Conserved Protein Domain Family
CENP-Q
?
pfam13094: CENP-Q (this model, PSSM-Id:315707 is obsolete and has been replaced by 432970)
CENP-Q, a CENPA-CAD centromere complex subunit
CENP-Q is one of the components that assembles onto the CENPA-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENPA nucleosomes directly recruit a proximal CENPA-nucleosome-associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENPA NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENPA-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. Fta7 is the equivalent component of the fission yeast Sim4 complex.
Links
?
Statistics
?
PSSM-Id: 315707
Aligned: 82 rows
Threshold Bit Score: 43.4313
Created: 28-Jul-2016
Updated: 4-Aug-2016
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q4X0T9        87 NLGKRLPRMPFPPVtkESVFDYEAALNEHVSLESSLATMNDSIDLLKAEIE-REEALLAKETKQLQEMEKNANRAEAE-R 164 Aspergillus fum...
XP_012428362 280 RVLRSFKTLTVPPG---KLGNLKNILGLQMAEKQMLETNEESLVQLQEEIT-EAERSAELIEENIQQLQYKIQVLKNQlK 355 zebra finch
EHB10238      30 RLLQLCEIMEAPP---RNLKYLTNVTRLLKAERAQDRDN-EGLALLQEEIDnKIVQTTESVTGNIQSLKNKTDILTHEiE 105 naked mole-rat
XP_003467922 112 RLLQLCETLKAPR---QKLTYLTNMSSLLKIERAQDRANEEGMALLQEEID-KIVQTTESVTGNIKSLKNKIEILTHEiE 187 domestic guinea...
XP_005318648 116 RLLQLCETMKVPP---RKLKYLTNVSNLLKMEKAQETANEEGLALLQEEID-KMVETTESMTENIHRLKNKIQIVAHEvE 191 thirteen-lined ...
XP_003510715 117 RLLQQCGTVKVPP---RQLNYLTNVSNLLKMETAQQRANKAELALLQEEID-KIVETTESMTETIQSLKHQIEILTNEvE 192 Chinese hamster
XP_016811147  30 RFLQVCETLKVPP---KKMEDLTNVSSLLNMERARDKANEEGLALLQEEID-KMVETTELMTGNIQSLKNKIKILASEvE 105 chimpanzee
XP_008261250 114 RLLQLYETLKAPS---KKLKDLTNVSSLLNMERAQERVNEDGLTLLQEEID-KLVETTELMTGKIQSLKNKIRILASEvE 189 rabbit
EFB15241      64 RLLQLCETLKVPP---KKLKDLTNVSSLLKMEKAQHRDNEEGLALLQEEID-KIVETLESMTGNIQSLRNKVQVLTSEvE 139 giant panda
KFO65340      63 RVLRSFKTLKVPP---GKLGNLKNILSLQMAEKQMLETNEESLVQLQEEIT-DAERSADRIEESVQQLQYKIQVLKSQlE 138 American crow

Q4X0T9       165 KR--QMKNvsslgwfrpynmsliilkehpALRqlddlpktqfqaahfrileaedsqsgFDELenDPETSSLLK---Q--L 237 Aspergillus fum...
XP_012428362 356 KDeeNARK---------------------VFQengsgalq----------lpelpkcsFQAPtlQEEILKVKN---QkgL 401 zebra finch
EHB10238     106 EEeeKAKE---------------------TLQldrrntls----------lpelsrhsLEAPtlQKEGLMLTLnqnV--L 152 naked mole-rat
XP_003467922 188 EEeeKAKE---------------------VLQldrhnvls----------lpelsqnsLKTPtlQKEMLMLIPnqkV--L 234 domestic guinea...
XP_005318648 192 EEeeKVKQ---------------------MLQmdssgvls----------lpelsqnsLKAPtlHKEILMLIPnqnA--L 238 thirteen-lined ...
XP_003510715 193 EEeqQVKE---------------------KFHvdsnrvls----------lpelpqksLKAPilQKEILAVIPnqkA--L 239 Chinese hamster
XP_016811147 106 EEeeRVKQ---------------------MHQinssgvls----------lpelsqktLKAPtlQKEILALIPnqnA--L 152 chimpanzee
XP_008261250 190 EEeqK------------------------MLQmsssgvls----------lpqlsqnsLKAPtlQKEILTLIPnqdA--L 233 rabbit
EFB15241     140 AEeeKVKQ---------------------MFQidssgvlc----------lpelsqksLKAPtlQKEILTLIPnhnA--L 186 giant panda
KFO65340     139 EDekEARK---------------------VFQengsgalh----------lpelpkrsFQAPtlQEEILK-VKnqkG--L 184 American crow

Q4X0T9       238 KDHLKSMQNNVAPLTGLKDALTRSEAALS 266 Aspergillus fumigatus
XP_012428362 402 LKDMNAIQQ-SANLKNLLTLIEKTYEKVD 429 zebra finch
EHB10238     153 LKDLDVL-HNSSQMKNMSVFIEEAYKKLN 180 naked mole-rat
XP_003467922 235 LKDLDIL-HNSSQMKNMAMFIEEAYKKLN 262 domestic guinea pig
XP_005318648 239 LKDLDVL-HSSSQMKNLSMFIEEAYKKLD 266 thirteen-lined ground squirrel
XP_003510715 240 LKDLDVL-HNSSPVKNMSAFIQEAYKKLD 267 Chinese hamster
XP_016811147 153 LRDLDIL-HNSSQMKSMSTFIEEAYKKLD 180 chimpanzee
XP_008261250 234 LKDLDVL-HTSSEVKNMLIFIEEAYKKLD 261 rabbit
EFB15241     187 LKDLHVL-HNSSQMKNMLTFIEEAYKRLD 214 giant panda
KFO65340     185 LKDMNAI-QQSADLKNLLNLIEKTYEKVD 212 American crow
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap