Conserved Protein Domain Family
API5

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pfam05918: API5 (this model, PSSM-Id:310479 is obsolete and has been replaced by 428672)
Apoptosis inhibitory protein 5 (API5)
This family consists of apoptosis inhibitory protein 5 (API5) sequences from several organisms. Apoptosis or programmed cell death is a physiological form of cell death that occurs in embryonic development and organ formation. It is characterized by biochemical and morphological changes such as DNA fragmentation and cell volume shrinkage. API5 is an anti apoptosis gene located in human chromosome 11, whose expression prevents the programmed cell death that occurs upon the deprivation of growth factors.
Statistics
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PSSM-Id: 310479
Aligned: 20 rows
Threshold Bit Score: 550.043
Created: 20-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8GXH2        12 IEKLYEFDERLSESTDK-SQNVQDYEGIIELSKTNIKTKQLGAQLIPRYFKFFTSLATEAFDAYLDIFDEVEVGVRVQAI 90  thale cress
Q9V431         4 IERLYKCYEILSEAGDKiSEHVDEYKEILKAVKGTSKEKRLASQFIGNFFKHFPDLADTAIDAQFDLCEDDDTQIRRQAI 83  fruit fly
Q16MI7         8 IEKLYKNYEILTDAKDKiGEHELEYREILDAVKGSAKEKRLASQFIGKFFKHFPNLAELAIDRQLDLCEDEDAQIRKQAI 87  yellow fever mo...
XP_011414695   4 IETMYQNFGVLADAKEKaGEHEEEFLSILNAVKGSPGEKRLASQFITRFFKYFPSHAGTAINAMFDLCEDDDPMTRKQAI 83  Pacific oyster
EFX89475       4 IDKLYQHYEILNEAKDDiAKHRKEYEDILLAVKGSDKEKKLASQFIAKFAKSFPDLENETIDAMFDLCEDDDVLIRKQAI 83  common water flea
XP_015787483   4 IDKMYDNYNILVDAGDKiTEHEDKYLEILNSVKGSPNEKRLASQFITKFFKHFPAHYNSAIDALLDLCEDDDINIRKQAI 83  two-spotted spi...
XP_003385268   6 VEALYRNYGILADAGDKaGEQTEAFLGLLESAKGSAAVKRLVSGFIAKFARFFPTLEGDIMNVLFDLVEDDESLVRQAAI 85  Amphimedon quee...
ETN60634       8 IEKLYKNYEILSDAKEKiTEHEAEYREILDAVKGSAKEKRLASQFIGKFFKHFPSLANTALDRQLDLCDDVDPQIRRQAI 87  Anopheles darlingi
NP_955834      5 VEELYRNYGILADAKEDlSTHKDAYQVILDGVKGGAKEKRLAAQFIPKFFSSFPELADAAINAQLDLCEDEDVSIRRQAI 84  zebrafish
XP_003529359  11 IEKLYEYGEQLNNAKDK-SQNVQDYQGIIDAAKTSVKAKQLAAQLIPRFYKFFPDLSSPALDAHLDLVEAEELGVRVQAI 89  soybean
Q8GXH2        91 RGLPLFCKDTPDF---ISKIIDVLVQCLNTEEFVERDAVHKALMSLFRQDTKASLTALFKHTEATLst--dEQIREKVLH 165 thale cress
Q9V431        84 KDLPKLCQGNADA---TIRVGDTLAQLLILDDPTELQQVNNSLLAIIKLDTKSSIAGLFQQISTGD-----ETTRERCLK 155 fruit fly
Q16MI7        88 KDLPQLCKDTKEH---TPKIADILAQLLITEDVTELQQVHQSLLTLAKFDATGTLTGIFSQIVSGD-----EPTRYRNFQ 159 yellow fever mo...
XP_011414695  84 KDLPTLCKSAPEQ---VSKIASALTQLMGTDDATENHLIQSSFLTLFKFDSKGSLDGIFSQILGED-----ETVREKAIK 155 Pacific oyster
EFX89475      84 KDLVNICKDNKGA---VRKIAYALAQILQSEDNSEVTAVHNSIASLYQIDPAATIEALFSELAEDN-----EVMRERTLK 155 common water flea
XP_015787483  84 KDLPSICRDCKEY---VPRITDILAQLLLAQDATELQIVNNSLITVCKLDPKGFLGGIFLQIEAGE-----DITRERVIK 155 two-spotted spi...
XP_003385268  86 KSLPELCKNNKSNkdlCTKVADVLTQLLVSDDPADVILVKSAMSTILIHDTPSALIGIFDQILGED-----ETLREKAIE 160 Amphimedon quee...
ETN60634      88 KDLPQLGRESTDH---TPRIADILAQLLGSEDVSELQQVHQSLMTLTKYDALGSLTGIFSQIGTGD-----ETVRDRCFQ 159 Anopheles darlingi
NP_955834     85 KELPRFASGEN-----LPRVADILTQLLQTDDSAEFNQVNTALISIFKIDAKGTLGGLFSQILQGE-----DIVRERAIK 154 zebrafish
XP_003529359  90 RGLPLFCKDTPEN---IGKMVDILVQILGSEEFVERDAVHKALMSLLRQDVKASLTALFKHIGSVEepstdDVIREKVIN 166 soybean
Q8GXH2       166 FIRDKVFPLKGELLKPQQEMERHITDLIKKSL-GDVTGEEFNMFMDFLKSLSIFGGKAPQERMQELVEIIEGQADLDS-- 242 thale cress
Q9V431       156 FIATKLLTMGPTVI--TKEIEDYIVEEIKKAL-QDVTADEFHLCMTILGATKL---GSTITGHAELVKLATEQAELNNtd 229 fruit fly
Q16MI7       160 FILNKLIKIGPEVI--TKEVEDFVIAEIKKIL-LDVSADEFHLCMSILNQTKL---SKTVTGHAELVAIAVEQADMEAd- 232 yellow fever mo...
XP_011414695 156 FLGAKIKTLPEDTLDS--HSEELLINMCKKVL-EDVTKDEFIAIMEILKCQKS---MTTVQGRQQLVDIVTEQAELDE-- 227 Pacific oyster
EFX89475     156 MLAMKLRTLETGVMKP--EVKELLVKECKKIL-QDVTADEFVLVMAILGQCKI---ADSVSGQQQLVDLVAEQCNFTQ-- 227 common water flea
XP_015787483 156 FLAAKIKTLPEDTW--TKEDEEFILAEGRKAL-QDCTKDEFVCLLNLLSSLKI---SKTITAQQVLVDMITEHAELDA-- 227 two-spotted spi...
XP_003385268 161 YVSVPLMDMRHVLFIPKEENEKCLLELVKKVL-GDVTAAEFETFVDVLGKLH---HLQSPEGANVIIDVIAEQAELDG-- 234 Amphimedon quee...
ETN60634     160 FINNKIMKIGPEII--TKPLEDFIIAEIKKALsEDVTADEFHQCMAILGQTKL---SKTLPGHVELVKIAAEQADLDNd- 233 Anopheles darlingi
NP_955834    155 FLSTKLKTMPEDIM--TKEVEDYIFVETKKVL-EDVTGEEFVLLMRILSGLKS---MQTVSGRQQLVELVVEQAFLEQ-- 226 zebrafish
XP_003529359 167 FVRDKVFPIKAELLKPQEEMERHITDLIKKSL-EDVTGIEFRMFMDFLKSLSLFGEKAPAERMKELIGIIEGQADLDA-- 243 soybean
Q8GXH2       243 -EFNVSDTDHIDRFISCLQTALPFFARGAPGSKFLNYLNKNIMPAF--DQLP-E------ERKLNLLRALAEMSPYTTA- 311 thale cress
Q9V431       230 aDIIAVDDEVVERFIQCASAAAPYFSKTIKSTAFVAHVCDKLLPIKtwNMIA-Tavs-qdQIQLRLLKVFAEMITNTDK- 306 fruit fly
Q16MI7       233 lGSLASDDETVERFIQCASEAMPYFSSQVESTQFIKFMCEKLLPLNvwNLIG-Aged-qhTTQLRLLKVFAEMCAFCGS- 309 yellow fever mo...
XP_011414695 228 -PFVASDPDCVDRLTQCIKHAAPLFSKNVHSKAFVGYLCDNVLPHI--DQLA-Sped-gvNGKLELLKLMAEISEFTGE- 301 Pacific oyster
EFX89475     228 -VFNPADQEHLDRIIICIKHALPYFSTQVKSTAFVSYICDQVLPHR--NEIGqS------EQKLDIFKLLAELSSNCGP- 297 common water flea
XP_015787483 228 -PLNPAETEQIEKFTMCVRAAIPHFSPFVPSNAFVQFICSQIIPCM--TEIV-SlaienpNIEVEILQQLAELSAFIQP- 302 two-spotted spi...
XP_003385268 235 -NFQSEGPEAIDRFITCFRLALKYCKKGGSSYQFVRYASVEILPSF--ASITdA------QKQQNVLQLLAEGSCYVQPe 305 Amphimedon quee...
