Conserved Protein Domain Family
DHC_N1

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pfam08385: DHC_N1 (this model, PSSM-Id:312031 is obsolete and has been replaced by 462457)
Dynein heavy chain, N-terminal region 1
Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.
Statistics
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PSSM-Id: 312031
Aligned: 257 rows
Threshold Bit Score: 249.417
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4Q9Z6          248 ITRLAQTVESWIQTVNEAV-------AQVPN------YEAElqderaGPKTEKELWKARLAKLRLLEEQLQRFSATQAVQ 314  Leishmania ...
227_pfamImport    1 IHLLESTIIGWIKQVKEVL-------KHDPmallahqGSEA------GVCQEEALWERRIQNLHYLNVQLDSEAAREILT 67  
178_pfamImport    1 IEQLEEIVLSWEKHIKRVLesyanksPQGK-----------------GPLAEYSYWHDRESGLSLLVEQLRSPAIARIHA 63  
195_pfamImport    1 LPLIEKMCITWLSQLQDSLsaldekyFVGS-----------------SPLNELEYWKDRYTNLDLLSKQLKNPTVAYIIN 63  
192_pfamImport    1 ITAVEATIEDWTQTIRSVVeaetqrrPIDK-----------------YPQAELDFWRERNSAVSTLYEQLTVLRTQRVLK 63  
18_pfamImport     1 VAALSAQLVIWTQAVDRLLedvnhmdRDGP-----------------GPQAELDYWVSRSTSLTALTEQLQVAEVSDTLK 63  
8_pfamImport      1 LRQVDTTVSQWQVEIGYAMsl----ePQKE-----------------GPLGEIEYWRERYSTISALYEQLNSSQAKFILK 59  
Q580B5           98 IRQVDITVGQWQAEISLAMsl----dPQKE-----------------GPLGEIEYWREKYSTISALYEQINSPEAKLIMK 156  Trypanosoma...
A0DCJ3           83 MDKYEEYIGKWSQTIRQTIlkeasrkTEKN-----------------SALADIMLWRSRSANLSTLYQQLQNPIVAKVRQ 145  Paramecium ...
6_pfamImport      1 CAELDQALDSYITLISRTIdt-----lTKQQ------PSSP------GPLAEVELWRSRYITSSSLLEQLHNPVIPEIIK 63  
Q4Q9Z6          315 YL-----REARSp-LVAQ-WTEMDTNLTEALAEAQENVKYLQSLDTYFDvlY-------SsNLQRIMTIMPTLITNIRMM 380  Leishmania ...
227_pfamImport   68 TL-----EQANS--TYVPaLKTMCKDIDKALSQAEENMQFLGSLLRWFE--Llr----sAdPLPEIIKYIPPLIHTLLLV 134 
178_pfamImport   64 IL-----KTAHS--AIGSgFDYFAHELNDCYEEAKENNKFLSTVLRYFK--Iva----eSdSFEGISKLMPSMYEHLKMI 130 
195_pfamImport   64 VQ-----NKING----LMtPTVE--RLESLLIEAKENNRFLSTCERHFK--Nie----mGaNYQIVIESIVPLMKSLRLI 126 
192_pfamImport   64 WL-----RNASPdsRSLEdFYSRFEELQKLYVEAKDTVRFLSTLERHFK--Sl-----aTgSLKIVAETIAPLLSAIRMV 131 
18_pfamImport    64 TL-----KQLNA--PELEqYNFSVSHLNKQRAEAKDNVRFLTTLERHFR--Hla----qCpSLPQVTEHLPALMNALRMV 130 
8_pfamImport     60 IA-----KEAGC--TSATmIDLTLQQFFRMYSESKDNVKFLGTLDRHFR--TlhsvdpkVgSLQPIIDTLFSMMTALRMV 130 
Q580B5          157 VA-----KEAEC--NSYHlISSTIQQFFRYYAEAKDNVKFLGTLDRHFR--TlhgvtpvTgSLQPIIDTLSSMMTGVRMV 227  Trypanosoma...
A0DCJ3          146 RLqtfleDNQSS----VLeFNGQFAELTKAQAEAKDNVKFLTTLERQFKnlD-------QdGLNGIKETLPSLMNGLKMV 214  Paramecium ...
6_pfamImport     64 IL-----EHIDS--QAVPnFATQMDELDRYVKEAKSNVEFLSLLERHFR--Nl-----eTaPLQTVYNSIPSIMDSLRLI 129 
Q4Q9Z6          381 YTIARYYPtREHMTALFFKITNEIVLACKRAINPSGtrsrIWdm---thDAAslqDLIARLQASAKLNEVYIREYrKAQE 457  Leishmania ...
