484 429 CIPDTVWSIGYWLCYVNSTINPACYALCNa-tFKKTF 464 Rhesus monkey
NP_001185865 428 CIPDTVWSIGYWLCYVNSTINPACYALCNa-tFKKTF 463 rabbit
EOB05439     440 CVPETVWSIGYWLCYVNSTINPACYALCNa-tFKKTF 475 mallard
AAI19776     428 CIPDTVWSIGYWLCYVNSTINPACYALCNa-tFKKTF 463 human

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