ETN60634     234 pGVLASDDETVERFINCATEAMPYFSSQVESTRFVKFVCEKFLQRNvwSLIG-Aade-hhQTQLRLLKVFAEICPSCGT- 310 Anopheles darlingi
NP_955834    227 -ALNPADTDSVDRLLQCTRQALPLFSKNVHSTRFVTYFCEFVLPNL--SQLT-Spva-elDIQLEVLKLLAEMSPYCGD- 300 zebrafish
XP_003529359 244 -QFNVSDADHIDRLISCLHMALPFVVRGASSNKFLNYINKYIISVF--DQLP-G------ERKVDLLRSLAEFSPYTTP- 312 soybean
Q8GXH2       312 Q------V-ARQILPSIVQLLKKYMPAR--------K----------T--------------G----EEMNFTYVECLLY 348 thale cress
Q9V431       307 L------DnASERINAVYNVLLEYMPLP--------Klsde--dlgdT--------------P----PSFQFSHAECLLY 352 fruit fly
Q16MI7       310 L------EkPAEKVEAIYNVLLEYMPLP--------Pada----dmnE--------------T----PSFQFSHAECLLH 353 yellow fever mo...
XP_011414695 302 Le-----D-LEQRLKNLYDCLISYMPLP--------P----------Eeened----esasgE----PKLAFSSVECLMY 349 Pacific oyster
EFX89475     298 L------DpVVERIQIVYDTLLEYMPLP--------P----------PvleetngdgsttetE----IRLEFTFVESLIF 349 common water flea
XP_015787483 303 TntnlpiN-LDECQEVVFSKLLEYMPSPslstdveeK----------Se-------------E----PSLQLFPLESLMF 354 two-spotted spi...
XP_003385268 306 N------D-VEICLESLHLFLLEHVPSP--------P----------Ee-------------TatesPKLQFSVVECLLF 347 Amphimedon quee...
ETN60634     311 L------EkASEKVQAIYEVLLEYMPLP--------Plda----dlnE--------------T----PSFHFSHAECLLY 354 Anopheles darlingi
NP_955834    301 M------DkLEVNLNMLFEKLLEFMPLP--------PeeengenaanE--------------E----PKLQFSYVECLLF 348 zebrafish
XP_003529359 313 Q------D-SRQMLPSIVQLLKKYMTWK--------K----------T--------------G----EEMNFTYVECLLY 349 soybean
Q8GXH2       349 VLHHLAHKAPNATNSLCGYKIVTGQPSDRLGEDFSEFNKEFTERLTSVEDLTKATMKKLTQGMSEhskaMSTAKTDEEKS 428 thale cress
Q9V431       353 ALHTLGKNHPNSLSF----------------VEDAEKLKDFRARLQYLARGTQGYIKKLEESLKGk--tGEELKTEENQL 414 fruit fly
Q16MI7       354 ALHTLGKQAAEFLTF----------------PEDAAKLKDFRSRLQYLARGTQGYIKKLQESVKGk--tMEEMKSEENQI 415 yellow fever mo...
XP_011414695 350 AFHQLCRKQPSFLAA----------------EENAERLKDFKIRLQYFARGVQVYIKHLRMALQGk--tGTELKEEENKM 411 Pacific oyster
EFX89475     350 AFHQLARQHREFLI------------------DNADRSKDFRSRLQYFARGVQGYIKKLRESLQDk--gVDQLRDEEGRI 409 common water flea
XP_015787483 355 TLYTLSVINPEF-NS----------------KVNEDRMKDYKLRLQYLARLIQSHIKKAKEVPSAd--kKVENEGDDALS 415 two-spotted spi...
XP_003385268 348 AFHQLVNKSPGFLAS----------------PENEERLKELRKRLQYFARGSQTYHNQLQVALKGk--tQLELKEEQNKL 409 Amphimedon quee...
ETN60634     355 ALHTLGKQATEFLTF----------------PDNPAKLKDFRSRLQYLARGTQGYIKKLQEAVKGk--tVEEMKSEENQI 416 Anopheles darlingi
NP_955834    349 SFHQLGKKLPDFLID----------------KVSAEKLKDFKIRLQYFARGLQVYIRQLRVALQGk--tGDALKTDENKI 410 zebrafish
XP_003529359 350 TFHHLAHKVPNATNSLCGYKIVTGQPSDRLGEDFSEHYNDFTERLNNVEEFTRATIKKLTQGMDEnnksMAGAKTDEEKE 429 soybean
Q8GXH2       429 IVktkkqsttTGLRTCNNILAMTKGLHAKAPSFIgNTSVTLSWKEptkVTKP--LAST--------------------TT 486 thale cress
Q9V431       415 KQ--------TALKTTSNINILIRDLFHSPPIF--KHDIVLSWIVpknNk------------------------------ 454 fruit fly
Q16MI7       416 KA--------TALKTTSNISTLIRDLFHTPPSF--KSVIHLSWLPpksKAVV--DAKt---------------------- 461 yellow fever mo...