227_pfamImport  135 WTHSRYYHqPKVFVSLLNSMATEITNIAVRII-GDD----VLk------DPS---SSFHQLKGALKVCATFRGCYlDVKA 200 
178_pfamImport  131 WILSKYYStEERMVSLLERISWQLRQNVMKNLAIKP----LFd--------EpleTVLEKTNAAHKMLKLWKTAYlNTRN 198 
195_pfamImport  127 WMISRHYNnDERMISLMEKIAKVLIDRVKKVNSFQT----LF--------MEgldVVKSRTSNAETLLKLWKQAYlETRH 194 
192_pfamImport  132 WITSRHYNtDEKMQPLMIRIAEQIADRVADAVKPNT----ILl--------GdvsAAGPLVREAKICLDKWQELYmDVRK 199 
18_pfamImport   131 WVISRHFNtDERMVALMERIAWLLCQRVKRSVVPRT----VL--------KKelaTAIELCEQAVALLQGWESSYlATRE 198 
8_pfamImport    131 WIISRFYStEERMVGLLEKIARLIAQKVSEHIDFRT----VL--------TLpseVAKGKVAEGQQCLVKWKAAYkSVQE 198 
Q580B5          228 WIISRYYCtEERMVGLLEKVAKLISQKVSQHIDFHR----IL--------SLpfaEAKAVVTEGQQCLLKWKAAYlGTQE 295  Trypanosoma...
A0DCJ3          215 WIISRHYKeGDKMQNLLQLISEEIADKVESQIKIPQ----LFtlrddlpYEQqleASINLIMQGSEILKSWKDLYhKTKL 290  Paramecium ...
6_pfamImport    130 WITSNYYNnDTIMPPLIERISQQLCDRVQAEIKTSM----LH---------GpldKAIQHTNTAYMVLTHWHERFnETRA 196 
Q4Q9Z6          458 YFL-SHSsssGGRLFDFDElRFLGHFNLFAKRVDKLITVFRKVEQFRLLKSF---H------VDQ-------MASLLPRF 520  Leishmania ...
227_pfamImport  201 KADeINTnicTITDLEGVNpIPLTQIRKFKPRCNDVLELVETIHHFQLLETVaeiGgagtasLDAv------VKDIQETY 274 
178_pfamImport  199 NIE-LSG---KGARWEFEQrRLFKDTDYLAAVSADLHEIAGVLRDF---------YnifgeeLKSivddparIDSIIDRV 265 
195_pfamImport  195 FIE-TSG---RGTRWEFDRkRLFQQTDYMAAISHDINAAVHIIDEF---------NqlyelnLFTvtikpskIAEMKQTM 261 
192_pfamImport  200 KIE-ESE---CDRRWEFDRrKLFSRTEYMSKVCTYLREVVEVINQF---------QrflgpeLKTvtryhkgIDRLNQDV 266 
18_pfamImport   199 TIE-QNG---RDARWEFDRqRLFRRTTYLIRVLNDLRQVAGITQEF---------LnifgneLKKvtgnpqvIQDVVKRV 265 
8_pfamImport    199 EIN-SSE---REQHWNFDErRLFEVTDYMSDRCTDLLEVVETVEYY---------TtvlsaqLKTvltdatdIERILKDV 265 
Q580B5          296 EIN-SSE---REQPWNFNQkRLFETTDYMSDRCTDLLEVIETVEYY---------TmvlgaqLKTvltdtsgIERILKDV 362  Trypanosoma...
A0DCJ3          291 AIE-EEN----LDRWDFTVrTIQERIEYMANRLDELRKVIDTVRKF---------LvflgpnLKKvtgnaqeIDKRIEDV 356  Paramecium ...
6_pfamImport    197 LIE-KSN---HIPRWDFEVsRLFERPTYIHERCRELINIAQKLQEL---------YlilgpeLKSvtnnprvIDETREQV 263 
Q4Q9Z6          521 DEYLGHLRGKTTDILDvHDNNK-FDVEFKIFESRLSELETSMQVAINSSF-ENITSTDNALLLLKKYQkILQSET----- 593  Leishmania ...
227_pfamImport  275 RRAFTSFTSKNMHMLS-TSQDQaFEKSFFDFRITIKELEHQIAGVLKVCF-QQCPSINSQLRLLEVFQgVISREC----- 347 
178_pfamImport  266 GQLLIPIRAAENDAFNeYNRES-WEATMSWFRGEVERLENEAKVFIDECF-NALIRAEDALAMLMKFRaMKTREA----- 338 
195_pfamImport  262 ASLQNSFQTCKFDPFDsTNERA-WVFKMESFSKELFEFEVTSQLYIQDAF-RNIRSPVMGLQLFKNLNmVLERSS----- 334 
192_pfamImport  267 QALARSFDVLGDNGFDeSSAAA-WEKLLANFRQQITVVETKSLRFLDTRF-KNLRSAVGAFTMLKSFStIESRPL----- 339 
18_pfamImport   266 QKLVNFVSELPFEPFDeNNATE-WGASMDAFYEQVAQIETQAVQFIDESF-RSLRSAQGAFEMLQNFQhIRSRET----- 338 
8_pfamImport    266 EKLKRPFGTLTFDPFErRATHN-WQVVFSAFLAAVTSLDHEVSLFINRIFdDDLRSAESAFELLVSFKcIRTRPNrggds 344 
Q580B5          363 ERVKRPFESLTFDPFErKATHN-WQLVFSNFVNMVANLDREVSDFINKIFdDDLRSAESAFELLLSFKcIGSRPQrvgea 441  Trypanosoma...
A0DCJ3          357 KQLITPIVNSPYNFFQkQNAGQ-WKTIYQKFQENQKQIVQKTIDLIDETF-KSLRSAEGAFDLLQNFKsIDTLED----- 429  Paramecium ...
6_pfamImport    264 DNLVSALDPLPYEIFDkRLRSA-WEGSYSRFLSGHNKIQEQLTQLINTSF-KDLRSSEAGLDLLDRFKkVQLAGD----- 336 
Q4Q9Z6          594 --FaaDLESKYLVIFHSYGMELEKDQKTYERYKEDP----PmarHMTPVAGAISWSRQLLRHIKEPMDKFK--------- 658  Leishmania ...
227_pfamImport  348 --VqeQLKDQAEGLLYMLIEEVNQVKTLYQMKDQTP----HmsaHTPPIVNRLLWVKGLQSRISEPVMKLKevfplalkg 421 
178_pfamImport  339 --VheRLAMKFDVIMQQFSKEIDEVEGIFNRGKRNP----PllrYHPPIAGAIYWERQLFHRLKGPILVFQeieelr--- 409 
195_pfamImport  335 --LtkMLNEKLKDISNSFFYQVNKTRQDFEDNFYNP----PlfkSQPPVAGTINWQRFLFVRLKNTLISLLydsdcl--- 405 
192_pfamImport  340 --InaKLREKFVDILQQFGNEVDSVREEFEAGKENP----PlakGYPRVAGSIAWARMSLQRLKESVLQFKcmpaff--- 410 
18_pfamImport   339 --InrQLELKYEDVLAKFAQEVAEVKRIFYEQKADP----PhavNMPPVAGSVKWARSLFERIKSAIIKFQerpsll--- 409 
8_pfamImport    345 ldIsaLLLEKTDRILAQYFTEVENVQRIFQDHKGAP----PltkNQPPVAGAIHWSMSLFQRLKKPIVRFQhegml---- 416 
Q580B5          442 fdTasLLLEKADRILAQFFNEVNRVRNIFVQLKDNP----PltkNQPPVAGAIHWSTSLFQRLKKPIIRFQqegml---- 513  Trypanosoma...
A0DCJ3          430 --IstTLQKKYQEVLFQYKNELKQNQGLFEKGQQStdvslIsskNRPPVAGSISWARSIFYRIKRPVLKFItreetfie- 506  Paramecium ...
6_pfamImport    337 --MkaQMDTKYTDVLEKYSEEVTAIEELYNTQWANP----PilpHHPPVTGRISWARSLFIRMKKPILRLRmhpqit--- 407 
Q4Q9Z6          659 -------Tnrtima----ntkdsKKVIRTYNKVSIALLEFEAIWLDAWKRSIESSKAG-MNATLLVRH--------EGR- 717  Leishmania ...