XP_011414695 412 KV--------AALKITSNINTMIKDLFHSPPSF--KSVITLSWKP---LVKPveKVTP--------------------TK 458 Pacific oyster
EFX89475     410 KV--------TALRTTSNINSLIRDLFRNPPSY--KVNVTLSFKP---TNAS--QAAK--------------------QT 454 common water flea
XP_015787483 416 KA--------IALKTATNINTLVKELFHPKPAS--KSSVTLSWKP---TKTK--SAAIkrtnstadttvaptatkledAT 480 two-spotted spi...
XP_003385268 410 RQ--------MALKMTANISTLIKDFFRNPPTY--NATVQLSWGA---KKID--LGTK--------------------RS 454 Amphimedon quee...
ETN60634     417 RV--------TALKTTSNISTLIRDLFHTPPSF--KSNVQLSWFVpkgKKQQ--QKEA--------------------EE 464 Anopheles darlingi
NP_955834    411 KV--------VALKITNNINVLIKDLFHNPPSY--KSTVTLSWKP---VQKT--EAAA--------------------Ai 455 zebrafish
XP_003529359 430 KIktkkqnatTGLRTCNNILTMTKPLHAKVPSFIgDKRINLSWKE---ATK----AAS--------------------TA 482 soybean
Q8GXH2       487 ---------------GGKRPAng---------------agN-------NVGAKKARVQN--QQQ-------VVNKRSEGI 520 thale cress
Q9V431       455 ---------------LGKRHApitfgeka----aangkdkD-------QEPEKKSRPSNd-qKFysppsgkYSNKVNQs- 506 fruit fly
Q16MI7       462 ---------------TAKRHAaitfee--------ngkphD-------SKGPKHAKSSSgtQKVytppsgkYSGKVQNYS 511 yellow fever mo...
XP_011414695 459 tv------------aGQKR-Tpi---------------tfE-------TNGAGGKKPHKqdRSIyhppsgkFSEKAGTFE 503 Pacific oyster
EFX89475     455 aavavgnestseasgVAKRHApit--------------feS-------SPPKVRVNTDNrvRQPyvvptgkFSANVSA-- 511 common water flea
XP_015787483 481 tn------------aSNPKRKpit-------------apeD-------SESSD---SKKrqRQLyappsgkFSYNFRGGY 525 two-spotted spi...
XP_003385268 455 latpl-----pssnpSKRKLSpir-------------fdeDkssggasGGAAKQRGGRReaRAIynpprrqPVTNGNSFD 516 Amphimedon quee...
ETN60634     465 vk------------aGNKRHApitfdangkagkgaatgggD-------TKGPKQSKPGPgsQKMytppsgkYSGKIHNn- 524 Anopheles darlingi
NP_955834    456 ---------------GQKRRSgedi-----------gataT-------TKKHPTNLPRRdaRQIynppsgkYSASIGN-- 500 zebrafish
XP_003529359 483 pa------------aGAKRPAnaa-------------ngsN-------NIASKKGRGAGglQNQ-------LVNRALEGL 523 soybean
Q8GXH2       521 -SHGggR-Gs-hRGrGRgqgqgrhsgGGGGRGR 550 thale cress
Q9V431       507 ------Y-GnnnRTrQRgg------gGGGGSGG 526 fruit fly
Q16MI7       512 tKNGsgG-GssnGGrRSgg------gGGSGGGG 537 yellow fever mosquito
XP_011414695 504 -SNetrsqgqrgrgggggyrrggwrgrgrgqrw 535 Pacific oyster
EFX89475     512 ------HgAd-sRPrgrggyrggrgyrrggy-- 535 common water flea
XP_015787483 526 -SNNrgrgrgtggfrganrgrnnryskrysy-- 555 two-spotted spider mite
XP_003385268 517 -EGSwkTggggggrggrrggwrsgrgfrrgrgt 548 Amphimedon queenslandica
ETN60634     525 -QQSknG-GsgrRGsVGgn------gGGGGGGG 549 Anopheles darlingi
NP_955834    501 ------F-SyeqRGgFR---------GGRGRGF 517 zebrafish
XP_003529359 524 --SGggR-Gg-mRGrGRg-------wGGRGRGR 545 soybean
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