227_pfamImport  422 digwklrHl-------------yTEVIEKLESLLHLHNRCERVAVESWLTTAEANLSNaTKMPLLVVssqhgelehNLK- 487 
178_pfamImport  410 ------------------dselrAFTFEQYVAVAKQMKAYEDAKFEDFGQKALSLLQGtMRRNVLTKLq-------QQIl 464 
195_pfamImport  406 ------------------sieeaDKLKDTYLTLCKEMKQYSQKKYSEWYEKVDQEMEQlLKSPVLAFPyftqlqkle--- 464 
192_pfamImport  411 ------------------qgndaEVVFTNYLNLARQLVAYQEAVFKKWQVRTSNTVANcLKMNILRRSas---------- 462 
18_pfamImport   410 ------------------eseagRLVSAQYLEVARDIHGYERTLHKEWSLGAEERLPRmLAENVLTLTa-------GPGs 464 
8_pfamImport    417 ------------------rspmgQQVKAKYVEASRKMKDYSTARFLQWREEVRVPVPAsLKWNILRAEpd---------- 468 
Q580B5          514 ------------------nthmgKQVRAKYAEVAQQMKDYATSRFMQWGERVRQGTTAsLKMNIIVKEsd---------- 565  Trypanosoma...
A0DCJ3          507 kkdeqekQenkesknpknlgsqyNEAKNEYRTLAKKLDQFQKEKFESWEKSITEKALQyQKNRILTKHeqpkee------ 580  Paramecium ...
6_pfamImport    408 ------------------saasyKDVKDHYTKVAKLIDKNNQQVFNEWNSKTESIARTaLEKPILRTTk-------GKLy 462 
Q4Q9Z6          718 --------------------------------------LY-VNFDSEINQLIKETRSLMLLg-DVDVPAAAKSLLMQEQK 757  Leishmania ...
227_pfamImport  488 --------------------------------------PMeVNLDPDFICLLSEASLLHkapfNIKLSEPVRTMLRSVDA 529 
178_pfamImport  465 kntelmrg----------------------aillenqiKLtVNFDRKVFDIIREAELLEHL--GFELPAVIREVGIQKDR 520 
195_pfamImport  465 ------------------------------fshrstqnQFkVNFDPYIFEVIMEAKYLAGM--GFNIPESVKTAVLLEQD 512 
192_pfamImport  463 -------------------------------------gKYeVNFAPEMWVVMQEARFLNQMg-GNDIPHTILNVALQKEK 504 
18_pfamImport   465 ngplasastaraassraaalaanvdvipdpsalfnrhtRLkVNYLPELRILMAESKYLDIL--ELQVPEKLVNLTLQDEK 542 
8_pfamImport    469 -------------------------------------gTYkVNFNWSIFDVIRETKYLDRL--GFEIPKAILHITLQDEA 509 
Q580B5          566 -------------------------------------nTYvTNFDIELFNLIREAKYLDRL--GFEVPQEALNVTLQDES 606  Trypanosoma...
A0DCJ3          581 ---------------------------------gswnrRYtVFFQDEFKTLIKETKQLEKM--GYKINQTTINISKLEKE 625  Paramecium ...
6_pfamImport    463 nt---------------------------------eivKHfVNFDPSLQQLINEAKHLERM--GYKLSLDVVNVLLQYPH 507 
Q4Q9Z6          758 --LKVFYNELTFLVKEYERVVgrpgesmrCAIIGITRPLLQPAIQRLDAIIRPGETTLTWTSMNVDTY 823  Leishmania major
227_pfamImport  530 hgLRTLATRLEAVVCKYNEIL--------RTINEFERRLLEGSLVAAQELLRSGLSSYTWSTEETADF 589 
178_pfamImport  521 --LHEDSEAVEKMINQYNDII--------EKFDDADILLLKHTLENVEKHIQPGVTRLNWYSLGINDY 578 
195_pfamImport  513 --FNERILLLKKFLNVFHEEI--------SKVNEVDFMVLEDHIKELFRVVFSGMKRINWRSAGVSDF 570 
192_pfamImport  505 --YIENCGLLDQMLHHLASAR--------DGMPPVQERLLNNHLEKLEKWLQPGLNSLNWTSLGSEEF 562 
18_pfamImport   543 --HHQLQHQLQLVIDRLHGVL--------SSLDAASERLLALHLKQLTICIYPGLTRINWTSLGVADF 600 
8_pfamImport    510 --YHAYVDALNAMLVSFNYEL--------RVLAGPERAILAAEVRELKQALEPGFRDINWTSLSIPDF 567 
Q580B5          607 --YHANVDALKAMLLNFNYELq-------NALEGPERVILARNIRELRQALEPGLHDINWTSLGIPDF 665  Trypanosoma brucei
A0DCJ3          626 --FYGYIDRLQIMLREYDEAV--------HTLQPIEKELLKEKIMKLNRALEPGHESLNLASLGIPDF 683  Paramecium tetraurelia
6_pfamImport    508 --YRKLQRLLETMLADWNQTL--------NSINADEVPIITGCMHAVEEVFSDGASYLNWNSLGVHEF 565 
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